Information and communication technologies (ICT) such as smart devices, the Internet of Things and wireless sensor networks are gradually being introduced into the health system for early diagnosis and management of certain diseases. The state of the art of the use of these technologies in mental health identified 37 articles published in indexed high impact journals in the period 2003-2021. The snowball sampling method was used to select these papers. From this literature review, it appears that several of these technologies are used to support the early detection of mental disorders. Various systems based on wearable sensor networks, the Internet of Things and pervasive and ubiquitous computing have been designed and implemented in this sense. However, most of the applications are designed for academic purposes. 29% of the papers deal with the use of mobile technology in the detection of mental illness, while 67% have studied other technologies such as wearable sensor networks. 4% of the papers concern the use of web platforms in the detection and assessment of mental health disorders.

In this paper, the influence of the method of production, on the content of vitamin C in the leaf and root of parsley was investigated. The research was conducted during two growing seasons: 2013 and 2014. Three varieties of parsley were used in the research. The experiment included three type of fertilization.: mineral, organic and organomineral. The application of different fertilizers affected the content of vitamin C in the parsley. In both years the research the highest content of vitamin C were recorded with the application of organomineral, then with the application of organic fertilizers. Parsley leaf has a higher content of vitamin C compared to the root.

U Zemaljskome muzeju Bosne i Hercegovine, u Franjevačkome samostanu u Tolisi, zatim muzeju u Doboju, Muzeju Hercegovine u Mostaru kao i drugim muzejskim ustanovama, između mnogobrojnih nalaza, čuva se i određeni broj predmeta koji se mogu uvrstiti u širu skupinu predmeta koji pripadaju pojasnim garniturama, okovima, falerama, dugmadima, pojasnim jezičcima, privjescima, vrhu korice mača te dijelovima kacige. Ovi predmeti u najvećoj mjeri pripadaju dijelu vojničke opreme za remenje, pojaseve, zatim kao dio konjske opreme, cipela, oklopa i drugih dijelova. Navedeni predmeti služili su u praktične svrhe, ali i kao dio dekorativnoga sadržaja. U nekim slučajevima pojedine forme su u odnosu na interpretaciju mogle imati i apotropejsko i profilaktičko značenje. S obzirom na široki spektar predmeta koji su obrađeni, i datacijski okvir je razmjerno širi te se kreće od 1. stoljeća pa do razdoblja kasne antike.

Introduction. The aim of this study was to evaluate the influence of the carbomer concentration (used as the gelling agent, in the range 0.5 - 2.0%) on textural and sensory characteristics of gels with 3% panthenol using sensory analysis as subjective and texture analysis as an objective assessment method. An active substance in the gels was panthenol, which also acted as a neutralizing agent of the carbomer. Participants and methods. Twenty female panelists, aged between 20 and 36, participated in the sensory study and had to fulfill a questionnaire regarding product attributes before, during and after application on the skin. Texture analysis was performed on CT3 Texture Analyzer, after each week for a month, and the following parameters were calculated: hardness cycle 1, hardness cycle 2, cohesiveness, adhesiveness, resilience and springiness. Results. The results showed that gels were stable over time and the structure of the gels was preserved regardless of compression. An increase in hardness and resilience was followed by an increase in the concentration of carbomer, while adhesiveness, cohesiveness and springiness did not differ much among different gels. The same trend was noticed when gels were compared during time. Sensory analysis confirmed findings of texture analysis and showed that with the increment of carbomer concentration, stickiness and density also enhanced, while absorption rate and spreadability decreased. Gel with 1% carbomer was chosen by the majority of panelists as favorite and as a gel they would regularly use. Conclusion. The methods of textural and sensory analysis represent valuable approaches in drug/cosmetic product design because they offer insight in the compliance of patients/consumers.

Introduction/purpose: The paper presents interesting research related to the performance analysis of the picture-wise just noticeable difference (JND) prediction model and its application in the quality assessment of images with JPEG compression. Methods: The performance analysis of the JND model was conducted in an indirect way by using the publicly available results of subject-rated image datasets with the separation of images into two classes (above and below the threshold of visible differences). In the performance analysis of the JND prediction model and image quality assessment, five image datasets were used, four of which come from the visible wavelength range, and one dataset is intended for remote sensing and surveillance with images from the infrared part of the electromagnetic spectrum. Results: The pap 86 er shows that using a picture-wise JND model, subjective image quality assessment scores can be estimated with better accuracy, leading to significant performance improvements of the traditional peak signal-to-noise ratio (PSNR). The gain achieved by introducing the picture-wise JND model in the objective assessment depends on the chosen dataset and the results of the initial simple to compute PSNR measure, and it was obtained on all five datasets. The mean linear correlation coefficient (for five datasets) between subjective and PSNR objective quality estimates increased from 74% (traditional PSNR) to 90% (picture-wise JND PSNR). Conclusion: Further improvement of the JND-based objective measure can be obtained by improving the picture-wise model of JND prediction.

Introduction/purpose: The article presents a model of a slow frequency hopping radio in the case of repeater jamming. The aim is to analyze the effectiveness of repeater jamming to a military tactical slow frequency hopping radio. Methods: It is assumed that the repeater jammer will be successful in detecting signals with slow frequency hopping at each hop and that it will perform successful partial jamming of the intercepted communication. Under partial jamming, it is considered that a certain part of the transmission time of each hop will be jammed. A theoretical analysis of the impact of a repeater jammer on a frequency hopping radio was performed based on the definition of the total probability of error. Various parameters that affect the segment of hop duration under jamming were considered. Results: The obtained results show that high effective jamming is achieved even when a short segment of hop duration is jammed. We discuss the conditions for the repeater jammer to detect the signal during each hop and emit the jamming signal with the required strength. It has been shown that increasing the frequency hopping rate can significantly reduce the effectiveness of the repeater jammer. Conclusion: Repeater jammers are highly effective against slow frequency hopping radio communication systems.

Uvod: Ranije se smatralo da prestanak moždane funkcije nastaje zbog gubitka respiratorne i cirkulacijske funkcije i uistinu gubitak moždane aktivnosti se smatrao ključnom komponentom smrti. Razvojem aparata za održavanje u životu kao što su respiratori i aparati za potporu cirkulaciji, definicija smrti i moždane smrti se počela modifikovati. Korištenjem različitih dijagnostičkih metoda i upotrebom dodatnih testova, došlo je do novih saznanja i do povećanog interesovanja u dijagnostici moždane smrti radi predviđanja ishoda bolesti ili eventualne transplantacije organa kod osoba sa utvrđenom moždanom smrti. Cilj: Utvrditi značaj kompjuterizirane tomografije (CT) kod potvrđivanja moždane smrti. Prikazati ulogu BA radioloških tehnologija u dijagnostici moždane smrti CT-om. Metode: Sistematska pretraga literature preko internet pretraživača PubMed. Uključeni su članci u kojima je pisano o moždanoj smrti, dokazivanju moždane smrti, te primjeni dijagnostičke CT-a, u periodu između januara 1996. i juna 2022. godine Rezultati: Pronađeno je 10 naučnih članaka koji su razmatrali moždanu smrt, dijagnostičke metode kod dokazivanja moždane smrti te primjenu i prednosti pojedinih metoda u dokazivanju moždane smrti. Zaključci: CT je metoda koja se koristi za potvrđivanje moždane smrti jer pokazuje izostanak opacifikacije kortikalnog segmenta srednje cerebralne arterije u obje hemisfere te odsustvo pojačanja unutrašnjiih vena koji se ujedno smatraju i najboljim CT kriterijem kod moždane smrti.

Background: HIV-positive patients may present lung infections differently, which may hinder differential diagnoses and the choice of treatment in the course of COVID-19, especially in countries with limited access to high standard healthcare. Here we aim to investigate the association between radiological changes and poor COVID-19 outcomes among HIV-positive patients from Central and Eastern Europe. Methods: Since November 2020, the Euroguidelines in Central and Eastern Europe Network Group started collecting observational data on HIV and COVID-19 co-infections. In total, 16 countries from Central and Eastern European submitted data (eCRF) on 557 HIV-positive patients. The current analyses included patients who had a radiological examination performed. Logistic regression models were used to identify the factors associated with death, ICU admission, and partial recovery (poor COVID-19 outcomes). Factors that were significant in the univariate models (p<0.1) were included in multivariate model. Results: Radiological data were available for 224 (40.2%) patients, 108 (48.2%) had computed tomography, and 116 (51.8%) had a chest X-ray. Of these, 211 (94.2%) were diagnosed using RT-PCR tests, 212 (94.6%) were symptomatic, 123 (55.6%) were hospitalized, 37 (16.6%) required oxygen therapy, and 28 (13.1%) either died, were admitted to ICU, or only partially recovered. From the radiologist’s description, 138 (61.6%) patients had typical radiological changes, 18 (8.0%) atypical changes, and 68 (30.4%) no changes. In the univariate models, CD4 count (OR=0.86 [95% CI: 0.76–0.98]), having a comorbidity (2.33 [1.43–3.80]), HCV and/or HBV co-infection (3.17 [1.32–7.60]), being currently employed (0.31 [0.13–0.70]), being on antiretroviral therapy (0.22 [0.08–0.63]), and having typical (3.90 [1.12–13.65]) or atypical (10.8 [2.23–52.5]) radiological changes were all significantly associated with poor COVID-19 outcomes. In the multivariate model, being on antiretroviral therapy (OR=0.20 [95% CI:0.05–0.80]) decreased the odds of poor COVID-19 outcomes;while having a comorbidity (2.12 [1.20–3.72]), or either typical (4.23 [1.05–17.0]) or atypical (6.39 [1.03–39.7]) radiological changes (vs no changes) increased the odds of poor COVID-19 outcomes. Conclusions: Among HIV patients diagnosed with symptomatic SARS-CoV-2 infection, the presence of either typical or atypical radiological COVID-19 changes independently predicted poorer outcomes.

Evidence-based Clinical Guidelines (CGs) for Good Clinical Practice (GCP) have emerged to synthesize and systematize a wealth of knowledge from scientific journals that health professionals have been unable to follow. Today, the COVID 19 pandemic requires them more than ever. CGs are defined as a set of systematized claims, based on a systematic analysis of scientific evidence, that point to the performance of GCP; contain an assessment of the usefulness and harmfulness of various diagnostic and therapeutic options. "The Good": CG is necessary for health professionals, patients and society, because the knowledge gained in studies is insufficient to perform GCP in further practice. "The Bad": The shortcomings of the CG stem from; (a) there are still many unknowns in medicine, as funding for scientific research is inadequate; (b) the disunity of different institutions that make recommendations at the global, even local level results in different guidelines, although they are based on identical scientific papers as evidence; (c) most clinical scientific studies exclude groups of patients that make up a significant population in everyday practice and the guidelines more or less (do not) apply to them; (d) the impossibility of implementing the CG, because they are not backed by state regulatory bodies and / or the economy cannot follow them. "The Ugly": (a) the ambition of a large number of practitioners and researchers to be among the authors of the guidelines, although many do not have competence for the subject matter; (b) industry (equipment, drugs, supplements) most often funds scientific research and the interdependence of industry and the "dependence" of the authors of guidelines is often intertwined; and (c) publishing (un) intentionally falsified study results which then serve to "support" some guidelines. often in (un) intentional alliance with the editors of the world's elite medical journals.

The traditional concept of drug discovery is based on the occupancy-driven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions. Therefore, proteins that do not have such binding sites are generally considered as pharmacologically intractable. Furthermore, drugs that act in this way must be administered in dosage regimens that often result in high systemic drug exposures in order to maintain sufficient protein inhibition. Thus, there is a risk of off-target binding and side effects onset. The landscape of drug discovery has been markedly changed since PROTAC (PROteolysis TArgeting Chimera) molecules emerged twenty years ago as a part of event-driven pharmacology model. These are bifunctional molecules that harness the ubiquitin-proteasome system, and are composed of a ligand that binds protein of interest (POI), a ligand that recruits E3 ubiquitin ligase and a linker that connects these two parts. Pharmacologically, PROTAC s bring POI and E3 ubiquitin ligase into the close proximity, which triggers the formation of a functional ternary complex POI-PROTAC -E3 ubiquitin ligase. This event drives POI polyubiquitination and subsequent degradation by the 26S proteasome. The development and exceptional properties of PROTAC molecules that brought them to clinical studies will be discussed in this paper.

The line graph L(G) of a graph G is defined as a graph having vertex set identical with the set of edges of G and two vertices of L(G) are adjacent if and only if the corresponding edges are incident in G. Higher iteration L i(G) is obtained by repeatedly applying the line graph operation i times. Wiener index W(G) of a graph G is defined as the sum of distances which runs over all pairs of vertices in G. The problem of establishing the extremal values and extremal graphs for the ratio W(L i(G))/W(G) was proposed by Dobrynin and Melnikov [Mathematical Chemistry Monographs, Vol. 12, 2012, pp. 85-121]. In this paper we establish the maximum value and characterize the extremal graphs for i = 1. In doing so, we derive unexpectedly an interesting relation that involves the Gutman index and the first Zagreb index.