Već nekoliko decenija, rak pluća najčešći je uzrok oboljevanja i umiranja od malignih tumora širom svijeta. Kako u svijetu tako i u BiH maligne neoplazme danas su visoko rangirane na listi vodećih uzroka smrti u gdje najveći udio u ukupnom broju čine maligne neoplazme bronha i pluća. Karcinom pluća, histološki gledano može se opisati kao bolest, koja ima mnogo podvrsta, te svaka od njih zahtjeva specifičan oblik terapije. Jedna od najprovjerenijih metoda u liječenju raka pluća je radioterapija. Razvoj informatičkih tehnologija doprinio je napretku medicine kao znanstvene grane, posebno u području radioterapije gdje je tehnološki napredak omogućio poboljšanje preciznosti prilikom zračenja malignih tkiva uz bolju kontrolu okolnog zdravog tkiva. Prilagodba radioterapije respiratornim pokretima oduvijek je bila glavna briga u radioterapiji karcinoma grudnog koša. Pokreti prilikom disanja ne utiču samo na pozicioniranje pacijenta tijekom provođenja terapije, već i na pogreške u procesu planiranja liječenja. Kako bi se riješio ovaj problem i reducirala pojava grešaka, već 1990.–ih godina predlaže se upotreba tehnike respiratornog gatinga. 4D – CT kao opcija je poželjan za procjenu tumorske kretnje i individualiziranje ciljnog volumena i njegovih margina. Dimenzija vremena zajedno sa CT-om čini savršenu 4D tehniku koja minimizira utjecaj respiracijskog kretanja tumora i omogućuje lakše ocrtavanje istog. Korist i rasprostranjenost primjene respiratornog gatinga predstavlja prioritet za poboljšanje kvalitete i rezultata radioterapije. Postizanje lokalne kontrole tumora zahtijeva razumijevanje i uključivanje pokreta tumora u simulaciji, planiranju i isporuci tretmana, što dovodi do višestrukih mogućnosti praćenja kretnji targeta. Tehnike respiratornog gajtinga koriste vanjske uređaje za predviđanje faze ciklusa disanja dok pacijent slobodno diše i omogućava isporuku doze samo u određenim fazama disanja. Isporuka snopa zračenja tehnikom respiratornog gatinga namijenjena je kako bi se ograničila ozračenost tumora koji se kreće tokom disanja, na odabrane dijelove respiratornog ciklusa i na taj način omogućava eskalaciju doze i smanjenje doze na rizične organe. Praćenje respiratornog ciklusa zajedno sa četverodimenzionalnim planiranjem pruža opcije kao što su ozračivanje integrisanog tumorskog volumena uz mogućnost aplikovanja zračenja u trenucima udisaja ili izdisaja. Brojna istraživanja predstavljaju tehniku respiratornog gatinga značajnim izazovom, ali i optimalnom tehnikom za liječenje karcinoma pluća uz znatno smanjenje nuspojava i komplikacija radioterapijskog tretmana.

Cement dust is created as a by-product during the production of cement, and in its composition it contains high concentrations of calcium oxide (CaO), potassium oxide (K2O) and other important micro and macro elements. Due to its composition, it is suitable for correcting the pH of the soil, as well as for the uptake of essential elements by plants. The ability to accumulate essential and non-essential heavy metals also depends on the cultivated plant species, and vegetables show the greatest affinity for these elements. The application of cement dust as a soil additive used to improve the physico-chemical soil properties is examined in the paper. After the addition, the soil was mechanically cultivated and planting of the vegetable crop tomato was carried out. The content of essential elements and heavy metals was determined in the soil, cement dust, and tomato fruits grown on soil with and without the addition of cement dust. Due to the high pH value, high conductivity as well as the high content of CaO, it is very important to examine in real conditions how the addition of cement dust to the soil affects the formation of micro and macro elements as well as the content of heavy metals when growing tomatoes. The results showed that the cement kiln dust is an effective addition to the soil because it is a source of calcium, potassium and other essential elements without affecting the loss of quality or contamination with heavy metals during production.

Background: The pandemic of the new corona virus has taken its toll on the mental health of entire humankind with special impact on vulnerable groups, such as drug users in substitution treatment. Objective: The aim of the study was to determine the impact of the COVID-19 pandemic on mental health in the population of opiate addicts who are on substitution therapy. Methods: The research was conducted in the Institute of Addiction Diseases of the ZE-DO canton on the population of patients addicted to opiates who are included in the substitution therapy program. The sample of 80 patients was randomly selected with respect to the inclusion criteria. An 8-parameter questionnaire with symptoms of anxiety and depressive disorder, ranked by intensity on the Likert scale from 0 to 4, was used as a measuring instrument. The change in these symptoms in the one-year period before the pandemic to the one-year period of the pandemic are compared. The results are analyzed in descriptive statistics using the SPSS program. The statistical significance was monitored by the χ2 test. Results: The results of this research show an apperent statistically significant increase in the symptoms of anxiety and depressive disorder, as well as an increase in drug abuse during the pandemic period compared to the period before it. Conclusion: Results imply the existence of a significant adverse effect of the COVID-19 pandemic on the mental health of treated opiate addicts. This research impose the need to affirm the prevention of further abuse of illegal substances, as well as the introduction of new customized programs through various psychosocial interventions and therapies carried out by psychiatrists and psychologists. Telemedicine presents itself as useful way of intervention and treatment.

Background: The VEPs provide an objective measure of brain function, analyzing integrity of visual processing. With patients affected with schizophrenia, the changes with the implementation of VEP are evident, such as symmetrical deceleration of the impulse (reduction of the amplitude) and the continuance of latency, which points to a degenerative illness, suggesting the presence of optical neuritis or hemianopsia conjoined with mentioned intracranial illness. Objective: The aim of the study was to determine the correlation of l P100 latency and P100 amplitude (µV) between patients with schizophrenia and patients with migraine headache. Visual evoked potentials (VEPs) were applied. Methods: The sample included 80 subjects: a) S group- 40 patients with schizophrenia (21 males; 19 females), b) H group-40 healthy subjects with migraine headache (10 males; 30 females). The study was conducted at the Department of Psychiatry, Neurology and Radiology, University Clinical Center Sarajevo. Results: Our research revealed positive correlations were registered in P100 latency in left view field of both eyes and in P100 amplitude in the region of right eye (p=0.01) in comparison with left eye region (p=0.05) in patients with schizophrenia. Conclusion: Results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing. Our study is useful to initiate new questions and recommendations for further studies, specifically on changes in the occipital lobe in the schizophrenic patient’s brain. Changes in the volume in the occipital lobe are quite evident and further studies are required to better understand how the progressive brain changes affect the structural, functional, and metabolic activities of the occipital lobe in schizophrenia.

Changes in the market, caused by globalization, have led to the fact that many companies needed to adapt their operations. In response to these changes, the concept of supply chain was developed to help companies from procurement to sales of products. This paper examines the effects of supply chains on competitiveness using the example of agro-food companies from the Republic of Croatia. The research was conducted through a questionnaire which included 188 agribusiness companies. The responses were systematized and statistically processed using descriptive statistics, correlation analysis and multivariate regression analysis. The results showed that the effects of supply chains play a major role in determining the competitiveness of agro-food companies. Therefore, it is necessary to improve the effects of the supply chain in these companies in order to improve competitiveness and achieve better results of these companies on the market.