Helminth parasites that inhabit mammalian body surfaces have a highly evolved relationship with the immune system. Many of these resident helminths carry out functions to ensure their survival in the hosts. To attain this objective helminth parasites adopt immunoregulatory mechanisms to counter host’s hostile immune response. Indeed, immunomodulatory molecules have been discovered in the worm’s extracts and in their excretion/secretion. In this review, we discuss the state of our understanding of the interplay between helminths and immune pathways. We also highlight the key challenges that must be confronted in identification of the helminth-derived molecules involved in immune modulation.  We consider whether helminth-derived signaling hold promise for the design of novel therapeutic approaches for the treatment of inflammatory disorders (inflammatory bowel disease, allergies, and autoimmune diseases).

Maturity of companies, organizational culture and costs are some of the major limiting factors for implementation of cost-effective six sigma methodology in Bosnian companies.  Purpose of this paper is to analyze possibilities of applying six sigma concept in a medium-sized company with 200 employees. Considering all characteristics of the company, in this case, implementation model was proposed and tested. The project included process monitoring using statistical process control charts for two different periods, before and after improvement. Dominant defect and its causes were identified and it was found out that the process was out of control. Implementation of improvement measures, dominant defect was eliminated but the process has remained out of control. As a conclusion, the test indicated that the model is effective but it takes more iteration to achieve the desired state.