A technical issue with fluid flow heating is the relatively small temperature increase as the fluid passes through the heating surface. The fluid does not spend enough time inside the heating source to significantly raise its temperature, despite the heating source itself experiencing a substantial increase. To address this challenge, the concept of the multiple circular heating of air was developed, forming the basis of this work. Two PTC heaters with longitudinal fins are located within a closed channel inside housing composed of a thermal insulation material. Air flows circularly from one finned surface to another. Analytical modeling and experimental testing were used in the analysis, with established restrictions and boundary conditions. An important outcome of the analysis was the methodology established for the optimization of the geometric and process parameters based on minimizing the transient thermal entropy. In conducting the analytical modeling, the temperature of the PTC heater was assumed to be constant at 150 °C and 200 °C. By removing the restrictions and adjusting the boundary conditions, the established methodology for the analysis and optimization of various thermally transient industrial processes can be applied more widely. The experimental determination of the transient thermal entropy was performed at a much higher air flow rate of 0.005 m3s−1 inside the closed channel. The minimum transient entropy also indicates the optimal time for the opening of the channel, allowing the heated air to exit. The novelty of this work lies in the controlled circular heating of the fluid and the establishment of the minimum transient thermal entropy as an optimization criterion.

Therapeutic approaches targeting proteins on the surface of cancer cells have emerged as an important strategy for precision oncology. To capitalize on the potential impact of drugs targeting surface proteins, detailed knowledge about the expression patterns of the target proteins in tumor tissues is required. In castration-resistant prostate cancer (CRPC), agents targeting prostate-specific membrane antigen (PSMA) have demonstrated clinical activity. However, PSMA expression is lost in a significant number of CRPC tumors. The identification of additional cell surface targets is necessary to develop new therapeutic approaches. Here, we performed a comprehensive analysis of the expression heterogeneity and co-expression patterns of trophoblast cell-surface antigen 2 (TROP2), delta-like ligand 3 (DLL3), and carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) in CRPC samples from a rapid autopsy cohort. We show that DLL3 and CEACAM5 exhibit the highest expression in neuroendocrine prostate cancer (NEPC), while TROP2 is expressed across different CRPC molecular subtypes, except for NEPC. We further demonstrated that AR alterations were associated with higher expression of PSMA and TROP2. Conversely, PSMA and TROP2 expression was lower in RB1-altered tumors. In addition to genomic alterations, we show a tight correlation between epigenetic states, particularly histone H3 lysine 27 methylation (H3K27me3) at the transcriptional start site and gene body of TACSTD2 (encoding TROP2), DLL3, and CEACAM5, and their respective protein expression in CRPC patient-derived xenografts. Collectively, these findings provide insights into patterns and determinants of expression of TROP2, DLL3, and CEACAM5 with implications for the clinical development of cell surface targeting agents in CRPC.

The aim of this paper is to investigate the quality of financial statements during the period of crisis. The crisis has a negative effect on the business performance of a company. It is necessary to measure and analyze various aspects of performance and take timely corrective actions in order to achieve business stability. Quality of financial statements can be expressed as one of the business performances. High-quality financial statements are created in an accurate, timely and reliable manner in accordance with all requirements of regulation. Professional accounting regulation determines a large number of obligatory disclosures which have a direct impact on the quality of financial statements. This paper will analyze the quality of financial statements from the aspect of disclosures according to the International Accounting Standard 2 – Inventory (IAS 2). Inventory represents significant assets for production and trade companies. Therefore, the quality of disclosures according to IAS 2 can be significant for adequate business decisions. The research is based on a sample of agricultural and manufacturing companies registered in the AP Vojvodina during the period 2020-2021. The research is based on a descriptive analysis of the quality of disclosures according to the IAS 2 and financial reporting quality index. The results indicate that 41% of the obligatory disclosures are presented in companies reports. Accounting policy for inventories and carrying amount according to inventory classification are identified as disclosures of high quality. On the other hand, disclosure of the write-down of inventories, recognized as an expense for the period is identified at the lower quality level. The research can be of interest for managers, owners, and creators of financial statements in order to improve the quality of financial reporting as a result of disruption during the period of crisis.

Global crises like pandemics and geopolitical turbulence have underscored the importance of responsible business practices and corporate transparency. In light of these circumstances, ESG reporting, which measures and expresses a company's concern for the environment, society, and transparent management, has become increasingly crucial. However, in challenging environments with limited resources, such as Bosnia and Herzegovina (BiH), adopting ESG reporting can present significant barriers to the accounting profession. Therefore, this paper aims to examine accountants' readiness in BiH to adopt ESG reporting under such circumstances. To achieve this goal, we surveyed a representative sample of 290 accountants from across BiH. The survey used a Likert scale to assess accountants' knowledge of ESG standards, their willingness to adopt different reporting methods, and their expectations regarding the impact of ESG reporting on their work, responsibilities, long-term career prospects, and professional development. Data analysis included descriptive statistics, ANOVA tests and t-tests in Excel and SPSS programs. Our study provides valuable insights into the readiness of accountants for ESG reporting, the measures necessary to support its implementation, and the impact of ESG on the development of the accounting profession in BiH. The study also discusses the role accountants can play in encouraging ESG reporting and answers questions about ESG standards' challenges and how accountants can prepare for their adoption. Our results demonstrate that the majority of accountants in BiH support ESG reporting, but they lack the necessary knowledge, tools, and resources to properly implement the new requirements. Hence, we strongly recommend taking measures to improve the preparation of accountants for ESG reporting.

The paper explores the key role of the last mile in the evolution of supply chains, with a focus on identifying challenges and solutions applied in the last phase of delivery. Today's challenges for logistics operators have significantly evolved over the past two decades due to current and growing trends. With the rise of e-commerce and urbanization, the last mile becomes a crucial point of competition, where fast, customized, and sustainable delivery emerges as an imperative for all involved stakeholders. The paper is divided into three parts. The first part refers to the identification of challenges faced by logistics operators in the last phase of the supply chain. The second part of the paper provides an overview of existing solutions and strategies that can be used to respond to challenges in the last mile of delivery. The third part offers case studies that provide a comparative cost analysis using different strategies in the last mile of delivery. Through the analysis of various solutions and strategies in the final stage of the supply chain, different aspects of efficiency and costs are illuminated in various scenarios. Understanding these dynamics is crucial for shaping the future of delivery that is efficient, sustainable, and tailored to the needs of the modern consumer.

Introduction: The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0–5) in the extended time window outside of trial settings remains unclear. We analyzed the effect of EVT among these stroke patients in real-world settings. Patients and methods: The CT for Late Endovascular Reperfusion (CLEAR) study recruited patients from 66 centers in 10 countries between 01/2014 and 05/2022. The extended time-window was defined as 6–24 h from last-seen-well to treatment. The primary outcome was shift of the 3-month modified Rankin scale (mRS) score. Safety outcomes included symptomatic intracranial hemorrhage (sICH) and mortality. Outcomes were analyzed with ordinal and logistic regressions. Results: Among 5098 screened patients, 2451 were included in the analysis (median age 73, 55% women). Of patients with ASPECTS 0–5 (n = 310), receiving EVT (n = 209/310) was associated with lower 3-month mRS when compared to medical management (median 4 IQR 3–6 vs 6 IQR 4–6; aOR 0.4, 95% CI 0.2–0.7). Patients undergoing EVT had higher sICH (11.2% vs 4.0%; aOR 4.1, 95% CI 1.2–18.8) and lower mortality (31.6% vs 58.4%, aOR 0.4; 95% CI 0.2–0.9) compared to medically managed patients. The relative benefit of EVT was comparable between patients with ASPECTS 0 and 5 and 6–10 in the extended time window (interaction aOR 0.9; 95% CI 0.5–1.7). Conclusion: In the extended time window, patients with ASPECTS 0–5 may have preserved relative treatment benefit of EVT compared to patients with ASPECTS 6–10. These findings are in line with recent trials showing benefit of EVT among real-world patients with large ischemic core in the extended time window. Trial registration number: clinicaltrials.gov; Unique identifier: NCT04096248 Graphical abstract

Rural tourism stands out as a specific form of tourism. The rural search for peace, rest and recreation is a growing trend at regional, national, European and international levels. It can be said that rural tourism represents a relatively new tourist activity that aims to return people to traditional values and the natural environment. This type of tourism produces numerous positive macroeconomic effects. These are, first of all: the development of underdeveloped areas, the employment of a larger number of household members, the placement of home-made products and agricultural products, and development of non-agricultural activities. Development of rural tourism, in addition to contributing to the economic empowerment of the rural population, also contributes to the strengthening of local and regional economies, as well as the overall economy. The most important consequence of rural tourism development in Federation of Bosnia and Herzegovina is the progress of rural communities, the improvement of the socioeconomic status of the rural population so that they would rather choose to stay in their surroundings than to migrate to larger cities in the country or outside the country. In FBiH, there are already a lot of guesthouses, rural households, camps, vineyard houses, mountain huts and ethnic villages that provide rural tourism services. However, there are also numerous difficulties faced by those who have decided to stay in their local community and develop it through the provision of tourist services. In the paper, we will point out the current situation in the field of rural tourism in FBiH, the challenges it faces and possible perspectives and directions in the future.

Our cross-sectional study demonstrates that there is a high rate of co-trimoxazole induced drug rash, in patients treated for immune related adverse events, with those developing rash appearing to have a reduced survival.

BACKGROUND: Acute ischemic stroke with isolated posterior cerebral artery occlusion (iPCAO) lacks management evidence from randomized trials. We aimed to evaluate whether the association between endovascular treatment (EVT) and outcomes in iPCAO acute ischemic stroke is modified by initial stroke severity (baseline National Institutes of Health Stroke Scale [NIHSS]) and arterial occlusion site. METHODS: Based on the multicenter, retrospective, case-control study of consecutive iPCAO acute ischemic stroke patients (PLATO study [Posterior Cerebral Artery Occlusion Stroke]), we assessed the heterogeneity of EVT outcomes compared with medical management (MM) for iPCAO, according to baseline NIHSS score (≤6 versus >6) and occlusion site (P1 versus P2), using multivariable regression modeling with interaction terms. The primary outcome was the favorable shift of 3-month modified Rankin Scale (mRS). Secondary outcomes included excellent outcome (mRS score 0–1), functional independence (mRS score 0–2), symptomatic intracranial hemorrhage, and mortality. RESULTS: From 1344 patients assessed for eligibility, 1059 were included (median age, 74 years; 43.7% women; 41.3% had intravenous thrombolysis): 364 receiving EVT and 695 receiving MM. Baseline stroke severity did not modify the association of EVT with 3-month mRS distribution (Pinteraction=0.312) but did with functional independence (Pinteraction=0.010), with a similar trend on excellent outcome (Pinteraction=0.069). EVT was associated with more favorable outcomes than MM in patients with baseline NIHSS score >6 (mRS score 0–1, 30.6% versus 17.7%; adjusted odds ratio [aOR], 2.01 [95% CI, 1.22–3.31]; mRS score 0 to 2, 46.1% versus 31.9%; aOR, 1.64 [95% CI, 1.08–2.51]) but not in those with NIHSS score ≤6 (mRS score 0–1, 43.8% versus 46.3%; aOR, 0.90 [95% CI, 0.49–1.64]; mRS score 0–2, 65.3% versus 74.3%; aOR, 0.55 [95% CI, 0.30–1.0]). EVT was associated with more symptomatic intracranial hemorrhage regardless of baseline NIHSS score (Pinteraction=0.467), while the mortality increase was more pronounced in patients with NIHSS score ≤6 (Pinteraction=0.044; NIHSS score ≤6: aOR, 7.95 [95% CI, 3.11–20.28]; NIHSS score >6: aOR, 1.98 [95% CI, 1.08–3.65]). Arterial occlusion site did not modify the association of EVT with outcomes compared with MM. CONCLUSIONS: Baseline clinical stroke severity, rather than the occlusion site, may be an important modifier of the association between EVT and outcomes in iPCAO. Only severely affected patients with iPCAO (NIHSS score >6) had more favorable disability outcomes with EVT than MM, despite increased mortality and symptomatic intracranial hemorrhage.

Red clover is an important forage plant species for the production of fodder, primarily in mountain areas and soils of poorer quality. Low pH reaction of the soil and poor supply of phosphorus are limiting factors for the cultivation of most plant species on soils with such chemical characteristics. The aim of these investigations was to determine the productivity and variation in the height of the plant, the yield of green mass and the yield of hay of red clover grown on acidic soil, in order to find out which varieties give the highest yields of green mass and hay, and for the purpose of their greater use in production. The research was carried out by analyzing five varieties of red clover in two cuts in each of the two years in the BDS area of the city of Banja Luka. A large part of the soil of Republic of Srpska has an acidic reaction and also mostly has a low level of phosphorus. The selection of the best varieties of red clover for production on such soils will enable obtaining satisfactory forage yields. For the examined parameters, statistically significant differences were obtained between swaths and varieties. The highest average values of plant height, yield of green mass and hay were obtained in the first cutting of the second year. The lowest average yields were achieved by the variety Viola. The highest average height was of the variety Una, the highest yield of green mass was of the variety K-39, and the hay of variety Kolubara. Based on the obtained results, varieties K-39, Kolubara and Una can be recommended for growing on acidic soil.

Winter wheat is the most important winter crop in Bosnia and Herzegovina as well as in the region. The yield of winter wheat varies depending on the variety and agroecological growing conditions. For sowing wheat, the sowing rate is 250-300 kg ha-1. About 50,000 ha are sown annually in Bosnia and Herzegovina, which requires about 15,000 tons of seeds. From this quantity, about 10% of needs are met from own production, and the rest of the seeds are imported. This paper analyzes the production of seed wheat at one of the largest domestic producers of wheat seeds. The paper presents data on seed production in two years, at three locations with four genotypes. The obtained results show that superior yields can be achieved using appropriate agricultural techniques and an assortment with good genetic predispositions. Due to the specificity of climatic and edaphic factors, good results are also achieved when growing specific genotypes with increased protein and gluten content. Statistically highly significant (p˂0.01) positive correlations were found between protein content and gluten content (0.98**). Highly significant correlations were found between hectolith mass and protein content (0.60**) and gluten (0.56**). The goal of the work is to increase the domestic production of seed wheat, as well as to carry out rezoning of the sowing of the appropriate assortment based on the analysis.