Computer-based simulator of water turbine and its environment has been developed for the purpose of turbine governor analysis, design and testing. During the final governor testing in the factory, the finished governor cubicle is linked with the hardware-in-the-loop turbine simulator using the signals which will later link it with the real hydroelectric power unit and other systems at the plant. During the earlier development phases, the governor is implemented as a part of the simulator. Besides helping in the governor design and subsequent improvements, the simulator significantly quickens commissioning of the governor system and thus both improves its quality and reduces costs.

Social media analytics has been attracting considerable attention in both research and industry due to the increasing popularity of social media usage. As a subset, social media monitoring describes the process of continuous monitoring of a subject matter in social media. From our point of view, the key requirements for such systems are i) high throughput and real-time processing of incoming data, ii) a user-friendly way to define complex situations of interests that make use of formalized background knowledge and iii) capabilities to perform actions based on gained insights instead of a pure monitoring system. In this paper, we propose a system for (pro) active, real-time social media monitoring. Firstly, we describe the conceptual architecture of our system and necessary pre-processing steps. Secondly, we introduce our concept of semantic requests that is capable to extend event pattern definitions with background knowledge. Finally, we show the usefulness of this system in two different domains: Real-time political opinion tracking and proactive establishment of relationships with consumers in order to perform a new form of real-time marketing. The main advantage of our approach is a simplified, expressive way to formulate event patterns in social media applications.

The 1691G>A FV variant has been described as a common genetic risk factor in venous thromboembolism. The purpose of this study was to provide a further frequency value for 1691G>A FV in Poland and to collate summary data from Central (Poland, Czech, Slovakia), Eastern (Russia, Belarus, Ukraine) and South-Eastern (Slovenia, Croatia, Bosnia and Herzegovina, Serbia, Montenegro, Macedonia, Bulgaria) European countries. For this purpose in 2007 the 1691G>A FV variant was analyzed by polymerase chain reaction-restriction fragment length polymorphism from DNA collected in 2005-2006. We studied 650 subjects: 400 newborns and 250 older individuals (mean age 46.1 y) from Poland and compared results with reports from other countries, as well as with the frequency trend of 845G>A HFE across South-Eastern European countries using centroid cities. From our 1691G>A FV study we identified 626 GG homozygotes, 23 GA heterozygotes, and 1 AA homozygote (n = 650), giving an A allele frequency of 1.9%, and a summed frequency value for Poland of 2.0% (n = 1588); the frequency in Central European countries was 3.9% (n = 4559), mostly due to the high value in the Czech Republic: 5.1% (n = 2819); the South-Eastern European countries had 2.5% (n = 2410). Among the Eastern European countries the 1691G>A FV allele frequency was 1.9% (n=791), between the South-Eastern and Eastern European countries there was no significant difference (p=0.17). We confirm that the 1691G>A FV allele frequency in Poland, as well as other countries compared, is significantly lower than that in Czech.

Pharmacokinetics is a first, but essential step to improve population-tailored postoperative analgesia, also after Caesarean delivery. We therefore aimed to quantify the impact of caesarean delivery on the pharmacokinetics of intravenous (iv) paracetamol (2 g, single dose) and iv ketorolac tromethamine (30 mg, single dose) in 2 cohorts eachof 8 women at caesarean delivery and to compare these findings with postpartum to quantify intrapatient changes. We documented a higher median paracetamol clearance at delivery when compared to 10–15 weeks postpartum (11.7 to 6.4 L/h·m2, P < 0.01), even after correction for weight-related changes. Similar conclusions were drawn for ketorolac: median clearance was higher at delivery with a subsequent decrease (2.03 to 1.43 L/h·m2, P < 0.05) in postpartum (17–23 weeks). These differences likely reflect pregnancy- and caesarean-delivery-related changes in drug disposition. Moreover, postpartum paracetamol clearance was significantly lower when compared to estimates published in healthy young volunteers (6.4  versus  9.6 L/h·m2), while this was not the case for ketorolac (1.43  versus  1.48 L/h·m2). This suggests that postpartum is another specific status in young women that merits focused, compound-specific pharmacokinetic evaluation.

The optic strut and the anterior clinoid process represent bony structures that are closely related to anatomically and clinically significant elements such as the cavernous sinus, the internal carotid artery, the optic nerve and the pituitary gland. The objective of our study was to quantify dimensions of the optic strut and anterior clinoid process, and to determine variations in positions and forms of these structures. A descriptive anatomical study was performed on 200 dry human skulls. We analyzed dimensions and variations in position of the optic strut, dimensions of the anterior clinoid process as well as the incidence and forms of the caroticoclinoid foramen. The average thickness of the optic strut on skulls belonging to males was 3 mm and 2.8 mm on those belonging to females. The optic strut was most commonly attached to the anterior two fifths on the lower side of the anterior clinoid process. On the male skulls the average width of the anterior clinoid process was 9.4 mm (right) and 9.1 mm (left). Its length was 9.9 and 9.3 mm. On female skulls the average width of the process was 8.7 mm (right) and 8.3 mm (left), while the length measured 9.3 mm on the right and 8.9 mm on the opposite side. In our sample, a complete caroticoclinoid foramen appeared in 4.25%, a contact form in 2.75%. At last, an incomplete form of the foramen was observed in 9.75%. The anatomic variations of the investigated structures must be considered during the approaches to the cavernous sinus and neurovascular elements of the sellar region.

In this paper we find exact formulas for the numbers of partitions and compositions of an element into $m$ parts over a finite field, i.e. we find the number of nonzero solutions of the equation $x_1+x_2+...+x_m=z$ over a finite field when the order does not matter and when it does, respectively. We also give an application of our results in the study of polynomials of prescribed ranges over finite fields.

O presente estudo, de natureza teorica, constitui-se em uma etapa de uma pesquisa maior que tem por objetivo contribuir na construcao de uma Pedagogia da Infância Oprimida. Analisa na obra de Paulo Freire quando, onde e como este autor explicitou sua compreensao de infância e crianca. Realiza, neste sentido, um rastreamento em suas obras publicadas em portugues, iniciando pelo periodo que antecede seu exilio em outubro de 1964. Defende a obra de Freire como um referencial teorico importante para analise das condicoes de vida das criancas e, assim, para a constituicao de uma pedagogia comprometida com a infância oprimida; pedagogia esta que possibilite abertura suficiente para ter com as criancas um olhar de respeito as suas singularidades, necessidades e direitos. Aproxima, entao, o conceito de infância em Giorgio Agamben ao de inacabamento em Paulo Freire na perspectiva de constituicao de uma Pedagogia pensada com as criancas. Conclui que ja em sua primeira obra, “Educacao e atualidade brasileira”, de 1959, Paulo Freire sinaliza para uma compreensao da crianca como protagonista de sua/nossa historia.

Objectives This study aimed to describe the long-term outcome and immunological status of children born to mothers with antiphospholipid syndrome, to determine the factors responsible for childhood abnormalities, and to correlate the child's immunological profile with their mothers. Methods A prospective follow-up of a European multicentre cohort was conducted. The follow-up consisted of clinical examination, growth data, neurodevelopmental milestones and antiphospholipid antibodies (APL) screening. Children were examined at 3, 9, 24 months and 5 years. Results 134 children were analysed (female sex in 65 cases, birth weight 3000±500 g, height 48±3 cm). Sixteen per cent had a preterm birth (<37 weeks; n=22), and 14% weighted less than 2500 g at birth (n=19). Neonatal complications were noted in 18 cases (13%), with five infections (4%). During the 5-year follow-up, no thrombosis or systemic lupus erythematosus (SLE) was noted. Four children displayed behavioural abnormalities, which consisted of autism, hyperactive behaviour, feeding disorder with language delay and axial hypotony with psychomotor delay. At birth lupus anticoagulant was present in four (4%), anticardiolipin antibodies (ACL) IgG in 18 (16%), anti-β2 glycoprotein-I (anti-β2GPI) IgG/M in 16 (15%) and three (3%), respectively. ACL IgG and anti-β2GPI disappeared at 6 months in nine (17%) and nine (18%), whereas APL persisted in 10% of children. ACL and anti-β2GPI IgG were correlated with the same mother's antibodies before 6 months of age (p<0.05). Conclusion Despite the presence of APL in children, thrombosis or SLE were not observed. The presence of neurodevelopmental abnormalities seems to be more important in these children, and could justify long-term follow-up.