Comparing portfolio performance is complex due to the fact that each model is dominant in its own risk space. Since there is no single dominant performance measure, the research problem is how to incorporate several different measures into a performance evaluation model that allows portfolios to be ranked. In this regard, the objective of this study was to develop a new comprehensive method for comparing portfolio performance based on multiple-criteria decision-making (MCDM). This paper proposes an integrated approach for stock market decision making that combines the Analytic Hierarchy Process (AHP) and the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE), which allow hierarchical evaluation of a finite number of alternatives according to different criteria. This hybrid approach is especially advantageous, utilizing the strengths of both individual methods. AHP enables the decomposition of a complex problem into its constituent parts and the determination of weights for criteria, while the PROMETHEE method allows the investor to determine the preference function, complete ranking, and analysis of the robustness of the results. For the MCDM model in this study, different dimensions of performance measures are considered criteria: return measures, risk measures, stability measures, and predictability measures. The methodology has been applied in comparing real portfolios selected on the basis of different risk measures. For this purpose, weekly return data were used for a sample of stocks that are components of the STOXX Europe 600 Index for the period 2000–2020. In addition, a sensitivity analysis is performed to investigate the strength of the results of this method. It suggests that the simultaneous consideration of different performance measures and the investor’s attitude towards the importance of these measures are notably important in the portfolio efficiency estimation process.

Malassezia is a lipophilic yeast that is a part of the human mycobiome. Malassezia folliculitis appears when the benign colonization of the hair follicles, by the Malassezia yeasts, becomes symptomatic with pruritic papules and pustules. Although Malassezia folliculitis is common in hospital departments, diagnosing and treating it varies among dermatologists and countries. The European Academy of Dermatology and Venereology Mycology Task Force Malassezia folliculitis working group has, therefore, sought to develop these recommendations for the diagnosis and management of Malassezia folliculitis. Recommendations comprise methods for diagnosing Malassezia folliculitis, required positive findings before starting therapies and specific treatment algorithms for individuals who are immunocompetent, immunocompromised or who have compromised liver function. In conclusion, this study provides a clinical strategy for diagnosing and managing Malassezia folliculitis.

With the rise in the number of robots in our daily lives, human-robot encounters will become more frequent. To improve human-robot interaction (HRI), people will require explanations of robots' actions, especially if they do something unexpected. Our focus is on robot navigation, where we explain why robots make specific navigational choices. Building on methods from the area of Explainable Artificial Intelligence (XAI), we employ a semantic map and techniques from the area of Qualitative Spatial Reasoning (QSR) to enrich visual explanations with knowledge-level spatial information. We outline how a robot can generate visual and textual explanations simultaneously and test our approach in simulation.

Selenium (Se) is a nonmetal that is essential for humans and other animals, and is considered beneficial for plants. The bioavailability of Se strongly influences its content in the food chain. Soils are the main source of Se, and their Se content primarily influences its availability, along with other soil properties. A field survey was conducted on soils of Southeast Europe, specifically in Croatia (Osijek), Bosnia and Herzegovina (Sarajevo, Banja Luka, Mostar, and Prud), and Serbia (Novi Sad). Soil samples were taken from the arable soil layer (0–30 cm depth), and two types of Se availability were measured: Se extracted using pure HNO3 (SeTot) and Se readily extracted in water (SeH2O). Only soils from the Mostar area had Se concentrations above deficit levels (0.5 mg kg−1), with the highest values of cation exchange capacity (CEC), soil organic matter (SOM) measured as loss of ignition (LOI), total C, total N, ZnTot and CdTot. The connections between the chemical characteristics of the soil and SeH2O were investigated. Principal component analysis (PCA) explained 73.7% of the variance in the data set in the first three principal components (PCs). Using the provided data, we developed a partial least squares (PLS) regression model that predicted the amount of SeH2O in the soil, with an accuracy ranging from 77% to 90%, depending on the input data. The highest loadings in the model were observed for LOI, CEC, total C, total N, and SeTot. Our results indicate the need for biofortification in these key agricultural areas to supplement the essential dietary requirements of humans and livestock. To efficiently and economically implement biofortification measures, we recommend utilizing regression models to accurately predict the availability of Se.

This study aimed to assess the efficiency of ketamine and medetomidine by two different doses and routes on anesthesia depth and cardiac stability in red-eared sliders. Each turtle was anesthetized two times, with seven days wash-out period. Induction of anesthesia consisted of a bolus combination of ketamine (10 mg/kg) and medetomidine (0.2 mg/kg) administered in the left brachial biceps in the intramuscular protocol, or a bolus combination of ketamine (20 mg/kg) and medetomidine (0.2 mg/kg) administered in subcarapacial sinus after clear blood presence confirmation in the intravenous protocol. Vital signs, reaction on the skin palpation, manual mouth opening for endotracheal intubation, palpebral and cloacal reflex, and the withdrawal reflex of the front and hind limbs were measured and recorded every 5 minutes for 60 minutes after anesthesia injection. Atipamezole (1 mg/kg) was administered in the right brachial biceps one hour after ketamine and medetomidine administration. Needle insertion and possible painful reactions to drug administration were also evaluated and recorded. Obtained data were analyzed for normality and paired t-tests, Wilcoxon, or McNamar tests were performed where appropriate. The values of P ≤ 0.05 were considered significant. A significantly less pronounced decrease in heart rate was observed with intravenous anesthesia protocol. Both protocols recorded complete anesthesia recovery 60 minutes after intramuscular atipamezole administration. A ketamine-medetomidine dose combination administered intravenously provides a more stable and consistent anesthetic plane in red-eared sliders than ketamine-medetomidine administered intramuscularly.

Introduction: The COVID-19 pandemic and the restrictions from routine life habits had a tremendous impact on psychological and physical health of youth. It is known that stress, anxiety and depression can be associated with the development of gastrointestinal (GI) symptoms and known to exacerbate present GI symptoms. The pandemic has forced many changes in the behavior of student population such as the studying in an asocial environment. The aim of this study was to examine and quantify the influence of stress onto the quality of life and GI symptoms in the student population in Bosnia and Herzegovina (B&H), before and during the pandemic lockdown. Methods: A total of 279 students from B&H were assessed for their GI and emotional status in pre-COVID period and during the COVID period using validated instruments: GI symptom rating scale (GSRS), Visceral Sensitivity Index, and the Patient Health Questionnaire 15-item Somatic Symptom Severity Scale. Results: The results showed that moderate and severe GI symptoms were more frequently present among student population at the time of the pandemic than in period before pandemic. The most pronounced symptoms were bloating syndrome and abdominal pain syndrome according to the GSRS. Conclusions: We concluded that concern for one’s health and changed way of life are directly related to a worsening of the symptoms of GI disorders in the student population. Further research should go in the direction of early prevention of GI disorders that take root in early youth and later develop into chronic forms.

The 16s-rRNA consists of hypervariable regions (V1 – V9) that demonstrate considerable sequence diver-sity among different bacteria. Species-specific sequences within a given hypervariable region constitute useful targets for diagnostic assays and other scientific investigations. Usually, the size of the gene region is 1500 bp, which is large enough to be analyzed using bioinformatic tools and applied for detection. The need to advance the knowledge of the 16s-rRNA gene segments in bacterial strains would allow better understanding and better diagnostic possibilities when dealing with them. This could also be the basis for investigation of pathogenic microorganisms.

Understanding consumers’ behavior and their handling of high-risk foods at home is essential for reducing the number of foodborne illnesses. This study shows the results of a cross-national analysis of consumers’ perception from nine countries, and the identification of customers’ clusters and its characteristics in order to understand customers’ behavior, and to build safe chilled ready-to-eat (RTE) foods prevention strategies. The cluster analysis resulted in two clusters: (1) “Precautious consumers” characterized by the orientation towards pre-packed RTE foods, with consumers mainly coming from Bosnia and Herzegovina, India, Poland, Portugal, Spain, and Turkey. Their attitudes and self-reported practices may be categorized as less risky in terms of food-borne illnesses connected with the consumption of RTE foods; (2) “Unconcerned consumers” preferred cutting and slicing RTE foods freshly at the point of purchase, usually sold at the delicatessen department in a supermarket or at open markets. Those consumers mostly came from Croatia, Serbia and Slovenia and their attitudes and self-reported practices were riskier. These results allow a better understating of what characterizes consumers of RTE foods in different countries.

This study investigates the genetic diversity and relatedness among a small local population in Bosnia and Herzegovina. In a genetic research study, a sample of 38 individuals was collected from the village of Vukotići, consisting of 21 male and 17 female subjects. The total genomic DNA was extracted using a mod-ified Miller protocol. The QUANTIFILER DNA identification kit was used to quantify the total human DNA in the sample. The sibship relationship was assessed by computing the likelihood ratio for each of the 15 STR loci in both relatives and non-relatives. Results showed a higher homogeneity of the small local population compared to the mixed population within the larger population. Variability in peak height ob-served in the genetic analysis was attributed to differences in DNA concentration in the extracted samples. Probability of relatedness among participants in the Vukotići village was found to be low. Central tendency and variability measures revealed valuable insights into sample distribution and variation. The study con-cludes that CSI=1 and CSI=3 can be used as reliable tools to determine sibship in small local populations without a "gray zone".

Background The ADAMTS7 locus was genome-wide significantly associated with coronary artery disease (CAD). Lack of the extracellular matrix (ECM) protease ADAMTS-7 was shown to reduce atherosclerotic plaque formation. Objective To identify molecular mechanisms and downstream targets of ADAMTS-7 mediating risk of atherosclerosis. Methods Targets of ADAMTS-7 were identified by high-resolution mass spectrometry of atherosclerotic plaques from Apoe-/- and Apoe-/-Adamts7-/- mice. ECM proteins were identified using solubility profiling. Putative targets were validated using immunofluorescence, in vitro degradation assays, co-immunoprecipitation, and Förster resonance energy transfer (FRET)-based protein-protein interaction assays. ADAMTS7 expression was measured in fibrous caps of human carotid artery plaques. Results In humans, ADAMTS7 expression was higher in caps of unstable as compared to stable carotid plaques. Compared to Apoe-/- mice, atherosclerotic aortas of Apoe-/- mice lacking Adamts-7 (Apoe-/-Adamts7-/-) contained higher protein levels of tissue inhibitor of metalloproteases 1 (Timp-1). In co-immunoprecipitation experiments, the catalytic domain of ADAMTS-7 bound to TIMP-1, which was degraded in the presence of ADAMTS-7 in vitro. ADAMTS-7 reduced the inhibitory capacity of TIMP-1 at its canonical target matrix metalloprotease 9 (MMP-9) As a downstream mechanism, we investigated collagen content in plaques of Apoe-/- and Apoe-/-Adamts7-/- mice after Western diet. Picrosirius red staining of the aortic root revealed less collagen as a readout of higher MMP-9 activity in Apoe-/- as compared to Apoe-/- Adamts7-/- mice. In order to facilitate high-throughput screening for ADAMTS-7 inhibitors with the aim to decrease TIMP-1 degradation, we designed a FRET-based assay targeting the ADAMTS-7 catalytic site. Conclusion ADAMTS-7, which is induced in unstable atherosclerotic plaques, decreases TIMP-1 stability reducing its inhibitory effect on MMP-9, which is known to promote collagen degradation and is likewise genome-wide significantly associated with CAD. Disrupting the interaction of ADAMTS-7 and TIMP-1 might be a strategy to increase collagen content and plaque stability for reduction of atherosclerosis-related events.

Advances in developed and developing countries are more attributable to growth in industrial activities that directly impact increasing energy demand. Energy availability has been inconsistent globally, necessitating energy storage (ES) for use as per requirement. Various energy storage technologies (ESTs) are available in mechanical, electrochemical, electrical, chemical, and thermal forms to fulfil the energy demand of a user as and when required. The factors responsible for making a commercially viable energy storage product are further being researched for an eco-friendly and optimal solution to store energy for a longer duration. Researchers are employing different strategies to evaluate the energy efficiency of storage technologies. This paper uses the VIKOR technique to analyze ESTs while assigning objective weights with the entropy weights method based on identified energy performance indicators and ranking them according to their commercialization viability. The method helps a consumer choose better ESTs as per their requirement while manufacturers compete with each other to enhance the commercial value of their energy storage products. Sensitivity analysis has been performed to understand the uncertainties, pros, and cons with the limitations and scope of using the decision model and thus taking an informed decision. The analysis of different energy storage technologies has indicated Hydrogen Fuel Cells (HFC) to be impressive and promising for the future.

Air pollution is a major problem for the environment and human health. As a component of the environment (the Earth’s sphere), air, that is, the atmosphere, represents the basis of life on Earth. The composition of the air is mostly unchanged, except in the case of air pollution, which represents one of the significant environmental problems of modern times. In the past, pollution was caused by natural sources, while today the source of pollution is mostly of an anthropogenic character. Air pollution with basic and specific pollutants is present, especially in the areas of larger and industrial cities. The sources of pollutants in the air are numerous, and pollutants are found in all places where people live. In addition to air pollution of ambient air, it is also necessary to point out air pollution in closed spaces, especially work environments. Areas of increased pollution, with high concentrations of pollution, can have a negative impact on the population and lead to unwanted health problems. In recent decades, the high level of air pollution has been particularly pronounced, both at the global level and in the Republic of Srpska. Air pollution requires the involvement of society as a whole in solving this problem. The proposed revision of the Ambient Air Quality Directive will set interim European Union (EU) air quality standards for 2030, more closely aligned with World Health Organization guidelines, while putting the EU on a path to achieve zero air pollution by 2050 at the latest in synergy with climate and climate neutrality. The aforementioned Directive has significant improvements, but it will not completely solve the problem of air pollution or reduce to a greater extent the consequences of air pollution on the health of citizens. Air pollution cannot be solved quickly. The implementation of the new revised directive will be a challenge for the EU, and when all provisions of the directive are transposed into the national legislation of the Republic of Srpska, the application of all provisions will be very demanding and complex, with a number of problems in its application.