Introduction: Gastric MALT lymphoma accounts aproximately 7% of all gastric tumors. Women are mostly affected by this disease (mean age 60 years). The aim of this study was to determine the incidence of gastric MALT lymphoma in the Endoscopy Unit of the Department of Gastroenterology Of University Clinical Center Tuzla, the degree of histological malignancy and correlation with the Helycobacter pylori infection and then to evaluate the effectiveness of triple-antibiotic therapy (protonic pump inhibitors and antacides) in treatment of these cases. Patients and methods: All the patiens in the study were performed with gastroscopy and mucosal tissue biopsy in the Endoscopy Unit of the Department of Gastroenterology of UKC Tuzla. PHD and IHH analysis of the given material were performed in the Patology Department of UKC Tuzla. The blood analyses on H. Pylori were done in the Department of Microbiology of UKC Tuzla. Results: 112 patients with gastric tumors were involved in this study, 91 of whom suffered from malignant tumors, six of them had MALT lymphoma (five of them had confirmed H. pylori infection, four had histologically confirmed low-grade tumors and two was categorised as high grade malignancies). Histological lesions were classified according to the actual Ann Arbor classification. Patients with high malignancy risk underwent the operative procedures, and then were treated by polychemiotherapy (CHOP protocole, VI-VIII cikluses). All the patients with confirmed H. pylori infection were treated with antibiotics for 2-4 months, after which complete eradication was accomplished in all cases. Patients histologicaly diagnosed with low grade malignancy showed complete histological regression. In addition to that, after triple antibiotic therapy none of the patients presented with the disease transformation into another histological form. Discussion and Conclusion: The results of this study prooved high incidence in use of triple antibiotic therapy in treatment of patients who suffer from MALT lymphoma with confirmed H. pylori infection. Besides, it is very important to emphasise the fact that patients had no side-effects during polychemiotherapy which was used to treat all the patients regardless of their histological type and malignancy degree of MALT lymphoma.

Introduction: Laparoscopic appendectomy becomes a usual method in the treatment of acute appendicitis, although its advantage over open appendectomy has been proven. In Bosnia and Herzegovina, a few medical centers are introducing laparoscopic appendectomy as a method of treatment of acute appendicitis. In this study we want to compare different methods of treatment of acute appendicitis. Patients and Methods: During 20 months we have analyzed 498 patients operated due to acute appendicitis. We followed the duration of operation, total hospitalization stay, complications of surgical procedure and reasons of conversion in patients operated by laparoscopic approach. Results: The duration of operation was 96 minutes in the group operated by open approach and 107 minutes in the group operated by laparoscopic approach. Total hospitalization stay was 3.9. days in the group operated by open approach and 2.3. days in the group operated by laparoscopic approach. The most frequent complication in the group operated by open approach was infection of the operative wound (56/452) and ileus (5/452), and in the group operated by laparosocopic approach ileus (1/46) was the most frequent complication. Conclusion: The patients operated by laparoscopic approach have fewer risk of wound infection, and the hospital stay is shorter. With the increase of surgeon’s experience this method of treatment of acute appendicitis will become a method of choice.

The most significant discoveries in the area of heart failure are the recognition of natriuretic peptide system and its multiple effects on cardiac structure and function with special effect on its natriuretic and hemodynamic processes. First information’s that heart, beside its function as a mechanical pump also has an important endocrine functions, exists for over 50 years. Chemical structure of atrial natriuretic peptide has been identified in 1984. and four years later a brain natriuretic peptide has been discovered owning its name because it has been identified in pig brain. Primary site of brain natriuretic peptide synthesis in heart has been identified in 1991. Natriuretic peptides are neither neurohormones that influence body fluid homeostasis through natriuretic and diuretic effect; regulate vascular tone by decreasing angiotensine II level and they inhibit nor epinephrine synthesis and increase parasympathetic tone. They are natural antagonists of renin-angiotensine-aldosteron system, and they have a great role in inhibition of ventricular hypertrophy and remodeling, protective effects in endothelial dysfunction are important; they increase effects of nitrite oxide, inhibit lipid deposition in vascular wall and inhibit thrombocyte activation, regulate coagulation and fibrinolytic processes as well. Natriuretic peptides clinical use is in early evaluation of heart failure, prognostic stratification and detection of systolic and diastolic dysfunction of left ventricle, assessment of prognosis during patient monitoring period, differential diagnosis of dyspnea, treatment adjustment and dosage titration, assessment during hospital admittance and discharge and forecast and reduction of coronary events.

Introduction: There is currently absolute increase in number of amputation being performed for peripheral vascular disease. The reasons are aging of population, high incidence of diabetes, physical inactivity, air, water and food contamination and smoking. Surgeon is required to perform amputation at lowest possible level and to ensure primary wound healing because dehiscence very often lead to reamputation on more proximal level. Beside clinical judgment as a method for determination of level of amputation, there are bunch of different methods that are currently used as objective predictors of primary amputation stump healing. We use different angiographies (DSA, CTA, and MRA). Objective of this study is to determine wheatear aforementioned angiographies are superior to clinical judgment in determination of level of amputation. Patients and methods: There were 135 patients in the study from our clinic, amputated below knee in period May 2004 – June 2007. They were separated in two groups; group of patients where clinical judgment was used in determination of the level of amputation; and group where different methods of angiography were used for determination of the level of amputation. Since we originally assumed that diabetic patients would fare a lot worse, we decided to monitor diabetics separately, also divided to groups with «clinical judgment» and angiography. All patients in the groups were matched according to age, gender and comorbidities. Results: We measured following parameters: Operative mortality, secondary wound healing, and reamputations. As shown from the study, operative mortality was the greatest in group - diabetics «clinical judgment» - 10%, and overall operative mortality was greater in groups with clinical judgment – 3.7-10%: 2-26%. Failure of primary wound healing was also more frequent in groups with clinical judgment – 30-33%: 12-13%, as well as incidence of reamputation – 18-20%: 4-5%. Discussion: Statistically significant difference in measured parameters between groups clearly indicates that angiography is reliable method for determination of the level of amputation and that it is superior to clinical judgment. Also, based on results of world studies, that were estimating reliability of other methods of determination of amputation level, we could conclude that angiography is the most reliable.

The consequences of hard hearing disturbances on psychological restructures were signed when it all is about communication in social interactions, cognitive development and certain characteristics of personality. Certain psychological characteristics were analyzed at deaf by testing deaf and hearing ones. Testing sample (N=45) had been chosen randomly and there were both male and female 18 to 55 years old, with target to prove certain psychological characteristics of deaf in relation to social interactions. For that purpose has been created this measurement: “Estimation scale of psychological characteristics at deaf”, tipe of Likerts, which is consisted of 15 variables. The results of sub samples of tested ones on used variables have been described by descriptive and comparative analysis, but hypothesis about not existing statistical important differences between hearing and deaf tested ones in estimation of psychological characteristics at deaf has been tested by discriminative analyses. The results of survey point that there is no statisticaly important differences in estimation of psychological charakteristics at deaf, beteween two used samples in subject survey.

The taxonomical relationship between Salvia pratensis and S. bertolonii has been unclear for a long time. Salvia bertolonii has alternatively been considered a synonym, a subspecies, a problematic subspecies and a form of Salvia pratensis. However, both these two species are sometimes used in traditional medicine instead of sage (Salvia officinalis) or as an adulteration for the same drug. In order to confirm the status of S. bertolonii, together with the potential identification characteristics for differentiation from sage, both taxa were analyzed through the analysis of their essential oils, together with the micromorphological characteristics of the leaf surface and the anatomy and morphology of the leaves. The obtained results show that there are clear differences in the quantity of essential oil (0.073% for S. pratensis and 0.0016% for S. berolonii). The major compound in the essential oil of S. pratensis was E-caryophyllene (26.4%) while in S. berolonii essential oil caryophyllene oxide was the major component (35.1%). The micromorphological differences are also pronounced in the leaf indumentum (density and distribution of certain types of non-glandular and glandular trichomes). Clear distinction between the investigated Salvia species is also observed in the leaf anatomy (in S. pratensis leaves are thinner, palisade tissue is made of 1-2 layers of cells, and leaves of S. bertolonii are characterized by 2-3 layers of palisade tissue cells, and consequently thicker).