Modelling of flicker in large real distribution networks has been a challenge until now, due to huge number of flicker sources contributing to total flicker levels in the network. In this paper, voltage flicker is modelled for a large real medium voltage (MV) distribution network. The total flicker is calculated from background flicker resulting from high voltage network and from flicker emission of a large number of sources in the analysed MV network. The flicker emission was modelled by statistical distributions of emission levels. Results of the simulation were compared to flicker measurements from several power quality monitors, installed in the feeders of the analysed MV network. The results show a significant similarity between the model and the measurements. Conclusion of this work is that the voltage flicker can be modelled with sufficient accuracy, even in large real MV networks.

Growth and development are indicators of good health, as well as a mirror of quality nutrition and quality of life. By monitoring growth and development, the relationship between motor abilities and morphological characteristics is recognized. The period of younger school age is characterized by strong growth and development of all anthropological dimensions, especially morphological and motor ones, which differ significantly in children, concerning adults. This transversal research aimed to determine the differences in morphological characteristics and motor abilities between lower primary school students. The research was conducted on a sample of 1233 girls, I - IV grades of primary schools from the area of the City of Tuzla. The sample of variables consisted of a set of 10 tests to assess certain anthropological dimensions (5 morphological and 5 motors), appropriate to the age of the study population. Univariate analysis of variance with multiple comparisons was used to determine the differences in the studied spaces between students of different grades, with the applied post hock Bonferroni test. The obtained results showed that there are statistically significant differences in all applied variables (morphological and motor). between treated groups at the level of significance (p≤0.05). The results of the research draw attention to the importance of early stimulation of morphological-motor development and a healthy lifestyle in female students, which are characterized by regular physical activity and a healthy diet. Optimal levels of motor skills, well-developed fundamental motor skills and a healthy body structure are of great importance for health, quality of life-related to health and overall well-being of younger school-age students.

1Medicinski fakultet, Katedra porodične medicine, Univerzitet u Banjaluci, 2Medicinski fakultet, Katedra porodične medicine, Univerzitet u Sarajevu, 3Medicinski fakultet, Foča, Katedra porodične medicine, Univerzitet u Istočnom Sarajevu, 4Dom zdravlja, Banjaluka, Bosna i Hercegovina Obrazac propisivanja benzodiazepina ambulantnim pacijentima koji nemaju dijagnozu mentalnih bolesti Retrospektivna studija

The aim of this chapter is to enable marketing managers to gain basic knowledge of the capabilities of the latest data management technology, big data, which has the potential of digitally storing huge amounts of data, processing and utilizing the results of processing different types of data, as well as data of different formats in real-time. Due to the enormous potential of implementing the big data, there are also tremendous expectations in terms of the direct financial benefits of its implementation. Realizing all these expectations is a very complex task, which is set to marketing and other managers. The knowledge and skills of managers acquired by education will greatly help to understand the benefits of faster adoption and implementation of new data management paradigms. This chapter emphasizes the differences between the big data concept and conventional data processing technologies, as well as the benefits and potentials that this concept offers, especially when it comes to the process of making quick marketing decisions or making decisions in a reasonably short time.

Autophagy is a dynamic process, conserved in all eukaryotes. It is responsible for the degradation of cytoplasmic content. Autophagy is crucial in cell survival and cell death. It plays a significant role in the cell response to stress, nutrient deficiencies, embryonic development, tumor suppression, response to pathogens and aging. The process of autophagy is also involved in the pathology of human diseases, such as cancer, diabetes, cardiomyopathy, and neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Autophagy is a mechanism that involves degradation of cells, proteins, damaged organelles and pathogens through the lysosomal mechanisms, thus autophagy supports cell survival during starvation, hypoxia and metabolic stress. However, if extensive and/or excessive, autophagy can promote apoptosis (type I) or function as an alternative cell-death pathway, called autophagic cell death (type II). Autophagy can either promote cancer cell death, or serve as a survival mechanism against apoptosis or necrosis induced by various anticancer treatments. Given the contradictory role of autophagy during tumor initiation and progression, the use of autophagy in therapy depends on the context and must be approached individually