Production enterprises are enterprises that produce goods or services that aim to meet human needs such as machinery-equipment materials and labour. In order for a manufacturing enterprise to carry out its activities successfully, it must make the right choice when choosing its inputs. The correct execution of production activities and the selection of machinery, which requires high capital investments, also affect the efficiency of the enterprises, the correct use of materials and their costs. Therefore, it is an important decision for business managers to choose the right machine. At this stage, multi-criteria decision making (MCDM) methods are used for choosing the right machine. MCDM methods are methods used in the evaluation of alternatives using more than one criterion. In addition, the MCDM method is used in machine selection as well as in many areas. In this study, PSI, SV and MARCOS methods, which are among the MCDM methods, were used for peanut butter machine selection. First, the criteria and alternatives to be used for the peanut butter machine selection were determined by interviewing a peanut butter factory manager. In the study, while the criteria weights were determined, PSI and SV methods were used, while the machines were ranked with the MARCOS method. In addition, the MARCOS method was compared with other MCDM methods such as PIV, CODAS and WEDBA methods. After the rankings were found according to the methods, the relations between the rankings were examined using the Spearman Correlation method. The main purpose of the study is to determine the suitable butter machine for a peanut paste production factory. Contribution of this study to the literature PSI, SV and MARCOS methods were used together for the first time. In addition, no study has been found in the literature related to peanut butter machine. Therefore, this study is original and contributes to the literature.

Advances in respiratory medicine have presented a clear need for the continuous training and accreditation of health professionals, as well as of institutions providing and delivering care to respiratory patients. EBAP holds a central overarching position across Europe and overseas as an independent accreditor of training centres and educational activities with transferable and recognised CME/CPD points across countries https://bit.ly/3uZb5WT

Aim To determine radiologic, clinic and laboratory characteristics of COVID-19 positive patients with acute arterial occlusion and compare them with post COVID-19 and non-COVID-19 patients. Methods In this retrospective study, 53 patients with acute occlusion of peripheral arteries admitted to the University Clinical Hospital Mostar in the period between 29 February 2020 and 30 September 2021 were involved. The first group was made of COVID-19 positive patients, the second group were post COVID-19 patients and a control group were non-COVID-19 patients. Results Most patients were males, 37 (69.8%). The average age of COVID positive patients was 66.09±11.25 years, post COVID-19 patients 71.33±5.22 years and COVID-19 negative patients 69.82±1.99 years. Lower extremities were most affected, 38 (71.6%), without significant alteration in the coagulogram. Acute arterial occlusion occurred about 2 weeks after the beginning of COVID-19 or at the time of the first appearance of symptoms. Conclusion We have to take special care about patients with risk factors for developing acute arterial occlusion due to thromboembolism or thrombosis 10 days after the beginning of the disease. We also recommend the use of low molecular weight heparin (LMWH) and monitoring coagulation state due to anti Xa and thromboelastometry.

Aim To examine a relation of thyroid function, neutrophil-lymphocyte ratio (NLR) with left ventricular function measured through the left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction treated with percutaneous coronary intervention (PCI). Methods This prospective research involved 160 consecutive patients with acute myocardial infarction. Patients were divided into those with normal thyroid hormone status (n=80) and those with hypothyroidism (newly diagnosed) (n=80). Inflammatory parameters and parameters of hormonal status were taken for analysis: thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), free thyroxine (FT4), and free triiodothyronine (FT3). All patients underwent transthoracic echocardiographic examination (TTE) five days upon admission, and left ventricular ejection fraction (LVEF) was analysed. Results Significant difference between the two groups was verified in values of T3, T4, erythrocytes, haemoglobin, haematocrit, neutrophil, lymphocytes, NLR, C-reactive protein (CRP) and sedimentation rate. Patients with euthyroidism had a higher frequency of coronary single-vessel disease (p=0.035) and a significantly lower frequency of triple vessel disease (p=0.046), as well as a higher median value of LVEF (p=0.003). There was a significant correlation between LVEF with haemoglobin values (p=0.002), NLR (p=0.001), and CRP (p=001). Conclusion The altered status of the thyroid gland in acute myocardial infarction is associated with the severity of the coronary blood vessel lesion, LVEF and correlates with inflammatory response.

Nondipole effects occurring in the process of atomic ionization by an intense, mid‐infrared, counter‐rotating bicircular laser field are investigated using the strong‐field approximation with leading‐order nondipole corrections. The time integrals appearing in the expression for the differential ionization rate are computed in two ways: numerically, and by applying the saddle‐point approximation. The nondipole corrections introduce an asymmetry in the photoelectron momentum distribution along the field propagation direction. The asymmetry is quantified by the partial average value of the propagation‐direction momentum component of the photoelectrons and by the normalized difference of the differential ionization rates computed including and excluding the nondipole corrections. Using the saddle‐point approximation, it is investigated how the nondipole corrections change the solutions for direct photoelectrons and how this affects the momentum spectra. The impact of nondipole corrections increases with increasing photoelectron energy. Analysis of the complete photoelectron spectra including both direct and rescattered photoelectrons shows that, in the low‐energy region, a shift against the propagation direction occurs. The partial average of the propagation–direction momentum component in the rescattering region exhibits a plateau structure and also a local minimum structure that was recently observed in an experiment with a linearly polarized laser field (Lin et al., Phys Rev. Lett. 128, 023201 (2022)).

Scanning tunneling microscopy tip-induced deprotonation has been demonstrated experimentally and can be used as an additional control mechanism in electric-field induced molecular switching. The goal of the current work is to establish whether (de)protonation can be used to inhibit or enhance the electric field controlled thermal and photoisomerization processes. Dihydroxyazobenzene is used as a model system, where protonation/deprotonation of the free hydroxyl moiety changes the azo bond order, and so modifies the rate of electric field induced isomerization. Through the combined action of deprotonation and applied field, it was found that the cis-to-trans thermal isomerization barrier could be completely removed, changing the isomerization half-life from the order of several months. In addition, due to the presence of multiple isomerization mechanisms, electric fields could modify the isomerization kinetics by increasing the number of energetically viable isomerization pathways, rather than reducing the activation barrier of the lowest energy pathway. Excited state calculations indicated that the protonation state and electric field could be used together to control the presence of electronic degeneracies along the rotation pathway between S0/S1, and along all three pathways between S1/S2. This work provides insight into the mechanisms that enable the use of protonation state, light, and electric fields in concert to control molecular switches.

This study deals with the selection of a sustainable supplier on the example of the agribusiness company Mamex from Bosnia and Herzegovina. The main problem of this research is the selection of a sustainable supplier as a part of the sustainable strategy of the Mamex company. One of the prerequisites is that suppliers must present sustainability principles in business by having an appropriate certificate. The results of the selection of sustainable suppliers are completed using a new hybrid fuzzy approach with the methods IMF SWARA (Improved Fuzzy Stepwise Weight Assessment Ratio Analysis) and fuzzy TRUST (multi-normalization multi-distance assessment) CRADIS (compromise ranking of alternatives from distance to ideal solution) methods. The innovative approach is reflected in the use of a combination of these methods, especially by combining the TRUST and CRADIS methods into one method. The IMF SWARA method shows that the most important main criterion is the economic criterion, while the least important is the social criterion. By applying the fuzzy TRUST CRADIS method, it is found that out of the observed six suppliers, the second supplier has the best indicators. These results are confirmed by other fuzzy methods: MABAC (multi-attributive border approximation area comparison), WASPAS (weighted aggregated sum product assessment), fuzzy SAW (simple additive weighting), MARCOS (measurement of alternatives and ranking according to compromise solution), ARAS (a new additive ratio assessment), and TOPSIS (technique for order preference by similarity to an ideal solution). This research shows that applying more normalization when ranking alternatives reduces the influence of individual normalizations, and this approach should be used in future research.

Dry eye syndrome and allergic conjunctivitis are the most common inflammatory disorders of the eye surface. Although eye drops are the most usual prescribed dosage form, they are characterized by low ocular availability due to numerous barrier mechanisms of the eye. The use of biopolymers in liquid ophthalmic preparations has numerous advantages, such as increasing the viscosity of the tear film, exhibiting bioadhesive properties, and resisting the drainage system, leading to prolonged retention of the preparation at the site of application, and improvement of the therapeutic effect. Some mucoadhesive polymers are multifunctional excipients, so they act by different mechanisms on increasing the permeability of the cornea. Additionally, many hydrophilic biopolymers can also represent the active substances in artificial tear preparations, due to their lubrication and moisturizing effect. With the modification of conventional ophthalmic preparations, there is a need for development of new methods for their characterization. Numerous methods for the assessment of mucoadhesiveness have been suggested by the literature. This review gives an overview related to the development of mucoadhesive liquid ophthalmic formulations for the treatment of dry eye and allergic conditions.

Finance is integral to civilizational prosperity yet has impacted the global development of recent centuries, proved inherently inconsistent, and created multiple issues, i.e., inequalities. In this regard, Islamic finance (IF) offers solutions. Moreover, contemporary appraisals of the Integration of Knowledge (IoK) methodology represent a novel alternative to extant challenges and issues. The paper’s objectives are, therefore, to propose an IoK model of Islamic and conventional financial (CF) convergence with leverage to fintech and demonstrate the potential of the waqf sector for such convergence and its equivalent revival and reform along such methodological contours. This paper is a methodological contribution. However, library research, critical content analysis, and heterodox methods of concretization, synthesis, and transdisciplinary analytical reasoning substantiate the paper’s methodology. Islamic sources of knowledge, i.e., Qur’an, justify this study’s unorthodox methodology. A background depicts the CF problems and persistent issues that justify alternatives. It is followed by rationalizing IE development via IoK to converge IF and CF. The IoK model developed for IE development follows and is schematically demonstrated as novel findings of this paper to bridge the gap between IF and CF and leverage waqfs’ role and potential. Greater reference to waqf projects institutionalized implications for IF and integration with CF. Further, leveraging waqf and even fintech as an indicator of digitalization within the IoK model has implications for attaining the defined maqāṣid and developing IE genuinely. A conclusion summarizes and provides actionable recommendations linked with the IoK model’s objectives to reform extant IF and conventional practice based on sound Islamic philosophical foundations and maqāṣid-oriented envisioning of IE development.

This paper aims to propose a statistical model to assess pubertal growth spurt using the ratio of the anterior height projection to the posterior (Vba) of the fourth cervical vertebra body (C4) on cephalograms and to calculate the residual proportion of skeletal maturation and the time for the pubertal growth spurt to end for a given Vba. A sample of 538 cephalograms from healthy-living children aged between 5 and 15 years was analyzed. A segmented regression model was used to explain the different Vba stages relative to the pubertal growth spurt. In addition, the time to achieve skeletal maturation was evaluated for a given Vba between the beginning (Vba1) and the end (Vba2) of the pubertal growth spurt. A longitudinal sample of 25 males and 25 females was analyzed to validate the proposed method. The values of Vba corresponding to higher pubertal development rate ranged from Vba1 = 0.677 (95%CI, 0.644–0.711) to Vba2 = 0.966 (95%CI, 0.905–1.028) and from Vba1 = 0.669 (95%CI, 0.645–0.693) to Vba2 = 1.073 (95%CI, 1.044–1.101) in males and females, respectively. The validation process results showed that our model did not produce any incorrect forecasts. The proposed method estimates the beginning and the end of the pubertal growth spurt together with the residual proportion of skeletal maturation for a given Vba.

Immunomodulators and biologicals are essential in current IBD management, but are associated with increased risk of infections. Considering the growing number of treatment options, the benefit-risk balance of drugs is becoming increasingly important in clinical decision making. To date, post-marketing surveillance studies mainly focus on severe infections. As a result, data on mild and moderate infections are scarce. These infections take longer to clear in immunosuppressed patients and can substantially impact quality of life. We aimed to assess the incidence of all infections and identify risk factors for the development of infections in IBD patients. We previously developed and validated a Patient-Reported Infections Questionnaire (PRIQ), with excellent diagnostic accuracy, covering 15 infection categories with a 3-month recall period. The current prospective, multicentre, observational cohort study was performed between Jun, 1 2020 and Jul, 1 2021, enrolling consecutive IBD patients using the PRIQ implemented in myIBDcoach, an established telemedicine platform. Infection severity was defined as mild (self-limiting or topical treatment), moderate (oral antibiotics, antivirals or antifungals) or severe (hospitalization or IV treatment). Incidence rates (IR) were calculated for all infections, stratified for severity and subtype. Risk factors for infections were identified using multivariable logistic regression. In total, 629 IBD patients were included which completed 2391 PRIQs during 572 person-years (PY) of follow-up, resulting in 990 reported infections, corresponding to IRs of 17.3, 11.8, 5.1, and 0.4 per 10PY for all, mild, moderate, and severe infections, respectively (Tables 1-2). Upper respiratory tract (IR 26.9/100PY) and urinary tract infections (IR 14.8/100PY) were the most commonly reported mild and moderate infections (Table 3). Compared to patients without treatment, patients on immunosuppressives more frequently experienced infections of any severity (mild: IR ratio (IRR) 1.57 [95%CI 1.21-2.06] p<0.001, moderate: IRR 1.42 [95%CI 1.20-1.69] p<0.001). On multivariable logistic regression, female sex (mild aOR 1.96; moderate aOR 1.71), smoking status (mild aOR 1.66; moderate aOR 1.86), higher BMI (moderate aOR 1.05), and more comorbidities (mild aOR 2.41; moderate aOR 1.82) were all significantly associated with the development of mild and moderate infections (Table 4). In this real-world prospective study, immune suppressive therapy was associated with mild and moderate infections of any kind in IBD patients. These infections particularly occur in females, smokers, patients with higher BMI and more comorbidities. This information should be considered in personalised treatment selection.

The selection of the most appropriate underground mining technology is not a simple process because it involves handling of a large amount of information about several potential methods. Multicriteria optimization approaches are proven useful tools for ranking alternatives, especially in cases where multiple complex criteria have to be considered simultaneously. An ore deposit is a complex system because of its geology, physical and mechanical properties, and hydrogeological conditions. As such, problem solving requires a heuristic approach and includes tasks involving expert judgement, intuition, estimation, and experience. Using a heuristic strategy to state a problem means that the analyst is placed in a position to apply past experience to a future situation and existing knowledge to new circumstances, as well as discover new avenues to creative problem solving. A complex algorithm was developed to pave the way to quality management of mining, by using the VIKOR method to rank various mining technologies relative to a set of criteria and select the optimum mining method that will primarily ensure profitable and safe mining.