<p>Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes. Due to the dramatic increase in the number of diabetes cases, the prevalence of DR has also risen, making it the leading cause of blindness among the working-age population worldwide, despite the availability of screenings and modern therapeutic options. Risk factors for the development and progression of DR (duration of diabetes, hypertension, hyperglycemia, dyslipidemia, and genetic factors) have been investigated in numerous epidemiological studies and clinical researches, but the research results were not consistent. In recent years, there has been considerable interest in the study of dyslipidemia in diabetes as one of the factors that could influence the onset and progression of DR, as well as apolipoproteins as potentially better biomarkers for DR. The results of our research also point in that direction. Identifying the risk factors for DR is crucial for enabling adequate prevention and raising awareness among individuals with diabetes about the importance of taking appropriate measures to prevent this microvascular complication.</p>

<p><strong>Introduction.</strong> Denture-induced fibrous hyperplasia (DFH) is a reactive lesion that occurs as a result of chronic trauma caused by the denture on the oral mucosa.</p> <p><strong>Case report.</strong> A female patient, 56 years old, reported to the Specialist Center for Dentistry at the Faculty of Medicine in Foča for the fabrication of complete dentures. She wore previous complete dentures for about 25 years and complained about their age and discoloration. Clinically, both dentures were poorly retained and stabilized by short wings, with pronounced signs of wear. Denture hygiene was poor. Multiple folds of hyperplasic connective tissue were observed in oral cavity upper vestibule mucosa. The lesion folds were pink and firm, corresponding to denture edges. Based on the anamnesis and clinical examination, a temporary diagnosis of denture-induced hyperplasia was made. The patient was informed about clinical condition assessment as well as possible therapeutic procedures and gave written consent to accept the offered therapeutic procedures. She was advised not to wear dentures for four weeks and to maintain proper oral hygiene. After that, the hyperplasia was surgically removed under local anesthesia. A tissue sample was sent for pathohistological analysis. A new pair of total dentures was made. Removed tissue pathohistological examination confirmed the diagnosis: &ldquo;Epulis fissuratum&rdquo;.</p> <p><strong>Conclusion.</strong> Education and regular check-ups are essential for the prevention of DFH. Patients should be given detailed oral and written instructions on oral and denture hygiene maintenance, with special reference to possible changes in oral tissues and the importance of regular follow-ups.</p>

The purpose of this paper is to present the results of archaeological research carried out in 2022 at the site of Baričko brdo – Lug near Lukavac. Having above mentioned in mind, the methodology used during the two phases of archaeological research and the flow of work in the field is first briefly described. Next, the condition of the site prior to the fieldwork is described, followed by a description of previous archaeological research. What follows is a presentation of the results of archaeological excavations carried out during all the phases of archaeological research and geophysical surveys carried out during 2022.

The specificity of architectural activity in the process of creation lies in its abstraction of reality. Architects, who often do not know the context within which they operate, define goals, problems and tools based on professional analytical methods. The traditional educational system emphasizes the role of the expert as a “conductor” who controls the outcome with a drawing. At the same time, authorship and creativity enable the designer (company or project client) to determine how the newly built context functions, its appearance, and the way it is used by the end users. An even more common phenomenon is intuitive spatial activity, where due to the pressure of modern parameters of time and money, decisions are made based on the unconscious process of creation. The results are responses to fragments of reality or reckless actions on existing complex spatial relationships. During the entire process of creating a new reality, experts – who are members of the system and the macro-social level, act on the micro-social level and implement the values of the system. Ultra-subjective alienation from reality and the manipulative practice of narrative design solutions serve individuals instead of common interests. What are the possibilities of resisting the ideological construction of the new reality? If we want to improve the existing context with architecture, we should solve contradictions through spatial activity instead of hiding them ideologically. By including the subjective and objective realities of the context within which the architect operates, the possibility of strengthening the user and the community is realized. It is necessary to include reality in the creative process, in the way of their mutual interweaving instead of differentiating. It should not be the final stage of the process, but a parallel part of its initiation, development and completion.

Bosnia and Herzegovina (BiH), a country rich in history and culture, has for centuries been at the crossroads between the West and the East, which has resulted in quite a mixture of cross-cultural elements that pose many obstacles for translators. As the issues of tourism-language translation have been relatively underexplored in BiH, this article attempts to investigate the extent to which the translators of tourism-related content available online succeeded in making the local color of architecture-related terms accessible to foreign visitors. The article also examines whether the issue of accessibility of local color was addressed adequately by local translators. Many formal and informal online sources were used for the selection of prominent cultural terms and their English translations, which were analyzed in terms of lexis and semantics. We identified many examples where the cultural content was made accessible to the target audience, as well as examples where the transfer of the cultural content was done less successfully. In cases where translators experienced difficulty while transferring cultural terms, we attempted to draw prospective translators’ attention to potential pitfalls in the process of cultural mediation in translation from BiH’s official languages into English. Keywords: Bosnia and Herzegovina, tourism online, mediation, (in)accessibility, local color, translation, architecture

Angiogenesis is the process of forming new blood capillaries from pre-existing vessels. Even though it is essential during normal development, it plays a major role in cancer progression. Neratinib is a pan-human epidermal growth factor receptor (HER) inhibitor that has recently been approved for the treatment of HER2-positive breast cancer. However, its effects on angiogenesis and embryogenesis remain unknown. This study examined the antiangiogenic effects of neratinib using the chorioallantoic membrane (CAM) of chicken embryos. We also evaluated neratinib’s toxicity during the early stages of normal development using the chicken embryos, primary embryonic fibroblasts (EFBs), and human umbilical vein endothelial cells (HUVEC). Our findings revealed that neratinib significantly inhibited the CAM angiogenesis compared to controls by reducing vessel percentage area and the average vessel length. Furthermore, neratinib downregulated vascular endothelial growth factor (VEGF), a key mediator of angiogenesis. At lower concentrations, neratinib was well-tolerated during early stages of normal development. Additionally, EFBs treated with neratinib showed no morphological or viability changes when compared to controls. However, at the highest concentration tested, neratinib treatment reduced HUVEC cell viability. This effect may be associated with the dysregulation of key apoptotic genes, including caspase-3, caspase-8, caspase-9, and the B-cell lymphoma 2 (Bcl2) gene. Our findings indicate a novel potential application of neratinib as an antiangiogenic agent, exhibiting tolerable toxicity in the early stages of embryogenesis.

Osvrt na knjigu The Height of Prophet Adam: At the Crossroads of Science & Scripture Muntasira Zamana

Physical inactivity and obesity are growing concerns, negatively impacting the general population. Moderate physical activity is known to have a beneficial anti-inflammatory effect. N-glycosylation of immunoglobulin G (IgG) reflects changes in the inflammatory potential of IgG. In this study, GlycanAge index of biological age (GlycanAge), one of the first commercially used biomarkers of aging, was employed to assess effects of exercise intensity in three different groups of athletes: professional competing athletes, regularly moderate active individuals and newly involved recreational individuals, compared to the group of inactive individuals. GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02). Competing female athletes had significantly higher GlycanAge comparing to active females exercising moderately (β = 20.206, p.adj = 2.71E-02), while the latter had significantly lower GlycanAge when compared with the inactive counterparts (β = -9.762, p.adj = 4.68E-02). Regular, life-long moderate exercise has an anti-inflammatory effect in both female and male population, demonstrated by lower GlycanAge index, and it has great potential to mitigate growing issues related to obesity and a sedentary lifestyle, which are relentlessly increasing world-wide.

Radiation and nuclear security and safety represent regulated and controlled area. First of all, because of the common importance for humanity. Bosnia and Herzegovina has an established legal, i.e. institutional framework, but due to the decentralized complex system, it is unclear whether CBRN teams have been formed, what tasks and roles they perform and whether the procedure is uniform. In this research, the main focus is on the analysis of the complexity of the system, and the role of the State Regulatory Agency for Radiation and Nuclear Safety as a central authority and the Federal Administration of Civil Protection as a lower entity body in training and equipping teams for incident situations related to CBRN materials. The research is of empirical character and qualitative design. With this research we will show the level of equipment of the institutions of Bosnia and Herzegovina including measures and activities that are undertaken to prevent events and incidents in the broadest view, which will indicate recommendations for improving the preparedness and performance of institutions in preventing extraordinary events and incident situations.

This study was conducted to investigate the relationship between vertical jump height and negative block performance of elite male volleyball players in the positions of spiker and middle player. Twenty-two players, 10 middle players and 12 spikers, aged 25-30 years, playing in professional volleyball league in Turkey participated in the study. During 15 training matches, vertical jump distances were recorded with VERT belt and negative block performances (-) ineffective block and (=) erroneous block percentages) were recorded with Data Volley4 software. Since the data did not show normal distribution as a result of normality analysis performed in SPSS 25 program, the relationship between the variables was determined by Spearman correlation analysis. As a result of the analysis, there was no correlation between the average jump height of the middle players and their block error percentages, while there was a strong positive significant correlation in ineffective block percentages. There was a strong positive correlation between the vertical jump height of the spikers and their ineffective block percentage, while there was a strong negative correlation in their block error percentage. As the vertical jump height of the middle players and spikers increased, ineffective block percentage increased. It can be said that as the vertical jump height of the spikers increases, the block error percentage decreases, while the vertical jump height of the middle players does not affect the block error percentage.

A research study was conducted on a sample of 110 male and female participants aged 11 and 12 years (±1.2 years) to compare two different methods for identifying spinal deformities. The aim was to determine which of the two methods is better and more applicable in practical school conditions. The methods compared were Napoleon Wolanski's method with 8 variables and the 3D method from Contemplas GmbH TEMPLO General Motion, assessed with a total of 11 variables. By analyzing the table of central dispersion parameters of body posture according to Napoleon Wolanski's method, the participants were classified into 5 groups based on the results. Participants with scores up to 8 points were considered to have good posture, while those with scores from 9 to 16 points were treated as having poor posture. The research revealed that a total of 66 out of 110 participants had poor posture, accounting for 60%. Results from the Contemplas method showed deviations from proper posture in almost all variables. The analysis indicated significant deviations in shoulder rotation, pelvic rotation, sagittal distances, and flexion/extension variables. Overall, the results demonstrated a high prevalence of body deformities in 11- and 12-year-old students. Analyzing the results of both methods for determining body deformities, it can be confidently stated that the frequency of body deformities in students aged 11 and 12 is significantly high. Napoleon Wolanski's method identified that 60% of participants had some form of spinal deformity, while the Contemplas method showed more pronounced results, with some variables indicating deformations in 80-85% of participants. Despite providing more detailed information about students' posture, the Contemplas method is less applicable in practical school conditions due to its significant cost. Therefore, Napoleon Wolanski's method remains indispensable in school settings.

Introduction: A bone fracture is a break in the continuity of bone tissue, caused by the action of an external or internal force on the bone. Ankle sprains are one of the most common injuries among athletes. Physically active people who participate in activities that require jumping, changing direction, and turning have an increased risk of ankle sprains. Ankle sprains and the repetitive trauma often associated with this condition can lead to long-term disability, lost time from activity, and financial burdens for athletes. Methods: The work is non-experimental (qualitative research), i.e. a review of scientific literature. The search included an overview of the relevant databases: Medline, PubMed, Google Scholar, Research Gate. The literature review includes 4 randomized clinical trials and 1 randomized single-blind trial. The mentioned databases were searched with the help of keywords: athletes, injury, ankle joint, rehabilitation. Results: Through a scientific review of the literature, the results of the significance and productivity of the application of rehabilitation in athletes with an ankle injury are presented. The results include the presentation and analysis of five published scientific papers in the period 2018-2020. The studies used for this review were published in India, Saudi Arabia, Iran, United States, Austria. Conclusion: By reviewing the scientific literature, it can be concluded that there are improvements in the quality of life of athletes after an ankle injury. The greatest improvements were noted in strength, balance and functional task performance. The application of the rehabilitation program plays an important role in reducing pain and stabilizing the knee joint.

This paper deals with the analysis of the main devices of lexical cohesion used in Arabic political discourse. We carry out the analysis applying Halliday and Hasan’s theoretical framework of cohesion. The data of the analysis consists of the inaugural speeches of two presidents of Egypt, Morsi and el-Sisi. The main goal of the research is to determine the types and function of lexical cohesion, to mark cohesive mechanisms in political speeches, and to confirm the hypothesis that the type of text and its function can indicate the extent to which certain types of cohesive ties will be used. The results of the study reveal that inaugural speech appears as a persuasive discourse and an argumentative space of dominant use of repetition, to a lesser extent synonymy, hyponymy, meronymy, antonymy and collocation, with the goals of highlighting topical issues of national relevance and promoting a certain ideology.

Introduction: Anterior cruciate ligament injury is an injury that occurs in both sexes and in the population of all ages. The anterior cruciate ligament (ACL) is a very strong internal ligament of the knee, whose injuries occur frequently in athletes (professional and recreational) and after which the recovery is very long and complicated. The aim of this study is to determine the effectiveness of a standardized rehabilitation program after anterior cruciate ligament reconstruction based on the time required for rehabilitation in athletes and recreational athletes. Methods: Research is designed as prospective study. The research was conducted in Polyclinic FM Sarajevo over a period of 10 months, starting in June 2018 and ending in March 2019. The collection of data required for the study was carried out using a form prepared for the analysis of patients included in the study. Results: Thirty-six people participated in the study, divided into two groups. In the first group, 52.8% belonged to recreational athletes, while in the second group, 47.2% belonged to athletes. At the end of the study, the flexion value in both studied groups was 120º. At the end of the study, the percentage of subjects with correct extension of the injured limb was 94.7% of recreational athletes and 64.7% of athletes. Of the total number of respondents included in this study, 33% were soccer players, 14% were basketball players, and 53% were recreational athletes. Conclusion: Based on the research results, it was confirmed that early rehabilitation after the established rehabilitation treatment program is shorter in recreational athletes than in professional athletes.