Este trabalho teve como objetivo enriquecer produtos de panificacao do tipo biscoito e rocambole com farinha de feijao-caupi (FFC), avaliar sua aceitabilidade e composicao quimica, incluindo o conteudo dos minerais (ferro, zinco, magnesio, potassio e fosforo) e das vitaminas (tiamina e piridoxina). Foram desenvolvidas tres formulacoes de biscoito contendo 10, 20 e 30% FFC e duas formulacoes de rocambole contendo 10 e 20% FFC. Observou-se um aumento no teor proteico do biscoito 30% FFC e do rocambole 20% FFC e na quantidade de cinzas dos biscoitos 20 e 30% FFC e rocambole 20% FFC, quando comparados as formulacoes padrao. O teor dos minerais analisados e de piridoxina aumentou a medida que FFC foi adicionada, enquanto a concentracao de tiamina aumentou somente no rocambole 20% FFC. O biscoito com 10% FFC apresentou maior aceitacao (84,4%), dentre os biscoitos formulados com FFC, alem disso, os rocamboles com 10 e 20% FFC tiveram boa aceitacao (86,7 e 77,8%, respectivamente). Todas as formulacoes contendo FFC tiveram notas superiores a 6, mostrando que os produtos foram aceitos sensorialmente. Desta forma, a adicao de FFC visando melhorar o valor nutritivo de formulacoes a base de cereais e viavel.

BACKGROUND Genetic susceptibility to cancer is multifactorial, and it is known that impairment of the immune system could contribute to risk for getting cancer. AIM OF THE STUDY Single-nucleotide polymorphisms (SNPs) of Toll-like receptor (TLR) 2, TLR3, TLR4, and TLR9 genes, which are important for innate immunity, were analyzed for the association with breast cancer. METHODS The SNPs comprised TLR2 (c.597T>C), TLR2 (c.1350T>C), TLR3 (c.1377C>T), TLR4 (c.896A>G), and TLR9 (c.1635A>G). The allelic and genotypic frequencies of these TLR SNPs were compared between patients (n = 130) and controls (n = 101) in a case-control study from Croatia. RESULTS TLR SNPs were not significantly different. From the population genetics viewpoint, we found that a hypomorphic variant of TLR4 (p.Asp299Gly) allele has no specific allelic frequency (8.4%) in the Croatian population (n = 496) compared to other Caucasians (6.5-10%). CONCLUSION These results suggest that polymorphisms in tested TLR genes are not likely to be associated with increased risk for developing breast cancer.