Abstract This paper describes the advantages of using data acquisition systems and software modelling tools to support the assessment and therefore redesign of the existing medium voltage switchgear. A 38kV/630A load break linear puffer (LP) will be used as an example for this study. In house testing was conducted to capture important design parameters of the switch such as displacement, velocity of mechanical parts and gas pressure using various sensors and three different measurement setups. The first setup, which is primarily intended for no-load measurements, consists of a DAQ system equipped with different types of sensors - two rotational encoders, three laser-based distance sensors, six pressure sensors, contact separation measurement, and a high-speed camera integrated and synchronized with the measurement system. The second and third setups, which are suitable both for no-load and on-load measurements, are based on state-of-the-art DAQ systems, which use three piezo-electric based pressure sensors, two fibre-optic based pressure sensors, three laser-based distance sensors and a high speed camera synchronized with the measurement system. The data acquired by the measurement systems is used in combination with an in-house developed simulation software HV CB Simulation, which enables simulating and predicting various variables of switching devices. Moreover, high speed camera videos analysed with both commercial and in-house developed image processing software, visualize and reveal many otherwise inaccessible occurrences. In addition to a comprehensive analysis of the proposed data acquisition and simulation setups, three design improvements in the linear puffer design - increase of the opening speed, removal of the flexible conductors and the length increase of the puffer cylinder - are presented and discussed in this paper.

ntroduction: Sleep is one of the most important components of overall health. Children with developmental disabilities are at a higher risk of having sleep problems. Purpose: The goal of the present study is to compare sleep patterns of children with developmental disabilities with those of typically developing children. In particular, we examined whether children with an intellectual disability (ID), children with an autism spectrum disorder (ASD) and typically developing children differ in sleep duration, number of night’s waking, screen time (time spent on smartphones, tablets, TV), and outdoor activities. Methods: The sample for this study consisted of 114 children (34 children with ASD, 40 children with ID and 40 typically developing children) aged 2 to 14 years (mean age= 6.4 years, SD = 3.0). Information on children’s sleep patterns was obtained through an online survey completed by the parents of the children. We also collected information regarding the strategies parents use to settle their children for sleep, as well as information regarding screen time and outdoor activities. Results: The results of this study indicate that sleep duration was shortest for children with ID and longest for children without developmental disabilities. Another finding in this study is that screen time and not the outdoor activities was associated with sleep duration. Children with ASD were more likely to use melatonin to fall asleep, while the children with ID were more likely to use medications. Conclusion: Children with ID have shorter sleep duration than children with ASD and typically developing children. Parents have several cognitive and behavioural strategies at their disposal to improve their children’s sleep.

Miltefosine is an alkylphosphocholine agent with a broad spectrum of antiparasitic properties. For over two decades now, miltefosine remains the first and only oral drug licensed and used in treatment of the neglected tropical disease leishmaniasis. An extensive review on the pharmacology of miltefosine was last published in 2012, while additional data on the clinical pharmacokinetics (PK) and pharmacodynamics (PD) of miltefosine became available in the past decade, along with ongoing and future studies in this area. Miltefosine PK are characterized by slow absorption and elimination resulting in accumulation of drug in plasma until the end of treatment. Several recent studies established exposure-response relationships for various treatment regimens of miltefosine in the treatment of visceral and cutaneous leishmaniasis, leading to the identification of PK parameters predictive of clinical relapse and outcome. This review provides an update on the most recent developments in the area of clinical pharmacology of miltefosine, including a discussion of the current dosing regimens.

Healthcare users and providers increasingly utilize social media to interact with one another. For a future understanding of when and how these interactions supplement or replace offline doctor-patient interactions, it is essential to understand who interacts, about what, and how these interactions can be categorized in a taxonomy. We draw on affordance theory and employ a mixed-methods approach to study social media interactions among healthcare users and providers. We first engage in qualitative content analysis, which is followed by cluster analysis. We identify five archetypal interactions and categorize these in a taxonomy that adds to current literature on how social media is utilized in the healthcare context. We also provide a clear and systematic overview of the interactions in different social media categories that can stimulate future research regarding doctor-patient interactions. Furthermore, we identify a new and distinct type of social media enabled interaction in healthcare, namely lifestyle support, focusing on prevention.

Abstract In recent years, significant achievements have been made with respect to the development of SF6-free gas insulated substations (GIS). In parallel, the interest in installing SF6-free GIS by utilities increased steadily and tenders for new substations or upgrades, which regularly also include alternative technologies. The excellent performance of SF6 was unequivocally accepted by all vendors and users so that the community became used to single technology solutions. This is no longer the case with alternative gas mixtures, and multiple technological solutions are available. However, from the present body of literature it is not possible to make a full and comparative evaluation of different alternative gas switchgear, i.e. circuit-breakers and disconnectors. Thus, the High-Voltage Laboratory of ETH Zürich started investigations and measurements of basic experiments that allow an unbiased comparison of properties of alternative gas mixtures relevant for switching. The two main purposes of these investigations are to define a set of measurements that allow an estimation and comparison of switching performance with different gas mixtures, independent of a specific interruption nozzle geometry, drive system, electrostatic design, and other design specific features, and to perform (some of) these measurements comparing pure SF6, with air, pure CO2, CO2/O2 mixture, and further specific gas mixtures that are currently proposed by manufacturers for SF6 replacement. The basic analysis behind the definition of measurements will be given in detail and the design principles of the chosen test devices and the derived test currents and diagnostics will be introduced. Test results themselves will not be given, rather they will be the subject of separate future publications.

Abstract The importance of the high voltage circuit breaker for the power system’s safe and reliable operation is paramount. This research aims to analyse and provide the most significant high voltage circuit breaker health state indices based on the non-invasive vibration fingerprint measurement method. Results obtained and presented in this paper are validated on the data set acquired from the vacuum circuit breaker.

The data on the relationship on gastroesophageal reflux (GER) and brief resolved unexplained events (BRUE) in infants are scarce. The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in children with suspected GER-related BRUE. Infants hospitalized due to BRUE and who were referred for 24-hour MII-pH monitoring from January 2012 to September 2017 were prospectively included in the study. All children underwent 24-hour MII-pH monitoring using a MIIpH ambulatory system (Ohmega, MMS, Enschede, Netherlands). The impedance recordings were analyzed using criteria described in a consensus statement on indications, methodology and interpretation of combined MII-pH monitoring in children. Twenty-one infants (mean age 4.7 months; range 0.9 to 8.9 months; male/female 10/11) participated in the study. Irregular breathing/apnea associated with GER was found in 10 (52.4%) of infants. Based on RI on pH-metry alone only 7 (33.3%) infants would be diagnosed with GERD. More than 100 GER episodes detected by MII were found in 10 (47.6%) infants. Nineteen percent of infants had GERD diagnosed based on both pH-metry and MII. Acid and non-acid reflux seems to have a significant role in the pathogenesis of GER-related BRUE.