Situs viscerum inversus totalis is a rare condition in which organs are transposed from the normal side to the opposite side in the abdominal and chest cavity. It occurs in a ratio from 1:5000 to 1:20000. In this case report, a case of a 50-year-old man who was diagnosed with the symptomatic presence of gallstones with the usage of ultrasound. The patient underwent the laparoscopic cholecystectomy, the surgical procedure lasted for 90 minutes, it was successfully completed and the patient was discharged on the first postoperative day.

Introduction: An ankle joint is a modified hinged joint consisted of three bones and ligaments. Muscles that result in plantar, that is, dorsal flexion, work through this functional unit. Aim of the Study: The aim of the paper is to analyze injuries of supra-syndesmotic fractures of the fibula, which were treated operatively with or without syndesmotic screw as well as to evaluate clinical results of the treatment after 3, 6 and 12 months. Patients and Methods: A retrospective-prospective study consisted of 102 respondents treated at the Clinic for Orthopedics and Traumatology UCC Sarajevo. Patients were divided into two groups. The first group (G1) consisted of 48 (47%) respondents who had met the required criteria – placement of a syndesmotic screw during the operation, and the second group (G2) consisted of 52 (53%) respondents who did not have a syndesmotic screw inserted during the operation. Results: The average value of the AOFAS score after 12 months in the group G1 was 91.15 points. The average value of the AOFAS score in the group G2 was 89.15 points. The value of the T-test was 1.688, p = 0.095 (p> 0.05). There was no significant difference in the average AOFAS score between the G1 and G2 respondents. Conclusion: The results obtained in the study confirm that there is no significant difference in the final outcome of the treatment between the G1 and G2 respondents. There is no significant difference in duration of treatment and hospitalization between groups G1 and G2. Significantly better average values regarding mobility for patients in the group G2 during the check-ups 3 and 6 months after the surgical procedure were transient.

Machine-type communications and large-scale information processing architectures are among key (r)evolutionary enhancements of emerging fifth-generation (5G) mobile cellular networks. Massive data acquisition and processing will make 5G network an ideal platform for large-scale system monitoring and control with applications in future smart infrastructures. In this work, we investigate a capability of such a 5G network architecture to provide the state estimate of an underlying linear system from the input obtained via large-scale deployment of measurement devices. Assuming that the measurements are communicated via densely deployed cloud radio access network (C-RAN), we formulate and solve the problem of estimating the system state from the set of signals collected at C-RAN base stations. Our solution, based on the Gaussian Belief-Propagation (GBP) framework, allows for large-scale and distributed deployment within the emerging 5G information processing architectures. The presented numerical study demonstrates the accuracy, convergence behavior and scalability of the proposed GBP-based solution to the large-scale state estimation problem.

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10−8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

LHCb experiment at CERN has recently reported a set of measurements on lepton flavour universality in $b \to s$ transitions showing a departure from the Standard Model predictions. I will review the main ideas recently put forward to make sense out of these intriguing hints. Focusing on the new physics explanation, I will discuss the correlated signals expected in other low- and high-energy observables, that could help clarify the mysterious anomalies.