The survey has been done on sample of 1252 people. The target was to estimate damage of noise on professional rehabilitation of deaf population, which is mostly directed to professions in heavy industry, for professions in metal industry. Sample has been divided to 3 sub samples: 137 hearing people in metal industry; 106 hearing impaired adults with different professions and control group of 1000 hearing people. The results of survey point that work conditions contribute to hearing damage at employers in metal industry by comparison with hearing impairment of usual population. By comparative analysis of registered hearing impairments concerning age, statistically important difference in frequency of hearing impairment of two sub samples (t= 3.27, sing=.05). The relation between hearing impairment and years of working has been identifi ed at employers in heavy industry, (r=.37).

Background Data on the epidemiology of hepatitis B and C in Bosnia and Herzegovina (B&H) are lacking. Objectives To assess the prevalence of hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (anti-HCV) in blood samples of first time blood donors in a well-defined region of B&H. Our secondary goal was to estimate the prevalence of HBsAg and anti-HCV in the general population of the same region. Patients and Methods We evaluated 8196 blood samples for the presence of HBsAg and/or anti-HCV, adjusted for differences in gender, and used the ratio estimation method to determine the prevalence in the general population. Results We analyzed 1263 (15.4%) female and 6933 (84.6%) male blood donors (male-to-female ratio: 5.49 to 1). The adjusted prevalence of HBsAg among blood donors was 0.787% (95% CI = 0.535-1.038), while the prevalence of anti-HCV was 0.267% (95% CI = 0.016-0.519). There was no difference in the prevalence of HBsAg or anti-HCV between men and women. We estimate that the prevalence of HBsAg and anti-HCV in the general population is 1.057% to 1.535% and 0.29% to 0.89%, respectively. Conclusions The prevalence of HBsAg and anti-HCV among blood donors suggests that our region has low endemicity for both hepatitis B and hepatitis C.

“My ideal, however is not to erase national characteristics in the manner leading towards intellectually uniform humanity. To the contrary, long live the variety of all forms and colors on our dear planet Earth. Beautiful is the existence of many races and peoples, multitude of languages, different mentalities and worldviews. If I feel the hostility and irreconcilable intolerance towards wars, conquering and annexations, it is caused by many reasons but mostly because of the fact that many organic, highly individual and sumptuous achievements of human civilization had been victim of those dark forces. I’m the opponent of “grands simplificateurs” and a fan of quality, original skill and uniqueness”. Herman Hesse, a part of his address while being awarded the Nobel Prize for Literature in 1946.1 Globalization, traditional values, rural architectural heritage, active protection of rural architectural heritage, integral active space protection, cultural landscape, cultural tourism, typology of rural architecture, methodology for identification and preservation of architectural heritage, identification and preservation of authenticity of rural architectural heritage, cultural landscape, ethno villages, methodology of the protection of integral rural spaces. Researches, which tackle or deeply intrude into tradition and the traditional within architectural heritage, only under superficial assessment, may create conflict with globalization in the widest sense. The changes of the general picture of the world happening on the architectural plan, which will certainly stop to manifest in such intensity in the times to come, are, on one side, the result of “exhibitionism” to which the investors are ready, and the result of the economic momentum that is actually passing by which marked its existence with unique facilities of universal characteristics, with no stylish and traditional characteristics, with extraordinary technological performances.

Human mammary glands arise from multipotent progenitor cells, which likely respond both to cell-autonomous and to extrinsic cues. However, the identity of these cues and how they might act remain unclear. We analyzed HER1 ligand effects on mammary morphogenesis using a three-dimensional organoid model generated from human breast tissue that recapitulates both qualitatively and quantitatively the normal ductal network in situ. Strikingly, different HER1 ligands generate distinct patterns of cell fate. Epidermal growth factor (EGF) causes a massive expansion of the myoepithelial lineage. Amphiregulin, in contrast, enables normal ductal development. These differences cannot be ascribed to preferential apoptosis or proliferation of differentiated cell populations, but are dependent on HER1 signal intensity. Inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2) effector RSK prevents the EGF-induced myoepithelial expansion. Notably, mouse mammary organoids are much less responsive to HER1 ligands. Little is known about the myoepithelial lineage or about growth factor effects on mammary progenitor differentiation, and our studies provide an important window into human mammary development that reveals unexpected differences from the mouse model.

Background Data on the epidemiology of hepatitis B and C in Bosnia and Herzegovina (B&H) are lacking. Objectives To assess the prevalence of hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (anti-HCV) in blood samples of first time blood donors in a well-defined region of B&H. Our secondary goal was to estimate the prevalence of HBsAg and anti-HCV in the general population of the same region. Patients and Methods We evaluated 8196 blood samples for the presence of HBsAg and/or anti-HCV, adjusted for differences in gender, and used the ratio estimation method to determine the prevalence in the general population. Results We analyzed 1263 (15.4%) female and 6933 (84.6%) male blood donors (male-to-female ratio: 5.49 to 1). The adjusted prevalence of HBsAg among blood donors was 0.787% (95% CI = 0.535-1.038), while the prevalence of anti-HCV was 0.267% (95% CI = 0.016-0.519). There was no difference in the prevalence of HBsAg or anti-HCV between men and women. We estimate that the prevalence of HBsAg and anti-HCV in the general population is 1.057% to 1.535% and 0.29% to 0.89%, respectively. Conclusions The prevalence of HBsAg and anti-HCV among blood donors suggests that our region has low endemicity for both hepatitis B and hepatitis C.