Verbal fluency (VF) is a good indicator of a child’s academic prowess and later academic success. The goal of the present study was to examine the association between VF and inhibitory control. An additional goal was to examine the developmental trajectories of VF in relation to the grade and gender of the children. The sample for this study consisted of 210 children attending grades 1 to 3. Children’s performance was measured on two VF tasks: semantic fluency and phonological fluency. As a measure of inhibitory control we used a number of commission errors committed on the Multiple Choice Reaction Test. The results of this study indicate the lack of association between VF and inhibitory control. Children improved significantly in VF from grade 1 to grade 3. In relation to gender, girls outperformed boys on the test of phonological fluency but not on the test of semantic fluency. Given the importance of VF, these skills need to be tackled during the elementary school period and even earlier in preschool.

Pleomorphic ductal carcinoma (PDC) is a very rare subtype of invasive ductal carcinoma of no‐special type (NST), characterized by the presence of highly atypical/bizarre (>6‐fold variation in nuclear size) and multinucleated (giant) neoplastic cells comprising >50% of the tumor cell population (Figure 1A). PDC is typically triple‐negative breast cancer (TNBC), associated with an aggressive clinical course and a poor outcome.2–4 So far, no single study explored novel predictive biomarkers for the precision medicine purposes in the patients with PDC. Formalin‐fixed paraffin‐embedded tissue samples of the six PDC patients (four primary and two metastatic cases) were sequenced for 592‐genes using NextSeq platform (Illumina, La Jolla, CA, USA). Tumor mutational load (TML) was calculated using only somatic nonsynonymous missense mutations; high TML was considered when it was ≥17 mutations/Mb. Microsatellite instability (MSI) status was explored by the direct analysis of known MSI loci in the target regions of the sequenced genes. Cases were considered microsatellite instable (MSI‐H) if they exhibited ≥46 altered microsatellite loci (the threshold was established by comparing to the PCR‐based MSI FA result from ~2100 cases). Copy number variations (CNVs) were determined by comparing the depth of sequencing of genomic loci with a diploid control. Calculated gains ≥6 copies were considered amplified. ArcherDx FusionPlex Assay was used to detect gene fusions (52 gene targets). Immunohistochemistry was used to detect expression of PD‐L1 (SP142 antibody, Ventana) in tumor cells (TC) and immune cells (IC). PD‐L1 positivity in TC was defined as 2+ intensity in ≥5% of tumor cells. PD‐L1 status

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status. Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors. Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006). Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.

Introduction. The rising need for quality health care, increased workload, accountability and healthcare reforms, are factors that resulted in growing requirements for recognition of the nursing profession, which are clearly defined in the Munich Declaration (2000). Unfortunately, in the current health care system in most of the transition countries of the Region of the South East Europe, nursing is still not adequately validated as a special profession. Aim. Presentation of legal solutions related to nursing profession in Bosnia and Herzegovina (B&H) from the aspect of definition of nursing activities, education standards, licensing and labor mobility. Methods. Desktop analysis as a method of quality research of legislative and strategic documents related to nursing in B&H. Analysis of the directive and legislation in the countries of the region and the EU. Comparison with the legislation of B&H. According to the constitutional solutions, within the competence of the Entities (Republic of Srpska), the area of health care in B&H is divided by the competencies of the entities and cantons (the Federation of B&H), that is, within the competence of the Brčko District of B&H, therefore, there is also a separate entity legislation. In 2013, the Government of the Federation of B&H adopted the Law on Nursing and Midwifery and secretly defined the nursing domains in accordance with the EU directives. In the Republic of Srpska and the Brčko District, this is partly defined in the systemic health care laws (amended in 2015). Conclusions. In all the legal acts reviewed, there are still shortcomings in the defined domains for the nursing profession. By addressing these issues, the progress of nursing development would speed up, strengthen and modernize the health system, which would undoubtedly increase the quality of health care to a higher level. The Ways of Development of Nursing as a Separate Health Profession: a Comparative Analysis of Legislative in the Nursing Profession in Bosnia and Herzegovina and Countries in the Region Croat Nurs J. 2018; 2(2): 141-148 142 Zelić S. et al. The Ways of Development of Nursing as a Separate Health Profession... Croat Nurs J. 2018; 2(2): 141-148 profession, increasing the mobility of nursing workforce, and improving the health care system in which nurses are an essential part, both as participants and as policymakers. The health of the population is undergoing significant changes in the current conditions of altered socio-environmental factors, the increasing challenges and risk factors in the environment, the new pathology, the need to strengthen health promotion and disease prevention, and bring new therapeutic approaches (4). Continuous monitoring and strengthening of health care is necessary. Consequently, the role of a nurse as a health care manager, from the planning, organization, management and control process is immeasurable in the health system of each country. There is not a single healthcare profession that treats individuals of all ages, families, groups and communities in a more comprehensive way, sick or healthy in all environments, such as nursing. Nursing involves health promotion, disease prevention, and care for sick, disabled and dying people. In addition, the key roles of nursing are the promotion of a healthy environment, research, participation in shaping health policy and managing hospital and health systems as well as education. Therefore, strengthening the profession of nursing is also a necessity and a need for the improvement of health systems in all countries of the world. Starting from the premise that health systems in countries all around the world are part of a global international health system, the EU, as an intergovernmental and transnational community of European states, emerged through the process of cooperation and integration, continuously implements the process of adapting health systems of all EU member states to the global health system and strives to achieve a recognizable quality of health education. Introduction The rising need for quality health care, increased workload and accountability, are factors that resulted in growing requirements for recognition of nursing and consequent health care reform. Relating to medicine as a science and profession, nursing must be defined as a specific branch of medical science, which has its own and completed framework of knowledge, methods, procedures and skills, as a part of the entire medical science. As a logical sequence of these demands, the Vienna Nursing Conference, 1988 and the Munich Conference, which further strengthened the status of nursing profession, were held. At the Munich Conference, the Munich Declaration 2000 was also adopted (1). Conclusions from these conferences became a guide to the legislative authorities of transition countries, such as the Southeastern European countries, which, through strong socio-economic reform processes, have begun to work on the development and advancement of nursing legislation and the advancement of nurses’ position in Europe, as independent and interdependent professionals. Furthermore, the European Union (EU) has defined the processes and norms of nursing education. The health systems of all EU Member States should be adapted to the global health system of the EU and achieve the prescribed and recognizable quality of health education. Implementation of those reforms requires the fulfilment of the Guidelines of the World Health Organization Regional Office for Europe, European Union Directives (2005/36/EC and 2013/55/ EC), and the Guidelines on the recognition of professional qualifications (2, 3). Unfortunately, in the current health care system in most of the transition countries of Southeastern Europe and the Western Balkans countries, nursing is still not adequately validated as a special profession. The aim of the paper is to analyze the legal and strategic solutions related to nursing and offered through legislation in Bosnia and Herzegovina (B&H) from the aspect of definition of nursing activities, education standards, licensing and labor mobility. By harmonizing these domains with EU standards, it can contribute to further strengthening the nursing Zelić S. et al. The Ways of Development of Nursing as a Separate Health Profession... Croat Nurs J. 2018; 2(2): 141-148 143 According to the constitutional solutions, within the competence of the Entities (Republic of Srpska), the area of health care in B&H is divided by the competence of the entities and cantons (the Federation of B&H), that is, within the competence of the Brčko District of B&H, and therefore there is a special entity legislation (6,7,8) complicated state system, poor coordination of competent sectors and many other problems, the process of harmonization of health laws will have to take place in those phases. The best example of this phase approach to solving the harmonization problem is the adoption of the special Law on Nursing and Midwifery of the Federation of B&H (Official Journal of the FB&H 43/13) (9). The basic goal of this law is to regulate the profession, i.e. define the activities, competencies, standards of education, licenses and other domains in order to place this profession in B&H at the same level with other regulated professions in health care. This would make nurses equal in rights and obligations with their counterparts in the EU, which would also enable the mobility of the personnel and the basis of this profession, the satisfaction of the end user or the patient. The law is mutually beneficial, both for nursing and for patients, and this is reflected in the following: • providing professional, efficient and effective nursing services for patients, • informing the patient about the possibilities of choosing services, • guarantee of quality of services, • encouraging the development of the profession, • recognition of the expertise, identity and social position of nurses. Through the Law, the nursing domains are clearly defined in accordance with EU Directives. Although not fully harmonized with European legislation, the part that could be harmonized is harmonized, and the part that is not harmonized due to existing obstacles will wait for the solution of these problems. In the Republic of Srpska and the Brčko District, this is partly defined in the systemic health protection laws (7, 8). Also, Directives 2005/36/EC and 2013/55/EC (2,3) provide the basis for mobility in the European labor market for sectoral professions, including nurses. Labor market mobility requires university education of Methods • Desktop analysis* as a method of quality research of legislative and strategic documents related to nursing profession in B&H • Analysis of directives and legislation in the countries in the region and the EU • Comparison with B&H legislation Directive 2005/36/EC of the European Parliament and of the Council on the Recognition of Professional Qualifications (2), (Directive 2005/36/EC) and its upgrading the Directive, Directive 2013/55/EC are two key EU Directives on Independent Professionals Of the European Parliament and of the Council on the Recognition of Professional Qualifications amending Directive 2005/36/EC on the recognition of professional qualifications and Decision (EU) no. 1024/2012 on administrative cooperation through the Internal Market Information System (3) (Directive 2013/55/ EC). These Directives contain standards that are the basis for the adoption of various legal acts in the field of nursing. In addition, the Bologna Declaration of June 1999 launched a series of reforms needed to make higher education in Europe more compatible and more comparable, more competitive and more attractive to its citizens and to citizens and scientists from other continents. Among the main objectives are the development of a progressive convergence of the overall framework of educational titles and cycles in the open European Higher Education Area, as a develo

Recent research has uncovered a developmental paradox within theory of mind. While spontaneous response measures indicate sensitivity to false beliefs in infants before their first birthday, tasks involving elicited response measures of false belief are only passed consistently from 4 years of age. In adults, it has been suggested that these spontaneous responses may result from a minimal theory of mind system, which allows rapid and automatic attribution of mental states to others.It has been proposed that the limitations of the minimal system in adults may resemble the limitations demonstrated by non-human animals in tasks thought to involve mental state attribution. Here we have adapted the specific satiety paradigm used with Eurasian jays to investigate adult humans’ anticipatory looking responses based on another individual’s specific satiety.Although no clear evidence was found for spontaneous desire attribution in this study, it is difficult to draw conclusions from these results given the small sample sizes available and the current replication failures of studies demonstrating spontaneous responses to false belief.

It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes.

Nanocrystalline domains can be used to create robust anti-fatigue-fracture hydrogels for artificial cartilages and soft robots. The emerging applications of hydrogels in devices and machines require hydrogels to maintain robustness under cyclic mechanical loads. Whereas hydrogels have been made tough to resist fracture under a single cycle of mechanical load, these toughened gels still suffer from fatigue fracture under multiple cycles of loads. The reported fatigue threshold for synthetic hydrogels is on the order of 1 to 100 J/m2. We propose that designing anti-fatigue-fracture hydrogels requires making the fatigue crack encounter and fracture objects with energies per unit area much higher than that for fracturing a single layer of polymer chains. We demonstrate that the controlled introduction of crystallinity in hydrogels can substantially enhance their anti-fatigue-fracture properties. The fatigue threshold of polyvinyl alcohol (PVA) with a crystallinity of 18.9 weight % in the swollen state can exceed 1000 J/m2.

The aim of the research was to make a socio-pedagogical description of the minors’ causal attributions for their own delinquent behavior, based on the attitudes expressed by juvenile delinquents. Moreover, the aim was to reveal whether there is a statistically significant correlation between internal and external factors of delinquent behavior. A method of theoretical analysis and a descriptive-analytical method were employed, while a Delinquent Behavior Attribution Scale (Ricijaš, 2009) was used as an instrument. The current research sample consisted of 205 juvenile delinquents aged 14-18 coming from the Zenica-Doboj Canton and showing some forms of risky and delinquent behavior. The results related to the internal causes of delinquent behavior showed that the young people mostly emphasize the following causes: antisocial tendencies, followed by unthoughtfulness, personal frustration, and susceptibility to peer pressure. The results associated with external causes of delinquent behavior indicated that the young people emphasize poverty and material benefit as causes in most cases, followed by excessive control and supervision by parents, poor family relationships, situation in which the minor is, narcotics, antisocial peers, permissive parents and alcohol. The results pertaining to the relationship between internal and external causes of delinquent behavior revealed that there is a statistically significant correlation between internal and external causes of delinquent behavior. It was concluded that socio-pedagogical preventive acting should include a range of factors exerting an influence on the personality development of young people, and that socio-pedagogical programs for providing support to juvenile delinquents should be created and realized with the aim to reduce and eliminate the causes of their delinquent behavior, and to contribute to their better resocialization.

Ḥadiths that have been discussed in this paper consist of narrations regarding divine attributes and having some problematic meanings between supporters of Bishr al-Marīsī and ʿUthmān al-Dārimī. These narrations were mostly accepted denounced (munkar) by Bishr alMarīsī and his supporters due to having an anthropormophist and corporealist content about God. They rejected divine attributes according to their understanding of God based on incomparability (tanzīh) which provided by Muʿtazilite approach towards divine attributes even though they conveyed some features of Ahl al-Ra’y. They found contradicted of attributing human features to God based on their tanzīh understanding, therefore, they interpreted such this kind of narrations in terms of their approach or rejected at all. At the other hand, a hard Ḥadith scholar ʿUthmān al-Dārimī believed that one should accept divine attributes as they are in the Qurʾān and Sunna. According to his belief, he considered the explicit meanings of the narrations without interpretation of divine attributes, and based on his perspective he denied Bishr al-Marīsī (d. 218 /833) and his supporters’ interpretations claiming they would cause divesting God of all attributes (ṭaʿtīl). He argues that these narrations should be taken into considerations based on their explicit meanings. The discussions on these ḥadiths are important due to showing different approaches of scholars from the schools of Ahl al-Raʾy and the ones from Ahl al-Ḥadīth towards the ḥadith during the period when the main Ḥadith works were collected. Discussions on the narrations studied in this paper reveal two schools’ understandings of divine issues, their approaches to divine attributes, as well inform us their perspectives of ḥadith in general.

Access to orphan drugs (In EU regulation Orphan Drugs are refered as Orphan Medi- cinal Products (OMP)) is a key role in determining whether patients with rare diseases (RDs) will receive adequate and efficient treatment. The objective of this article is to identify differences in patient access to orphan drugs in 3 pharmaceutical markets: Serbia, Croatia and Macedonia. Patient access was defined: as the market access (availability) and affordability (financial accessibility). We analysed the legislative requirements for the authorisation process and made a cross country comparison. Retrospective cross-sectional analysis was done on drug lists in selected countries and a cross-comparison between the List of Orphan Drugs in Europe (LODE) for a six-month period (May 2014-October 2014). We included all 179 OMPs marketed in EU in our analysis, which had received market authorization in Croatia upon its membership in the EU. Total number of marketed drugs in Serbia was 59 (32.96%) drugs and in Macedonia 52 (29.05%) drugs. However, market authorization does not guarantee patient access to any given drug, so only 39.11% of OMPs could be accessed by Croatian patients (70 drugs).The number of refunded drugs in Serbia and Macedonia was smaller (32 and 20, respectively) which makes respectively, 17.88% and 11.17% of drugs on the LODE. The present study showed some variations between countries in selected indicators of availability and access to orphan drugs. Patients in Croatia had greater number of registered and refunded drugs, but in Serbia more than a half of registered OMPs could be refunded from National Health Insurance Fund. Macedonia had smaller number of inhabitants and also had the smaller number of patients from certain RDs which results in lower total number of OMPs. Acta Medica Medianae 2018;57(4):43-51. (OMP), affordability, availability, rare diseases, legislative requirements

Explosive forming appeared at the end of the 19th century as unconventional technology that provides new methods to get workpieces with bigger dimensions and complex geometries. As a source of energy this technology uses explosives. Explosive, as such, is relatively inexpensive and theoretically with it, it is possible to get any amount of energy that is needed. Explosive forming is used with other technologies such as deep drawing, expansion of pipes, welding etc. One of the main explosive characteristics is the velocity of detonation that can be determined, inter alia, with the Dautrich method. This paper clarifies the method and gives a case study with explosive Vitezit 20.

The paper presents results of combined, conventional and non-conventional, approach for evaluation of mechanical and technological properties of structural steel's welded joints. The selected structural steels are in the range of most common used strength level(s), as well as corresponding various chemical composition concept(s) and processing routes. A short review regarding weldability is presented based on recommendation provided in EN 1011-2, manufacturers recommendation, and own results. However, even it is a well-known fact, mismatching of properties is presented rather to provide sense of its level for particular steel grades. Moreover, the level of under-matching of weakest weld zone (coarse grained heat affected zone), provided by mean of welding thermo-cycle simulation is presented. This is due to the fact that such estimation is not possible with everyday conventional (standardized) testing. The most important design and technological properties of welded joint(s) are considered; e.g. strength, ductility, hardness, microstructure and toughness.