Na presente investigacao estudou-se o comportamento parental na situacao de cancro infantil. Foram analisadas dezassete entrevistas semi-estruturadas, de acordo com o metodo Grounded Theory. Treze das entrevistas pertencem a estudos anteriores (Goncalves P Silva, Pires, Goncalves, & Moura, 2001; Silva, 2002). Desde o aparecimento dos primeiros sintomas ate a fase da recaida, passando pela participacao do diagnostico, internamento e tratamentos, a principal preocupacao que estes pais experimentam e a de ocultar aspectos relacionados com a doenca, nomeadamente, a confirmacao do diagnostico, o choque do mesmo, a palavra pesada, o sofrimento, a gravidade da doenca, a dor, os efeitos secundarios e a possibilidade de morte. Para isso os pais desenvolvem estrategias, tais como: nao proferir a palavra, mentir, brincarem com a situacao, nao chorar, igualizacao do comportamento, nao pensar, sofrer a vez, entre outras; que lhes permitem realizar ocultar ao mesmo tempo que procuram adaptar-se e adaptar os seus filhos doentes de forma mais adequada possivel. Deste modo, consideram que o facto da crianca nao tomar conhecimento sobre os aspectos da sua doenca e um importante factor para uma adaptacao bem conseguida.

Background: Cyclosporine has been shown effective drug in suppressing acute rejection in recipients of allograft organ transplants. Methods: The cyclosporine concentration of 96 blood samples was determined using CMIA (chemiluminesecent microparticle immnoassay) Architect i 2000 and FPIA (fluorescence polarization immunoassay) AxSYM Abbott diagnostic. All patients have transplantation of kidneys and were hospitalized at Department of Nephrology at the Clinical center of University of Sarajevo. The reference serum range of cyclosporine for kidney organ transplantation for maintenance lies between 50 and 150 ng/mL. The quality control, precision and accurancy of Architect i 2000 were assessed. Results: The quality control was done using quality control serums for low (= 91 ng/mL), medium (= 328 ng/mL) and high (= 829 ng/mL). We have used commercial BIORAD controls and got reproducibility CV 5.83 % to 13 % for Architect i 2000. It was established that the main difference between Architect i 2000 and AxSYM and it was statistically significant for P < 0.05 according to Student t-test. Correlation coefficient was r = 0.903. Conclusion: The CMIA Architect assay has significant reduced cyclosporine metabolite interference relative to other immunoassay and is a convenient and sensitive automated method to measure cyclosporine in whole blood.

Introduction: Colorectal cancer is the third most common tumor which causes high percentage of mortality in the general population. Etiologic factors which cause this disease are various, while diagnostic methods involve very complex protocols from detection of tumor markers to a combination of endoscopic and imaging methods. Goal: To determine the number of patients suffering from colon cancer for a period of two years and with endoscopic methods to verify and localize the tumor and its spread. Histopathological determination of the tumor type. Determine the concentration of CEA and CA 19-9 in the serum. Depending on the tumor location asses its progression, severity and extent by radiological imaging methods. Material and Methods: The study was prospective and retrospective, performed at the Gastroenterohepatology Clinic of the Clinical Center of Sarajevo University. During the two-year follow-up, 91 patients were hospitalized underwent endoscopy, targeted biopsy and histologically proven adenocarcinoma of the colon in which a pathologist determined grade of the cancers. Samples were eosin stained and underwent pathological histological analyzes. All patients according to tumor localization underwent CT scan and MRI of the rectum and pelvis. Results: The most common location of the cancer regardless of sex was in the recto sigmoid colon. Prevalence of colorectal cancer spread to other organs was not related to location. No significant dependence of the localization of the tumor by gender was found (p-value = 0.313). Ca 19-9 had the highest value in localization of tumors in the rectum. There was no statistically significant difference in age between men and women. The largest number of patients has adenocarcinoma grade 2 and the localization at the rectum. Conclusion: The combination of laboratory parameters (CEA and CA 19-9) with endoscopic and radiological imaging methods is essential in diagnosis of colorectal cancer and assessment of the process progression. There is a need to impose additional diagnostic parameters to detect the disease at an earlier stage.

Aims: Since its description in 1980, percutaneous endoscopic gastrostomy has become the modality of choice for providing enteral access to patients who require long-term enteral nutrition. This study aimed to evaluate current indications and complications associated with PEG feeding. Methods: We conducted a retrospective analysis of all patients who referred to our endoscopic unit of the Department of Gastroenterology and Hepatology of the Medical Center University of Sarajevo for PEG tube placement over a period of 7 years. Medical records of 359 patients dealing with PEG tube placement were reviewed to assess indications, technical success, complications and the need for repeat procedures. Results: The indications for enteral feeding tube placement were malignancy in 44% (n=158), of which 61% (n=97) patients were suffering of head and neck cancer and 39% (n=61) of other malignancy. Central nervous disease was the indication in 48.7 % (n=175) of patients. Cerebrovascular accidents (CVA) accounted for 20% (n=73), head injury for 16% (n=59) and cerebral palsy for 11% (n=38). In 6.13% (n=22) of patients minor complications occur which included wound infection (0.8%), inadvertent PEG removal (2.5%) and tube blockage (1.1%). 11 patients experienced major complications including hemorrhage, tube migration and perforation. There were no deaths related to PEG procedure placement and the overall 30-day mortality rate due to primary disease was 15.8%. Oral feeding was resumed in 23% of the patients and the tube was removed subsequently after 6 -12 months. Conclusions: Percutaneous endoscopic gastrostomy is a save and minimally invasive endoscopic procedure associated with a low morbidity (9.2%) rate, easy to follow-up and to replace when blockage occurs. Over a seven-year period we noticed an increase of 63% in PEG placement at our department.

UDK 630*68(497.6)          630*9(497.6) In order to define functional model of governing of forest resources in F B-H, as well as efficient and effective organizational model of the forest enterprises, qualitative research has been conducted for the purposes of this paper. Through direct interviewing of all key forest policy decision makers in F B-H, opinions and attitudes about these questions were collected. Based on analysis of interest groups importance as well as influence and involvement in the process of creation of the functional forest governing model in F B-H - functional governing model has been proposed with clear emphasis of advantages concerning present model. Principles of sustainable governing and management of forest resources, assurance of participative approach in the process of decision making and transparency were basis for definition of functional governing model for management of forest resources. For provision of optimal model of organization of forest sector in F B-H, it has been crucial to define ecological, sociological, economical and other criteria, that user of forest resources should respect. The optimal number of organizational units, which manage forest resource on the territory of F B-H, depends from the achievement of the established criteria and real capacities for establishment of the enterprise. This would lead to further decentralization in management of forest resources in F B-H; that would have its positive effects.

The current JMRI reviewer pool includes approximately 2000 names. Evaluation of the 992 manuscripts submitted in 2011 was accomplished through the efforts of 1174 reviewers representing 33 countries. By listing their names here, we attempt to express our sincere appreciation to the 1174 individuals who were willing to give their time and expertise to evaluating and improving JMRI manuscript submissions.