The article discusses the reception and circulation of programmed instruction at the Universidade Federal de Minas Gerais as an example of the appropriation of behavioral analysis in Brazil and sheds light on part of this appropriation in the 1960s and 1970s in the context of Brazil's higher education reform and of US social and intellectual influence. Results indicate that the indigenization of programmed instruction involved its circulation as an educational resource that emphasized the student's role and his autonomy from the teacher. Sources point to clashes that derived from preconceptions about both the teaching-learning process and US influence, key elements to understand the reception and circulation of programmed instruction in Brazil.

Abstract Background We report a case of isolated metastasis on the anterior clinoid process (ACP) mimicking meningioma. Clinical Presentation A 58-year-old male presented with headaches, right-sided visual disturbances, and blurred and double vision. The cause of double vision was partial weakness of the right III nerve, resulting from compression of the nerve by “hypertrophied” tumor-involved right anterior clinoid. Medical history revealed two primary malignant tumors—male breast cancer and prostate cancer (diagnosed 6 and 18 months prior, respectively). The patient was treated with chemotherapy and showed no signs of active disease, recurrence, or metastasis. Postcontrast head magnetic resonance imaging (MRI) showed extra-axial well-bordered enhancing mass measuring 1.6 × 1.1 × 1 × 1 cm (anteroposterior, transverse, and craniocaudal dimensions) on the ACP, resembling a clinoidal meningioma. Extradural clinoidectomy with tumor resection was performed via right orbitozygomatic pretemporal skull base approach. Visual symptoms improved. Follow-up MRI showed no signs of tumor residual or recurrence. Conclusion This is the first case report of a metastasis of any kind on ACP. Metastasis should be included as a part of the differential diagnosis of lesions of the anterior clinoid. Extradural clinoidectomy is a safe and effective method in the treatment of these tumors.

It is known that oxidoreductase is responsible for the regulation of oxidative stress in organisms, and pathological changes occur within the cell in the form of accumulation or lack of superoxide and peroxide radicals if the oxidoreductase activity is disturbed. Currently, the development of drugs that target the affected cells while leaving healthy cells unaffected is of great interest. The action of potential drugs is based on the inhibition / activation of oxidoreductase. In this work, we studied the electrochemical parameters of superoxide dismutase as well as the action of the potential drug of boroxine - dipotassium trioxohydroxytetrafluorotriborate (K2[B3O3F4OH]) as a target therapeutic for enzyme activity. Electrochemical tests were carried out in a classical three-electrode system using cyclic voltammetry and chronoamperometry techniques, and the obtained results were presented in the form of the kinetic parameters with the maximum value of the current obtained when the solution was saturated with the substrate (Imax) and the Michaelis-Menten constant (Km). K2[B3O3F4OH] was proven to be a reversible inhibitor, and the obtained Imax without inhibitor value of 0.014 mM and Km = 12.09 mM. The results from the Lineweaver - Burk diagram show that the inhibition is a partial noncompetitive inhibition type.

Summary Background: There is still no reliable, specific biomarker for precision diagnosis and clinical monitoring of systemic lupus erythematosus. The aim of this study was to investigate the importance of the determination of immunofenotypic profiles (T, B lymphocytes and NK cells) and serum cytokine concentrations (IL-17 and IFN-alpha) as potential biomarkers for this disease. Methods: The study included 55 patients with SLE and 25 healthy controls. The proportion of T, B, NK cells were assessed in peripheral blood using flow cytometric assays while the serum cytokine concentration (IL-17 and IFNalpha) was determined by ELISA test. Results: ROC curve analysis showed good accuracy to distinguish between patients and healthy individuals for activated T cells (AUC=0.798; p<0.001), Treg (AUC= 0.651; p=0.036), and memory B cells (AUC=0.285; p=0.002). We found statistically significant difference (p=0.036) in the levels of serum IL-17 between patients with SLE (IL-17=49.27 pg/mL) and controls (IL-17= 28.64 pg/mL). Conclusions: Significant increase in the relative number of Treg lymphocytes, and decrease in memory B cells, as well as decrease level of IL-17, in SLE patients may be implicated in the pathogenesis of the disease. These parameters, as biomarkers, could distinguish SLE patients and no-SLE patients. Monitoring subpopulations of immune cells in peripheral blood using flow cytometry provides insight into abnormal T and B cell function in SLE. Progress in understanding the immunity at SLE, results in concrete benefits for the SLE patients, which include new clinical management and therapeutic strategies.

Cardiovascular diseases (CVDs) are the major cause of disability and premature death all over the world. Annually, 17.5 million people die from CVDs, representing 30% of the total number of deaths. Despite established guidelines for the treatment of acute coronary syndrome, cardiac weakness, atrial fibrillation and CVD prevention, many patients remain inadequately treated, particularly in less developed nations. A brief overview of the development of CVDs, description of the current practice guidelines, and a cross sectional analyses of the status of CVD prevention and control in the Federation of Bosnia and Herzegovina is given. In the past 7 years, there has been a steady increase in deaths, where half of all deaths in the Federation of Bosnia and Herzegovina are attributed to CVDs. Deaths from the acute myocardial infarction had a rate of 91.0/100,000 inhabitants, a significant increase compared to 2010, when this rate was 69.2. The second leading cause of death, a stroke, with a rate of 87.1 showed a slight decrease compared to 2010, when it was 89.9. The third leading cause of death, heart failure, with a rate of 68.4, has a slight decrease compared to 2010, when the rate was 75.7. CVDs are the leading cause of mortality in Federation of Bosnia and Herzegovina, which, in addition to the large number of premature deaths, also causes major costs for the health sector and economy.

<p style="text-align: justify;">The paper analyzes the behavior of the plastic container during the buckling, ie during the load effect on the containers. The analysis was experimentally performed on several different types of containers. The container material is polypropylene. Experimental determination of pressure force and corresponding deformation was performed in the<br />laboratory at the Faculty of Technical Engineering Bihać. The analysis includes experimental testing on assembled containers and on container side. Places where deformation occurs on the container sides are shown.</p>

<p style="text-align: justify;">The aim of this paper was to investigate the connection between student motivation and Content and Integrated Language Learning (CLIL) approach at the technically-oriented faculties of the University of Zenica. The past few decades have been marked with ongoing debates on what teaching approaches are most motivating for foreign language learners. It has been agreed upon that student-centered approaches are the most efficient ones. CLIL is one of them. Inherently, CLIL uses foreign language for teaching a particular content, in our case &ndash; the engineering one. For the purpose of the research, a questionnaire was conducted among the CLIL students, subsequent to their conference - CLIL 2017, which is the last stage of the CLIL approach to English language teaching at the aforementioned faculties. We hypothesized that the CLIL approach bolsters student<br />motivation for English language learning more than the ex-cathedra approach. The questionnaire proved the hypothesis true as the results indicated high level of motivation in students. In addition, students expressed great satisfaction with the CLIL in terms of its effect on their foreign language proficiency as well as the knowledge in the content matter<br />related to engineering. Also, students seem to be well aware of the fact that good knowledge of English language and good knowledge of engineering content create a solid basis for employment.</p>

<p style="text-align: justify;">This paper deals with the resistance of the shed of a steel hall in Drvar according to technical regulations for snow from 1961 and EC1 regulations. The paper aims to check the reliability of the shed with probabilistic approach. That also implies calibration of the steel hall construction analyzed with classic deterministic method. Statical system of the shed of a steel hall is a beam with a given span, Figure 1. Steel sections are hot rolled INP sections with specified statistic parameters. The length of the beam span is &lambda; = 2,4 m. The reliability indexes have to be analyzed in point 1(relevant statical forces and displacements for ULS and SLS) and according to equations of limit states.</p>