Department of Hygiene, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Department of Hygiene, Public Health Institute of Republic of Srpska, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Institute for Medicinal Plant Research "Dr Josif Pančić", Belgrade, Serbia. Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Centre for Biomedical Research, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Public Health Institute of the Republic of Srpska, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Agency for Certification, Accreditation and Healthcare Quality Improvement of the Republic of Srpska (ASKVA), Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.

Background/Aim. The aim of the study was investigating the significant difference in: a) the dosimetric calculation of the radiotherapy treatment planning system (TPS) in relation to the values obtained by measuring on the linear accelerator (Linac), b) the accuracy of the dosimetric calculation between the calculating algorithms Anisotropic Algorithm (AAA) and AcurosXB in various tissues and photon beam energies. Methods. For End-to-End test we used the heterogeneous phantom CIRS Thorax002LFC, which anatomically represents the human torso with set of inserts known relative electron density (RED) for obtaining a CT calibration curve, comparable to the “reference” CIRS 062M phantom. For the AAA and AcurosXB algorithms and for 6 MV and 16 MV photon beams in the TPS Varian Eclipse 13.6, four 3D conformal (3DCRT), and one intensity modulated (IMRT) and volumetric modulated arc (VMAT) radiotherapy plans were made. Measurements of the absolute dose in the Thorax phantom, by PTW-Semiflex ionization chamber, were carried out on three Varian-DHX Linacs. Results . The difference between "reference" and measured CT conversion curves in the bone area is 3 %. For 476 phantom measurements, the difference between measured and TPS calculated dose of (3-6) %, we had in 30 (6.3 %) cases. According to regression analysis, the standardized Beta coefficient for relative errors, 6 MV vs 16 MV, was 0.337 (33.7 %, p < 0.001). Mean relative errors for AAA vs AcurosXB, using Mann-Whitney test, for bones were 1.56 % and 2.64 % (p = 0.004). Conclusion. The End-to-End test on Thorax002LFC phantom proved the accuracy of TPS dose calculation in relation to the one delivered to the patient by Linac. There is a significant difference for photon energies relative errors (higher values are obtained for 16 MV vs 6 MV). A statistically significant minor relative error in AAA vs. AcurosXB was found for the bone. test, heterogeneous phantom, calculating algorithms.

Pharmacy activity in Bosnia and Herzegovina was regulated in 1879 by an Order of the Provincial Government, at the beginning of the Austro-Hungarian occupation. The pharmacy owner had to have a doctorate in chemistry or a master's degree in pharmacy obtained at an Austro-Hungarian faculty. The Law on Pharmacies was adopted in 1907. The first modern pharmacy in Banja Luka was opened by Moritz Brammer in 1879. The pharmacy was inherited by his son Robert, who had sons, Ernest, Hans and Alfred, pharmacists. Ernest inherited father's pharmacy, where he worked as of 1921. Hans, also a writer and a publicist, worked in this pharmacy (1921-1930). He emigrated to Israel in 1949. Before World War II, Alfred owned a pharmacy and a drugstore in Zagreb. The Brammer family, a well-known one in Banja Luka, contributed greatly to the cultural and social development of the city in the time in which they lived.

Introduction/Objective. Benign transient hyperphosphatasemia (BTH) is a pathogenetic insufficiently clear clinical entity that is mostly seen in infants and young children. The objective of this paper is to present our experience regarding the age of occurrence, the conditions of the discovery, and the length of duration of BTH in children. Methods. The study was realized on a sample of 18 children, nine boys and nine girls, aged 10?42 (21.06 ? 9.35) months with BTH. The diagnosis of BTH is based on the absence of bone and hepatobiliary diseases, and its spontaneous disappearance over the course of several months. Results. One patient was in the first year, 13 in the second, three in the third, and one in the fourth. Isolated high activity of serum alkaline phosphatase, which was 2.04?21.9 (8.05 ? 5.31) times above the upper reference value for the corresponding age, in 14 cases it was found during the acute diarrhea, and in four with acute rhinopharyngitis, of which in two complicated with otitis media. The cause of diarrhea in six cases was rotavirus, in two Campylobacter, and in one adenovirus, and otitis media in one case was caused by Streptococcus pneumoniae, while in others, etiologic factors of infection were not identified. Spontaneous normalization of serum alkaline phosphatase activity was recorded between one and three months after the onset. Conclusion. BTH is a harmless biochemical disorder that spontaneously subsides within three months after initial observation. It is found randomly as a routine laboratory finding most often within the treatment of acute gastrointestinal and respiratory infections.

1Academy of Medical Sciences of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina 2 Clinic of Urology, University Clinical Center of Republika Srpska, Banja Luka, Banja Luka, Bosnia and Herzegovina 3 Medical Faculty, University of Banja Luka, Banja Luka, Bosnia and Herzegovina 4Primary Health Care Center, Banja Luka, Bosnia and Herzegovina 5Day Oncology Hospital ZU Estetic, Banja Luka, Bosnia and Herzegovina

In Issues 1 and 2 the scientific biomedical journal Scripta Medica devoted a total of six articles to the aetiological, epidemiological and clinial aspects of serious acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease caused by this virus coronavirus disease 2019 (COVID-19). The present Issue 2 also contains an obituary on the occasion of demise of Professor Folke Sjöqvist, one of the founding fathers of clinical pharmacology as a discipline and several other articles from the fields of quality assurance in healthcare, experimental and clinical medicine.

This editorial presents the analysis of volumes 50 (2019) and 51 (2020) of Scripta Medica. Original articles made 53 % of 80 articles published in these two volumes. Article rejection rate was 38 %. Mean duration of period until reaching the first decision on an article was 20 days, while mean time until reaching the final decision was 31 days. Mean time needed for accepting the revised manuscript was 3 days, reflecting a significant decrease from 5 days in 2019 to 2 days in 2020. Mean time needed for reaching a decision to reject an article was 7 days. Coverage of the journal included both basic and clinical research and a considerable space was devoted to articles on COVID-19. Further efforts will be made in order to reach a more international recognition of the journal.

Grass pea belongs to the legume family and it is traditionally used as a grain for human consumption while its foliage is used for fodder. In this study morpho-agronomic evaluation and characterisation of different grass pea accessions (Lathyrus sativus L.) from Slovenia and Bosnia and Herzegovina (B&H)/Republic of Srpska was performed. A collection of 8 grass pea accessions was cultivated in Slovenia (Jablje) and Bosnia and Herzegovina/Republic of Srpska (Banja Luka) in the open field trials during the growing season of 2019. A number of quantitative and qualitative IPGRI descriptors for Lathyrus spp. concerning the vegetative growth, stem, branch, leaf, inflorescences, pods, and seeds were measured and/or visually estimated. The results of the present study will add value through the enrichment of the Lathyrus spp. collection in both countries, improving the existing data and documentation, as well as creating a certain basis for further studies of the morpho-agronomic traits of the grass pea.