Introduction: While the influence of type 1 diabetes mellitus (T1DM) on periodontal health is well established, results of previous studies regarding the association of this metabolic disease and caries experience are rather inconsistent. The aim of this study was to assess the differences between caries status of healthy and adolescents with T1DM, as well as to determine the differences in caries experience among diabetic patients in relation to their metabolic control.Methods: Assessment of caries status was performed using the DMFT index (decayed, missing, and filled teeth). The study group (Diabetic) included 60 patients diagnosed with T1DM, aged 12-18 years, from Sarajevo Canton. This group was divided into two sub-groups: a sub-group Diabetic-W consisted of 30 patients with well-controlled glycaemia, while a subgroup Diabetic-P comprised of 30 patients with poorer glycemic control. The control group consisted of 30 age-matched metabolically healthy individuals.Results: The T1DM adolescents had a significantly higher (p < 0.01) mean DMFT score than the healthy subjects, 11.49 and 6.19 respectively. Statistically, the diabetic group had also significantly higher values of the D and M components. Concerning the metabolic control, mean DMFT score in the Diabetic-W subgroup was lower (10.57) than in the Diabetic-P subgroup (12.39), however the difference was not statistically significant.Conclusions: The results demonstrate that the T1DM patients have a higher caries experience, regardless of the degree of metabolic control. The level of untreated dental decay and missing teeth components among the diabetic adolescents indicates irregular dental attendance.

It has been shown that up to 64 percent of personal computers in office buildings are left running during after-hours. Enabling power management options such as sleep mode is a straightforward method to reduce the energy consumption of computers. However, choosing the right timeout can be challenging. A sleep timeout which is too low leads to discomfort, whereas a timeout which is too high results in poor energy saving efficiency. Having the users choose their own sleep timeout is not viable as research shows that most users disable the sleep timeout completely, or choose a suboptimal timeout. Unlike existing context based power management systems which use predefined rules, we propose a solution which can determine a personalized sleep timeout for any point in time solely based on the users behaviour. We propose multiple models which have the goal of maximizing the energy savings while minimizing discomfort. The models are tested on the computers of employees of the University of Groningen over several weeks. We analyse the results of the experiments and determine which model performs best. We can potentially save between 4.02 and 17.17 kWh per computer per year, depending on the model that used.

In the context of English as a global language, and Netspeak as a new electronic medium of communication, the present paper examines the linguistic properties and distinctive features of online communication in postponed time, bearing in mind that synchronicity is one of the dimensions upon which electronic communication can be categorised. This corpus-based study, for which data were collected from several Internet sites, places particular focus on the features of English used in asynchronous settings. The analysis, based on the model proposed by David Crystal (2001), portrays a number of highly distinctive features of Netspeak, proving an immense impact of thethis type of commucniation in terms of graphology (emoticons, punctuation) and the lexicon (blending, compounding), these being areas where it is relatively easy to introduce both innovation (nonce formation and other ludic Netspeak extensions) and deviation (abbreviations, acronyms). Keywords: Netspeak, Internet, asynchronus settings, distinctive linguistic features, synchronicity

Mixed-lineage leukemia (MLL) is a subtype of acute myeloid leukemia with more aggressive prognosis than other subtypes. Translocations of MLL gene with other partner genes, forming the MLL-fusion proteins (MLL-FPs), are the main characteristics of MLL leukemia. Many studies have demonstrated that MLL-FPs such as: MLL-AF4, MLL-AF6, MLL-AF9, MLL-AF10, MLL-ENL, MLL-ELL, MLL-EPS15, as well as partial tandem duplication are the most common abnormalities that play significant role in MLL-rearranged leukemia. Gene expression profiles from 197 patients and 180 clinical data were downloaded from TCGA database. R statistical program has classified clinical and genomic data simultaneously according to cytogenetic abnormalities. As a result of this analysis, the most frequent 47 MLLFPs genes expression have been detected and compared with other cytogenetic abnormalities such as t(4;11), t(9;11), t(8;21), t(15;17), complex, inversion 16, trisomy 8 and cytogenetically normal AML. 35 out of 46 MLL-FPs genes presented with abnormal gene expression profile. This study showed that MLL-FPs are not just active and related with MLL, but also with other subtypes of AML.

By observing the equivalence of assertions on determining the jump of a function by its differentiated or integrated Fourier series, we generalize a previous result of Kvernadze, Hagstrom and Shapiro to the whole class of functions of harmonic bounded variation and without finiteness assumption on the number of discontinuities. Two results on determination of jump discontinuities by means of the tails of integrated Fourier-Chebyshev series are derived.