Spatial identity surpasses geographical boundaries of a certain space, and denotes not only physical characteristics of space, but its meaning to people that use it, as well as their intercommunication, which produces new social and spatial meaning. Unless there is an abrupt change in social structure or formal/functional transformation of (un)built environment, we perceive spatial identity as something almost permanent. However, it is in a constant state of change, existing in a present state that relies on our past experiences and contains projections of our future, maintained through constant background processes of disorganization and concomitant organization – in other words, identity is in the state of (perpetual) liminality. Liminality is the product, as well as the initiator of autopoietic processes within identity, which leads to the main premise of this article – (spatial) identity is an autopoietic system. This is analyzed through three chosen aspects of place attachment: ritual, memory and architecture.

Fexofenadine hydrochloride (FFN), (±)-4-[1-hydroxy-4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl] α,α-dimethylbenzeneacetic acid hydrochloride, is a second-generation antihistamine that is used to treat allergies. The drug is highly hydrophobic and slightly soluble in water. Cyclodextrins are widely used to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules.Cyclodextrins can molecularly encapsulate various drugs into their hydrophobic cavity without forming any covalent bonds. Cyclodextrin (CDs), especially ß-Cyclodextrin (ß-CD), are widely used in the pharmaceutical field due to its ability to stabilize drug molecules and taste masking purposes. The phase solubility study was performed according to the method of Higuchi and Connors by adding the fexofenadine hydrochloride in excess to different concentrations of cyclodextrin solutions. Phase solubility study records show that the stability constant and complex stoichiometry of FFN-CD complexes increases linearly with CD concentration. Also, an increase in the concentration of β-cyclodextrin leads to an increase in the aqueous solubility of FFN. Complexes were analyzed by UV-VIS spectroscopy using the calibration curve of FFN. Also, UV-VIS spectra indicate a bathochromic shift which proves that complex formation has occurred.Solid inclusion complexes of fexofenadine/β-cyclodextrin and its derivatives were prepared at the molar ratios of 1:1 by the physical mixing method. Characterization of the complexes was performed by using infrared spectroscopy. 

Introdução: A Candidíase é uma micose provocada pelo fungo do gênero Candida. A infecção pode ocorrer de forma aguda ou crônica, sendo possível apresentar uma fase invasiva sistêmica, correspondente à importante causa de morbimortalidade em neonatos prematuros e em crianças menores de cinco anos em situações graves. Objetivo: O presente estudo objetiva analisar a tendência temporal da taxa de mortalidade por Candidíase em crianças de 0 a 4 anos de idade no Brasil, entre 2010 a 2019. Metodologia: Trata-se de um estudo de séries temporais, de caráter observacional, analítico, longitudinal, retrospectivo e ecológico. Para tal, obtiveram-se as informações do Departamento de informática do Sistema Único de Saúde (DATASUS). Os dados utilizados correspondem ao número de nascidos vivos, disponíveis no Sistema de informações de Nascidos vivos (SINASC), e óbitos de crianças de 0 a 4 anos por Candidíase, disponível no Sistema de Informações sobre Mortalidade (SIM). O cálculo para obtenção da taxa de óbito correspondeu a: (óbitos de 0 a 4 anos ÷ nascidos vivos) x 100.000, para o país, no intervalo de 2010 a 2019. A análise de regressão temporal para a taxa de óbitos de crianças menores de 5 anos por Candidíase foi realizada no software Stata 14.0, utilizando a Regressão de Prais-Winten. Assim, obteve-se a taxa de incremento anual, de modo que a tendência só foi considerada significativa com p-valor < 0,05. Resultado: Após análise dos dados, observou-se no período entre 2010 e 2019 o total de 125 óbitos por Candidíase de crianças com idade inferior a 5 anos no Brasil. A maior taxa de óbitos foi expressa em 2019 (0,63/100.000), enquanto a menor referiu-se ao ano de 2017 (0,31/100.000). Os resultados apresentaram p-valor significante < 0,05 (0,031), com tendência crescente expressando uma taxa de variação média anual positiva de 5,3%, o que evidencia o agravamento do cenário da mortalidade por Candidíase no decorrer do período estudado. Conclusão: A partir desta apresentação, o estudo demonstrou o significativo aumento da taxa de mortalidade da Candidíase em crianças menores de 5 anos, a qual deve ser combatida através da conscientização da sociedade acerca do seu mecanismo de transmissão.

Due to COVID-19 pandemic, there is an increasing demand for mobile robots to substitute human in disinfection tasks. New generations of disinfection robots could be developed to navigate in high-risk, high-touch areas. Public spaces, such as airports, schools, malls, hospitals, workplaces and factories could benefit from robotic disinfection in terms of task accuracy, cost, and execution time. The aim of this work is to integrate and analyse the performance of Particle Swarm Optimization (PSO) algorithm, as global path planner, coupled with Dynamic Window Approach (DWA) for reactive collision avoidance using a ROS-based software prototyping tool. This paper introduces our solution – a SLAM (Simultaneous Localization and Mapping) and optimal path planning-based approach for performing autonomous indoor disinfection work. This ROS-based solution could be easily transferred to different hardware platforms to substitute human to conduct disinfection work in different real contaminated environments.

Introduction: Axial-loaded magnetic resonance imaging (MRI), which can simulate an upright position of the patient may cause a significant reduction of the dural sac cross-sectional area (DCSA) compared with standard MRI, thus providing valuable information in the assessment of the lumbar spinal canal. The purpose of this study was to investigate excessiveness of the change in DCSA and depth of lateral recesses (DLRs) before and after axial-loaded imaging in relation to body mass index (BMI) of the subjects.Methods: Twenty patients were scanned to evaluate DCSA and DLR at three consecutive lumbar spine intervertebral disc levels (L3/4, L4/5, and L5/S1) on conventional-recumbent MRI, and after axial loading were applied.Results: Axial-loaded MRI demonstrates a significant difference of DSCA in comparison to conventional MRI. Furthermore, results show a significant correlation between the DCSA and BMI on level L3/L4, both before and after axial loading MRI. With axial loading, there is a reduction of DSCA of 12.2%, 12.1%, and 2.1% at the levels L3/L4, L4/L5, and L5/S1, respectively. After axial loading has been applied, the depth of the neural foramen has been reduced by an average of 10.1%.Conclusion: Axial-loaded MRI reduces DCSA and DLRs in comparison to standard MRI. Information obtained in this way may be useful to explain the patient’s symptomatology and may provide an additional insight that can influence the treatment decision plan accordingly.

This article presents a comparison of the results obtained using the newly proposed Simple Weighted Sum Product method and some prominent multiple criteria decision-making methods. For comparison, several analyses were performed using the Python programming language and its NumPy library. The comparison was also made on a real decision-making problem taken from the literature. The obtained results confirm the high correlation of the results obtained using the Simple Weighted Sum Product method and selected multiple criteria decision-making methods such as TOPSIS, SAW, ARAS, WASPAS, and CoCoSo, which confirms the usability of the Simple Weighted Sum Product method for solving multiple criteria decision-making problems.

Introduction: The world population is ageing, resulting in increased prevalence of age-related comorbidities and healthcare costs. Limited data are available on intestinal health in elderly populations. Structural and functional changes, including altered visceroperception, may lead to altered bowel habits and abdominal symptoms in healthy individuals and irritable bowel syndrome (IBS) patients. Our aim was to explore age-related changes in gastrointestinal symptoms and underlying mechanisms. Methods: In total, 780 subjects (IBS patients n = 463, healthy subjects n = 317) from two separate studies were included. Subjects were divided into different age groups ranging from young adult to elderly. Demographics and gastrointestinal symptom scores were collected from all participants using validated questionnaires. A subset of 233 IBS patients and 103 controls underwent a rectal barostat procedure to assess visceral hypersensitivity. Sigmoid biopsies were obtained from 10 healthy young adults and 10 healthy elderly. Expression of the visceral pain-associated receptors transient receptor potential (TRP) Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) genes were investigated by quantitative RT-PCR and immunofluorescence. Results: Both elderly IBS and healthy individuals showed significantly lower scores for abdominal pain (p < 0.001) and indigestion (p < 0.05) as compared to respective young adults. Visceral hypersensitivity was less common in elderly than young IBS patients (p < 0.001). Relative TRPA1 gene transcription, as well as TRPA1 and TRPV1 immunoreactivity were significantly lower in healthy elderly versus healthy young adults (p < 0.05). Conclusions: Our findings show an age-related decrease in abdominal pain perception. This may in part be related to decreased TRPA1 and/or TRPV1 receptor expression. Further studies are needed to reveal precise underlying mechanisms and the associations with intestinal health.

ABSTRACT This article situates itself in the theoretical space between the field of genocide, and postcolonial studies, advocating for a closer relationship between the two, particularly in relation to the emerging field of postcolonial genocide. The Rwandan genocide is illustrative of this need, as a case which remains firmly rooted in identity categories that have been imposed on the native populations during the colonial era. The article traces the persistence of the colonial racial hierarchies in Rwanda and the role they played in the Rwandan genocide of 1994. It fosters a particularly significant focus on modernity as the symbolic line that divides the imagined racial categories in the colonial gaze, resulting in a crucial impact of nesting colonialisms in the genocidal rhetoric of the late twentieth century. The Rwandan genocidal project contains within it a desire to fulfil the promise of modernity by facilitating the emergence of an ethnically cleansed nation state, while simultaneously rejecting it as the heritage of violence ridden exploitation colonialism. This paradox of ambivalent modernity presents itself both as a crucial characteristic of the Rwandan genocide as well as a persistent rupture in the formation of contemporary Rwandan identities.

Aims: The aims of this study was to investigate the susceptibility of extended-spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae clinical isolates to antibiotics and essential oils - Origanum compactum, Origanum majorana and Thymus serpyllum. Study Design: Study included 30 isolates of Klebsiella pneumoniae obtained from clinical material provided from the University Clinical Center Tuzla. Place and Duration of Study: Department of Biology, Faculty of Science, University of Tuzla, BiH, between September 2019 to September 2020. Methodology: Antibiotic susceptibility testing was performed by the Kirby-Bauer disk diffusion method. The following commercially available antibiotic discs were used: amoxicillin (30µg), cefalexin (30 µg), gentamicin (10 µg), amikacin (30 µg), imipenem (10 µg), piperacillin (75µg), ampicilin (10 µg), meropenem (10 µg), ciprofloksacin (10 µg), ceftazidim (30 µg), cefotaksim (30 µg), ceftriaxone (30 µg), cefepime (30 µg) and aztreonam (30 µg). The antibacterial effect of the essential oils was tested for ESBL K. pneumoniae isolates using the diffusion method according to Clinical laboratory standards institute (CLSI) guidelines. Results: O. compactum and O. majorana essential oils showed the same antimicrobial activity with 80.0% effect on ESBL K. pneumoniae isolates, Thymus serpyllum EO showed antimicrobial activity of 60.0%. The lowest MIC value had the O. compactum essential oil (MIC 6 mg/ml-10.5 mg/ml), followed by the T. serpyllum (MIC 17.2 mg/ml-43 mg/ml), while the O. majorana essential oil showed MIC values in range from 11 mg/ml to 39 mg/ml. Conclusion: The results of the study showed the exceptional sensitivity of ESBL K. pneumoniae clinical isolates to the essential oils from Origanum and Thymus genera, which highly suggests their potential application in the struggle against these pathogens in the future.

Background On January 30, 2020, the World Health Organization Emergency Committee declared the rapid worldwide spread of COVID-19 a global health emergency. By December 2020, the safety and efficacy of the first COVID-19 vaccines had been demonstrated. However, international vaccination coverage rates have remained below expectations (in Europe at the time of manuscript submission). Controversial mandatory vaccination is currently being discussed and has already been introduced in some countries (Austria, Greece, and Italy). We used the Twitter survey system as a viable method to quickly and comprehensively gather international public health insights on mandatory vaccination against COVID-19. Objective The purpose of this study was to better understand the public’s perception of mandatory COVID-19 vaccination in real time using Twitter polls. Methods Two Twitter polls were developed (in the English language) to seek the public’s opinion on the possibility of mandatory vaccination. The polls were pinned to the Digital Health and Patient Safety Platform’s (based in Vienna, Austria) Twitter timeline for 1 week in mid-November 2021, 3 days after the official public announcement of mandatory COVID-19 vaccination in Austria. Twitter users were asked to participate and retweet the polls to reach the largest possible audience. Results Our Twitter polls revealed two extremes on the topic of mandatory vaccination against COVID-19. Almost half of the 2545 respondents (n=1246, 49%) favor mandatory vaccination, at least in certain areas. This attitude contrasts with the 45.7% (n=1162) who categorically reject mandatory vaccination. Over one-quarter (n=621, 26.3%) of participating Twitter users said they would never get vaccinated, as reflected by the current Western European and North American vaccination coverage rate. Concatenating interpretation of these two polls should be done cautiously as participating populations might substantially differ. Conclusions Mandatory vaccination against COVID-19 (in at least certain areas) is favored by less than 50%, whereas it is opposed by almost half of the surveyed Twitter users. Since (social) media strongly influences public perceptions and views, and social media discussions and surveys are specifically susceptible to the “echo chamber effect,” the results should be interpreted as a momentary snapshot. Therefore, the results of this study need to be complemented by long-term surveys to maintain their validity.

Ḥasan ibn Muṣṭafā al-Būsnawī al-Madanī, Hasan Bošnjak, was born in Medina in the last decade of the 12th century AH, and he wrote in the first half of the 13th century (the end of the 18th and the first half of the 19th century). With regards to the year of Hasan Bošnjak’s death, we might assume that he died in the mid-13th century AH. Analyzing his Divan, we come to the conclusion that he wrote tarihs in different periods of life from 1215/ 1800 to 1247/1831 – approximately in the period of thirty years. We do not come across any tarih written after the year of 1247 H, so based on that we assume that the author died in 1247 H/ 1831 or a year or two after. As a famous muhaddith (an expert on hadith, the tradition of the Prophet) he sang, among other things, about Buhari and Muslim, saying that the Mufti of Medina and later Shaykh al-Islam Ahmed Arif Hikmet commented on the works. The most significant source, after the Qur’an, is the Prophet’s tradition (al-sunnah) based on the Prophet’s words, acts, and tacit approval. From the time of the Prophet s.a.w.s. the writing down of the al-sunnah began, and in the 2nd century AH the intensive work on the codification (al-tadwin) of the Prophet’s tradition based on written and oral sources began. It was the time of flourishing the hadith sciences and in the first half of the 3rd century the greatest hadith experts lived and worked. Hundreds of works were written, among which the best-known are two hadith collections called ṣaḥīḥim. The authors are Abū ‘Abd Allāh Muḥammad ibn Ismā‘īl al-Buẖārī (194 / 810-256 / 870) and Abū al-Ḥusayn Muslim ibn al-Ḥağğāğ ibn Muslim al-Qušayrī al-Naysābūrī (- - 261/875). In Divan by Hasan Bošnjak there are, among other things, four songs, one dedicated to Buhari and three to Muslim. Keywords: Hasan Bošnjak, Buhari, Muslim, hadith, poetics, Islamic tradition.