Background: The serum prostate specific antigen for the early detection and screening for prostate cancer are very common used among physicians as the best screening tool for prostate cancer. The result of prostate specific antigen levels discriminates whether or not a prostate biopsy should be performed. The lack of specificity is a limitation of PSA as tumor marker, increased PSA concentrations are found not only in patients with prostate cancer but also in patients with benign prostatic disease. The object of this study was to improve the specificity and sensitivity of prostatic cancer detection. We evaluated total PSA levels, free PSA levels and the prostate volume in asymptomatic patients which came for routine check without medical history of prostate cancer. Methods: We received medical record of 90 patients between 50-60 years. Total and free PSA in serum was measured with the analyzer Architeckt i2000 SR. Prostate volume was determined by transrectal ultrasound. Results : The ratio of total and free PSA levels to prostate volume was significantly (p < 0.001) between all three groups. It was observed that increased prostate volume correlates with increased level of total and free PSA in serum. Conclusion: Early studies have demonstrated the advantage of measuring prostate volume with PSA total and free levels in serum as a useful tool for early diagnosis of prostate cancer. Data from this study on 90 patients with total PSA in the range from 0,22-7,0 ng/ml confirmed the well known correlation. All three parameters total PSA, free PSA and prostate volume showed significant correlation and a useful tool in prediction of prostate cancer for Bosnia and Herzegovina men.

A bstractWe investigate the phenomenology of flavored dark matter (DM). DM stability is guaranteed by an accidental Z3$$ {\mathcal{Z}}_3 $$ symmetry, a subgroup of the standard model (SM) flavor group that is not broken by the SM Yukawa interactions. We consider an explicit realization where the quark part of the SM flavor group is fully gauged. If the dominant interactions between DM and visible sector are through flavor gauge bosons, as we show for Dirac fermion flavored DM, then the DM mass is bounded between roughly 0.5 TeV and 5 TeV if the DM multiplet mass is split only radiatively. In general, however, no such relation exists. We demonstrate this using scalar flavored DM where the main interaction with the SM is through the Higgs portal. For both cases we derive constraints from flavor, cosmology, direct and indirect DM detection, and collider searches.

This research was conducted with the aim of determining the effects of the sports elements of the military training on qualitative changes of morphological characteristics, in soldiers - conscripts of the Armed Forces, and which is not only designed to achieve scientific results that would be academically defended, but also it should represent a way of controlling the results achieved by applying the scientific methods, critical reviewing and correcting any noticed weaknesses. The population from which the sample was derived were soldiers-conscripts who were on a quarterly training at the training centre in Pazaric. The total sample consisted of 435 conscripts-soldiers (men) from all over Bosnia and Herzegovina, aged 19-26 years. The variables chosen for this scientific work hypothetically covered spaces of morphological characteristics (10), and included spaces: longitudinal dimensionality of the skeleton, subcutaneous fat and circular dimensionality of the skeleton and body mass in soldiers conscripts who were on a quarterly training in training centre for basic training in Pazaric. The gained results of the factor analysis in the area of morphological characteristics show that the two main components (factors) were isolated (extracted) on the initial and final measurements, which tells us that the Plan and the program of physical training, greatly contributed to the qualitative transformation of morphological characteristics with conscripts of Armed Forces conditioned by sports content of military training for a period of three months.