Science aims at promoting knowledge by gathering and discovering the objective truth, the facts that are independent of human interests, their values, ideology and biases. The way in which scientists come to this goal is through the universally accepted and thoroughly regulated processes – the scientific method. There is no clear definition which will answer the question what is unethical in biomedical research. All people recognize some common ethical norms but different individuals interpret, apply, and balance these norms in different ways in light of their own values and life experiences. Generally, it can be said that unethical behaviour in science is any significant mistreatment of intellectual property or participation of other parties, deliberately hampering the research process or distortion of scientific evidence,as well as all the behaviours that affect the integrity of scientific practice. Given theimportance of the primary goal of scientific enterprise, that is search for truth and trustworthy results, ethics in science has increasingly come into focus. There are several reasons why it is important to adhere to ethical norms in research. Norms promote the aims of research, such as knowledge and truth, variety of moral and social values and help to build public support for research. This paper analyzes the major principles of ethical conduct in science and closely related topics on ghost authorship, conflict of interest, co-authorship assignment, redundant/repetitiveand duplicate publications. Furthermore, the paper provides an insight into the fabrication and falsification of data, as the most common forms of scientific fraud.

Objective: evaluating stride events can be valuable for understanding the changes in walking due to aging and neurological diseases. However, creating the time series necessary for this analysis can be cumbersome. In particular, finding heel contact and toe-off events which define the gait cycles accurately are difficult. Method: we proposed a method to extract stride cycle events from tri-axial accelerometry signals. We validated our method via data collected from 14 healthy controls, 10 participants with Parkinson's disease, and 11 participants with peripheral neuropathy. All participants walked at self-selected comfortable and reduced speeds on a computer-controlled treadmill. Gait accelerometry signals were captured via a tri-axial accelerometer positioned over the L3 segment of the lumbar spine. Motion capture data were also collected and served as the comparison method. Results: our analysis of the accelerometry data showed that the proposed methodology was able to accurately extract heel and toe-contact events from both feet. We used t-tests, analysis of variance (ANOVA) and mixed models to summarize results and make comparisons. Mean gait cycle intervals were the same as those derived from motion capture, and cycle-to-cycle variability measures were within 1.5%. Subject group differences could be similarly identified using measures with the two methods. Conclusions: a simple tri-axial acceleromter accompanied by a signal processing algorithm can be used to capture stride events. Clinical impact: the proposed algorithm enables the assessment of stride events during treadmill walking, and is the first step toward the assessment of stride events using tri-axial accelerometers in real-life settings.

We investigate the phenomenology of flavored dark matter (DM). DM stability is guaranteed by an accidental Z3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\mathcal{Z}}_3 $$\end{document} symmetry, a subgroup of the standard model (SM) flavor group that is not broken by the SM Yukawa interactions. We consider an explicit realization where the quark part of the SM flavor group is fully gauged. If the dominant interactions between DM and visible sector are through flavor gauge bosons, as we show for Dirac fermion flavored DM, then the DM mass is bounded between roughly 0.5 TeV and 5 TeV if the DM multiplet mass is split only radiatively. In general, however, no such relation exists. We demonstrate this using scalar flavored DM where the main interaction with the SM is through the Higgs portal. For both cases we derive constraints from flavor, cosmology, direct and indirect DM detection, and collider searches.

UDK: 582.282.16:712.2(1-751.2) (497.6 Sutjeska) In August 2014, a short mycological research was carried out in the Sutjeska National Park, Bosnia and Herzegovina, at several localities along the rivers Sutjeska and Hrčavka. The main objective of this research was to start documenting presence of fungal species in this area so that a provisional list of potentially rare and endangered species could be proposed in the future. Over 20 species, members of the phylum Ascomycota, were collected and examined (families Pyronemataceae, Pezizaceae, Ascobolaceae and Helotiaceae), some of which were recorded for the first time for Bosnia and Herzegovina. As a first step towards the aforementioned goal, three identified species - Peziza polarispinosa J. MORAVEC, Parascutellinia carneosanguinea (FUCKEL) T. SCHUMACH., Marcelleina brevicostatispora J. MORAVEC were selected to be presented in this paper.

Aim: To determine the rural–urban differences in primary care practice, hospital inpatient care and total services. Methods: This cross-sectional study used data from Zenica-Doboj Canton in Federation of Bosnia and Herzegovina (FBiH). The overall sample size for the study was 1,995. Individual interviews were conducted in one randomly selected day of the week, except Monday and Friday, on the basis of EUROPEP (European Task Force on Patient Evaluations of General Practice Care) standardized questionnaire. Results: Out of total number (n=1 995), 47.9% was urban population and median of age was 42 years for both populations. The most of urban residents (81.4%) had finished high school or higher education compared with rural residents (58.5%) (p < 0.001). There are significant differences in employment status between rural and urban population (p < 0.001). Rural residents are more likely to travel more than 15 minutes to see their health facilities compared with urban residents (61.7% vs. 24.4%, respectively). Median of distance (kilometers) from residence location to the nearest hospital was statistically significantly higher in rural Me = 8.0 (5.0 do 14.5) km compared to urban population Me = 1.5 (1.0 to 3.0) km (p < 0.001). The rural population was more likely to buy drugs for medical treatment (p < 0.001) and parenteral injections in primary care practice (p < 0.001). Conclusion: There are significant differences in the overall health care assessment of rural populations as compared to urban populations.

BACKGROUND Triple-negative breast cancer (TNBC) is an aggressive disease without established targeted treatment options for patients with metastatic disease. This study was undertaken to evaluate potentially actionable biomarkers in a large cohort of TNBC and compare them with non-TNBCs. MATERIALS AND METHODS We evaluated 6341 (2111 TNBC and 4230 non-TNBC) breast cancer samples at a central laboratory for biomarkers of potential drug response across multiple platforms, including gene sequencing, protein expression, and gene copy number. RESULTS TNBC expresses androgen receptor (AR) in a significantly (P < .05) lower percentage of cases (17%) than hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-positive breast carcinomas (59% and 79%, respectively), and gene comutations were differentially associated with AR-positive versus AR-negative cases. Higher AR expression levels in TNBC predicted for lower Ki-67 levels. Seventy percent of TNBC harbored a phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), v-akt murine thymoma viral oncogene homolog 1 (AKT1), or phosophatase and tensin homolog (PTEN) aberration. TNBC patients had a significantly lower PIK3CA mutation rate (13%) than all other subtypes (P < .05) and a higher tumor protein p53 (TP53) mutation rate (64%) than the estrogen receptor (ER)-positive cases (approximately 30%; P < .05). Topoisomerase 2 (TOP2A) amplification was observed in 1.3% of TNBC and in 1.6% of HER2-negative, HR-positive cancers; in contrast, HER2-positive, HR-negative or HR-positive cancers exhibited TOP2A amplification in 19% and 40% of cases, respectively (P <.05). CONCLUSION Multi-platform molecular profiling identifies subgroups of TNBC with different biomarker profiles, suggesting numerous potentially targetable alterations in TNBC. TNBC is further characterized by different gene mutations and proliferative activity relative to AR expression, highlighting a need for comprehensive pathologic examination with potential to develop different, individualized treatment options.

UDK: 630*222:582.632.2 (497.6 Sarajevo)           582.632.2:630*5(497.6 Sarajevo) The paper represents a methodological approach in categorization of coppice beech stands in Sarajevo Canton area in relation to their ecological, productive, structural and silvicultural characteristics. For the collection of necessary data, method of temporary experimental surfaces, systematically allocated in squares 200 meters distant from each other has been used, in accordance to design of simple systematic sample. Concentric circles whose radius depend on tree diameter has been used as sample units (STOJANOVİĆ & DRİNİĆ, 1975). Data have been conducted in 659 locations. Stands have been categorized in three categories in relations to predefined criteria of categorization based on stand environment, productiveness, structure, economic value and fostering needs. For each of the categories, average units of basic productive indicators of the stand have been determined: number of trees, basal area, volume and volume increment per year for marked and unmarked, as well as same indicators of marking timber volume and the intensity of felling. Statistical significance of difference between the indicators has been tested by the method of variant analysis. Based on the results, indirect conversion has been recommended for the first stand category, direct and combined conversion for second one, and third category didn't need conversion because they have predominantly protective character