Gallium nitride (GaN) is the main component of modern-day high electron mobility transistor electronic devices due to its favorable electronic properties. As electronic devices become smaller with more complex architecture, the ability to deposit high-quality GaN films at low temperature is required. Herein, we report a new highly volatile Ga(III) triazenide precursor and demonstrate its ability to deposit high-quality epitaxial GaN by atomic layer deposition (ALD). This new Ga(III) triazenide precursor, the first hexacoordinated M–N bonded Ga(III) precursor used in a vapor deposition process, was easily synthesized and purified by sublimation. Thermogravimetric analysis showed single step volatilization with an onset temperature of 150 °C and negligible residual mass. Three temperature intervals with self-limiting growth were observed when depositing GaN films. In the second growth interval, the films were found to be near stoichiometric with very low levels of impurities and epitaxial orientation on 4H-SiC without an AlN seed layer. The films grown at 350 °C were found to be smooth with a sharp interface between the substrate and film. The bandgap of these films was 3.41 eV with the Fermi level at 1.90 eV, showing that the GaN films were unintentionally n-type doped. This new triazenide precursor enables ALD of GaN for semiconductor applications and provides a new Ga(III) precursor for future deposition processes.

Quality of measurement results and their accuracy in not neccessary to be high in conventional systems, approximate results are enough to know exactly what happens in the system. However, with increased penetration of renewable sources in the grid, need for high quality and precise measurements has risen. In order to have precise information about power quality, good knowledge of the behaviour of power quality analyzers is needed. Good knowledge can only be obtained by calibration of those meters. This paper describes start of development of a fully traceable power quality reference setup for the calibration of power quality analyzers based on digital sampling of voltage/current signals, and shown preliminary results.

Juvenile systemic sclerosis (JSSc) is a rare disease of childhood and currently no international consensus exists with regard to its assessment and treatment. This SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) initiative, based on expert opinion informed by the best available evidence, provides recommendations for the assessment and treatment of patients with JSSc with a view to improving their outcome. Experts focused attention not only on the skin assessment but also on the early signs of internal organ involvement whose proper treatment can significantly affect the long-term outcome. A score for disease severity is proposed in order to perform a structured assessment of outcome over time but a validation in a wider patient population is recommended. Finally, a stepwise treatment approach is proposed in order to unify the standard of care throughout Europe with the aim to reduce morbidity and mortality in this disease.

Rad predstavlja javne, građanske apoteke koje su otvorene u Sarajevu u periodu austrougarske vladavine. Uspostavljanjem austrougarske uprave uređuje se apotekarska djelatnost i počinje otvaranje većeg broja javnih, građanskih apoteka. Koncesije za otvaranje apoteke većinom su dobijali stranci, jer domaćih apotekara nije bilo. Prva moderna apoteka u ovom periodu je otvorena 1878, a posljednja 1913. godine. U periodu 1898–1918. u gradu su otvorene samo dvije nove apoteke, a tokom četrdeset godina austrougarske vladavine radilo ih je ukupno sedam. Apoteke su često reklamirane u raznim publikacijama kao dobro snabdjevene svim potrebnim lijekovima i drugim proizvodima, kao što su kozmetika, pića, fotografski pribor. Apotekari su svojim radom doprinijeli unapređenju zdravstvene zaštite u gradu, kao i građanskoj kulturi i opštem razvoju društva zajedno sa svojim savremenicima.

We show a case of endophthalmitis presenting 7 weeks after intravitreal aflibercept injection. An unusual species of viridans streptococci, S. intermedius, was isolated. The case highlights the need to consider infection even in cases of very delayed-onset postinjection inflammation, and the potential wide variability in severity of Streptococcus viridans endophthalmitis. Purpose: Endophthalmitis following intravitreal anti–vascular endothelial growth factor injections is frequently caused by Streptococcus viridans organisms and tends to be aggressive. Herein, we present a case of postinjection Streptococcus viridans endophthalmitis presenting in an atypically delayed fashion with good visual outcome. Methods: Single clinical case report. Results: A 91-year-old woman treated with aflibercept for exudative age-related macular degeneration of the left eye presented to the emergency department with mild pain and visual acuity decline to counting fingers, pigmented anterior chamber cells and vitreous haze 7 weeks after her most recent intravitreal injection. She had no symptoms of systemic infection. The presumptive diagnosis initially was vitreous hemorrhage. Over 10 days of observation, she developed worsening pain and vitritis suggestive of endophthalmitis, leading us to perform vitrectomy with intravitreal vancomycin and ceftazidime. Vitreous biopsy was culture positive for Streptococcus intermedius, a type of viridans streptococcus typically associated with head and neck abscesses. The infection resolved and the patient's visual acuity returned to her baseline of 20/100, with no recurrence of infection after 4 months of follow-up. Conclussion: The virulence of viridans streptococci capable of producing postinjection endophthalmitis may vary widely. Infection ought to be suspected even in cases of delayed-onset intraocular inflammation.

This paper presents a laboratory setup for testing and experimental verification of fault detection methods based on contactless measurement of power line magnetic field. The setup consists of a physical power line model scaled to laboratory conditions with two orthogonal measuring coils installed on one support pole underneath phase conductors. Voltages induced in the coils are amplified and filtered out by using analog electrical circuits and are fed to a digital data acquisition board. The sampled voltages are digitally processed by employing a generalized fault detection method previously developed by the authors. In this paper the main steps for designing the measuring coils, analog amplifying and filtering circuits are described in detail. The developed laboratory setup is verified by experiments for different shunt and series faults.

Optimal sizing of standalone hybrid renewable power supply for mobile telephony base stations is considered in this paper. This task is very complex due to stochastic nature of input variables such as wind speed, solar irradiance, ambient temperature and electric load. Further concern is modeling of the power consumed by cooling devices which is also uncertain variable dependent both on ambient conditions and power dissipation of telecommunication equipment. The realistic behavior of the station both in electrical and thermal terms can be analyzed only by a comprehensive probabilistic simulator. The basic idea of this paper is to systematically vary the main input parameters (rated powers of wind turbine and photovoltaic system along with battery capacity) and to run a Monte Carlo simulation for each considered variant observing the technical and economic indicators. Based on the minimum annual costs, it is possible to choose the best available investment solution. Simple optimization can be extended to multi-objective by adding some additional goals, such as minimizing the operating time of a diesel backup generator. The optimization method is tested on an illustrative example of a base station located in the Mediterranean area.

Dedifferentiation and acquisition of chromosomal instability in renal cell carcinoma portends dismal prognosis and aggressive clinical behavior. However, the absence of reliable experimental models dramatically impacts the understanding of mechanisms underlying malignant progression. Here we established an in vivo genetic platform to rapidly generate somatic mosaic genetically engineerd immune-competent mouse models of renal tumors, recapitulating the genomic and phenotypic features of these malignancies. Leveraging somatic chromosomal engineering, we demonstrated that ablation of the murine locus syntenic to human 9p21 drives the rapid expansion of aggressive mesenchymal clones with prominent metastatic behavior, characterized by early emergence of chromosomal instability, whole-genome duplication, and conserved patterns of aneuploidy. This model of punctuated equilibrium provides a remarkable example of cross-species convergent evolution. Significance To better understand the role of 9p21 in malignant progression, we generated a somatic mosaic GEMM of renal cancer, capturing the histological, genomic and evolutionary features of human disease. With this technology we demonstrated a critica role of 9p21 loss in metastatic evolution of RCC and provide a unique tool for testing new therapeutic treatments.

Manufacturers of self-driving cars need to significantly improve the safety of their products before the series of such cars are deployed in everyday use. A large number of architecture proposals for Automated Driving Systems (ADS) are aiming at addressing the challenge of safety. These solutions typically define redundancy schemes and quite commonly include self-checking pair structures, e.g., commander/monitor approaches. In such structures, the problem of false positive failure detections arises, i.e., the monitor may falsely classify the output of the commander as being faulty. In this paper, we review an ADS architecture for fully automated driving and propose a concept to remove false positives in a systematic way. We formalize our proposal in an abstract model and prove the absence of false positives by-means of k-induction. A reference to a technical report is given that contains a detailed discussion of the proof procedure.

Electrical power systems throughout the world experience an unprecedented transformation. One of the main motivation for this is a transition from conventional power generation technologies towards renewable energy sources (RES). This transformation has numerous positive effects on power systems, environment and social engagements on a global level. However, poorly planned and allocated RES add complexity to power systems operations and can cause numerous challenges. This paper investigates some of the most common parameters used in the RES grid integration process. In particular, the impact of different PV penetration levels on energy losses and transformer current loading in a PV predominated power system are presented. The analysis is performed in DigSILENT® Powerfactory software using quasi-dynamic analysis on a modified IEEE 14 bus system. The results demonstrated that the energy losses could be reduced until the critical point of PV penetration. After the critical point is reached, the energy losses start to grow rapidly. The current loading of the transformers also tend to reduce with the increase in PV penetration until the critical point and rapidly grow after the critical point. In conclusion, results presented in this work demonstrate the importance of appropriate RES integration planning and analysis, which remains an important engineering task.