Placental insufficiency is a common cause of intrauterine growth restriction (IUGR). It affects ~10% of pregnancies and increases fetal and neonatal morbidity and mortality. Although Wnt and Hh pathways are crucial for embryonic development and placentation, their role in the pathology of IUGR is still not sufficiently explored. The present study analyzed the expression of positive regulators of the Wnt pathway, WNT5A and β-catenin, and the expression of the Hh pathway negative regulator suppressor of fused (SUFU). Immunohistochemical and reverse transcription-quantitative PCR (RT-qPCR) assays were performed on 34 IUGR and 18 placental tissue samples from physiologic singleton-term pregnancies. Epigenetic mechanisms of SUFU gene regulation were also investigated by methylation-specific PCR analysis of its promoter and RT-qPCR analysis of miR-214-3p and miR-378a-5p expression. WNT5A protein expression was higher in endothelial cells of placental villi from IUGR compared with control tissues. That was also the case for β-catenin protein expression in trophoblasts and endothelial cells and SUFU protein expression in trophoblasts from IUGR placentas. The SUFU gene promoter remained unmethylated in all tissue samples, while miR-214-3p and miR-378a-5p were downregulated in IUGR. The present results suggested altered Wnt and Hh signaling in IUGR. DNA methylation did not appear to be a mechanism of SUFU regulation in the pathogenesis of IUGR, but its expression could be regulated by miRNA targeting.

The coronavirus disease 2019 (COVID19) pandemic continues to represent a substantial public health concern. It can rapidly progress to severe disease, with poor prognosis and a high mortality risk. An early diagnosis and specific prognostic tools can help healthcare providers to start interventions promptly, understand the likely prognosis and to identify and treat timely individuals likely to develop severe disease with enhanced mortality risk. Here we focused on an impressive set of systematic reviews and meta-analyses that were performed since the start of the COVID19 pandemic and summarized their results related to the levels of hematologic, inflammatory, immunologic biomarkers as well as markers of cardiac, respiratory, hepatic, gastrointestinal and renal systems and their association with the disease progression, severity and mortality. The evidence outlines the significance of specific biomarkers, including inflammatory and immunological parameters (C-reactive protein, procalcitonin, interleukin-6), hematological (lymphocytes count, neutrophil-to-lymphocyte ratio, D-dimer, ferritin, red blood cell distribution width), cardiac (troponin, CK-MB, myoglobin), liver (AST, ALT, total bilirubin, albumin) and lung injury (Krebs von den Lungen-6) that can be used as prognostic biomarkers to aid the identification of high-risk patients and the prediction of serious outcomes, including mortality, in COVID19. Thus, these parameters should be used as essential tools for an early risk stratification and adequate intervention in improving disease outcomes in COVID19 patients.

This paper raises a discussion on innovation, nature of knowledge and the growing significance of skills in contemporary society. We propose the argument that knowledge is commonly perceived in terms of skills only, as a result of an applicability logic rule in knowledge based social orders. Moreover, innovation is recognized as yet another central issue of our times that is strongly interrelated to technological developments and the realm od science. Creativity as a specific human feature, on the other hand, is widely accepted as a critical precondition for generating innovative products and ideas. The essential problem lies in the oversight of the role humanities and arts play in nurturing humanistic values, whereas means are commonly mistaken for an end.

The movie mother! is a psychological horror movie, written and directed in 2017 by Darren Aronofsky. The plot of the movie revolves around a couple living in an isolated house, as their serene lives become thrown into disarray by a series of bizarre events started by the arrival of a mysterious couple and many other strange guests. This movie is known for its representation of biblical symbolism, with underlying warnings of the inevitable self-destruction of human race through their historically repetitive torment of Mother Earth.The main topic of this article is going to be an analysis of the symbolic milieu of the movie, with special attention to the depiction of power dynamics of the represented (divine) feminine and masculine, as well as power relations of the characters, in general. In that process, we hope to understand the stages of their transformation, with regards to the question of the nature of their transformation - was it social or structural? Interpretation of the transformation and its nature, we also contemplate the nature of recognized process of othering in the movie, that relies on the root of the recognized power relations? All of these questions are explored through interpretation of symbolic communication, in which the architectural setting acts as a character "anchor" and a sustenance for its development, as well as the indicator and medium of its transformation.

Introduction: Today, a lot is said and written about the hospital as a health institution. Various international bodies and organizations, including the World Health Organization, deal with the problem of work, functions, and organizations.Aim: This paper aims to perform a situational analysis of the organization of the hospital for emergencies; determine the availability of material and personnel resources in the hospital available in emergencies; examine the types of hazards that may have an impact on the safety of the hospital; determine the state of constructive and non-constructive safety of the hospital; examine the organization of services and support for patients and staff during emergencies.Methods: The research is descriptive and analytical. Standardized evaluation lists prescribed by the World health organization (WHO), which determines the hospital safety index, and the original survey questionnaire, according to the defined methodology of the WHO, were used as research instruments.Research results: For this work, a survey was conducted of 117 respondents, employees of the Clinical Center of the University of Sarajevo, who work in responsible positions. The majority of respondents believe that the conditions for preparing the hospital for emergencies can be improved by providing more human resources, educating staff, and ensuring important modern technologies. The situational analysis at the Clinical Center of the University of Sarajevo was carried out with an internal self-assessment of the hospital's safety index. The evaluation of the safety index for emergencies was calculated based on the defined WHO methodology.Conclusion: It is important to point out that there are many dangers (hazards) that can have an impact on the safety of hospitals and that different factors have a significant role in the preparedness of hospitals for an emergency or disaster.

Transmit power control is one of the most important issues in wireless networks, where nodes typically operate on limited battery power. Reducing communicating power consumption is essential for both economic and ecologic reasons. In fact, transmitting at unnecessarily high power not only reduces node lifetime, but also introduces excessive interference and electromagnetic pollution. Existing work in the wireless community mostly focus on designing transmit power policies by taking into account communication aspects like quality of service or network capacity. Wireless networked control systems (WNCSs), on the other hand, have different and specific needs such as stability, which require transmit power policies adapted to the control context. Transmit power design in the control community has recently attracted much attention, and available works mostly consider linear systems or specific classes of non-linear systems with a single-link view of the system. In this paper, we propose a framework for the design of stabilising transmit power levels that applies to much larger classes of non-linear plants, controllers, and multi-link setting. By exploiting the fact that channel success probabilities are related to transmit power in a non-linear fashion, we first derive closed-loop stability conditions that relate channel probabilities with transmission rate. Next, we combine these results together with well-known and realistic interference models to provide a design methodology for stabilising transmit power in non-linear and multi-link WNCSs.

Oxytocin (OT) has a well‐established role in reproductive behaviours; however, it recently emerged as an important regulator of energy homeostasis. In addition to central nervous system (CNS), OT is found in the plasma and OT receptors (OT‐R) are found in peripheral tissues relevant to energy balance regulation. Here, we aim to determine whether peripheral OT‐R activation is sufficient to alter energy intake and expenditure.

Based on the available archival material and additional literature, this paper approaches the analysis of the textbooks of the Bosnian Franciscans Ambroža Matić and Augustin Miletić from the sociolinguistic aspect in the context of language naming and linguistic identity. The textbooks serve as examples from the corpus of our initial textbook literature referring to the early period or the very beginning of the contemporary (more modern) type of public schooling in Bosnia and Herzegovina, with the aim of looking at identitarian language issues closely related to the issue of national identity. The starting point is the curriculum of the state (Franciscan) primary school in Tolisa (Orašje) from 1823, on the basis of which we can speak of a significant jubilee that today marks two centuries of a particularly important tradition: the official Bosnian language at the beginning (in the early period) of modern public schooling in Bosnia and Herzegovina. Furthermore, the paper shall analyze textbooks from the beginning of the 19th century, at a time when the processes of nationalization and significant mutual identitarian alienation of the local population had not yet taken root.

Objetivo: avaliar a relação entre a violência e a qualidade de vida de mulheres isoladas socialmente em decorrência da COVID-19. Método: estudo transversal, quantitativo, desenvolvido em Campina Grande – PB, Brasil. A amostra constituiu-se de mulheres maiores de 18 anos, em isolamento social pela COVID-19. Utilizaram-se três instrumentos para coleta de dados, estes analisados por meio de estatística descritiva e inferencial, sendo adotado significância p<0,05. Resultados: houve predominância de mulheres com baixa qualidade de vida (53,1%) e vítimas de violência psicológica (61,1%). A relação da violência física, psicológica e geral apresentou significância estatística entre todos os domínios de qualidade de vida nos testes de correlação de Spearman (p<0,05) e de comparação de Mann Whitney (p<0,05). Conclusão: o desfecho da violência física e psicológica relaciona-se de forma negativa nos aspectos físicos, psicológicos, relações sociais e meio ambiente da qualidade de vida de mulheres isoladas socialmente em decorrência da COVID-19.

Classroom experiments related to investigating the centripetal force are often underrepresented in the physics teaching practice. This is largely due to the fact that schools lack the proper equipment and teachers lack the time to perform the rather tedious data collection procedures which are characteristic for some of the traditional experimental setups. A possible solution to this problem is to develop and utilize alternative experimental setups within the digital environment. In fact, earlier research has shown that new generations of students are highly motivated to learn physics in digital environments and that these environments often provide at least as efficient learning of concepts as traditional environments. In this article, we present an augmented reality Android application named CEntripetalForceAR (CEFAR) that allows students to experimentally investigate how centripetal force depends on the period of orbital motion and the orbital radius. A possible pedagogical approach to using CEFAR is also described, including suggestions on how CEFAR can be used to overcome some of the most common misconceptions related to circular motion. A user experience survey which included 163 first-year university students showed that CEFAR can be awarded an excellent usability rating. Most students stated that the application helped them to improve their understanding about centripetal force either by visualization or by the possibility to explore cause and effect relationships.

Aleksandar Halmi, "Contemporary approaches in the methodology of social sciences: Chaos and complexity theory: New methodological genres", 2nd amended and modified edition, Novi redak, Zagreb, 2022

Without public administration reform there is no continuation of European integration of B&H – while European integrations can only be executed by reformed, professional and depoliticized public administration. Since it is expected that Bosnia and Herzegovina will finally receive candidate status at the end of the current year, and that the process of EU integration will intensify, public administration reform will once again be one of the unavoidable reform areas. This study provides an overview of the strategic framework and scope of public administration reform in Bosnia and Herzegovina in the last 18 years that the reform has been formally implemented, followed by a contextual and legislative analysis, critical points of the reform, and a package of recommendations, conclusions and topics for further research.

The paper deals with linguistic research in ANUBiH in two directions – the organization of work on linguistic examinations and the analysis of the titles published in publications of ANUBIH. The first part follows the work of the Department of Historical-Philological Sciences, later the Department of Social Sciences, then the Humanities, and the Commission for Linguistics and the Center for Lexicology and Lexicography, through their most important activities and projects, along with the work of the Balkanological Institute, later the Center for Balkanological Studies. The second part of the paper provides an overview of published linguistic texts. In the end, a bibliography of linguistic works published in ANUBIH is provided.