Background: Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. Although there has been a noticeable increase in incidence over the last decades, the exact incidence is difficult to establish, because data and cancer registries are heterogeneous among countries. Objective: The study aimed to analyze the recent clinical trends of basal cell carcinoma by reviewing a six-year single institution’s experience. Methods: A total number of 582 patients with histologically diagnosed BCC were included in the study. All relevant data were collected from medical records and patients, using short questionnaire. Results: BCC was slightly more common among the male population with female to male ratio of 1:1.24. At the time of diagnosis, male patients were statistically significantly older (70.47±11.9 years) compared to female patients (67.64±12.22 years) (p=0.005). The most common types of BCC were nodular (51.64%) and superficial (25.95%), affecting most commonly the head and neck region (71.2%). Relative risk (RR) for development of BCC is 2.79 times higher in sun-exposed skin areas (p<0.001). Conclusion: Sun exposure remains one of the most important risk factors for the development of BCC, with episodes of sunburns, occupational and recreational risks noted among the majority of patients. Although non-fatal disease, due to morbidity and high frequency, prevention and early diagnosis are important to prevent further increase in the incidence of BCC among the population.

Two main types of cardiac amyloidosis (CA) exist, as a result of either aberrant plasma cell production of misfolded monoclonal light chains, known as immunoglobulin light chain amyloidosis (AL), or production of disintegrated and misfolded transthyretin (TTR) proteins by the liver, also called transthyretin amyloidosis (ATTR). Non-invasive diagnostics (cardiac uptake on diphosphonate scintigraphy, Perugini score 2 or 3) have gained prominence in modern cardiology in correlation with the negative findings of free light chains in serum and the results of negative immunofixation in serum and urine. Additionally, criteria related to echocardiography or cardiac magnetic resonance are necessary for establishing a diagnosis. A total of 3.063 99mTc-MDP bone scintigrams were analyzed between August 2018 and March 2023, of which Perugini score 1 was validated in 13 patients, Perugini score 2 in 10 patients and Perugini score 3 in 1 patient. From our experience, we could observe that cardiac uptake can be verified in daily clinical practice and that is meaningful for monitoring patients with ATTR-cardiomyopathy (ATTR-CM). Although the sample size is not large, the importance of the study lies in the fact that it involves patients whose findings have been incidentally verified. If patients are selected according to clinical characteristics, the number of positive findings may potentially increase. Our study aimes to raise awareness among physicians of various specialties about the significance of the diagnostic algorithm for infiltrative cardiomyopathies. This is to ensure early diagnosis of this problem and initiation of treatment in the earliest stages when the therapeutic effect is most optimal. Such an approach would yield benefits for both patients and the entire healthcare system. A meticulous diagnostic and therapeutic approach is therefore fundamental for improving clinical outcomes in patients with ATTR-CM, including careful attention to specific TTR genetic variants and long-term follow-up.

During vibrations, the structure passes through different behavior areas (elastic or inelastic). Different areas of behavior correspond to different approaches to analysis and design. Modeling vibrations as a phenomenon includes its presentation in the form of a mathematical model, with certain parameters specific to the system, which define and control the vibration process itself, namely mass, stiffness and damping. While mass and stiffness can be more accurately described mathematically, damping modeling involves the state and medium in which the system resides. Due to differences in understanding of the state variables that control damping forces, there is still no single accepted model of damping. The wrong selection of damping model in the dynamic analysis of structures can result in the response of the structure being underestimated, which can be the cause of the collapse of the structure. The paper analyzed the response of the bridge structure to pedestrian excitation, applying different numerical damping models and the damping determined experimentally. At the end of the paper, a comparative analysis with conclusions is given.

Background/Aim: The aim of this study was to determine the accuracy of overall and anterior Bolton's ratio measurements obtained with an intraoral scanner compared to standard caliper measurements on plaster models. Material and Methods: This study included 33 subjects (18 female and 15 male), aged 12 to 18 years. All subjects were taken impression for the purpose of making study plaster models. In addition, all subjects underwent intraoral scanning for the purpose of creating digital models. Tooth width was measured with a caliper on plaster models, while digital models were analyzed using Cerec Ortho SW 2.0.2 software. The overall and anterior Bolton ratios were derived using both methods. Statistical data processing was performed using an independent t-test. Results: The results obtained using these two methods for measuring the anterior and overall Bolton ratio showed that there was no statistically significant difference in the measurements obtained on plaster models and the measurements obtained by intraoral scanning. For the overall Bolton ratio, T-test was 0.828 and is not statistically significant (p<0.05). The value of T-test for the anterior Bolton ratio was 0.001 and it was also not statistically significant (p<0.05). Conclusions: Determination the overall and anterior Bolton ratio using an intraoral scanner is an accurate and acceptable method for clinical work in orthodontics.

This study focuses on the theoretical analysis of the application of modeling and mathematical, particularly linear programming, in managerial processes within the agro-industrial complex. The authors have dedicated themselves specifically to defining planning processes, classifying models, and organizing production structures, including vertical and horizontal structures. Despite the fact that the benefits of linear programming have been proven, it is still not widely accepted and applied in our region. The reasons for this can be found in the relative complexity of the process, both in creating logical and mathematical models, and in interpreting results. Although there are specialized software and add-ons such as Solver in MS Excel, they are still not accessible enough to a wider range of users in the agro-industrial sector. It is evident that there is a need for the development of new specialized software solutions with user-friendly interfaces, which would make them more accessible, primarily to advisors, and then to agricultural producers.

Paper presents a model for the optimization of primary milk production in the hillymountainous regions of the Republic of Serbia. The goal of creating the model is to demonstrate and analyze the conditions and outcomes of production at the farm, while to find the optimal production structure, considering the organizational, economic, technical, and technological circumstances in which the farm performs its agricultural activities. The model is based on the linear programming optimization method. A mathematical model, or objective function, was established, and constraints were identified. A logical model was created for optimization. The main goal of solving the linear programming problem is to find the maximum or minimum of the objective function. In presented model, the task is to maximize the objective function, what is represented by the farm's net income. By using the linear programming, it is possible to determine the optimal quantities of resources and products to maximize net income, while adhering to resource constraints and other relevant factors.

Introduction: Adequate individual physical activity after COVID 19 infection as a inevitable part of postoperative therapy of surgically treated vascular and endovascular patients witch still remains a scientific unexplored international neglected secret. General post-covid symptomatology is increasingly present in patients with surgical or endovascular procedures on the iliac segment in the form of a manifestation of various complaints that can affect the very accessibility of the choice of treatment according to the TASC II guidelines, but also affect physical activity and quality of life. Besides the medicament treatment, the management of moderate intensity exercise therapy and future consistency of self-controlled exercise after surgical and endovascular after treatment in iliac critic stenosis with other asymptomatic systemic atherosclerosis can be important factor to support and improve benefits of surgical and endovascular treatment outcome in variable symptomatology of POSTCOVID 19 patients treated classical surgical and endovascular. Goals: The focus is on priority of investigation of remodeling the pattern of cultural smoking behavior and increasing the dynamic of physical activity trying to prevent and avoid potential risk of sudden death, myocardial infarction, stroke graft (stent) occlusion, and cardiovascular mortality in patients with POSTCOVID 19 symptomatology in which is besides other asymptomatic systemic atherosclerosis is the main disease critical iliac artery stenosis (TASC II A and B). Scientifically unproven that sometimes can be associated with poor outcome of surgical intervention the which are in deficit with scientific studies to confirm these scientific observations. Second goals are to investigate the potential possibility of POST COVID 19 symptomatology associated with the success of classic surgical bypass or endovascular intervention and the possibility of reflection on physical activity after vascular intervention. Also the improving and secure the quality of life after successful surgical bypass and endovascular revascularization treatment with influence on primary iliac (TASC II A and B) vascular intervention potency one of main goals as well suppress permanent or permanent consequences of the Covid 19 virus during therapeutic surgical or endovascular procedures of the iliac segment (TASC II A and B) Traditional food as well wrong choice of diet and continuous fight with nicotinism is still remains generally main health threat. Subjects and Methods: 266 Symptomatic post COVID 19 Patients with were observed during 3 years (134 patients with surgical dacron reconstruction and 132 with endovascular treatmant of short segment critical iliac artery stenosis) Moderate interval Intensity Training with Short Interval Repetitions on standard treadmill procedure. Results: The connection of the outcome of surgical and endovascular treatment with post and long covid 19 symptomatology is possible and has a significant impact on the quality of the continuation of physical medication therapy. Difference between the surgical and endovascular groups was observed after the implementation of the treatment as well as factors affecting the outcome of therapy. the outcome is devastating with the prevention of the risk factor of nicotism as well as with the lack of physical activity in some groups. Conclusion: Primary potency after Three years of Endovascular procedure and Dacron bypass Revascularization, has shown as successful with support of supervised exercise training in POSTCOVID 19 patients. Nicotiism still remains highly potency outcome threat when supporting exercise therapy. Also, future and recent studies on this topic should expand their understanding of the effect of the COVID 19 virus on the body in this patients, as well as improving the quality of life in order to improve the patency of bypass or endovascular intervention on the arterial iliac segment.

Introduction: We are increasingly witnessing the self-initiated, uncontrolled stacking of incompatible anabolic substances in various cycles in the young Balkan Recreational Bodybuilding population group, increasingly frequent acts of violence in our country and the emergence of a neglected and very silent epidemic that is taking on an increasingly aggressive course of illness and psychological behavior. Black market anabolic steroids are associated with many generally health problems and uncontrolled aggression behavior by abusers. Young unsolicited recreate bodybuilding are also associated with generalized atherosclerosis and potential increased high risk for heart disease that can structural and functional damage the cardiovascular system during muscle mass steroid cycles. Besides high calorie intake, elevating serum blood lipid cholesterol levels LDL lowering HDL levels, elevating, systolic and diastolic blood pressure take a certain participation in cardiovascular risk and therefor need a development of certain cardiovascular protection strategies for this avoiding medical supervision anabolic steroids abuser group which are not yet appropriate established. The aim of the short study was to estimate Cardiovascular Protective Strategy Measures on lipid levels, and blood pressure status in a young recreational bodybuilder with different ethnic groups who Abuse Anabolic Steroids during controversial and different mass Cycles with and without taking Polyunsaturated Fatty Acids and Acetylsalicylic Acid (ASA) and Statins. Subjects and methods: This study was conducted from beginning of January, 2022 till end of July, 2022. 140 subjects are included age 17-30 (74 male Recreational Bodybuilder Who Abuse Anabolic Steroids on Simvastatin’s 10mg and Acetylsalicylic Acid 150mg doses of (ASA) and 10 grams of Polyunsaturated Fatty Acids during mass Steroid Cycles and 66 impellers group of male Recreational Bodybuilder Who Abuse Anabolic Steroids consisting without consume Statins and Acetylsalicylic Acid (ASA) during mass Steroid Cycles). For the testing of statistical significance of differences between the exanimated groups non-parameter and parameter tests were used. The difference at a level of p< (0,001) was statistically significant. Results: In all the tested subjects we investigated increasing lipid levels and blood pressure after six months of study. Analysis shows the statistically insignificant influence of antiplatelet therapy (150mg Acetylsalicylic acid) (ASA), combined with Simvastatin 10mg p<(0,001) in steroid abuse subjects during irrational muscle mass steroid cycles. Conclusion: Lack of familiarity with combinations of anabolic substances, as well as the danger of oral applications of very harmful steroids from the former Soviet Union and German Democratic Republic (GDR), this study showed. Avoidance of physician supervision by recreate bodybuilders by deceiving of the athletic subjectivity look, seams appears almost always in gym. This cardiovascular protective measures have poor benefit appeared to be usefully blind preventing strategy of controlling blood lipid levels during muscle mass steroid cycles, with no guaranty of worsen cardiovascular condition by abusing anabolic steroids. The influence of the reflection of the COVID 19 virus on such dramatic therapeutic results in this population group of two groups cannot be ruled out for sure.

In this study, the selection of suppliers within an alternative food supply network for fruits and vegetables, specifically Box Schemes, was conducted using multi-criteria decision-making methods. The Entropy-MABAC method was used as the multi-criteria decision-making approach, and the research focused on five suppliers from the city of Novi Sad. Eleven socioeconomic criteria were chosen for the research to identify the most favourable supplier. The results indicate that the criterion "product character," i.e., whether the final agricultural product is organic or conventional, was rated the highest, and the first supplier was selected as the most favourable. These results provide a solid foundation for future research, which should focus on further examining the impact of supply methods on end consumers of agricultural products within the alternative food network and developing new methods to aid in selecting the most favourable supplier.