When solving real problems, and to make a quality decision, it is necessary to consider a great number of often complex parameters. For these reasons, the development of decision-making process modeling has seen significant growth in recent years, and multi-criteria optimization models have stood out among them as useful for solving complex and conflicting phenomena. Multi-criteria optimization models make it easier for decision-makers to find the optimal solution in situations where there are many different criteria, which can often conflict with each other. The choice of the appropriate method of exploitation of mineral deposits follows the consideration of the problem and the approach to further development, which is primarily the determination of the criteria that influence the choice of the optimal alternative.

Here we will focus on two of the four indexed biomedical journals that were published in Sarajevo during wartime conditions in 1992-1995. The first is the Medical Archives, which was founded in 1947 and whose last editor until 1991 was the respected Academician Mirko Grujic, and whose last edited issue remained in storage (then the printing was done on Heidelberg machines and the text was typed using lead letters) and that unprinted issue – the number one volume in 1991 never even came out. Given that the contracts with the strongest index database MEDLINE included the Contract of the Assembly of doctors of Bosnia and Herzegovina (BiH), which at that time was the owner of the journal, and the pause in printing had already been going on for two years, Medline withdrew this journal as well. Numerous correspondences with the main responsible person Mr. Sheldon Kotzin, we received an unexpected consent from the Medline database to try to fill the gap with at least a few double-issues within 6 months, and Medline will meet us and reactivate the depositing of the Medical Archive in Medline. In addition to these facts, I was reminded of the incredible activities related to the preparation and printing of 47 books and monographs out of a total of 98 in B&H in the war period 1992-1995, and their list is in the attached tables. Those war publications were created in various ways. Very important collection of published monographs are printed during wartime written by very famous scientists from Golden Arabic Ages: Ibn Sina, Ibn Haitham, Ibn Rushd, Ibn Nafis, Al Biruni, Ar Razi, which has been forgotten, translated by famous professors Sakir Sikiric and Hamdija Karamehmedovic until 1962. In addition to these facts, I was reminded of the incredible activities related to the preparation and printing of 4 scientific journals out of 8 biomedicine which today indexed journals in Bosnia and Herzegovina. Very important item from wartime was recording documetary movie "Amputation or Reconstruction in Wartime Conditions" recorded by Izet Masic and Zoran Ridjanovic which made in 1994 and showen in Lisbon during MIE '94 Conefernce as one of war miracles. Finaly, during wartime in B&H Avicena organized and published Proceedings of ten scientific meetings held in sieged Sarajevo and all presented papers were published and deposited in PubMed Central database. Total amount of published books and monographs during past thirty years is more than 200, and, also published papers by Avicena during 30 years in four Avicena Publisher's journals have number more than 15,000 papers writen at least by 60,000 authors, from over 50 countries from all continents, and almost a half of them are stored in most influential indexed databases. It is incredible job of one very small publisher from small countriy.

Background: The Social Medicine and organization of health is science organized on the application of modern medicine principles in the health care of human groups and nations. The significant difference of social medicine from clinical disciplines is that the clinical medicine deals with problems of individuals and social medicine is devoted to community health and illness of the family, schools and work organizations from population groups to the overall people of one area or country. Public health refers to all organized measures (whether public or private) to prevent disease, promote health and prolong life among the population as a whole. Its activities aim to provide conditions in which people can be healthy and focus on entire populations, not on individual patients or diseases . Objective: The aims of this article are to show, based on the available literature: a) The development of Social medicine and Public health in the World and Bosnia and Herzegovina from the medieval period until the today. b) The most significant historical events that marked the development of Social medicine and Public health with emfesized most important scientists and discoverers with their achievements. Methods: The subject of this study was the development of Social medicine and Public health in the world and in the areas of Bosnia and Herzegovina from the uncient peertiod until today. In order to achieve the set goals, a) Retreival of professional and scientific literature; and b) Search of scientific databases and web pages on the Internet that offer adequate and relevant data and historical facts related to the subject of studies were carried out. Most of the facts are covered in previously published articles by the author of this paper and deposited in the PubMed and PubMed Central databases, as well as in books and monographs by the author of this text. Results and Discussion: Social medicine with the organization of the health care system is the scientific discipline, defined by the huge contents, clear goal and specific methodology. It has been presented flow of socio-medical development and implementation on worldwide during the past. Public health was defined by Charles-Edward A. Winslow, in 1920. as „the science and art of preventing disease, prolonging life, and promoting physical health and efficiency through organized community efforts for the sanitation of the environment, the control of community infections, the education of the individual in principles of personal hygiene, the organization of medical and nursing service for the early diagnosis and preventive treatment of disease, and the development of the social machinery which will ensure to every individual in the community a standard of living adequate for the maintenance of health“. The names of those who are deserved for socio-medical development and its insufficiency on the organization on health system and some specific parts of it. Social medicine, and Public health as sciences and profession had high level among other disciplines, but also as profession per se, specially at the international level. There is huge evidence of numerous projects, books, papers, recognized by indigenous and international audience. Conclusion: The most importants role in organizatiionn and realization of all kind of public health activities and measures at every healthcare protection levels has World Health Organization (WHO) with its brench offices at all continents and all countries in the world. The author described information flow how it was happened during the history of its development.

This study focuses on the theoretical analysis of the application of modeling and mathematical, particularly linear programming, in managerial processes within the agro-industrial complex. The authors have dedicated themselves specifically to defining planning processes, classifying models, and organizing production structures, including vertical and horizontal structures. Despite the fact that the benefits of linear programming have been proven, it is still not widely accepted and applied in our region. The reasons for this can be found in the relative complexity of the process, both in creating logical and mathematical models, and in interpreting results. Although there are specialized software and add-ons such as Solver in MS Excel, they are still not accessible enough to a wider range of users in the agro-industrial sector. It is evident that there is a need for the development of new specialized software solutions with user-friendly interfaces, which would make them more accessible, primarily to advisors, and then to agricultural producers.

Paper presents a model for the optimization of primary milk production in the hillymountainous regions of the Republic of Serbia. The goal of creating the model is to demonstrate and analyze the conditions and outcomes of production at the farm, while to find the optimal production structure, considering the organizational, economic, technical, and technological circumstances in which the farm performs its agricultural activities. The model is based on the linear programming optimization method. A mathematical model, or objective function, was established, and constraints were identified. A logical model was created for optimization. The main goal of solving the linear programming problem is to find the maximum or minimum of the objective function. In presented model, the task is to maximize the objective function, what is represented by the farm's net income. By using the linear programming, it is possible to determine the optimal quantities of resources and products to maximize net income, while adhering to resource constraints and other relevant factors.

Introduction/purpose: The study of vehicle suspension is a challenge for researchers in the field of vehicles regarding the impact of the suspension system on vehicle performances such as ride comfort, road holding, and working space. This paper presents the simulation of the Land Rover Defender 110 vehicle in the roll plane (half vehicle) in Simulink/MATLAB. The obtained results were compared with the results obtained in the ADAMS/CAR software package of the Land Rover Defender 110 simulation model previously experimentally validated. The Defender 110 vehicle has a dependent suspension system in both axles and a passive suspension type with four degrees of freedom (4 DOF). Methods: The equations of the system can be solved mathematically with a scheme in Simulink/MATLAB while half-vehicle modeling has been done in ADAMS/CAR. Results: The comparison of the vehicle characteristics obtained by the two simulation methods was done for three different scenarios, and it was noticed that there is a good correlation between them. Conclusion: It was concluded that the Defender 110 vehicle simulation model in Simulink/MATLAB is validated. The validated model can be used to perform suspension system optimization in future work.

Fine motor skills are a good indicator of a child’s overall development. They underpin almost all everyday activities from self-care skills such as dressing to academic skills such as writing and drawing. In this study we examined the development of fine motor skills of early elementary school children. The sample for this study consisted of 175 children (93 boys, 82 girls, mean age= 120 months; SD = 10.7 months). attending 3rd, 4th, and 5th grades. We used Grooved Pegboard test for measuring fine motor skills. We found a medium, statistically significant, correlation between age and motor skills, with stronger correlation at younger age. In relation to child’s grade, there were statistically significant differences in motor skills between children attending 3rd and 4th grade, but no differences between children in 4th and 5th grade. As for the gender, there were no mean differences between boys and girls in the 3rd grade, but there were differences in 4th and 5th grade with girls achieving statistically significantly better scores on Grooved Pegboard test. Fine motor skills should routinely be examined in children and appropriate remediation programs should be set if a child falls behind in motor skills. We concluded a paper with several ways how elementary schools can include fine motor exercises in their curricula.

In this study, pyrophyllite was used for the first time in the composition of protective refractory coatings together with supplementary waste resources. The proposed refractory coatings are applicable for metallic and non-metallic structures, with the option of using them to protect machinery components in the chemical industry, metallurgy, and mining. Given that pyrophyllite has a low hardness, the goal was to improve the coating's resistance to cavitation erosion by adding 20 wt.% of hard refractory materials, i.e., crushed and micronized waste bricks based on mullite and corundum, respectively. Previous studies have demonstrated that protective coatings using a pyrophyllite filler have refractory qualities but insufficient resistance to cavitation erosion. As a result, the composition of refractory coatings, the preparation techniques, and the coating manufacturing process were altered. This study presents a simple method for combining conventional coatings made of refractory fillers (primary resource: pyrophyllite) with waste materials (mullite brick and corundum brick) used as reinforcement in protective refractory coatings for metal and non-metal structural elements that are highly resistant to cavitation erosion.

: This study explores the accessibility of critical infrastructures (CRITIS) in urban planning, focusing on the City of Sarajevo. CRITIS, essential for societal functioning, encompasses diverse services vital to social, economic, political, health, educational, and administrative systems. The authors leverage geographic information system (GIS) tools to construct an accessibility model for Sarajevo, analysing the spatial availability of critical functions. Six groups of CRITIS indicators, composed of 29 CRITIS elements, were used in the derivation of critical infrastructure accessibility index. The methodological framework was based on implementation of network GIS analysis, interpolation method (IDW) and GIS multi-criteria analysis, which could be applicable to similar research studies. Local communities concentrated in the strict urban core (Ferhadija, Baščaršija) have the best accessibility of CRITIS, while peripheral local communities with a large area, such as Mošćanica and Reljevo, have the lowest. Results suggest a zonal categorization of the urban area, providing valuable insights for spatial planning and future urban development management. The study reveals that the highest value of CRITIS accessibility doesn't necessarily align with the most densely populated areas at local community level.

Background: Radical surgical resection for pancreatic head carcinoma offers a chance for cure but unfortunately is only available to a limited number of patients. For a significant number of patients, palliative surgery remains the only option. The question of the most effective approach for patients with borderline resectable pancreatic head carcinoma (BRPHC) remains unresolved. Objective: The aim of the study was to compare the morbidity and mortality following R1 duodenocephalic pancreatectomy and double palliative bypass to explore the most optimal surgical treatment for patients with BRPHC. Methods: Our retrospective cohort study included 64 patients with BRPHC who underwent surgery from 2012 to 2019, with postoperative follow-up for three years. Morbidity and mortality parameters were examined based on the type of surgical treatment: R1 duodenocephalic pancreatectomy or palliative double bypass. Chi-square test, univariate regression, and Kaplan-Meier analysis were used as basic statistical methods in the analysis of the results. Results: Patients undergoing R1 duodenocephalic pancreatectomy had a 3.69 times higher risk of developing biliary leak (p=0.039; 95%CI:1.066, 1.181) and shorter survival compared to those undergoing palliative double bypass (p=0.022). No statistically significant association was found between the type of surgical procedure and other postoperative complications. Conclusion: Our study suggests that the double palliative bypass procedure may be a better option than R1 resection for patients with BRPHC.

Background: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide. Studies often consider colon and rectal cancers together. The combination of CA 19-9 and CEA markers is used to improve diagnostic accuracy, but there are no reports on the use of this combination as a prognostic predictor for CRC. The study by Kamada et al. was the first to use the "tumor marker index" (TMI), the geometric mean of normalized CEA and CA 19-9 in CRC, demonstrating the prognostic capabilities of this novel marker. However, it is not known how the preoperative value of TMI compares and fits into the current system of prognostic factors for preoperative prediction of overall survival (OS) and disease-free survival (DFS). Objective: The aim was to investigate the significance of preoperatively determined TMI in predicting three-year overall survival (3Y-OS) and three-year disease-free survival (3Y-DFS) in patients with stage III adenocarcinoma of the upper and middle rectum. Methods: Our retrospective cohort study included 93 patients who underwent open anterior resection of the rectum between January 2015 and December 2020. Optimal cut-off values of the markers were determined by ROC analysis. Statistical analysis was performed using IBM SPSS Statistics 22 and R 4.4.0. Results: Patients with TMI ≥1.0158 had a statistically significantly higher likelihood of mortality within three years (p=0.012). Patients with TMI ≥0.979 had a statistically significantly higher likelihood of disease-free survival of less than three years (p=0.003). Compared to CEA and CA 19-9, TMI had the highest AUC for predicting 3Y-OS (0.740, p=0.020) and 3Y-DFS (0.780, p=0.012). Adding TMI to other predictors increased the AUC for predicting both 3Y-OS (from 0.748 to 0.853) (p=0.001) and 3Y-DFS (from 0.711 to 0.850) (p=0.001). Conclusion: Our study confirmed previous findings on the usefulness of preoperative TMI as a prognostic marker, further expanding knowledge about its accuracy by comparing and combining it with established prognostic factors, including CEA and CA 19-9.

Background: Human papillomavirus is a risk factor in the development of cervical cancer. Other risk factors are frequent vaginal infections, cigarette smoking, use of oral contraceptives, but also lack of lacrobacillus in women with HPV infection. Objective: The objective of our study was to determine the risk factors for the development of cervical intraepithelial lesions in women with normal and pathological Pap test results. Methods: The research is a prospective study conducted in the Gynecology Center "Dr. Mahira Jahić" Tuzla and Dom Zdravlja Tešanj since February. 2023 to March 2024. The research included 200 respondents aged 25 to 50. Tested group: 100 subjects with pathological Pap smear findings (ASCUS, LSIL and HSIL) and a control group of 100 subjects with normal Pap smear findings. Sociodemographic data were obtained from the subjects during interviews and examinations: age, cigarette consumption and frequency of previous vaginal infections and the presence of lactobacilli. The obtained results were processed using the methods of descriptive statistics, student's t test and X2 test. A difference for a value of p<0.5 was considered statistically significant. Results: The mean age of the dpbo examined group was 38.1±1.7, while in the control group it was 39.6±1.9 years. Cigarettes were consumed by 62 (31%), 38 (19%) of the examined group, and 24 (12%) of the control group with a statistically significant difference of p<0.05. Out of a total of 100 in the examined group, 60 subjects had LSIL, 9 subjects had HSIL (CIN 2 two subjects and CIN 3 had 7), and ASCUS 29 and ASC-H 2 subjects. Subjects with pathological findings had significantly more vaginal infections during one year (p<0.05). HPV was positive in 65 (65%) subjects with a pathological Pap smear test, and negative HPV in 35 (35%). HPV 16,18 was present in 19 (19%) test subjects in combined form, and mono-isolate HPV 16 in 14 (14%) and HPV 18 in one case. In the combined form of several HPVs, HPV 16 and HPV 31, 33, 35, 45, 56 were found in 5 (5%), and HPV 18 in 4 (4%) with HPV 36, 59, 68. The most frequently isolated HPV 16 in 38 (38%) as monoisolate and in combined form. Lactobacilli were present in 26 (13%) subjects in the test group and in 60 (30%) subjects in the control group, with a statistically significant difference (p<0.05). The presence of Lactobacillus in subjects with a regular Pap test is significantly more frequent compared to women with cervical intraepithelial lesions (ASCUS, LSIL, ASC-H and HSIL) ) in the finding of the Pap test. Conclusion: Altered microflora of the vagina, lack of lactobacilli, frequent vaginal infections and smoking are risk factors for the development of CIN lesions in women positive for high-risk HPV.

Value changes in the real estate market affect both the quality of bank loan portfolios and financial stability and the real economy. The Republic of Serbia is one of the countries facing an upward trend in demand for housing. This paper investigates the impact of macroeconomic and banking variables on the real estate price index in Serbia for the period from 2014 to 2023 on a quarterly basis. Also, panel regression and correlation analysis are applied in this research. The selected independent (explanatory) variables are the gross domestic product, the consumer price index, the interest rate on bank loans, the exchange rate of the domestic currency against the Euro and household saving. The research results showed that the independent variable consumer price index had the most significant impact on the housing price index. On the other hand, the following independent variables had the most significant negative impact on the dependent variable (housing price index): interest rate on bank loans and the domestic currency against the Euro.