The optimal diagnostic test in the work-up of suspected acute coronary syndrome (ACS) may differ between men and women. The aim of this study was to compare sex-associated differences between using a diagnostic strategy including early coronary computed tomography angiography (CCTA) and standard of care (SOC). In total, 500 patients who presented with symptoms suggestive of ACS at the emergency department were randomised between a diagnostic strategy supplemented with early CCTA and SOC. Women were generally older than men (mean ± standard deviation 56 ± 10 vs 53 ± 10 years, p < 0.01) and were less often admitted to hospital (33% vs 44%, p = 0.02). Obstructive coronary artery disease on CCTA (> 50% luminal narrowing) was less frequently seen in women (14% vs 26%, p = 0.02), and ACS was diagnosed less often in women (5% vs 10%, p = 0.03). Women underwent less outpatient testing when early CCTA was used in the emergency department evaluation of suspected ACS (p = 0.008). Women had a lower incidence of obstructive CAD on CCTA and were less often admitted to hospital than men. They were subjected to less outpatient testing when early CCTA was used in the emergency department evaluation of suspected ACS.

What are the results of embryo transfer cycles with low mosaic embryos? The clinical and ongoing pregnancy rates were 50%. The results of Amniocentesis were reported as normal karyotype for all the pregnant women. Many current studies, quote the rates of mosaicism in blastocyst biopsies to be higher at 20–30%. Embryonic mosaicism was found to result from mitotic errors occurring after fertilization, occasionally in the first cleavage but more commonly in the second or third cleavage. The increased reporting of mosaicism in embryos has given rise to new challenges in PGS results interpretation and patient counseling. Previously, embryos were diagnosed as either euploid or aneuploid, and in most cases only euploid embryos were considered for transfer. Now, if mosaic embryos are considered to represent a third category of results. Case Report for The results of 10 embryo Transfer Cycles with Low Mosaic Embryos Participants/materials, setting, methods: We are presenting the results of ten embryo transfer cycles with low mosaic embryos at Bahceci BIH IVF Center, Sarajevo BIH, between January 2019 – October 2020. All the patients have been informed by a written informed consent form, and had genetic counseling before embryo transfer. Amniocentesis has been performed for all the pregnant women between 14–18 weeks of the pregnancy as prenatal testing. Out of the total ten patients, 5 had pregnancy, and the 5 other were not pregnant. The average age of the whole group was; 34.0 ± 5.49 years. The average age of the pregnant women was ; 30.6 ± 5.54 years, and 37.40 ± 2.88 years who were not pregnant There are limited number of papers in literature about transferring of the low mosaic embryos. The strength of our presentation is, amniocentesis have been performed as prenatal testing for all the pregnancies. Wider implications of the findings: There were no correlation between the type of low mosaicism and pregnancy. Since all the pregnant women were 35 years of age or less, It was the only factor which is influencing the pregnancy.We hope that, the results of our cases will improve the management protocols for these cases. Not applicable

Abstract STUDY QUESTION What are the data on ART and IUI cycles, and fertility preservation (FP) interventions reported in 2017 as compared to previous years, as well as the main trends over the years? SUMMARY ANSWER The 21st ESHRE report on ART and IUI shows the continual increase in reported treatment cycle numbers in Europe, with a decrease in the proportion of transfers with more than one embryo causing an additional slight reduction of multiple delivery rates (DR) as well as higher pregnancy rates (PR) and DR after frozen embryo replacement (FER) compared to fresh IVF and ICSI cycles, while the number of IUI cycles increased and their outcomes remained stable. WHAT IS KNOWN ALREADY Since 1997, ART aggregated data generated by national registries, clinics or professional societies have been gathered and analyzed by the European IVF-monitoring Consortium (EIM) and communicated in a total of 20 manuscripts published in Human Reproduction and Human Reproduction Open. STUDY DESIGN, SIZE, DURATION Data on European medically assisted reproduction (MAR) are collected by EIM for ESHRE on a yearly basis. The data on treatments performed between 1 January and 31 December 2017 in 39 European countries were provided by either National Registries or registries based on personal initiatives of medical associations and scientific organizations. PARTICIPANTS/MATERIALS, SETTING, METHODS Overall, 1382 clinics offering ART services in 39 countries reported a total of 940 503 treatment cycles, including 165 379 with IVF, 391 379 with ICSI, 271 476 with FER, 37 303 with preimplantation genetic testing (PGT), 69 378 with egg donation (ED), 378 with IVM of oocytes, and 5210 cycles with frozen oocyte replacement (FOR). A total of 1273 institutions reported data on 207 196 IUI cycles using either husband/partner’s semen (IUI-H; n = 155 794) or donor semen (IUI-D; n = 51 402) in 30 countries and 25 countries, respectively. Thirteen countries reported 18 888 interventions for FP, including oocyte, ovarian tissue, semen and testicular tissue banking in pre- and postpubertal patients. MAIN RESULTS AND THE ROLE OF CHANCE In 21 countries (20 in 2016) in which all ART clinics reported to the registry, 473 733 treatment cycles were registered for a total population of approximately 330 million inhabitants, allowing a best-estimate of a mean of 1435 cycles performed per million inhabitants (range: 723–3286). Amongst the 39 reporting countries, the clinical PR per aspiration and per transfer in 2017 were similar to those observed in 2016 (26.8% and 34.6% vs 28.0% and 34.8%, respectively). After ICSI the corresponding rates were also similar to those achieved in 2016 (24% and 33.5% vs 25% and 33.2% in 2016). When freeze all cycles were removed, the clinical PRs per aspiration were 30.8% and 27.5% for IVF and ICSI, respectively. After FER with embryos originating from own eggs the PR per thawing was 30.2%, which is comparable to 30.9% in 2016, and with embryos originating from donated eggs it was 41.1% (41% in 2016). After ED the PR per fresh embryo transfer was 49.2% (49.4% in 2016) and per FOR 43.3% (43.6% in 2016). In IVF and ICSI together, the trend towards the transfer of fewer embryos continues with the transfer of 1, 2, 3 and ≥4 embryos in 46.0%, 49.2%, 4.5% and in 0.3% of all treatments, respectively (corresponding to 41.5%, 51.9%. 6.2% and 0.4% in 2016). This resulted in a reduced proportion of twin DRs of 14.2% (14.9% in 2016) and stable triplet DR of 0.3%. Treatments with FER in 2017 resulted in a twin and triplet DR of 11.2% and 0.2%, respectively (vs 11.9% and 0.2% in 2016). After IUI, the DRs remained similar at 8.7% after IUI-H (8.9% in 2016) and at 12.4% after IUI-D (12.4.0% in 2016). Twin and triplet DRs after IUI-H were 8.1% and 0.3%, respectively (in 2016: 8.8% and 0.3%) and 6.9% and 0.2% after IUI-D (in 2016: 7.7% and 0.4%). Amongst 18 888 FP interventions in 13 countries, cryopreservation of ejaculated sperm (n = 11 112 vs 7877 from 11 countries in 2016) and of oocytes (n = 6588 vs 4907 from eight countries in 2016) were the most frequently reported. LIMITATIONS, REASONS FOR CAUTION As the methods of data collection and levels of reporting vary amongst European countries, interpretation of results should remain cautious. Some countries were unable to deliver data about the number of initiated cycles and deliveries. WIDER IMPLICATIONS OF THE FINDINGS The 21st ESHRE report on ART, IUI and FP interventions shows a continuous increase of reported treatment numbers and MAR-derived livebirths in Europe. Being already the largest data collection on MAR in Europe, efforts should continue to optimize data collection and reporting with the perspective of improved quality control, transparency and vigilance in the field of reproductive medicine. STUDY FUNDING/COMPETING INTEREST(S) The study has received no external funding and all costs are covered by ESHRE. There are no competing interests.

This paper explores the potential use of conductive alginate capsules encapsulating a bitumen rejuvenator as a new extrinsic self-healing asphalt method. The capsules combine two existing self-healing asphalt technologies: (1) rejuvenator encapsulation and (2) induction heating to create a self-healing system that will provide rapid and effective asphalt pavement repair. The work presents a proof of concept for the encapsulation process, which involves embedding the capsules into the bitumen mortar mixture and the survival rate of the capsules in the asphalt mixture. A drip capsule production process was adopted and scaled up to the production of 20l wet capsules at rate of 0.22 l/min. To prove the effectiveness and its ability to survive asphalt production process, the capsules were prepared and subjected to thermogravimetric analysis (TGA) and uniaxial compression Test (UCT). The test results demonstrated that the capsules had suitable thermal characteristics and mechanical strength to survive the asphalt mixing and compaction process. Scanning electron microscopy (SEM) was employed to investigate physiological properties, such as rejuvenator (oil) and iron particle distribution, within the capsules. The electrical resistance tests proved that the capsules were capable of conducting electrical current. The capsules were also tested for their conductive properties in order to determine whether they are capable of conducting and distributing the heat once subjected to induction heating. The results showed that capsules containing higher amounts of iron (alginate/iron powder in a ratio of 20:80 by weight) can efficiently conduct and distribute heat. To prove its success as an asphalt healing system, conductive alginate capsules encapsulating a bitumen rejuvenator were embedded in a bitumen mortar mix. The samples where then subjected to local damaging and healing events, and the degree of healing was quantified. The research findings indicate that conductive alginate capsules encapsulating a bitumen rejuvenator present a promising new approach for the development of an extrinsic self-healing asphalt pavement systems.

The environmental and faunistic research conducted included defining the composition and distribution of caddisflies collected using ultraviolet (UV) light trap at 11 stations along the Cetina River, from the spring to the mouth, and also along its tributaries the Ruda River and the Grab River with two sampling stations each, and the Rumin River with one station. The research was conducted in the period from August 2004 until August 2005 on the Cetina and the Ruda rivers, and from April 2007 to September 2007 on the Grab and the Rumin rivers. A total of 71 caddisfly species and 10,048 individuals were recorded in the study area. Results of the composition and structure of caddisflies were processed with statistical methods using the NMDS analysis. There were differences in the composition of caddisflies in the upper, middle and lower reaches. The paper also presents some ecological features of caddisflies, such as seasonal dynamics and diversity of caddisflies communities. Results of this work contribute to faunistic and ecological knowledge of Croatian caddisflies.

Bosnia and Herzegovina has responded to the COVID-19 pandemic by implementing quarantine and other social distancing measures. These measures, however, have mental, social, and economic consequences on diet and food behaviors. The Bosnian case is particularly pertinent since the country has one of the highest global mortality rates relative to its population. In addition, its health system is fragmented and under-resourced. Consequently, in this study, we analyze the effects of the COVID-19 pandemic on Bosnians’ behaviors relating to food. It is based on an online survey performed during October–November 2020 with 3133 adult respondents. The statistical analysis encompassed descriptive statistics (means, percentages, and frequencies), as well as cluster analysis. The results reveal that the pandemic transformed consumers’ shopping behaviors and food sourcing, reducing shopping frequency and increasing food bought on each trip. Furthermore, there was an increase in the consumption of local food items due to food safety concerns. Additionally, the pandemic improved the awareness of Bosnians towards food with a decrease in food waste. Regarding diets, Bosnians tried to have healthier diets during the pandemic. Therefore, COVID-19 might have opened a ‘window of opportunity’ to promote the shift towards more sustainable food consumption and lifestyles.

The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. Here, we examined the expression of DDR1 in prostate cancer (PCa), and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters. We investigated the association between the expression level and subcellular localization of DDR1 protein and PCa aggressiveness by immunohistochemistry, using tissue microarrays (TMAs) encompassing 200 cases of PCa with various Gleason scores (GS) and pathologic stages with matched normal tissue, and a highly specific monoclonal antibody. DDR1 was found to be localized in the membrane, cytoplasm, and nuclear compartments of both normal and cancerous prostate epithelial cells. Analyses of DDR1 expression in low GS (≤ 7[3 + 4]) vs high GS (≥ 7[4 + 3]) tissues showed no differences in nuclear or cytoplasmic DDR1in either cancerous or adjacent normal tissue cores. However, relative to normal-matched tissue, the percentage of cases with higher membranous DDR1 expression was significantly lower in high vs. low GS cancers. Although nuclear localization of DDR1 was consistently detected in our tissue samples and also in cultured human PCa and normal prostate-derived cell lines, its presence in that site could not be associated with disease aggressiveness. No associations between DDR1 expression and overall survival or biochemical recurrence were found in this cohort of patients. The data obtained through multivariate logistic regression model analysis suggest that the level of membranous DDR1 expression status may represent a potential biomarker of utility for better determination of PCa aggressiveness.

Deep learning is considered one of promising tools to develop intelligent wireless techniques in the fifth-generation (5G) wireless communication systems. However, existing researches are conducted based on the channel datasets in fourth-generation (4G) wireless communications systems. Also, some 5G nonstandard channel dataset generators are proposed for frontier technology research. However, these datasets cannot be applied in real 5G new radio (NR) systems. In this letter, we propose a generalized channel dataset generator for 5G NR systems. Furthermore, this letter also proposes a data sampling scheme called RB replacement, which improves the resolution of the dataset and greatly reduces the size of the dataset. The dataset generator can set different channel parameters according to different needs of users, and also can generate massive multiple input multiple output (MIMO) channel. The data generator is open source at GitHub,1 which can be downloaded and used by researchers for free.1The code of this letter can be downloaded from GitHub link:https://github.com/CodeDwan/5G-NR-data-generato.git.

By using a case-study on a fall-prediction device for elderly patients with orthostatic hypotension we aim to demonstrate how the MAFEIP tool, developed as part of the European Innovation Programme on Active and Healthy Ageing (EIP on AHA), can be used to inform manufacturers on their product development based on a cost-effectiveness criterion. Secondly, we critically appraise the tool and suggest further improvements that may be needed for a larger-scale adoption of MAFEIP within and beside the EIP on AHA initiative. The model was implemented using the MAFEIP tool. Within the tool one way sensitivity analyses were performed to assess the robustness of the model against the relative effectiveness of the fall-prevention device at different price levels. The MAFEIP tool was applied to a novel fall-prediction device and used to estimate the expected cost-effectiveness and perform threshold analysis. In our case study, the device produced estimated gains of 0.035 QALYs per patient and incremental costs of £ 518 (incremental cost-effectiveness ratio £14,719). Based on the one-way sensitivity analysis, the maximum achievable price at a willingness to pay threshold of £20,000 per QALY is estimated close to £900. The MAFEIP allows to quickly create early economic models, and to explore model uncertainty by performing deterministic sensitivity analysis for single parameters. However, the integration within the MAFEIP of common analytical tools such as probabilistic sensitivity analysis and Value of information would greatly contribute to its relevance for evaluating innovative technologies within and beside the EIP on AHA initiative.

Xanthohumol (XN), isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) are important prenylflavonoids present in hops with potential beneficial properties. In this study, we examined differences in the content of XN, IX and 8-PN in hops and beer produced under organic and conventional production regimes. A An ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) method for analysing XN, IX and 8-PN in hops and beer was developed and validated, with LOQ ranging from 0.5 to 10 ng/mL. Finally, we examined 15N/14N and 12C/13C isotope ratios in the hops and beer using isotope ratio mass spectrometry (IRMS). The results show no statistically significant difference in the content of the selected prenylflavonoids between organic and conventionally produced hops and beer—in the whole sample group, as well as between the matched pairs. Stable isotope analysis indicated that only δ15N values are statistically higher in organically produced hops and beer. However, the differentiation according to the type of production could not be made solely based on the δ15N signature, but it could be used to provide supporting evidence.

With stress echo (SE) 2020 study, a new standard of practice in stress imaging was developed and disseminated: the ABCDE protocol for functional testing within and beyond CAD. ABCDE protocol was the fruit of SE 2020, and is the seed of SE 2030, which is articulated in 12 projects: 1-SE in coronary artery disease (SECAD); 2-SE in diastolic heart failure (SEDIA); 3-SE in hypertrophic cardiomyopathy (SEHCA); 4-SE post-chest radiotherapy and chemotherapy (SERA); 5-Artificial intelligence SE evaluation (AI-SEE); 6-Environmental stress echocardiography and air pollution (ESTER); 7-SE in repaired Tetralogy of Fallot (SETOF); 8-SE in post-COVID-19 (SECOV); 9: Recovery by stress echo of conventionally unfit donor good hearts (RESURGE); 10-SE for mitral ischemic regurgitation (SEMIR); 11-SE in valvular heart disease (SEVA); 12-SE for coronary vasospasm (SESPASM). The study aims to recruit in the next 5 years (2021–2025) ≥10,000 patients followed for ≥5 years (up to 2030) from ≥20 quality-controlled laboratories from ≥10 countries. In this COVID-19 era of sustainable health care delivery, SE2030 will provide the evidence to finally recommend SE as the optimal and versatile imaging modality for functional testing anywhere, any time, and in any patient.