Autor u ovom radu upućuje na ciljeve odgojnog djelovanja u medresi, čiji rezultat je ličnost određenih dinskih svojstava i sposobnosti, koja se želi i nastoji odgojem formirati kod učenika. Radom je obuhvaćena i elaborirana sintagma „domski odgoj“. Osnovni organizacijski element domskog odgoja čini odgojna grupa. Naglašena intencija domskog odgoja je nadogradnja roditeljskog odgoja. S obzirom na to da u medresu učenici dolaze s različitim pretpostavkama, cilj domskog odgoja je da ih primjeri osnovnim principima islama. Put (tarik) izgradnje ličnosti učenika medrese ide preko Šerijata. Čvrstinu mu obezbjeđuju farz, vadžib i sunnet. Autor nudi i obrazac formiranja ličnosti učenika, u skladu s principima islama. U radu su sadržane i upute za odgojno djelovanje prema učenicima, te načini njihovog vođenja do cilja. Autor odgoj učenika sagledava u kontekstu islamske duhovnosti, te duhovni odgoj smatra osnovom odgojnog djelovanja. Na kraju rada elaborirani su principi odgojnog djelovanja.

This paper presents a novel current control methodology for grid connected doubly-fed induction generator (DFIG) based wind energy conversion systems. Controller is based on a proportional controller with additional first order low pass filter disturbance observer which estimates the parameter dependent nonlinear feed-forward terms. The results in simulations and experimental test bed obviously demonstrate that decoupled control of active and reactive power is achieved without the necessity of additional machine parameter.

Abstract We describe an as yet unreported neocentric small supernumerary marker chromosome (sSMC) derived from chromosome 1p21.3p21.2. It was present in 80% of the lymphocytes in a male patient with intellectual disability, severe speech deficit, mild dysmorphic features, and hyperactivity with elements of autism spectrum disorder (ASD). Several important neurodevelopmental genes are affected by the 3.56 Mb copy number gain of 1p21.3p21.2, which may be considered reciprocal in gene content to the recently recognized 1p21.3 microdeletion syndrome. Both 1p21.3 deletions and the presented duplication display overlapping symptoms, fitting the same disorder category. Contribution of coding and non-coding genes to the phenotype is discussed in the light of cellular and intercellular homeostasis disequilibrium. In line with this the presented 1p21.3p21.2 copy number gain correlated to 1p21.3 microdeletion syndrome verifies the hypothesis of a cumulative effect of the number of deregulated genes - homeostasis disequilibrium leading to overlapping phenotypes between microdeletion and microduplication syndromes. Although miR-137 appears to be the major player in the 1p21.3p21.2 region, deregulation of the DPYD (dihydropyrimidine dehydrogenase) gene may potentially affect neighboring genes underlying the overlapping symptoms present in both the copy number loss and copy number gain of 1p21. Namely, the all-in approach revealed that DPYD is a complex gene whose expression is epigenetically regulated by long non-coding RNAs (lncRNAs) within the locus. Furthermore, the long interspersed nuclear element-1 (LINE-1) L1MC1 transposon inserted in DPYD intronic transcript 1 (DPYD-IT1) lncRNA with its parasites, TcMAR-Tigger5b and pair of Alu repeats appears to be the “weakest link” within the DPYD gene liable to break. Identification of the precise mechanism through which DPYD is epigenetically regulated, and underlying reasons why exactly the break (FRA1E) happens, will consequently pave the way toward preventing severe toxicity to the antineoplastic drug 5-fluorouracil (5-FU) and development of the causative therapy for the dihydropyrimidine dehydrogenase deficiency.

Objective: We aimed to investigate the frequency of seizure after acute carbamazepine poisoning and the important risk factors related to the outcomes of therapy. Methods: In this two-year cross-sectional study conducted in a University Hospital in Iran, 114 patients with acute carbamazepine poisoning were divided into two groups of with seizure (n = 8) and without seizure (n = 106) after intoxication. Demographic data, average amount of drug ingestion, time elapsed from ingestion to hospital admission, history of seizure before poisoning, mental status, visual disturbances and nystagmus, duration of hospitalization, the outcomes of therapy, arterial blood gas values and serum biochemical indices were compared between the two groups. Findings: Patients with seizure had an estimated (Mean ± SD) ingestion of 14,300 ± 570 mg carbamazepine, which was significantly higher (P < 0.0001) than the seizure-free group (4600 ± 420 mg). The estimated average time between drug ingestion and hospital admission in patients with seizure and the seizure-free group were 515 ± 275 and 370 ± 46 minutes, respectively (P < 0.0001). In this study, 104 out of the total number of patients had recovered without any complication. Need for respiratory support, including airway support or intubation were the most recorded complication. One patient died after status epilepticus and aspiration pneumonia. Conclusion: The ingested amount of carbamazepine and the time elapsed from the ingestion of drug to hospital admission may influence the occurrence of seizure after acute carbamazepine poisoning; however, the outcome of supportive care in these patients seems to be positive.

Hospitality, as a cultural receptional factor, has a great importance for a tourism planning and tourism & geographical destination development. Research problem considers an analysis and evaluation of hospitality in Sarajevo tourism destination. The aim of this article is to research the basic parameters/ indicators of hospitality in order to understand their value. Parameters of hospitality are: qualifications, affability and English language skills. The basic methodology will include collecting data for statistical analysis and survey research that will be used to assess opinions of tourists, tourism managers and tourism employees.