Abstract Background: Serbs mainly live in the territory of the recently re-established state of Serbia. However, the turbulent history in the Balkan Peninsula has led to settlement of Serbs not only within present day Serbia, but also in different parts of neighbouring countries. Aim: To define polymorphisms of 23 Y-chromosomal short tandem repeat (STR) loci in a modern Serbian population from the central part of the Balkan Peninsula. Subjects and methods: The reference sample consisted of 303 men declared as Serbs over three generations. Localities of the collected materials include the territories of Serbia, Bosnia and Herzegovina, Croatia and Montenegro. DNA samples were typed using the PowerPlex®Y23 amplification kit. Results: The highest locus diversity was observed for DYS385 and DYS481. In this study the most abundant haplogroups were I2a, E1b1b, R1a and I1. The largest genetic distances between the Serbs and other close Southern Slavs were for the Macedonians and Slovenians. Conclusion: This study is the first one to define STR polymorphism of Serbian people not only from Serbia but also from other parts of the Balkan Peninsula. The presented genetic data may be useful in further examinations of the genesis and genetic structuring of the present-day Serbian gene pool.

ABSTRACT Objective/Background: About 15% of grievers experience complicated grief. We determined cross-sectional and longitudinal relations of grief and complicated grief with sleep duration and quality in the general population of elderly adults. Participants: We included 5,421 men and women from the prospective population-based Rotterdam Study. Methods: The Inventory of Complicated Grief was used to define grief and complicated grief. We assessed sleep with the Pittsburgh Sleep Quality Index. Results: After 6 years, 3,511 (80% of survivors) underwent the follow-up interview. Complicated grief was cross-sectionally associated with shorter sleep duration and lower sleep quality. These associations were explained by the presence of depressive symptoms. The prospective analyses showed that sleep duration and sleep quality did not decline further during follow-up of persons who experienced grief or complicated grief. Conclusion: In community-dwelling, middle-aged and older adults, persons with normal and complicated grief had both a shorter sleep duration and a lower sleep quality, mainly explained by depressive symptoms. However, prospective analyses showed that sleep quality and sleep duration do not decline further in persons with normal grief and complicated grief.

NEXTA is a new workshop on test automation that provides a meeting point for academic researchers and industry practitioners. While test automation already is an established practice in industry, the concept needs to evolve to go beyond its current state to support the ever faster release cycles of tomorrow's software engineering. NEXTA implications for research and practice will include test case generation, automated test result analysis, test suite assessment and maintenance, and infrastructure for the future of test automation. The rst instance of NEXTA was co-located with the 11th IEEE Conference on Software Testing, Veri cation and Validation (ICST 2018) in Vasteras, Sweden on April 9, 2018. NEXTA 2018 o ered an interactive setting with a keynote and paper presentations, stimulated by two novel awards to incentivize interaction and dissemination: a Best Questions Award and a Most Viral Tweet Award. The workshop attracted 15 paper submissions and about 50 participants. Based on the positive feedback, we plan to organize the workshop again next year.

NEXTA is a new workshop on test automation that provides a meeting point for academic researchers and industry practitioners. While test automation already is an established practice in industry, the concept needs to evolve to go beyond its current state to support the ever faster release cycles of tomorrow's software engineering. NEXTA implications for research and practice will include test case generation, automated test result analysis, test suite assessment and maintenance, and infrastructure for the future of test automation. The first instance of NEXTA was co-located with the 11th IEEE Conference on Software Testing, Verification and Validation (ICST 2018) in Vasterfias, Sweden on April 9, 2018. NEXTA 2018 offered an interactive setting with a keynote and paper presentations, stimulated by two novel awards to incentivize interaction and dissemination: a Best Questions Award and a Most Viral Tweet Award. The workshop attracted 15 paper submissions and about 50 participants. Based on the positive feedback, we plan to organize the workshop again next year.

ABSTRACT In this introduction to special issue ‘After Utopia: Leftist Imaginaries and Activist Politics in the Postsocialist World’, we explore the theoretical implications for thinking about activism as a form of historically situated practice in the former socialist world. Building on insights from the papers included in this issue, which draw on ethnographic research in Ukraine, Armenia, Bosnia and along the Balkan refugee route, our introduction considers both the fragility and resilience of leftist imaginaries in the aftermath of lost utopian dreams of socialism and the betrayed promises of post 1989 democratic transformation. We do so in four moves, (i) by offering a reframing of postsocialism as a problem-space of historical and political consciousness; (ii) by interrogating the figure of the activist in its self-conscious and ethnographically embedded guises; (iii) by heeding Sherry Ortner’s call to think beyond ‘dark anthropology’ and finally, (iv) by considering what it might mean to imagine, and model, political alternatives in both activist and scholarly work.

Supply chain management (SCM) has a dynamic structure involving the constant flow of information, product, and funds among different participants. SCM is a complex process and most often characteri...

There are many challenges in accurately measuring cigarette tar constituents. These include the need for standardized smoke generation methods related to unstable mixtures. In this research were developed algorithms using fusion of artificial intelligence methods to predict tar concentration. Outputs of development are three fuzzy structures optimized with genetic algorithms resulting in genetic algorithm (GA)-FUZZY, GA-adaptive neuro fuzzy inference system (ANFIS), GA-GA-FUZZY algorithms. Proposed algorithms are used for the tar prediction in the cigarette production process. The results of prediction are compared with gas chromatograph (high-performance liquid chromatography (HPLC)) readings.

Intelligence in large-brained vertebrates might have evolved through independent, yet similar processes based on comparable socioecological pressures and slow life histories. This convergent evolutionary route, however, cannot explain why cephalopods developed large brains and flexible behavioural repertoires: cephalopods have fast life histories and live in simple social environments. Here, we suggest that the loss of the external shell in cephalopods (i) caused a dramatic increase in predatory pressure, which in turn prevented the emergence of slow life histories, and (ii) allowed the exploitation of novel challenging niches, thus favouring the emergence of intelligence. By highlighting convergent and divergent aspects between cephalopods and large-brained vertebrates we illustrate how the evolution of intelligence might not be constrained to a single evolutionary route.

Rationale: Hydrocele of the canal of Nuck is a rare developmental disorder and represents of a homolog of hydrocele of spermatic cord in males. Hydrocele of the canal of Nuck is a very rare cause of inguinal swelling in female infants and children. It results from the failure of obliteration of the distal portion of evaginated parietal peritoneum within the inguinal canal, which forms a sac containing fluid. Patient concerns: We describe a case of hydrocele of the canal of Nuck in an 11-month-old girl with a past medical history of duodenal atresia and Arnold-Chiari malformation. Diagnosis: Physical examination and ultrasound revealed a soft, cystic, noncompressible, and non-fluctuant labial mass measuring approximately 5 cm. Interventions: The patient underwent surgical exploration through a right skin crease incision. The cystic lesion was histologically confirmed to be a non-communicated hydrocele of canal of Nuck. Outcomes: The child is doing well at 1-year follow-up with no swelling or recurrence on the operated side. Lessons: Hydrocele of the canal of Nuck is a rare developmental disorder but should be considered in a differential diagnosis in young girls with an inguino-labial swelling.

Background: The potential of angiography to evaluate the hemodynamic severity of a left main coronary artery (LM) stenosis is limited. Noninvasive transthoracic Doppler echocardiographic coronary flow velocity reserve (CFVR) evaluation of intermediate coronary stenosis has demonstrated remarkably high negative prognostic value. The aim of this study was to assess clinical outcomes in patients with angiographically intermediate LM stenosis and preserved CFVR (>2.0) as evaluated by transthoracic Doppler echocardiographic CFVR. Methods: The initial study population included 102 patients with intermediate coronary stenosis of the LM referred for transthoracic Doppler echocardiographic CFVR assessment. Peak diastolic CFVR measurements were performed in the distal segment of the left anterior descending coronary artery after intravenous adenosine (140 &mgr;g/kg/min), and CFVR was calculated as the ratio between maximal hyperemic and baseline coronary flow velocity. Nineteen patients had impaired CFVR (≤2.0) and were excluded from further analysis, as well as two patients with poor acoustic windows. The final group consisted of 81 patients (mean age, 60 ± 9 years; 76 men) evaluated for adverse cardiac events including death, myocardial infarction, and revascularization. Results: Mean follow‐up duration was 62 ± 26 months. Mean CFVR was 2.4 ± 0.4. Total event‐free survival was 75 of 81 (92.6%), as six patients were referred for revascularization (five patients with coronary artery bypass grafting, one patient with percutaneous coronary intervention). There were no documented myocardial infarctions or cardiovascular deaths in the follow‐up period. Conclusions: In patients with angiographically intermediate and equivocal LM stenosis and preserved CFVR values of >2.0, revascularization can be safely deferred. HIGHLIGHTSWe performed TDE CFVR of the intermediate coronary stenosis of LM.TDE CFVR>2 is associated with good long‐term clinical outcomes.TDE CFVR might be used as a valuable diagnostic tool in assessing LM stenosis.

Brain bioenergetics could be affected by many intrinsic and extrinsic factors, yet no link has been established between markers of bioenergetics in specific brain regions and educational level. In this cross-sectional study, we evaluated N-acetylaspartate-to-creatine ratio (NAA/Cr), a biomarker of brain functionality, using multivoxel proton magnetic resonance spectroscopy in twelve brain locations among healthy volunteers (n = 51; 30 females; age 47.8 ± 16.3 years) who earned either a high school diploma (36 out of 51) or a college degree (15 out of 51). Hierarchical multiple regression analysis revealed that our model as a whole (including level of education as a predictor variable, and age and gender as control variables) explained significant percentage of the variance in the NAA/Cr levels at 8 out of 12 specific brain locations (P< 0.05). This was highlighted in left anterior mesial cortex where the model explained 63.1% of the variance in brain NAA/Cr, with education and age make significant contributions (72.6% and 48.5%, respectively) to our model (P< 0.05). Having superior brain N-acetylaspartate-to-creatine ratio appears to be related with higher education in healthy men and women.

PURPOSE Co-administration of creatine and guanidinoacetic acid (GAA) has been recently put forward as an advanced dietary strategy to optimize tissue bioenergetics. We hypothesized that creatine-GAA mixture would result in a more powerful rise in brain and skeletal muscle creatine, as compared to creatine supplementation alone. METHODS A randomized, double-blinded, crossover superiority trial has been performed at the University of Novi Sad from December 2016 to November 2017. A total of 14 healthy young men were randomized to receive GAA-creatine mixture (1 grams of GAA and 3 grams of creatine per day) or equimolar creatine (4 grams per day) by oral administration for 4 weeks. RESULTS Creatine-GAA mixture was superior to creatine alone to increase mean creatine levels in skeletal muscle (16.9 ± 20.2 vs. 2.0 ± 6.0%; P = 0.02) and grey matter (5.8 ± 5.3% vs. 1.5 ± 3.2%; P = 0.02), also for bench press performance (6.0% vs. 5.1%; P < 0.01). Compared with creatine administration alone, combined GAA and creatine resulted in less weight gain (1.6 ± 0.2 kg vs. 0.7 ± 0.2 kg; P < 0.01). No inter-group differences were observed in terms of cardiorespiratory endurance, serum biomarkers, or adverse events. CONCLUSIONS Creatine-GAA mixture appeared to be superior to creatine alone for up-swinging tissue creatine content and upper body strength, and tended toward a lower risk of weight gain in healthy active men. The formulation might be considered as a novel energy-boosting alternative to creatine alone in weight-sensitive setups. TRIAL REGISTRATION ClinicalTrials.govNCT03350282.