The scoring of sleep stages is an essential part of sleep studies. The main objective of this research is to provide an algorithm for the automatic classification of sleep stages using signals that may be obtained in a non-obtrusive way. After reviewing the relevant research, the authors selected a multinomial logistic regression as the basis for their approach. Several parameters were derived from movement and breathing signals, and their combinations were investigated to develop an accurate and stable algorithm. The algorithm was implemented to produce successful results: the accuracy of the recognition of Wake/NREM/REM stages is equal to 73%, with Cohen's kappa of 0.44 for the analyzed 19324 sleep epochs of 30 seconds each. This approach has the advantage of using the only movement and breathing signals, which can be recorded with less effort than heart or brainwave signals, and requiring only four derived parameters for the calculations. Therefore, the new system is a significant improvement for non-obtrusive sleep stage identification compared to existing approaches.

In this text, we analyze the presence of dramatic texts in the teaching of literature based on the previous experiences from the Curricula, as well as the current presence of dramatic texts in the Curriculum for the Sarajevo Canton. In the science and methodology of literature education, the issue of a lack and insufficiency of the dramatic genre in literature teaching has been recognized for a long time. Our objective is to present how dramatic texts may and have to be more present in teaching through more significant inter-subject correlation. Thereby the importance of scene education is emphasized, which is primarily acquired in the literature and language teaching, but it may be applied in the teaching of other subjects as well.

The Bosnian-Herzegovinian drama was occasionally performed on the Czechoslovak and Czech stages. The plots were not systematically translated, nor cultural-artistic contacts were planned, especially when it came to the twentieth century. With the arrival of students in the Czech Republic in the last two decades, systematic translation began, various stage readings were organized and Bosnian-Herzegovinian literature, including drama, began to be published. In the history of Czech theater, Ahmed Muradbegović was the first Bosnian dramatic who was tagged in Czechoslovakia, while the audience could also read contemporary playwrights, which were either published (Bašović, Imširević) or represented by theater agencies (Bukvić, Karahasan, Milenić, Šljivar). Text adaptations of Bosnian authors, dramalets, performances, and various stage events are presented and held in the Czech Republic thanks to the Bosnian community in Prague.

Cyclotides are plant-derived disulfide-rich peptides comprising a cyclic cystine knot, which confers remarkable stability against thermal, proteolytic, and chemical degradation. They represent an emerging class of G protein-coupled receptor (GPCR) ligands. In this study, utilizing a screening approach of plant extracts and pharmacological analysis we identified cyclotides from Carapichea ipecacuanha to be ligands of the κ-opioid receptor (KOR), an attractive target for developing analgesics with reduced side effects and therapeutics for multiple sclerosis (MS). This prompted us to verify whether [T20K]kalata B1, a cyclotide in clinical development for the treatment of MS, is able to modulate KOR signaling. T20K bound to and fully activated KOR in the low μM range. We then explored the ability of T20K to allosterically modulate KOR. Co-incubation of T20K with KOR ligands resulted in positive allosteric modulation in functional cAMP assays by altering either the efficacy of dynorphin A1–13 or the potency and efficacy of U50,488 (a selective KOR agonist), respectively. In addition, T20K increased the basal response upon cotreatment with U50,488. In the bioluminescence resonance energy transfer assay T20K negatively modulated the efficacy of U50,488. This study identifies cyclotides capable of modulating KOR and highlights the potential of plant-derived peptides as an opportunity to develop cyclotide-based KOR modulators.

This paper presents some of our first experiences and findings in the ARPA-E project ReNew100, which is to develop an operator support system to enable stable operation of power system with 100% non-synchronous (NS) generation. The key to 100% NS system, as found in many recent studies, is to establish the grid frequency reference using grid-forming (GFM) inverters. In this paper, we demonstrate in Electro-Magnetic-Transient (EMT) simulations, based on Hawai'i big island system with 100% NS capacity, that a system can be operated stably with the help of GFM inverters and appropriate controller parameters for the inverters. The dynamic security optimization (DSO) is introduced for optimizing the inverter control parameters to improve stability of the system towards N-1 contingencies. DSO is verified for five critical N-1 contingencies of big island system identified by Hawaiian Electric. The simulation results show significant stability improvement from DSO. The results in this paper share some insight, and provide a promising solution for operating grid in general with high penetration or 100% of NS generation.

The COVID-19 pandemic, or better known as the coronavirus pandemic, brought many challenges in education, and one of them was the transition to online teaching, that is. use of information and communication technologies in teaching. Information technology is a term that describes parts (hardware) and programs (software) that allow access to download, organize, manipulate and present information electronically, and communication technology (CT) is a term that describes telecommunications equipment that can send, receive information, search and access them. This research aimed to examine the subjective experience of teachers about personal competencies in the use of information and communication technology in teaching. The population of this research consists of primary school teachers in the area of Tuzla Canton, and the total sample consists of 138 respondents. An anonymous internet survey was used, which is distributed with the help of social networks “Facebook” and a Facebook group called “Prosvjeta TK”, which brings together educators from the Tuzla Canton area. In this paper, we assume that teachers assess their information and communication competencies as positive and they consider themselves competent in their use in the teaching process. It also explores aspects of teachers’ digital competencies as essential competencies for 21st-century education. The paper will provide insight into the personal perception of teachers regarding ICT competence, which is included in the fund of previous knowledge and theoretical knowledge. The results of this research could help understand and analyze further practices, decide on further steps to build teachers’ ICT competencies in and for the future of the school.

Data from clinical trials suggest that CT-confirmed nondisplaced scaphoid waist fractures heal with less than the conventional 8–12 weeks of immobilization. Barriers to adopting shorter immobilization times in clinical practice may include a strong influence of fracture tenderness and radiographic appearance on decision-making. This study aimed to investigate (1) the degree to which surgeons use fracture tenderness and radiographic appearance of union, among other factors, to decide whether or not to recommend additional cast immobilization after 8 or 12 weeks of immobilization; (2) identify surgeon factors associated with the decision to continue cast immobilization after 8 or 12 weeks. In a survey-based study, 218 surgeons reviewed 16 patient scenarios of CT-confirmed nondisplaced waist fractures treated with cast immobilization for 8 or 12 weeks and recommended for or against additional cast immobilization. Clinical variables included patient sex, age, a description of radiographic fracture consolidation, fracture tenderness and duration of cast immobilization completed (8 versus 12 weeks). To assess the impact of clinical factors on recommendation to continue immobilization we calculated posterior probabilities and determined variable importance using a random forest algorithm. Multilevel logistic mixed regression analysis was used to identify surgeon characteristics associated with recommendation for additional cast immobilization. Unclear fracture healing on radiographs, fracture tenderness and 8 (versus 12) weeks of completed cast immobilization were the most important factors influencing surgeons’ decision to recommend continued cast immobilization. Women surgeons (OR 2.96; 95% CI 1.28–6.81, p  =  0.011), surgeons not specialized in orthopedic trauma, hand and wrist or shoulder and elbow surgery (categorized as ‘other’) (OR 2.64; 95% CI 1.31–5.33, p  =  0.007) and surgeons practicing in the United States (OR 6.53, 95% CI 2.18–19.52, p  =  0.01 versus Europe) were more likely to recommend continued immobilization. Adoption of shorter immobilization times for CT-confirmed nondisplaced scaphoid waist fractures may be hindered by surgeon attention to fracture tenderness and radiographic appearance.

Cold Atmospheric Plasma (CAP) is an ionized gas near room temperature. Its anti-tumor effect can be transmitted either by direct treatment or mediated by a plasma-treated solution (PTS), such as treated standard cell culture medium, which contains different amino acids, inorganic salts, vitamins and other substances. Despite extensive research, the active components in PTS and its molecular or cellular mechanisms are not yet fully understood. The purpose of this study was the measurement of the reactive species in PTS and their effect on tumor cells using different plasma modes and treatment durations. The PTS analysis yielded mode- and dose-dependent differences in the production of reactive oxygen and nitrogen species (RONS), and in the decomposition and modification of the amino acids Tyrosine (Tyr) and Tryptophan (Trp). The Trp metabolites Formylkynurenine (FKyn) and Kynurenine (Kyn) were produced in PTS with the 4 kHz (oxygen) mode, inducing apoptosis in Mel Im melanoma cells. Nitrated derivatives of Trp and Tyr were formed in the 8 kHz (nitrogen) mode, elevating the p16 mRNA expression and senescence-associated ß-Galactosidase staining. In conclusion, the plasma mode has a strong impact on the composition of the active components in PTS and affects its anti-tumor mechanism. These findings are of decisive importance for the development of plasma devices and the effectiveness of tumor treatment.

Introduction: Active aging is a process of optimizing of opportunities for health, participation, and safety to improve the quality of life as people age. Therapeutic exercises to strengthen muscles are especially important for the elderly, and the results of such exercises are positive in people with functional limitations. The aim of the study was to assess functional mobility of people in the 3rd age of life after programmed therapeutic exercises.Methods: The prospective study included two groups of 130 respondents over the age of 65 who came to the “Centre for Healthy Aging” in Novo Sarajevo in the period from September 1, 2014, until March 1, 2015. Using the time up and go test (TUG), the basic functional mobility was assessed and it represents the minimum time the respondent needs to get up from the armchair, walk a distance of three meters, turn around, and sit back in the armchair. We tested the respondents at the beginning, in the middle, and at the end of the study, which lasted for 6 months.Results: Analysis of the gender structure of the control and the test groups, using the Chi-square test, found a statistically significant difference, and in the test group, there were more female subjects than in the control group, χ2 = 50.620; p = 0.001. Analysis of the functional mobility of the respondents of the test groups using the TUG at the end of the study found that the respondents of the test group needed statistically significantly less time to perform the test (8.84 seconds) compared to the control group (9.59 seconds) and test Group B (9.41 seconds), F = 4.711; p = 0.041.Conclusion: Programmed therapeutic exercise leads to a significant improvement in functional mobility of persons in the 3rd age of life.

Information communication technologies are evolving rapidly and have huge impact on everyday life. This does not come without dangers, i.e., it is actively followed by wide range of malicious activities that impact the companies forcing them to protect their information at all costs. Cyber attacks today are usually consisting of multiple carefully planned hardly detectable steps causing severe damage to companies. This paper examines the capability of security information and event management (SIEM) system with applied partial rules in detecting the multi-step attacks. Fine tuning was focused on detecting partial attack patterns that were important and specific to environment and positive results were gained. The results show that when using the partial rule approach in SIEM for incident detection, the number of detected advanced multistage cyber attacks has increased, thereby contributing to the overall security in cyber space.

Although functional asymmetry is very common and normal in professional athletes, the better interlimb symmetry between dominant and nondominant sides (bilateral symmetry) could contribute to successful performance in basketball. The aim of this study was to evaluate the importance of bilateral symmetry of the one-leg jumping and agility performances in differentiating basketball players according to their (i) playing position (guards, forwards, and centers) and (ii) performance levels (first division vs. second division). The participants were 102 professional male basketball players, with all members of the teams competing in the two highest national divisions at the moment of testing (height: 194.92 ± 8.09 cm; body mass: 89.33 ± 10.91 kg; 21.58 ± 3.92 years of age). Performance levels (first division, N = 58 vs. second division, N = 44) and playing positions (guards, N = 48; forwards, N = 22; centers, N = 32) were observed as dependent variables. We measured one-leg jumping capacities (running vertical jump and lay-up vertical jump), basketball-specific preplanned agility (CODS), and basketball-specific reactive agility (RAG), all executed on dominant and nondominant sides. Accordingly, the bilateral symmetry of jumping and agility was calculated by calculating the ratio of the corresponding performances on the dominant and nondominant sides. Factorial analysis of variance (performance levels × positions) indicated that the bilateral symmetry of one-leg jumping differentiated players according to their playing position, with better bilateral symmetry among guards (F-test = 6.11 (medium effect size) and 5.81 (small effect size), p < 0.05 for lay-up and running-jump symmetry, respectively). Performance levels significantly differed in the bilateral symmetry of lay-up jump, with better symmetry for first-division players (F-test = 10.11 (medium effect size), p < 0.001), which was mostly influenced by significant differences among guards. Playing positions and performance levels did not differ in bilateral symmetry of the CODS and RAG. The study reveals the importance of bilateral symmetry of the sport-specific performance in differentiating playing positions and performance levels in basketball. Further studies in other multidirectional sports and other sport-specific performances are warranted.

Single seismometer structure Because of the lack of direct seismic observations, the interior structure of Mars has been a mystery. Khan et al., Knapmeyer-Endrun et al., and Stähler et al. used recently detected marsquakes from the seismometer deployed during the InSight mission to map the interior of Mars (see the Perspective by Cottaar and Koelemeijer). Mars likely has a 24- to 72-kilometer-thick crust with a very deep lithosphere close to 500 kilometers. Similar to the Earth, a low-velocity layer probably exists beneath the lithosphere. The crust of Mars is likely highly enriched in radioactive elements that help to heat this layer at the expense of the interior. The core of Mars is liquid and large, ∼1830 kilometers, which means that the mantle has only one rocky layer rather than two like the Earth has. These results provide a preliminary structure of Mars that helps to constrain the different theories explaining the chemistry and internal dynamics of the planet. Science, abf2966, abf8966, abi7730, this issue p. 434, p. 438, p. 443 see also abj8914, p. 388 Data from the InSight mission on Mars help constrain the structure and properties of the martian interior. Clues to a planet’s geologic history are contained in its interior structure, particularly its core. We detected reflections of seismic waves from the core-mantle boundary of Mars using InSight seismic data and inverted these together with geodetic data to constrain the radius of the liquid metal core to 1830 ± 40 kilometers. The large core implies a martian mantle mineralogically similar to the terrestrial upper mantle and transition zone but differing from Earth by not having a bridgmanite-dominated lower mantle. We inferred a mean core density of 5.7 to 6.3 grams per cubic centimeter, which requires a substantial complement of light elements dissolved in the iron-nickel core. The seismic core shadow as seen from InSight’s location covers half the surface of Mars, including the majority of potentially active regions—e.g., Tharsis—possibly limiting the number of detectable marsquakes.