Seila CiloviC-lagarija1, NiNo HaSaNiCa2,3, MilaN radojiCiC4, elMa SokiC-BegoviC5 , Maida MuliC6, BiljaNa MijoviC7 , aida Pilav8, doriS BardeHle9, SaNjiN MuSa1 1Institute for Public Health of FB&H, Sarajevo, Bosnia and Herzegovina 2Institute for Health and Food Safety Zenica, Institute for Public Health, Bosnia and Herzegovina 3Department of Healthcare, Faculty of Medicine, University of Zenica, Bosnia and Herzegovina 4Institute for Public Health of Herzegovina-Neretva Canton, Bosnia and Herzegovina 5Ministry of Health of Federation of Bosnia and Hercegovina 6Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina 7Faculty of Medicine, University of East Sarajevo, Bosnia and Herzegovina 8Institute for Public Health of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina 9Foundation of Men ́s Health Berlin; Germany

Leptin is a hormone secreted from adipose tissue (AT) that plays important role in metabolism of carbohydrate, proteins, and lipids. Also, leptin and its receptors are key regulators of body weight and energy metabolism. Previous studies, demonstrated that plasma leptin improved glucose and lipid metabolisms independently of the food intake reduction by decreasing in blood glucose and insulin levels as well as triacylglycerol stores in the body. Objective of this study was to evaluate the relationship between plasma leptin concentration and lipid profile in healthy and diabetic individuals. Twenty-six participants were recruited in the study, 13 newly diagnosed and non-treated Type 2 diabetes (T2D) patients and 13 healthy controls. Metabolic variables including glucose, glycated hemoglobin, lipids: total cholesterol, triacylglycerol, high density lipoprotein, low density lipoprotein and very low-density lipoprotein, and hormone concentrations leptin and insulin were measured. Plasma leptin concentration was an increased significantly (p<0.001) in diabetic patients compared to controls. Values of other biochemical characteristics were significant different between cases and controls (p<0.001). A significant association was demonstrated between leptin with BMI levels in participants (p<0.05) but not between leptin and lipid levels (p>0.05). Also, strong negative associations were observed between leptin and glucose levels among controls (p<0.009) as well a positive association leptin with HOMA-IS in diabetics (p<0.05). These results suggest that plasma leptin concentrations were affected by the increased levels of glucose, insulin and lipid profile in Bosnian study population. Therefore, leptin can be used as a biomarker of glucose and lipid control in newly diagnosed diabetic patients.

This work sets out the methodology and presents the calculation results of fuel consumption of the BelAz dump trucks at the Open Pit "Turija" of the Brown Coal Mine Banovići itd. based on monitoring data. Properly determined fuel consumption allows the preventive measures and selection of strategy to reduce it. Data collection took six months, the data were analyzed, and thus the results by month of all dump trucks were presented.