ABSTRACT Not being subject to various restrictions common to more formal contexts and thus establishing complete control, users are ready for a considerable investment in the target language use, in this case the English language use, on social sites. Their investment here is motivated by the desire to assume the identity of a global citizen, the identity of unique individuals deserving the attention of the target social group. In that attempt they start playing with language, foreign and multilingual language play presenting appropriate means of creating the desired identity positions. The present study, exploring the use of English by young adult Bosnian speakers on Facebook and Instagram and the reasons underlying it, aimed at investigating the aforementioned claims. Using English the participants tried to show they possess the attributes associated with English as the global language, such as modern, trendy, omnipresent, etc. Moreover, they seemed to find being both local and international, traditional and modern, and above all unique and creative more important than being correct following native-like norms. The study is expected to broaden the understanding of the interrelation between the language use and identity negotiation, and contribute to awakening a stronger interest into the potential of language play.

ABSTRACT The goal of this study is to empirically examine the potential impact of supply chain practices on the supply chain performances of the agro-food industry. The constructs of interest are three-dimensional, including supplier partnerships, customer relationships and level and quality of information sharing, thus representing supply chain practices, flexibility, agility and innovation as the main characteristics of supply chain performance. To gain better understanding of the possible impact of the supply chain practices on the supply chain performances of the agro-food industry we use structural equation modelling. The analysis has revealed statistically significant positive impact of customers’ relationships as well as statistically significant negative impact of a supplier partnership on the supply chain performance. From a theoretical point of view, this study has indicated contribution of different supply chain practices on supply chain performances. The results obtained from this study provide practical implications that assist managers in improving supply chain performance and highlight limitations for implementation of supply chain practice for the improvement of business operations.

ABSTRACT The first generation of installed optical cables in Eastern Europe has been in use for more than 20 years. This paper analyzes the change of optical fibers from the aspect of aging under the influence of transmitted signals and the aspect of parameter degradation during exploration. The paper provides the answer for how to repair the increased attenuation at 1310 nm. We also proposed the method of solution NG PON access for small remote villages that are situated along the analyzed route.

ABSTRACT Introduction There are positive aspects regarding the prescribing of fixed dose combinations (FDCs) versus prescribing the medicines separately. However, these have to be balanced against concerns including increased costs and their irrationality in some cases. Consequently, there is a need to review their value among lower- and middle-income countries (LMICs) which have the greatest prevalence of both infectious and noninfectious diseases and issues of affordability. Areas covered Review of potential advantages, disadvantages, cost-effectiveness, and availability of FDCs in high priority disease areas in LMICs and possible initiatives to enhance the prescribing of valued FDCs and limit their use where there are concerns with their value. Expert commentary FDCs are valued across LMICs. Advantages include potentially improved response rates, reduced adverse reactions, increased adherence rates, and reduced costs. Concerns include increased chances of drug:drug interactions, reduced effectiveness, potential for imprecise diagnoses and higher unjustified prices. Overall certain FDCs including those for malaria, tuberculosis, and hypertension are valued and listed in the country’s essential medicine lists, with initiatives needed to enhance their prescribing where currently low prescribing rates. Proposed initiatives include robust clinical and economic data to address the current paucity of pharmacoeconomic data. Irrational FDCs persists in some countries which are being addressed.

Abstract Cadmium is a heavy metal, toxic even in trace amounts and its biological function in the human body has not been described to date. It is assumed that cadmium manifests in dose-dependent genotoxic and cytotoxic effects on many organs and tissue types. In this study, we have analyzed the biochemical parameters in the serum of Japanese quails (Coturnix japonica) after chronic in vivo exposure to cadmium. Adult animals were exposed to cadmium in the form of CdCl2 dissolved in water (0.20 mg/L) for 20 days. Significant differences between controls and exposed animals were found in 12 out of 13 analyzed biochemical parameters. Total bilirubin concentrations did not show any significant differences between the two groups. Exposure to cadmium has resulted in a significant increase in lactate dehydrogenase activity, sodium and chloride concentration, as well as significant reductions in total proteins, albumins, globulins, glucose, triglycerides, cholesterol, calcium concentration, and alkaline phosphatase activity. In this sense, chronic in vivo exposure to low doses of cadmium has induced severe changes in the levels of observed biochemical parameters and enzyme activity. Additionally, evident cytogenetic changes in the liver were also noted, where hepatocyte damage and even lack of organized nuclei, including nuclear fragmentation, clearly indicated ongoing apoptotic processes.

The aim of this study was to compare cost-utility of tafenoquine (TQ) and primaquine (PQ) for a radical cure (prevention of relapse) of Plasmodium vivax (PV) malaria in Serbia using A five-state, 1-month cycle Markov model. The perspective of Republic Health Insurance Fund was chosen, and the time horizon was 10 years. The model results were obtained after Monte Carlo microsimulation of a sample with 1000 virtual patients. After base case analysis PQ was dominated by TQ, as the net monetary benefit was positive (20,713.84 ± 7,167.46 RSD (99% CI) (174.95 ± 60.54 €)) and incremental cost-effectiveness ratio was below the willingness-to-pay line of 1 Serbian gross national product per capita per quality-adjusted life year gained. Multiple one-way sensitivity analysis and probabilistic sensitivity analysis confirmed the results of the base case simulation. In conclusion, TQ was cost-effective in comparison to PQ for radical cure of PV malaria in socio-economic settings of a South-Eastern European country.

ABSTRACT Introduction: Seizures, which could not be controlled by drug therapy, have profound negative influence on the quality of life of the affected person. If with clear locus of origin and accompanied by loss of consciousness, drug-resistant epilepsy could be treated by surgery. Areas covered: The aim of this article was to review current status of epilepsy surgery through description of the most important operative methods and narrative comparison of their benefits and harms. In total 1154 articles were retrieved from MEDLINE, SCOPUS, EBSCO, and SCINDEKS databases, and 78 included in the review. The review included systematic reviews, meta-analyses, clinical trials, observational studies on humans, case series, and case reports. Expert opinion: Sophisticated diagnostic methods nowadays offer much more precise localization of epileptogenic focus and detailed planning of a surgical procedure which will make minimal damage of neural pathways and structures essential for movements, speech, cognition, and emotions. Advent of perioperative care, and improved diagnostics and surgical techniques resulted with significant drop in rates of postoperative complications, long-term neurological deficit, and mortality in the last decade, while seizure freedom rate and quality of life increased.

Abstract Using a person-centred statistical approach (latent class analysis) this study aims to categorise young citizens in Bosnia and Herzegovina according to their citizenship norms, level of trust in institutions and propensity toward political gender stereotyping. We employed the data from The National Survey of Citizens’ Perceptions in Bosnia and Herzegovina (NSCP-B&H) 2017, which documents the civic attitudes of a nationally representative sample of adults (18+) from Bosnia and Herzegovina. Since this study focuses on the youth, we extracted a sub-sample of 831 young individuals born between 1987 and 2001. Applying latent class analysis, we derived two distinct classes of young citizens with a unique set of beliefs, attitudes, and behaviours related to the role of citizens in modern societies, namely ‘enthusiastic citizens’ and ‘outsiders’. The findings offer valuable insights for policy-makers about the design and implementation of measures that aims to foster active citizenship in the laggard transitional economy. Also, it advances the research agenda on citizenship norms beyond the Western European context.

Abstract This study investigates the impact of perceived formal, informal and regulatory support on entrepreneurial intention. In addition, entrepreneurial capacity and fear of failure are analyzed as predictors of the propensity toward entrepreneurship. An empirical analysis of students in B&H finds that informal support perceived as support of family and friends exert a significant positive influence on entrepreneurial intentions. Fear of failure has a significant adverse impact on entrepreneurial intentions while entrepreneurial capacity enhances entrepreneurial intention. The negative relationship between the fear of failure and entrepreneurial intention is moderated by informal support. In other words, support by family and friends dampens the negative relationship between fear of failure and entrepreneurial intention. The findings were confronted with an ex-post literature review.

Abstract In the present study, several logit models were tested to identify the antecedents of entrepreneurial intention among the youth of Bosnia and Herzegovina (B&H). Specifically, we explore whether demographic and socio-economic characteristic or whether perceptions of education curriculum and social and political engagement as well as the perception of media influence have an impact on the intention to start one’s own business. Data analysis was done on a sample of 3,611 young people. Education level and perception of the standard of living have an impact on the attitude towards self-employment. In addition, the perception of education curriculum and parents support in education is linked with the entrepreneurial intention. Furthermore, some campaigns of social and political engagement are significant predictors of the propensity towards starting the business. Finally, the perception of media influence impacts entrepreneurial intention positively. The findings have important implications for policymakers and universities.

Abstract During radiotherapy treatment for cervical cancer, up to 84% of patients exhibit some form of acute radiation toxicity (ART). The primary aim of this clinical study is to determine the impact of angiotensin-converting enzyme (ACE) inhibitors, β-blockers and other risk factors such as the patient’s anatomical characteristics on ART emergence in patients with locally advanced cervical cancer treated by chemoradiotherapy. This is a combination of two nested case–control studies within the cohort of patients with locally advanced cervical cancer based on the analysis of potential risk factors for the onset of ART in patients treated with 3D conformal radiotherapy (3D-CRT) and 2D conventional radiotherapy (2D-RT), prospectively followed up from January 2017 to September 2018 in a tertiary care hospital. The ACE inhibitors and bladder volume were identified as factors that significantly affect the occurrence of ART in patients treated with 3D-CRT. In patients treated with 2D-RT, the factors that significantly affect the occurrence of ART were ACE inhibitors, body mass index (BMI), brachytherapy rectal and bladder dose. This study has shown that BMI, radiation dose received by the bladder and rectum are of exceptional importance for the occurrence of the ART and also that therapy with ACE inhibitors was associated with the decreased chances of the ART.

Abstract Introduction Aneurysmal subarachnoid hemorrhage is a type of spontaneous hemorrhagic stroke, which is caused by a ruptured cerebral aneurysm. Cerebral vasospasm (CVS) is the most grievous complication of subarachnoid hemorrhage (SAH). The aim of this study was to examine the risk factors that influence the onset of CVS that develops after endovascular coil embolization of a ruptured aneurysm. Materials and methods The study was designed as a cross-sectional study. The patients included in the study were 18 or more years of age, admitted within a period of 24 h of symptom onset, diagnosed and treated at a university medical center in Serbia during a 5-year period. Results Our study showed that the maximum recorded international normalized ratio (INR) values in patients who were not receiving anticoagulant therapy and the maximum recorded white blood cells (WBCs) were strongly associated with cerebrovascular spasm, increasing its chances 4.4 and 8.4 times with an increase of each integer of the INR value and 1,000 WBCs, respectively. Conclusions SAH after the rupture of cerebral aneurysms creates an endocranial inflammatory state whose intensity is probably directly related to the occurrence of vasospasm and its adverse consequences.