The aim of this paper is to consider the relationship between the regulation of state property and the rule of law, and for this purpose the authors analyze the Decision of the Constitutional Court of BiH No. U-4/21 which declared certain provisions of the Law on Forests of Republika Srpska unconstitutional. The paper discusses not only the issues of the relationship between state property and the rule of law, but also the issues of judicial activism and the rule of law. In particular, the authors analyze the extent to which the courts, and in this particular case the Constitutional Court of BiH, in order to protect the rule of law, may interfere in the competences of the legislature. In this context, the authors consider the justification of judicial activism of the Constitutional Court of BiH in case U-4/21, considering whether the Constitutional Court of BiH has the right to protect the principle of the rule of law in such a way. Finally, the authors explain why judicial activism is necessary when it comes to the relationship between constitutional and legislative power and why judicial activism of the BiH Constitutional Court was necessary in the case U-4/21.

Chronic myeloid leukemia (CML) is a myeloproliferative haematological malignancy characterized by constitutive activation of BCR-ABL1 tyrosine kinase in the majority of patients. BCR-ABL1 expression activates signaling pathways involved in cell proliferation and survival. Current treatment options for CML include tyrosine kinase inhibitors (TKI) with resistance as a major issue. Various treatment options for overcoming resistance are being investigated. Among them, phytochemical curcumin could play an important role. Curcumin has been found to exhibit anti-cancerous effects in various models, including CML, through regulation of multiple molecular signaling pathways contributing to tumorigenesis. We have evaluated curcumin’s effects on imatinib-sensitive LAMA84S and K562, as well as imatinib-resistant LAMA84R cell lines. Our results indicate a significant dose-dependent decrease in cell viability and proliferation of imatinib-sensitive and imatinib-resistant cell lines after curcumin treatment. Suppression of key signaling molecules regulating metabolic and proliferative events, such as Akt, P70S6K and NF-kB, was observed. Increased expression of caspase-3 suggests the potential pro-apoptotic effect of curcumin in the imatinib-resistant CML model. Additional in silico molecular docking studies revealed binding modes and affinities of curcumin with different targets and the results are in accordance with in vitro findings. Altogether, these results indicate the potential role of curcumin in the treatment of CML.

This paper is describing a new finding of Carcharhinus plumbeus (Nardo, 1927) caught at the insular shelves off the Sazan Island at the depth of 120 m, which is the southernmost record for a sandbar shark in the Adriatic Sea. The individual had a partially healed umbilical scar and is considered as neonatal. Examined shark appeared in good body condition with showed no macroscopic signs of diseases or macroscopic parasites. Detailed morphometric measurements are compared with four neonate and juvenile specimens from the north and central Adriatic Sea and are provided in the paper. Despite it is not possible to establish a certain conclusion on whether our specimen was born in the studied area or elsewhere, presented finding provides the very first evidence that neonatal sandbar sharks can be found along the coast of Albania. Knowing the exact locations and movements of both neonates and juveniles is of high importance for the effective long-term in-situ conservation.

The kaolinite content is principally responsible for the durability performance of Limestone Calcined Clay Cement (LC3), which calls into question its global applicability. The clay supply has a significant impact on the LC3 system’s reduced carbon footprint advantage. The influence of kaolinite concentration from two separate clays (collected in East South-East Europe) on the durability performance of concrete was investigated in this study. The low-kaolinitic clay had 18% kaolinite, while the medium-kaolinitic clay contained around 41% kaolinite. The compressive strength, chloride intrusion, electrical conductivity, surface resistivity, and sorptivity index were measured on concrete after 28 days. Furthermore, the pore structure development of these mixtures was investigated in relation to the kaolinite content of the mixtures. The reactivity test was performed on clays to measure their reactivity levels within the cementitious system. The results show that kaolinite content has a moderate effect on compressive strength, but it has a considerable effect on other durability indices. When compared to the Portland cement mixture, the chloride migration and diffusion coefficients were reduced by 50% and 36%, respectively, in the combination with a medium kaolinite content (more than 40%). The low-kaolinitic clay, on the other hand, achieved 60% of the chloride penetration resistance of the medium-kaolinitic clay. Furthermore, low-kaolinitic clay has been demonstrated to be suitable for low-carbon concrete in moderate exposure conditions.

Purpose: Orbital cellulitis is a serious condition with potentially severe complications. Treatment requires interdisciplinary care and early introduction of antimicrobial therapy. In our tertiary center, a team of pediatricians, pediatric ophthalmologists, and otorhinolaryngologists successfully participated in the management of pediatric periorbital/orbital cellulitis. This study aimed to demonstrate our interdisciplinary approach and to investigate clinical profile and management of pediatric periorbital/orbital cellulitis. Methods: A retrospective chart review was performed of all pediatric patients hospitalized for periorbital and orbital cellulitis in a tertiary hospital center from September 15, 2016, to March 15, 2020. Results: A total of 26 children—median age 2.7 years (range 0.5–12)—were treated during the study period. Disease presentation was unilateral, mainly during winter (n = 12) and autumn (n = 12), without ophthalmoplegia/proptosis. Seven patients had orbital cellulitis (Chandler classification of ≥III) and were older (6.5 years, P = 0.011) with sinusitis (P < 0.001), required surgery (P = 0.004), underwent longer antimicrobial treatment (13 days, P < 0.001), and had a longer length of hospital stay (13.43 days, P = 0.001). Orbital cellulitis occurred in a median of three days (range 1–12) of acute rhinosinusitis. Radiological survey was performed in 11 patients, whereas six patients were treated surgically. All intraoperatively collected cultures (sinus swabs) were positive, whereas Streptococcus pyogenes and Peptostreptococcus were isolated in five cases. All patients fully recovered. No recurrence was documented. Conclusion: Sinusitis is associated with severe orbital cellulitis and surgical management. Orbital cellulitis occurred early in the course of acute rhinosinusitis, as a distinctive presentation of rhinosinusitis. Interdisciplinary care and early management are crucial in treatment of pediatric periorbital/orbital cellulitis.

For any society that strives for growth and development, focus on quality education is of particular importance. With the adoption of the Lisbon strategy in 2000, the European Union (EU) started an upward trajectory towards the most competitive economy in the world. Cooperation in education has become an important instrument for mutual understanding and sharing of European values. This cooperation is supported with numerous relevant policy strategies, action plans, available statistical data, evaluation reports, road maps, thematic working groups and programmes, special network structures and idea exchange platforms within the EU. Key relevant strategies, plans and respective indicators are analyzed in this paper. Special attention is given to progress in candidate and potential candidate countries with regards to recommendations and goals of EU. It is concluded that more effort of the educational authorities is needed in all countries and one of the areas that needs to be further developed is evidence based policy making in education.

The paper discusses the visual response to text as a reading strategy employed to determine which parts or main ideas of the text the reader focuses on while reading. It starts with an assumption that every reading is a unique experience to which readers bring their previous experiences, cultural and social backgrounds, as well as general or specific knowledge. Therefore, the aim of the paper is to provide a better insight into active reading (Carillo 2017) and present results of a case study that, through visual responses to reading, also addresses text processing in a multimodal setting. The methodological framework comprises a visual response task that requires that the readers draw or sketch a visual interpretation of the text. In this way, sketching in response to reading is used as a complementary component and a visualization tool in the reading process (Wilhelm 1995; Fernandes 2018). Based on the results of the research, it is proposed that visual response to reading can be used to enhance multimodal creativity, and vocabulary acquisition and fully immerse readers in the reading process.

The collection of short stories Pobune was mainly analyzed from a literary theoretical perspective. The paper deals with the linguistic analysis of phrasemes modifications and the expansion of phrasemes in the mentioned work. The paper distinguishes between phrasemes modifications and phrasemes variations. Since the term phrasemes in modern phraseology is interpreted in different ways, this paper will analyze those phrasemes that have at least two autosemantic words in their composition, at least one of which has a transferred meaning. In the excerpted corpus, no author's modifications of idioms resulting from the reduction or condensation of certain lexemes were found, but only idioms created by expanding/adding lexemes that affected the modified meanings of those idioms. The aim of the work is the analysis of the author's phrasemes, finding synonymous phrasemes in consulted sources and giving meaning to those author's phrasemes that have not been recorded in both phraseological and general dictionaries of the Bosnian, Croatian and Serbian languages, but also in other consulted sources. Structurally and semantically modified phrasemes are found in the analyzed corpus. The recorded examples of idioms in the five short stories were used only once, and their unrepeatability also affects their more expressive value. The analyzed examples of the author's modifications of phrasemes are an indicator of the writer's ability to make recorded phrasemes more expressive, to change their meanings, and to construct new phrasemes that were not recorded.

This text is a review of a book Mujo Koštić's Lexicon of Elementary School Teachers in Sarajevo from 1878 to 1918, Sarajevo: National and University Library of Bosnia and Herzegovina, 2020.

This paper contains an analysis of the selected scenes from the play Krokodil Lacoste / Silvertown by Zlatko Topčić. The play won the “Alija Isaković” award in 2010, while the Cultural Association of Bosniaks Preporod published its dual Bosnian and English edition in 2016. The segments are analyzed parallelly in Bosnian and English for the purpose of observing the level of functional equivalence in the target text. The analysis entails extralinguistic and linguistic categories in accordance with the model developed by Hatim and Mason (1990) and later expanded by Zhang et al. (2015). The extralinguistic category includes, among others, the culture-translation relationship, and the linguistic category entails three dimensions: communicative, pragmatic, and semiotic. The analysis in this case includes the communicative and semiotic components.

Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in several human biological matrices. This enables its non-invasive detection, but the origin of these volatile organic compounds (VOCs) and their relation to the gut microbiome are not yet fully understood. This systematic review provides an overview of the current understanding of this topic. A systematic search using PubMed, Embase, Medline, Cochrane Library, and the Web of Science according to PRISMA guidelines resulted in seventy-one included studies. In addition, a systematic search was conducted that identified five systematic reviews from which CRC-associated gut microbiota data were extracted. The included studies analyzed VOCs in feces, urine, breath, blood, tissue, and saliva. Eight studies performed microbiota analysis in addition to VOC analysis. The most frequently reported dysregulations over all matrices included short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to the tricarboxylic acid cycle and Warburg metabolism. Many of these dysregulations could be related to the shifts in CRC-associated microbiota, and thus the gut microbiota presumably contributes to the metabolic fingerprint of VOC in CRC. Future research involving VOCs analysis should include simultaneous gut microbiota analysis.

The object of research in this scientific paper is the treatment of waste generated by paper production in industrial landfills. In the part of the paper production process, i.e. in its subsystem for wastewater treatment, a significant amount of solid waste is generated, which ends up in industrial landfills. The reason for the impossibility of returning to the production process lies in the fact that the sludge contains larger amounts of moisture and present chemical components that are isolated in the paper production process or during wastewater treatment. In the experimental part of the paper, a “trial plot” was selected on which seedlings of the paulownia elongate plant were planted in the waste sludge. The process of plant growth was monitored for two years and bioremediation, i.e. transfer of elements from sediments to plants, was analysed by modern instrumental methods. Based on the results obtained by research, it can be said with certainty that Paulownia elongate can be used in bioremediation of areas where these sediments are deposited.

Road capacity utilization is causally connected with an appropriate level of efficiency and an optimal level of traffic safety. Therefore, in this paper, it is considered the issue of maximum utilization of road capacity through the maximization of the input parameter AADT (Annual Average Daily Traffic), and the minimization of output parameters related to the categories of traffic accidents. It was defined six main road sections, which were evaluated based on seven techno-operational criteria using an integrated Multi-criteria decision-making (MCDM) model. The data refer to buses as a vehicle category. The Improved Fuzzy Step-Wise Weight Assessment Ratio Analysis (IMF SWARA) method was chosen to determine the weights of criteria, while the road sections were ranked using the Evaluation based on distance from average solution (EDAS). In addition, in one of the stages of applying the model when it comes to AADT, the Bonferroni operator (BFO) is used. The results show that the highest level of safety refers to a main road section with the following characteristics: average AADT, minimal deviation from the speed limit, an ascent of 7% and the lowest number of traffic accidents by all categories. In the paper, it was performed a multi-phase sensitivity analysis in order to identify possible differences in results when determining new circumstances.

The paper discusses the concept of interdisciplinarity from the perspective of humanities and social sciences. As both an idea and practice, interdisciplinarity is understood within the context of the complex dynamics of creating and reshaping institutional arrangements that regulate the processes of knowledge production, distribution, and instrumentalization in Western society, with universities, research centers, and departments at its core, organized according to separate academic disciplines. The paper questions the understanding of disciplines as closed, homogeneous, and static structures of knowledge organization. Instead, it reflects on the complex, multiple, and topological relationships of mutual interpenetration and constitution of disciplines, emphasizing their inherent hybridity, especially within the context of the synoptic identity of humanities disciplines. Furthermore, the paper highlights the moral assumptions underlying interdisciplinary research initiatives. The productivity of the conceptual framework concerning the centralistic, pluralistic, and integralistic models of interdisciplinarity is highlighted in analyzing the possibilities and outcomes of interdisciplinary approaches in social and humanities studies.

The study aimed to examine the characteristics of Bosnian daily newspaper coverage of the Jewish community of Bosnia and Herzegovina for the period 2005-2021. Content analysis of relevant journalistic messages (N=1173) was employed to examine the frequency of their appearance, positioning and formatting patterns, dominant thematic fields, distribution of voices, and overall tone. The results of the analysis point to the contradictory features of media coverage of the Bosnian Jewish community, the limited possibility to achieve "symbolic contact" with the minority community, and the affirmative context of presentation. The study yields empirically grounded insights that allow a better understanding of the process of journalistic coverage of minority groups in multi-ethnic states marked by a history of violent conflicts. The study highlights the relevance of the theoretical understanding of journalism as a performative practice that participates in the process of (re)defining symbolic boundaries between different social groups.