Rudolf Ludwig Carl Virchow (1821-1902) was a German doctor, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician, known for his advancement of public health (1-4). He is known as “the father of modern pathology” because his work helped to discredit humourism, bringing more science to medicine (1). He is also known as the founder of Social medicine and Veterinary pathology, and to his colleagues, the “Pope of medicine” (2).

Eugene Ackerman (1920-2014), PhD, FACMI, Emeritus Professor of Laboratory Medicine and Pathology at the University of Minnesota (1-4). He studied Physics at Swarthmore College and Brown University, where he met and married Dorothy Hopkirk in 1943. His studies were interrupted by serving as a Conscientious Objector during World War II. After completion of a doctoral degree in Biophysics at the University of Wisconsin-Madison, he joined the Physics faculty at Pennsylvania State University, with several sabbaticals at the University of Pennsylvania in the Biophysics laboratory of Dr. Britton Chance. In 1960 he became Associate Professor of Biophysics at Mayo Clinic, working on mathematical models of physiological systems. He was instrumental in obtaining one of the first National Institutes of Health (NIH) resource grants for Biomedical Computing Facilities, followed by many research grants modeling ultrasonic behaviors of cells, enzyme kinetics, blood glucose regulation, and patterns of infectious disease epidemics (2). As adjunct Professor of Biophysics and Computer Science at the University of Minnesota, he developed a Mayo satellite program awarding a MS degree in Biophysics. In 1967 he left Mayo Clinic for the University of Minnesota, becoming Hill Family Foundation (now Northwest Area Foundation) Professor of Biomedical Computing and Professor of Biometry. A NIH grant to establish a Biomedical Computing Facility had been awarded to the University of Minnesota in 1965, and Eugene Ackerman became its director in 1968 after the illness of its first director, Dr. Eugene Johnson. With the establishment of the Academic Health Center in 1969, the entire biomedical computing program became the Division of Health Computer Sciences in the Medical School’s Department of Laboratory Medicine. Charged with developing core and collaborative research, training, dissemination and a service unit, the growing cadre of informatics faculty, fellows and graduate students helped develop departmental computer systems in the clinical laboratories, surgery, electrocardiography, pulmonary function, and nuclear medicine (4). Eugene was a superlative scientific educator and writer. One of the first and longest funded National Library of Medicine training grants in health computing was awarded to the University of Minnesota, which eventually trained over a hundred fellows from the health sciences, including ones from medicine, nursing, pharmacy, dentistry and public health. He personally directed the graduate theses of nearly a hundred students and postdoctoral fellows. Over his long career, he published hundreds of journal articles, conference abThe Most Influential Scientists in the Development of Medical Informatics (24): Eugene Ackerman (19202014)

Jules Rene Guerin (Boussu, Belgium, 1801–Hyres, 1886) commenced his medical studies at Paris in 1821, obtaining his doctorate at that university in 1826 (1-3). He was early attracted to journalism, and two years later he founded the medical journal Gazette de sante, of which he was both editor and publisher, and for which he also wrote articles.

This paper, on the basis of experimental research of the system in exploitation, identifies the main disadvantages of the existing troubleshooting scenarios for IPTV over xDSL. Also, this paper shows how the process of troubleshooting can be made more efficient in practice, with the already existing test solutions and other possibilities of test devices and xDSL transceivers.

Introduction: Noise represent an unwanted sound that endangers human health in multiple manners and in work setting causes reduction of productivity on one side, and increased waste on the other. Noise pollution occurs when the ear is exposed to the volume of sound that is disturbing, stressful or directly damaging hearing, but also acting on the organism as a whole. Aim: The aim of the article is to examine the vulnerability of workers working on the „press“ machine, and to carry out an analysis and examine the press operator workplace, then perform the noise spread measurement in the press operator work area and compare the current measurements with the permissible levels and analyze the time period of worker exposure, as well as presentation of the effects of noise on productivity and workers health. The aim of the article also includes the proposal for decrease of noise pollution. Methods: A noise analysis at the workplace of workers working on a „press“ machine was performed, which is exposed to a high impulse noise due to which the quality and quantity of production are reduced. For the purpose of calculating the noise level for one working day at the press operator site 1, 2 and 3, it is necessary to analyze the noise level in time. Operators spend most of their working hours at stations 1 and 3 where the measured noise level is Lm1 = 94.7 dB is taken, or at position 3, Lm3 = 97.2 dB. The measured noise level at these locations without the operation of the press is Lm1 = 80.1 dB, or at station 3 is Lm3 = 80.1 dB. Results: It was found that these operators working on the machine in question were exposed to a noise over the limit for more than three years. Their health problems that arise as a result of noise exposure are documented in their health charts. In order to achieve uninterrupted work at the press machine, during the eight hours shift, a noise correction is required to allow the equivalent sound level to fall within one day to the permissible 85 dB. In this regard, we consider the fact that we have known that the press produces a sound level of 110 dB, and that there is a reverberation (reflecting) sound. Given the technical characteristics of the plant, the reduction of the sound intensity of the source itself is not possible, so the suggestions of the technical solution will be based on reduced reflected sounds and to prevent the spread of direct sound to the operator. Conclusion: Workers are exposed to permanent noise during a working day, which produces a number of consequences for the health of the worker, but also the employer and the community. The imperative of the employer is to reduce the number of rejects, increase profitability and to have a positive impact on the health of the individual.

Introduction: Hypertension is significantly contributing to global mortality and morbidity and has been identified as the most important modifiable risk factor for early development of cardiovascular diseases (CVD). Aim: The aim of this study was to investigate the efficacy of different combinations of antihypertensive therapy on blood pressure, arterial stiffness and peripheral resistance in patients with essential hypertension using the brachial oscillometric ambulatory blood pressure monitor. Methods: This study was designed as an observational, prospective, multi centric study conducted in eight primary care centers of the Health Center of Canton Sarajevo during the period of six months. The study included 655 participants, both genders, aged between 30 and 75, who were diagnosed with hypertension according to the ESC/ESH guidelines. Participants were divided into six treatment groups based on the hypertensive drug therapy they were using; lisinopril, losartan or valsartan alone or in combination with hydrochlorothiazide (A, B and C group respectively) or combination of lisinopril, losartan or valsartan with/without hydrochlorothiazide together with amlodipine (D, E and F respectively). The participants were monitored at baseline, after 3 and 6 months (1st and 2nd follow-up). Brachial oscillometric ambulatory blood pressure monitor was used for measuring systolic (SBP), diastolic (DBP), pulse pressure (PP), pulse wave velocity (PWV) and peripheral resistance (PR). Results: SBP, DPB, PP, and PWV significantly decreased from baseline to 2nd follow-up in all treatment groups. The mean reductions in SBP were from -11.7 (95%CI; 9.3- 14.1) to -23.2 (95%CI; 18.3-28.1) mmHg and DBP reductions varied from -5.5 (95%CI; 3.9- 7.1) to -13.4 (95%CI; 7.7-19.1) mmHg. PWV decreased in all treatment groups (from -3.3% to -8.2%). Treatment regiment was not associated with significant differences in SBP, DBP, PP or PWV reductions or their values measured at 2nd follow-up. Peripheral resistance significantly decreased only in group C (p=0.011), group D (p=0.009) and group F (p=0.027). Conclusion: These data suggest that lisinopril/lisinopril + hydrochlorothiazide, losartan/losartan + hydrochlorothiazide and valsartan/valsartan + hydrochlorothiazide alone or in combination with amlodipine are equally effective and well tolerated for the reduction of both systolic and diastolic blood pressure and improve arterial stiffness in patients with essential hypertension.

Introduction: Breast augmentation is one of the most frequently performed aesthetic surgical procedures in the world. The most important preoperative decisions which influence the final appearance of the augmented breast are the breast implant pocket choice and selection of the most appropriate implant. Described pocket locations are subglandular, subfascial, partially retropectoral, totally submuscular and dual plane. Aim: We have introduced a new method of pocket forming for implant placement, which is combination of Tebbett’s dual-plane 2 or 3 and Graf’s subfascial. We named it as dual plane subfascial. Methods: Between January 2016 and April 2018, total of 27 patients were operated using dual plane subfascial breast augmentation. The pinch test in the medial pole less than 2,0 cm and in upper pole less than 2,5 cm are indications for this technique. In our modification, in primary cases a dissected flap in front of muscle is fasciocutaneous (not cutaneous as in Tebbett’s technique). It will be finally located caudally of pectoral muscle and in front of the lower pole of implant. Fasciocutaneous flap in primary cases and two independent levels of soft tissue coverage (fascial and cutaneous) in secondary cases (subglandular to dual plane subfascial conversion) in front of the lower pole of implants provide better coverage than cutaneous flap alone. Results: Hematoma and infection did not occur in any patient in our study. A capsular contracture grade I/II without the need for reoperation occurred in two patients. In one patient with secondary augmentation minimal bottoming out was noticed (before reoperation patient had significant bottoming out deformity). Minimal palpability of implants is recorded in three patients. Conclusion: Dual plane subfascial is a good option in primary breast augmentation with a well set indication especially in the breasts with the upper pinch test less than 25 mm and medial pinch test less than 20 mm. The idea can be followed even in secondary breast augmentation (subglandular to dual plane subfascial conversion). There is additional soft tissue in front of the implant which led to a less implant palpability, especially in thin patient with smaller amount of subcutaneous fat.

Objective The association between the neck circumference (NC) and components of metabolic syndrome in different countries and ethnic groups has been insufficiently investigated. The aim of the present study was to assess the impact of gender on NC values and to determine whether NC correlates with standard anthropometric measures and blood pressure values in Bosnian young adults. Materials and Methods Study participants were recruited by the snowball method. The NC, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured by trained personnel. Differences between the means were assessed by a Student's t-test. Coefficients of correlation were determined by Pearson's test. Results In young men (n=49), the value of NC was 37.71±1.79 cm, while in young women, (n=62) the value of NC was 32.23±1.83 cm (p<0.001). A significant positive correlation in both genders between the NC and BMI (r=0.70, p<0.001 in men; r=0.53,p<0.001 in women), and between the NC and WC (r=0.48, p<0.001 in men; r=0.38, p=0.01 in women), was found. A significant correlation between the NC and SBP (r=0.08, p=0.57), and DBP (r=0.20, p=0.17), in young men was not determined. Likewise, in young women, a significant correlation between the NC and SBP (r=0.08, p=0.54), and DBP (r=0.09, p=0.49), was not observed. Conclusion Our results suggest that the NC measurement can be used as a valid method in obesity assessment in young adults. A lack of association between the NC and blood pressure requires additional investigation.

The purpose of this study was to perform a systematic review and meta-analysis on the effect of contrast training(CT) on vertical jump performance. Thirteen out of 83 studies were included for syst ...

The bacteria Helicobacter pylori (H. pylori) have been identified in the extragastric tissues in the head and neck. The origin and pathogenicity of these bacteria in the head and neck are not known. Gastric reflux and nasal or oral routes are the possible modes of spread. In many sinonasal, pharyngeal, laryngeal, and middle ear disorders, laryngopharyngeal reflux has been identified as a contributing or causative factor. One possible mode by which laryngopharyngeal reflux may contribute is by seeding of the extragastric mucosa with H. pylori. The clinical significance of the discovery of H. pylori in extragastric tissues in the head and neck is unclear. There is no evidence of a pathologic or active role of H. pylori in otorhinolaryngological disorders. The suggestion that the sinonasal cavities and pharynx may serve as a reservoir for H. pylori and that reinfection of the stomach occurs after eradication therapy awaits further studies for confirmation. No connection was observed between H. pylori found in the stomach and H. pylori found in the head and neck. Also, these bacteria, found in the head and neck tissues, may be accidental or innocent bystanders that do not affect the pathways of otolaryngological and gastroduodenal diseases. This review examines the evidence for a possible relationship of H. pylori with otorhinolaryngological diseases.

Side-scan sonar mapping of an unknown large-scale seafloor area by a marine vehicle is nowadays very common. It is also important that a-priori unknown interesting parts of the seafloor area are scanned in more detail, i.e. sonified from both sides. However, completely autonomous and time-efficient coverage path (re)planning for such missions is still an open issue. In contrast to the standard overlap-all-sonar-ranges lawnmower pattern offline static coverage problem solution for side-scan sonar missions, in this paper two online sonar data-driven coverage algorithms are proposed as extensions of authors’ prior work. Analytical upper and lower bounds on performance of the proposed coverage planning algorithms are given and validated through extensive mission parameters variation simulations. Statistical performance analysis of the proposed coverage planning algorithms’ performance shows significant complete coverage time efficiency improvements w.r.t. the classical unadaptive lawnmower approach. Also, a detailed comparison of coverage planning algorithms proposed by the authors so far is provided.

For measuring lightning strokes, it is necessary to select the appropriate sensor. The nominal sensor parameters (lightning current peak and frequency range) should be selected taking into account that the lightning current peak which strikes the tower top can be up to 400 kA. In addition, sensors should be able to store all the components in one flash. This paper presents the system of testing and sensor calibration.