E. De Vita, H. Hyare, C. Carswell, A. Thompson, A. Lukic, T. Yousry, P. Rudge , S. Mead, J. Collinge, and J. Thornton Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, London, United Kingdom, Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, MRC Prion Unit, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom, National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, London, United Kingdom

diagnosed clinically as having acute appendicitis were recruited.60%were males, mean age 28±6years. Patients with previous medical, surgical or gynecological complaints, severe debilitating diseases like hypertension, diabetes, obesity, blood dyscrasias, anemia or previous surgeries were excluded from the study. All the patients later underwent either elective or emergency appendicectomy and the preoperative leukocyte count was compared with histopathology findings of resected appendix. Results: Total leukocyte count (TLC) was calculated in each case individually and was compared with the histopathological report from the laboratory accordingly. The sensitivity and specificity of WBC count was calculated by standard formula and was found to be 82.4% and 78.7% respectively. The positive predictive value of WBC count (raised TLC) in diagnosing acute appendicitis was 93.8% showing that raised TLC along with clinical history is really a diagnostic marker for this condition. Conclusion: Clinical history and physical examination are the key factors in diagnosing acute appendicitis as radiological findings are not much helpful. Although WBC count and raised TLC is not a standard criteria for diagnosing acute appendicitis, but still it is one of the strong predictor of this acute condition in emergency room and should strongly be considered while making the diagnosis of acute appendicitis.

The genotoxicity of fumagillin was evaluated assessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses 5, 10 and 20 mg/kg bw. All doses significantly (p<0.001) reduced the mitotic index. The medium and maximum doses led to significant (p<0.01 and p<0.001, respectively) increases in numeric aberrations. The highest dose induced both structural and numeric aberrations (p<0.001), and insertions on the first pair of autosomes that were amplified in the 1C and 1E regions. These results pointed to the genotoxic potential of fumagillin in the range of medium and maximum doses applied.