U oslobođenom Sarajevu je od 26. do 28. aprila 1945. godine održano treće i posljednje ratno zasjedanje ZAVNOBiH-a. Odlukama Trećeg zasjedanja ZAVNOBiH-a je zaokružena državna struktura federalne Bosne i Hercegovine, ZAVNOBiH se konstituisao u Privremenu Narodnu skupštinu Bosne i Hercegovine i donesen je Zakon o Narodnoj vladi Bosne i Hercegovine. Nakon što su odlukama Drugog zasjedanja ZAVNOBiH-a, održanog od. 30 juna do 2. jula 1944. godine u Sanskom Mostu, narodnooslobodilački odbori ozakonjeni kao lokalni organi državne vlasti, na Trećem zasjedanju ZAVNOBiH-a promijenjeni su nazivi mjesnih (lokalnih) organa državne vlasti u seoske, opštinske, gradske, sreske, okružne ili oblasne narodne odbore. Nazivi narodnooslobodilački odbori zamijenjeni su nazivom narodni odbori, što će kasnije biti potvrđeno prvim Ustavom Narodne Republike Bosne i Hercegovine iz 1946. godine. Tokom poslijeratnog razvitka njihov karakter i uloga kao organa vlasti postepeno su se mijenjali od lokalnih organa državne vlasti u administrativno-teritorijalnim jedinicama do položaja opšteg predstavničkog tijela lokalnih zajednica opština i srezova, kada su evoluirali u nove predstavničke organe – opštinske, odnosno sreske skupštine. Ustavom FNRJ i Opštim zakonom o narodnim odborima od 1946. godine narodni odbori su ozakonjeni kao osnovni organi vlasti nove državne organizacije. U radu je elaboriran proces razvoja mreže narodno - oslobodilačkih odbora između Drugog i Trećeg zasjedanja ZAVNOBiH u cjelovit sistem institucionalne organizacije državne vlasti.
Mercury (Hg) has been listed as a global high priority pollutant by many international organizations due to its mobility and persistence in the environments and high toxicity to organisms. This research was conducted with the aims to determine: (i) total Hg content (THg) and its spatial distribution in sediments of river Tisa along the river course, (ii) possible sources of THg and (iii) degree of THg pollution in sediments from the river Tisa through different criteria. Total Hg in the sediments ranged from 0.07 to 0.49 mg kg-1, with mean ? S.D. value of 0.26 ? 0.10 mg kg-1. The highest mean value of THg (0.30 mg kg-1) was found in the lower stream, while the lowest (0.13 mg kg-1) was found in the tributary. According to Principal Component Analyses (PCA) strong positive loading of metals in all parts of the river Tisa is mainly controlled from the same sources. These sources are related to anthropogenic activities based on calculated Enrichment Factor (EF) values. Total Hg are higher than background value. According to the Republic of Serbia official standard, THg values of river Tisa sediments were within the range of maximum permissible values. Compared with National Oceanic and Atmospheric Administration (NOAA) guideline, 80.49% of sediment samples indicated that THg in the river Tisa sediments represented minimal and possible risk towards the living organisms. Integrating the results of pollution assessment, it could be concluded that THg in river Tisa sediments in Serbia demonstrates considerable contamination according to Geoaccumulation Index (Igeo), and Contaminant Factor (CF), and high pollution risk according to Potential Environmental Risk Index (PERI).
The sequential extraction procedure was applied for partitioning of metals in river sediments collected along the course of the river Tisa (Serbia). Eight elements (Sb, Sn, As, Cd, Cu, Hg, Pb and Zn) from twenty-one sampling site were analyzed using the modified BCR sequential extraction procedure in combination with ICP-OES. The results of sequential extraction, statistical analyses and calculation of EF and lithogenic and anthro?pogenic ratio of metals are similar. In the river Tisa sediments Sn, Cd, Hg, Pb and Zn are of anthropogenic origin, while As, Cu and Sb are of lithogenic and anthropogenic origin. The sediments from the river Tisa show high risk for Cd, medium risk for Hg and Zn, low risk for Sn, As, Cu and Pb, whereas Sb does not show the risk for the aquatic environment.
Cytochrome P450 3A4 is the most significant enzyme in metabolism of medications. Flavonoids are common secondary plant metabolites found in fruits and vegetables. Some flavonoids can interact with other drugs by inhibiting cytochrome P450 enzymes. Thus, the objective of this study was to determine inhibition kinetics of cytochrome P450 3A4 by flavonoids: acacetin, apigenin, chrysin and pinocembrin. For this purpose, testosterone was used as marker substrate, and generation of the 6β-hydroxy metabolite was monitored by high performance liquid chromatography coupled with diode array detector. IC50 values, inhibition constants, and rates of inhibition were determined. IC50 values ranged between 0.6 and 11.4 μM. The strongest inhibitor was chrysin (IC50 0.6 μM, inhibition constant 0.6 μM, inhibition rate constant 0.065 min–1, inhibition efficacy 0.108 min–1 μM–1). Compared to other flavonoids analyzed, chrysin’s inhibitory effect can be attributed to the hydrophobic nonsubstituted B ring, as well as rigidity of the structure. When foods rich in chrysin are consumed, e.g. honey and propolis, chrysin can cause food-drug interactions. Further in vitro studies are needed to determine the reactive intermediate responsible for inactivation of cytochrome P450 3A4 enzyme, as well as in vivo studies to determine possible clinical significance of this inhibition.
Teaching sustainability and resilience on the level of both materials and structure is today's imperative for a more environmentally friendly tomorrow, but also for the enrichment of human life and preservation of historical structures. Re-examining sustainability in its reverence for pre-existing structures, conceiving projects by first taking inventory of what already exists, has become the starting point of defining research cases for students in the past few years at the Džemal Bijedić University of Mostar's Civil Engineering Faculty. The paper presents the approach developed and work done in the past several years, mainly within two subjects at the Civil Engineering Faculty. The developed methodological approach was based on the combination of the knowledge creation and case-based learning method. Case studies are always based on heritage buildings. The aim of the approach is to teach how to find an opportunity of doing more with existing structures, and argues their future use and possibilities for improvement, upgrade and re-use. Demolishment is a decision of easiness and has a major impact on the history and identity of the city and its community. Therefore, it is our task to search for various conservation approaches in order to preserve the city's layers and provide progress.
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