The Wiener index W(G) of a simple connected graph G is defined as the sum of distances over all pairs of vertices in a graph. We denote by W[T_{n}] the set of all values of Wiener index for a graph from class T_{n} of trees on n vertices. The largest interval of contiguous integers (contiguous even integers in case of odd n) is denoted by W^{int}[T_{n}]. In this paper we prove that both sets are of the cardinality (1/6)n^3+O(n^2) in the case of even n, while in the case of odd n we prove that the cardinality of both sets equals (1/(12))n^3+O(n^2) solving thus two conjectures posed in literature.

Introduction: Perinatal asphyxia (PA) results in hypoxic damage to almost all organs, kidneys being most frequently (40%) affected. Objectives: was to determine the incidence of acute renal failure (ARF) in term neonates with PA and to correlate it with severity of hypoxic ischemic encephalopathy (HIE). Materials and methods: This prospective study of 54 term neonates with PA was performed in tertiary level neonatal intensive care unit at Pediatric Clinic Sarajevo from June 2014 to June 2016. The severe PA was defined as 5. minute Apgar score < 3 and moderate PA as 5. minute Apgar score 4-6. Criteria adopted for ARF were serum creatinine > 1.5 mg/dl (> 133 micromol/L) on 3rd day of life or urine output < 0.5 ml/kg/hr for > 6 hrs beyond 24 hrs of life. Results. Out of 54 neonates with PA, 22 (40.74%) had ARF. Most of them (63.6%) had non-oliguric ARF with mean renal output of 2.2 ± 0.5 ml/kg/h. Eight neonates (36.4%) had oliguric ARF with mean renal output of 0.35 ± 0.6 ml/kg/h. Most of the neonates with oliguric ARF (63.4%) had severe PAwhile in those with non-oliguric ARF moderate PA was predominant. ARF was highest in the neonates with HIE III (85.71 %) (Figure 1). This showed that as HIE stage progressed, more renal dysfunction was seen in asphyxiated babies and this difference in incidence was found statistically significant (p < 0.05). Conclusions. Neonates with severe PA had more frequent ARF and the predominant type of renal involvement was non oliguric. Neonates with HIE stage II and III had significantly higher incidence of ARF.

Introduction: An incarceration of inguinal hernia is a life-threatening condition and represents the most frequent complication, particularly in the elderly patients. It may compromise vascularisation of the contents of the hernia. A surgical treatment of the incarcerated inguinal hernia represents one of the most frequent surgical interventions in elderly patients and it grows proportionally with the age. Aim of the Study: The aim of the study is to investigate some of the factors that may have an impact on the incarcerated inguinal hernias surgical treatment outcome in elderly patients. Patients and Methods: The study included 149 patients classified in two groups: the study group (> 60 years of age), which included 96 patients, and the control group (≤ 60 years of age) , which included 53 patients, treated in the period from January 1st, 2012 to December 31st, 2016 at the Clinic of General and Abdominal Surgery UCC RS Banja Luka. Results: Most of the patients had right inguinal hernia (51.16% in the study group, 60.37% in the control group). 82 patients (85.41%) of the study group suffered from some of the accompanying chronic diseases, opposite to 20 patients (37.73%) of the control group. Polypropylene mesh was implanted in 105 (70.47%) patients, while the tension technique was performed in 44 (29.53%) patients. The duration of incarceration longer than 24 h (p=0.015), previous abdominal surgery (p=0.001), the American Society of Anaesthesiologists physical status classification system (ASA classification) (p=0.033) and the presence of chronic diseases (p=0.01) appeared to be statistically significant risk factors for performing intestinal resection in the study group, while in the control group, they represented risk factors, but not at the level of statistical significance (p > 0.05), except for the duration of incarceration (p=0.007). A higher ASA stage (p=0.001), is the most important risk factor for lethal outcome in both groups of patients. Conclusion: Incarcerated inguinal hernia is a very serious and demanding surgical problem, particularly in elderly patients. A higher ASA score and the presence of bowel resection are the most important risk factors related to very difficult complications.

Despite being known for 5000 years, after the records of imperial Chinese doctors, cannabinoids as a subject of scientific research experienced its rise after 1964, when delta nine tetrahydrocannabinol (Δ 9 THC) by Israeli scientists was identified. This was followed by the discovery of endogenous ligand / endocannabinoids, as well as receptors CB1 and CB2. In a broader sense, endocannabinoids act as neuromodulators and immunomodulators. They are included in the various physiological processes such as: the occurrence of pain, cognition, memory formation and neuroplasticity, physical activity, respiratory processes, appetite regulation, control and heart rate, nausea and emesis, intraocular pressure, inflammatory and immune processes (antigen recognition).

Objective – The aim of this study is to summarize the epidemiology of vaccine preventable diseases in the Federation of Bosnia and Herzegovina from 1996 to 2015, and assess the impact of immunization. Methods – The analyses presented in this paper are based on the data collected by the Institute for Public Health of the Federation Bosnia and Herzegovina or by reviews of historical data. Results – Data suggests clear evidence of the reduction of burden of vaccine-preventable diseases after introduction of vaccines in the immunization program. Diphtheria and poliomyelitis have been eliminated, and tetanus and pertussis have been significantly reduced. Since the target of 95% vaccination coverage against measles, mumps and rubella was not achieved and the number of susceptible individuals’ increased, infectious agents still circulates and delayed outbreaks occur. Conclusion – Despite impressive achievements in vaccine-preventable diseases control, continued trust and investments in the immunization program in the Federation of Bosnia and Herzegovina are essential.