INTRODUCTION Every clinical trial has to meet all ethical criteria in addition to the scientific ones. The basic ethical principles in the clinical trials are the following: nonmaleficence, beneficence, respect for autonomy and the principle of justice. OBJECTIVE The aim of the study was to analyse clinical cases with the outcomes leading to the changes in regulatory-ethical framework related to the clinical trials, as well as the outcomes of key clinical trials that influenced the introduction of the ethical principles into clinical trials. METHODS This was a descriptive research (methods of analysis and documentation; desk analysis of the secondary data). RESULTS By analysing the cases from the secondary sources as well as clinical and ethical outcomes, it may be noticed that the codes, declarations and regulations have been often preceded by certain events that caused their adoption. Moral concern and public awareness of the ethical issues have initiated not only the development of numerous guidelines, codes, and declarations, but also their incorporation into the legislative acts. CONCLUSION It is desirable that ethical instruments become legally binding documents, because only in this way will be possible to control all phases of the clinical trials and prevent abuse of the respondents.

Duplex stainless steels (DSS's) have been placed as an excellent alternative for applications where high corrosion resistance and high mechanical strength are required. However, the DSS's, including the lean duplex stainless steels, present lower weldability than the austenitic stainless steels. This study aims to evaluate the corrosion resistance of welded joints using multipass welding of lean duplex stainless alloy UNS S32304 plates 22 mm thick, using the SMAW, GMAW and FCAW consumables with two types of chemical composition, 22%Cr9%Ni3%Mo and 23%Cr7%Ni, giving a total of six experiments. The welded joints were evaluated using the anodic potentiodynamic polarization technique to determine the pitting potential of the material. The electrolyte studied was 3.5% w/v sodium chloride aqueous solution. The lean duplex steel welded by GMAW process with consumable with 22%Cr9%Ni3%Mo showed the best behavior against corrosion in saline solution. The root of the weld region had the highest pitting potential compared to the top of the welded joints. The lean duplex steel joints welded using FCAW process showed a behavior characteristic of general corrosion in the medium of saline solution, unlike the other samples.

The process of domestication has arguably provided dogs (Canis familiaris) with decreased emotional reactivity (reduced fear and aggression) and increased socio-cognitive skills adaptive for living with humans. It has been suggested that dogs are uniquely equipped with abilities that have been identified as crucial in cooperative problem-solving, namely social tolerance and the ability to attend to other individuals’ behaviour. Accordingly, dogs might be hypothesised to perform well in tasks in which they have to work together with a human partner. Recently, researchers have found that dogs successfully solved a simple cooperative task with another dog. Due to the simplicity of the task, this study was, however, unable to provide clear evidence as to whether the dogs’ successful performance was based on the cognitive ability of behavioural coordination, namely the capacity to link task requirements to the necessity of adjusting one’s actions to the partner’s behaviour. Here, we tested dogs with the most commonly used cooperative task, appropriate to test behavioural coordination. In addition, we paired dogs with both a conspecific and a human partner. Although dogs had difficulties in inhibiting the necessary action when required to wait for their partner, they successfully attended to the two cues that predicted a successful outcome, namely their partner’s behaviour and the incremental movement of rewards towards themselves. This behavioural coordination was shown with both a conspecific and a human partner, in line with the recent findings suggesting that dogs exhibit highly developed socio-cognitive skills in interactions with both humans and other dogs.

Introduction: Factors of cardiovascular risk (CVR) are often grouped in cases with diabetes mellitus (DM) with significant increasment of risk for CV disease . The aim of this research is to determine the frequency of CVR and and total CVR in cases with DM and to investigate connection of CRP of other factors of CVR in total cardiovascular risks. Material and methods: In 92 cases with DM weist values were taken as well as body mass index (BMI), blood pressure, sugar in blood, cholesterol, triglycerides, C reactive protein (CRP) and according to SCORE system the 10 year period of CVR were determined. Results: Out of 92 tested cases with age 55,22± 8,3 years, 63,05% were males and 36,95% were women, 81,5% were with values of sugar in blood >7mmol/l, 44,6% were with values of HbA1C>7% and 63,0% >6,5%. The value of cholesterol were >4,5mmol/l in 87%, triglycerides >1,7mmol/l in 78.3% of tested cases. 81,5% of tested cases were overweight and 49% with larger weight values. Average cardiovascular factor according to SCORE system was 3, 92± 3,7% with significant difference among sexes (M-4,86; W-2,32, p3mg/l) 52% of tested cases were with high cardiovascular risk. There is significant positive correlation between CRP and cholesterol level (p<0, 01), triglycerides, blood in sugar, HbA1c and upper values of blood pressure (p<0, 05). Significant correlation between CRP and total cardiovascular risk (p=0, 63) was not evident. Conclusion: Cases with diabetes mellitus have high level of non regulated cardiovascular risk factors. Even though there is significant correlation between CRP and and pressure values, sugar in blood, HbA1c, cholesterol, triglycerides, significant correlation between CRP and total cardiovascular risk in cases with diabetes mellitus is not evident.