LHCb experiment at CERN has recently reported a set of measurements on lepton flavour universality in $b \to s$ transitions showing a departure from the Standard Model predictions. I will review the main ideas recently put forward to make sense out of these intriguing hints. Focusing on the new physics explanation, I will discuss the correlated signals expected in other low- and high-energy observables, that could help clarify the mysterious anomalies.

The Tactile Internet presently constitutes a vision of an Internet over which, in addition to current communications modalities, a sense of touch can be transported. In that case, people would no longer need to be physically near the systems they operate, but could control them remotely. The main problem that needs to be solved to realize the Tactile Internet is summarized by the “1 ms challenge.” If the response time of a system is below 1 ms, the end-user will not be able to tell the difference between controlling a system locally or from another location. This paper offers a summary of the requirements for haptic communications, followed by an overview of challenges in realizing the Tactile Internet. In addition, possible solutions to these challenges are proposed and discussed. For example, the development of the fifth generation mobile communication networks will provide a good foundation upon which a Tactile Internet could be built. This paper also describes the design of a modular testbed needed for testing of a wide variety of haptic system applications.

Objectives Efficacy, safety and immunogenicity results from the phase III study of SB2, a biosimilar of reference infliximab (INF), were previously reported through 54 weeks. This transition period compared results in patients with rheumatoid arthritis (RA) who switched from INF to SB2 with those in patients who maintained treatment with INF or SB2. Methods Patients with moderate to severe RA despite methotrexate treatment were randomised (1:1) to receive SB2 or INF at weeks 0, 2 and 6 and every 8 weeks thereafter until week 46. At week 54, patients previously receiving INF were rerandomised (1:1) to switch to SB2 (INF/SB2 (n=94)) or to continue on INF (INF/INF (n=101)) up to week 70. Patients previously receiving SB2 continued on SB2 (SB2/SB2 (n=201)) up to week 70. Efficacy, safety and immunogenicity were assessed up to week 78. Results Efficacy was sustained and comparable across treatment groups. American College of Rheumatology (ACR) 20 responses between weeks 54 and 78 ranged from 63.5% to 72.3% with INF/SB2, 66.3%%–69.4% with INF/INF and 65.6%–68.3% with SB2/SB2. Treatment-emergent adverse events during this time occurred in 36.2%, 35.6% and 40.3%, respectively, and infusion-related reactions in 3.2%, 2.0% and 3.5%. Among patients who were negative for antidrug antibodies (ADA) up to week 54, newly developed ADAs were reported in 14.6%, 14.9% and 14.1% of the INF/SB2, INF/INF and SB2/SB2 groups, respectively. Conclusions The efficacy, safety and immunogenicity profiles remained comparable among the INF/SB2, INF/INF and SB2/SB2 groups up to week 78, with no treatment-emergent issues or clinically relevant immunogenicity after switching from INF to SB2. Trial registration number NCT01936181; EudraCT number: 2012-005733-37.

The goal of the paper is to analyze the Sino-Russian relations in Central Asia since the collapse of the Soviet Union. The analysis will briefly touch upon the relations between Beijing and Moscow in general but the focus will remain on their relations in the post-Soviet era in Central Asia. Today, China and Russia are BRICS member states. They are united in opposing US unipolarity and they are among the largest and most populous countries in the world. Their border is over 4.000 km long and they are both veto powers on the United Nations Security Council. However, relations between China and Russia have always been complex. At times they waged wars and had border disputes, only to become close allies shortly after. Period of severe conflicts between 1917 and 1950 was followed by a progressive era of oil exploration, student exchanges and various other partnerships. Their rapprochement ended in 1960 and started again in 2008. But the question is: How long wills the rapprochement last? They currently have many things in common but Central Asia remains a potential area of dispute for both countries. Analyzing some accounts on Chinese investments in Central Asia (e.g. Tiezzi, 2014), it becomes obvious that Beijing is highly unlikely to withdraw from the region in case of Russian pressure. On the other hand, Russia is highly unlikely to continue tolerating the rising Chinese influence in Central Asia, as its role has already been significantly reduced in this region. The pipeline that was supposed to connect Siberia with the Chinese province of Xinjiang has been postponed because Putin believes that it could give China leverage over Russia’s internal, as well as external political processes. Putin’s decision will certainly not stop China’s expansion in Central Asia and the Russian Federation will try to avoid a subordinate position in its former republics. This situation complicates their relationship in Central Asia, especially if growing US investments in the region are taken into account. This is why selecting a single IR theory to analyze the Sino-Russian relations in Central Asia is not a simple task. Considering the current circumstances and initiatives by both countries in their internal affairs, as well as in Central Asia, neoclassical realist approach to Sino-Russian relations might give the best results and it will therefore be applied in this paper.

This text critically reflects on cultural events organized to mark the 100th anniversary of the start of the First World War in Sarajevo and Bosnia & Herzegovina. It elaborates on disputes which showed that culture is in the centre of identity politics and struggles (which can also take a fascist nationalist form, accept the colonizer’s perspective, etc.), on how commemorations ‘swallowed’ the past and present, but primarily contextualizes, historicizes and politicizes Sarajevo 2014 and its politics of visibility. This case is approached as an example and symptomatic of the effects of the current state of capitalism, coloniality, racialization and subjugation, as central to Europe today. Article received: June 2, 2017; Article accepted: June 8, 2017; Published online: October 15, 2017; Original scholarly paper How to cite this article: Isanovic, Adla. "Sarajevo: Politics and Cultures of Remembrance and Ignorance."  AM Journal of Art and Media Studies 14 (2017): 133-144. doi:  10.25038/am.v0i14.199

Introduction Faecal calprotectin (FC) is a routinely used marker for identifying and monitoring children with inflammatory bowel disease (IBD). This non-invasive test is useful for screening children with gastrointestinal symptoms to avoid unnecessary invasive procedures. In this study, we validated for the first time the performance of a fully automated particle-enhanced turbidimetric immunoassay (PETIA) on the VITROS® 5600 analyzer for measurement of FC in symptomatic children and adolescents. Materials and methods For performance validation of the PETIA (fCAL® turbo, Bühlmann Laboratories, Switzerland) on the VITROS® 5600 analyzer (Ortho Clinical Diagnostics, USA) limit of quantitation (LoQ), linearity, precision data and calibration curve stability were defined. Additionally, 95 faecal samples were measured using the PETIA, an enzyme-linked immunosorbent assay (ELISA; fCAL®, Bühlmann Laboratories, Switzerland) and a semi-quantitative lateral flow assay (Quantum Blue Reader®, Bühlmann Laboratories, Switzerland) for agreement evaluation. Results The LoQ for calprotectin using PETIA on the VITROS® 5600 analyzer was 21 µg/g. The linearity range was 20 - 2100 µg/g and the precision study showed a total coefficient of variation (CV) between 2.3% and 8.9%. The calibration curve was stable for 4 weeks. Using the clinical samples quantifiable by PETIA, ELISA and the semi-quantitative lateral flow assay, Passing-Bablok regression analysis and Bland-Altman plots showed good agreement. Conclusions Due to good performance characteristics and agreement with established methods, the fully automated PETIA on the routine chemistry analyzer VITROS® 5600 is a new analytical option for the rapid determination of FC.