Models with massive vector leptoquarks, resulting from an SU(4) gauge symmetry spontaneously broken at the TeV scale, are of great phenomenological interest given the current “anomalies” in semileptonic B decays. We analyze the relations between low- and high-energy observables in such class of models to next-to-leading order accuracy in the SU(4) gauge coupling g4. For large values of g4, motivated by recent B-physics data, one-loop corrections are sizable. The main effect is an enhanced contribution at low energy at fixed on-shell couplings. This result has important implications for current and future high-energy searches of vector leptoquark models.

The identification of mutually exclusive somatic mutations shared among myeloproliferative neoplasm (MPN) subtypes has provided a powerful tool for studying disease evolution. Clinical features, gene mutations, and survival over 18 years were analyzed in MPN patients. One hundred thirty-eight MPN patients were subcategorized according to MPN subtypes: essential thrombocythemia (ET, n = 41), polycythemia vera (PV, n = 56), primary myelofibrosis (PMF, n = 10), and MPN unclassified (MPN-U, n = 31). Patient characteristics included clinical parameters, overall survival (OS), and mutational status of the Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) genes. We compared hematologic and clinical features of JAK2V617F-ET vs. CALR-mutated ET vs. JAK2V617F-PV patients. JAK2V617F-patients had higher values of erythrocytes, hemoglobin, and hematocrit compared to CALR-mutated patients (p < 0.05). The mutant allele burden in JAK2V617F-PV and JAK2V617F-ET patients directly correlated with erythrocyte, hemoglobin, and hematocrit values, but it inversely correlated with platelet count. Thus, mutant allele burden was an indicator of the clinical phenotype in JAK2V617F-MPN patients. OS was not affected by the mutational status. In general, mutated JAK2, CALR, and MPL genes left specific hematological signatures.

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a human FAD‐dependent enzyme that plays a crucial role in the antioxidant defense system. A naturally occurring single‐nucleotide polymorphism (NQO1*2) in the NQO1 gene leads to an amino acid substitution (P187S), which severely compromises the activity and stability of the enzyme. The NQO1*2 genotype has been linked to a higher risk for several types of cancer and poor survival rate after anthracycline‐based chemotherapy. In this study, we show that a small molecular chaperone (N‐(2‐bromophenyl)pyrrolidine‐1‐sulfonamide) repopulates the native wild‐type conformation. As a consequence of the stabilizing effect, the enzymatic activity of the P187S variant protein is strongly improved in the presence of the molecular chaperone in vitro.

Measuring the efficiency of athletes during competition has been a subject of interest both for experts and scientists in sports for more than a hundred years. Basketball has recognized in the 1940s how important it is to analyze efficiency indicators because these procedures allow coaches to increase their knowledge. There are two basic methods – objective and subjective – for evaluating the efficiency, or real quality of basketball players. The aim of this research is to establish the level of correlation between these two methods and to identify clusters, i.e. player hierarchy based on the results of both methods of efficiency evaluation. The sample of variables consisted of 12 basketball players who participated in the 2010 FIBA World Championships in Turkey. The subjective evaluation, also called expert evaluation, was performed by coaches of seven national teams that participated in the Championship. The objective evaluation was performed using the EEF efficiency index. The data was processed using z-scoring, the Pearson coefficient, and hierarchical cluster analysis. The Pearson coefficients of linear correlation between the efficiency index and the expert evaluation is r = 0.859 with a statistical significance of p ≤ 0.01. The cluster analysis distinguished two groups of players, which were named quality and super quality. The variance analysis showed that the probability of the clusters being equal is less than p ≤ 0.00. The research has shown that the evaluation by coaches is relevant and is fully consistent with the efficiency index formula. Also, the distinction of two groups of players by clustering is not uncommon in the basketball practice and is linked with efficiency at the given time.

We address the problem of maximizing privacy of stochastic dynamical systems whose state information is released through quantized sensor data. In particular, we consider the setting where information about the system state is obtained using noisy sensor measurements. This data is quantized and transmitted to a (possibly untrustworthy) remote station through a public/unsecured communication network. We aim at keeping (part of) the state of the system private; however, because the network (and/or the remote station) might be unsecure, adversaries might have access to sensor data, which can be used to estimate the system state. To prevent such adversaries from obtaining an accurate state estimate, before transmission, we randomize quantized sensor data using additive random vectors, and send the corrupted data to the remote station instead. We design the joint probability distribution of these additive vectors (over a time window) to minimize the mutual information (our privacy metric) between some linear function of the system state (a desired private output) and the randomized sensor data for a desired level of distortion–how different quantized sensor measurements and distorted data are allowed to be. We pose the problem of synthesising the joint probability distribution of the additive vectors as a convex program subject to linear constraints. Simulation experiments are presented to illustrate our privacy scheme.

This article explores the possibilities and challenges of genetic testing, genetic counseling, and genome editing (collectively referred to in this piece as precision medicine) in Bosnia and Herzegovina, in the era of CRISP-Cas9. It is informed by recent developments in the field which reached new heights in the radar of global awareness in the wake of the research scandal from China in November of 2018. The scandal generated intense debates, some of it still ongoing, regarding the appropriate boundaries for scientific research on human DNA. Bearing on independent developments within this country, complemented with global events, the article covers several grounds related to the topic, including: the nature and limits of emerging legislation; measures of genetic testing and genetic counseling; public engagement meant to increase awareness among stakeholders, beginning with the public, regarding these novel technologies; and corresponding bioethical and social implications. BH decision makers must work to ensure that socioeconomic factors do not pose obstacles to healthcare access, including matters bordering on precision medicine, and they must strive to realize standards for citizens, whether in healthcare delivery, research, or general educational services, that do not lag behind the rest of Europe. The route to reaching these governance goals will be through well-timed legislation, level-headed implementation, and diligent legislative oversight of the work of administrative agencies.

This article explores the possibilities and challenges of genetic testing, genetic counseling, and genome editing (collectively referred to in this piece as precision medicine) in Bosnia and Herzegovina, in the era of CRISP-Cas9. It is informed by recent developments in the field which reached new heights in the radar of global awareness in the wake of the research scandal from China in November of 2018. The scandal generated intense debates, some of it still ongoing, regarding the appropriate boundaries for scientific research on human DNA. Bearing on independent developments within this country, complemented with global events, the article covers several grounds related to the topic, including: the nature and limits of emerging legislation; measures of genetic testing and genetic counseling; public engagement meant to increase awareness among stakeholders, beginning with the public, regarding these novel technologies; and corresponding bioethical and social implications. BH decision makers must work to ensure that socioeconomic factors do not pose obstacles to healthcare access, including matters bordering on precision medicine, and they must strive to realize standards for citizens, whether in healthcare delivery, research, or general educational services, that do not lag behind the rest of Europe. The route to reaching these governance goals will be through well-timed legislation, level-headed implementation, and diligent legislative oversight of the work of administrative agencies.

Conference Report: Izvještaj sa NAUČNE MANIFESTACIJE „HISTORIJSKI POGLEDI“, Tuzla, 8. i 9. novembar 2018. godine

Newespapers, either daily or periodic, represent a significant source of study on cultural and entertainment life in Bosnia and Herzegovina. The magazine Pregled dealed with social, economic and cultural issues of Bosnia and Herzegovina. Through our work, we follow the writings on agrarian issues of the magazine Pregled in the first period of his appearance running from 1910 until 1913. Pregled shows an agrarian issue as a crucial one and consequently apporoaches it from all sides. It follows the agrarian events in other countries of Europe, draws parallels, and eventually gives proposals for the same events in Bosnia and Herzegovina.