Abstract The cold spray technique was employed in this study to produce pure nickel (Ni) and nickel-Inconel 718 powder deposits on duplex stainless steel substrates. High quality coatings were manufactured using nitrogen as the propellant gas. The coatings exhibited satisfactory Inconel 718 (In718) retention within the Ni matrix due to the highly ductile binder phase necessary for fabrication. The characterization of the coating microstructures was implemented by means of X-ray diffraction, electron microscopy, energy-dispersive X-ray spectroscopy, and microhardness testing. In addition, the erosion resistance of both coatings was evaluated by performing cavitation erosion tests, with the analysis of the eroded surfaces revealing different erosion mechanisms for each coating. The results demonstrated the efficiency of the cold spray technique for use in the production of metal-metal matrix composite coatings and the potential of In718 use in applications which demand enhanced cavitation erosion resistance.

Abstract Using a person-centred statistical approach (latent class analysis) this study aims to categorise young citizens in Bosnia and Herzegovina according to their citizenship norms, level of trust in institutions and propensity toward political gender stereotyping. We employed the data from The National Survey of Citizens’ Perceptions in Bosnia and Herzegovina (NSCP-B&H) 2017, which documents the civic attitudes of a nationally representative sample of adults (18+) from Bosnia and Herzegovina. Since this study focuses on the youth, we extracted a sub-sample of 831 young individuals born between 1987 and 2001. Applying latent class analysis, we derived two distinct classes of young citizens with a unique set of beliefs, attitudes, and behaviours related to the role of citizens in modern societies, namely ‘enthusiastic citizens’ and ‘outsiders’. The findings offer valuable insights for policy-makers about the design and implementation of measures that aims to foster active citizenship in the laggard transitional economy. Also, it advances the research agenda on citizenship norms beyond the Western European context.

Abstract This study investigates the impact of perceived formal, informal and regulatory support on entrepreneurial intention. In addition, entrepreneurial capacity and fear of failure are analyzed as predictors of the propensity toward entrepreneurship. An empirical analysis of students in B&H finds that informal support perceived as support of family and friends exert a significant positive influence on entrepreneurial intentions. Fear of failure has a significant adverse impact on entrepreneurial intentions while entrepreneurial capacity enhances entrepreneurial intention. The negative relationship between the fear of failure and entrepreneurial intention is moderated by informal support. In other words, support by family and friends dampens the negative relationship between fear of failure and entrepreneurial intention. The findings were confronted with an ex-post literature review.

Abstract In the present study, several logit models were tested to identify the antecedents of entrepreneurial intention among the youth of Bosnia and Herzegovina (B&H). Specifically, we explore whether demographic and socio-economic characteristic or whether perceptions of education curriculum and social and political engagement as well as the perception of media influence have an impact on the intention to start one’s own business. Data analysis was done on a sample of 3,611 young people. Education level and perception of the standard of living have an impact on the attitude towards self-employment. In addition, the perception of education curriculum and parents support in education is linked with the entrepreneurial intention. Furthermore, some campaigns of social and political engagement are significant predictors of the propensity towards starting the business. Finally, the perception of media influence impacts entrepreneurial intention positively. The findings have important implications for policymakers and universities.

Abstract STUDY QUESTION What are the European trends and developments in ART and IUI in 2015 as compared to previous years? SUMMARY ANSWER The 19th ESHRE report on ART shows a continuing expansion of treatment numbers in Europe, and this increase, the variability in treatment modalities and the rising contribution to the birth rates in most participating countries all point towards the increasing impact of ART on European society. WHAT IS KNOWN ALREADY Since 1997, the ART data generated by national registries have been collected, analysed and reported in 18 manuscripts published in Human Reproduction. STUDY DESIGN, SIZE, DURATION Collection of European data by the European IVF-Monitoring Consortium (EIM) for ESHRE. The data for treatments performed between 1 January and 31 December 2015 in 38 European countries were provided by national registries or on a voluntary basis by clinics or professional societies. PARTICIPANTS/MATERIALS, SETTINGS, METHODS From 1343 institutions in 38 countries offering ART services a total of 849 811 treatment cycles, involving 155 960 with IVF, 385676 with ICSI, 218098 with frozen embryo replacement (FER), 21 041 with preimplantation genetic testing (PGT), 64 477 with egg donation (ED), 265 with IVM and 4294 with FOR were recorded. European data on IUI using husband/partner’s semen (IUI-H) and donor semen (IUI-D) were reported from 1352 institutions offering IUI in 25 countries and 21 countries, respectively. A total of 139 050 treatments with IUI-H and 49 001 treatments with IUI-D were included. MAIN RESULTS AND THE ROLE OF CHANCE In 18 countries (14 in 2014) with a population of approximately 286 million inhabitants, in which all institutions contributed to their respective national registers, a total of 409 771 treatment cycles were performed, corresponding to 1432 cycles per million inhabitants (range: 727–3068 per million). After IVF the clinical pregnancy rates (PRs) per aspiration and per transfer were slightly lower in 2015 as compared to 2014, at 28.5 and 34.6% versus 29.9 and 35.8%, respectively. After ICSI, the corresponding PR achieved per aspiration and per transfer in 2015 were also slightly lower than those achieved in 2014 (26.2 and 33.2% versus 28.4 and 35.0%, respectively). On the other hand, after FER with own embryos the PR per thawing continued to rise from 27.6% in 2014 to 29.2% in 2015. After ED a slightly lower PR per embryo transfer was achieved: 49.6% per fresh transfer (50.3% in 2014) and 43.4% for FOR (48.7% in 2014). The delivery rates (DRs) after IUI remained stable at 7.8% after IUI-H (8.5% in 2014) and at 12.0% after IUI-D (11.6% in 2014). In IVF and ICSI together, 1, 2, 3 and ≥4 embryos were transferred in 37.7, 53.9, 7.9 and in 0.5% of all treatments, respectively (corresponding to 34.9, 54.5, 9.9 and in 0.7% in 2014). This evolution towards the transfer of fewer embryos in both IVF and ICSI resulted in a proportion of singleton, twin and triplet DR of 83.1, 16.5 and 0.4%, respectively (compared to 82.5, 17.0 and 0.5%, respectively, in 2014). Treatments with FER in 2015 resulted in twin and triplet DR of 12.3 and 0.3%, respectively (versus 12.4 and 0.3% in 2014). Twin and triplet delivery rates after IUI-H were 8.9 and 0.5%, respectively (in 2014: 9.5 and 0.3%), and 7.3 and 0.6% after IUI-D (in 2014: 7.7 and 0.3%). LIMITATIONS, REASONS FOR CAUTION The methods of data collection and reporting vary among European countries. The EIM receives aggregated data from various countries with variable levels of completeness. Registries from a number of countries have failed to provide adequate data about the number of initiated cycles and deliveries. As long as incomplete data are provided, the results should be interpreted with caution. WIDER IMPLICATIONS OF THE FINDINGS The 19th EIM report on ART shows a continuing expansion of treatment numbers in Europe. The number of treatments reported, the variability in treatment modalities and the rising contribution to the birth rates in most participating countries point towards the increasing impact of ART on reproduction in Europe. Being the largest data collection on ART worldwide, detailed information about ongoing developments in the field is provided. STUDY FUNDING/COMPETING INTEREST(S) The study has no external funding and all costs are covered by ESHRE. There are no competing interests.

Abstract Although prostate cancer accounts for the highest number of newly diagnosed cases of cancer in men, it represents a specific diagnostic challenge in modern oncology. The standard diagnosis of prostatic carcinoma begins with the screening of serum concentrations of PSA (Prostate Specific Antigen). If the concentration of serum PSA levels is above 4 ng/mL, the patient is further referred to a digital rectal examination in order to determine an increase in prostate volume. In cases where enlargement of the prostate is observed, the next step is biopsy of prostate tissue. This physically painful and invasive approach to confirm the diagnosis is often unnecessary because, in many cases, the patohistologic analysis determines diagnosis of benign prostatic hyperplasia, and not a tumor. In this study, we investigated the possibilities of detection and measurement of the relative level of gene expression of the KLK3 (Kallikrein-related peptidase 3), PCA3 (Prostate Cancer Gene 3) and TEMPRSS: ERG (Transmembrane protease serine2 and in-ETS erythroblostosis virus E26 oncogene homolog) genes from the urine samples of patients with prostatic diseases and healthy controls. Urine was the sample of choice because it is taken in a non-invasive manner, and could potentially serve to make better selection to biopsy. One of the selected genes (KLK3) differed significantly in the samples of various pathological conditions of the prostate, and therefore we consider that its further investigation is reasonable.

BACKGROUND Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation between nonoptimal neuromotor development and autistic traits in the general population. METHODS In a population-based cohort in The Netherlands (2002-2006), we calculated polygenic risk scores (PRSs) for ASD and attention-deficit/hyperactivity disorder (ADHD) using genome-wide association study summary statistics. In 1921 children with genetic data, parents rated autistic traits at 6 years of age. Among them, 1174 children (61.1%) underwent neuromotor examinations (tone, responses, senses, and other observations) during infancy (9-20 weeks of age). We used linear regressions to examine associations of PRSs with neuromotor scores and autistic traits. We performed a bivariate genome-based restricted maximum likelihood analysis to explore whether genetic susceptibility underlies the association between neuromotor development and autistic traits. RESULTS Higher PRSs for ASD were associated with less optimal overall infant neuromotor development, in particular low muscle tone. Higher PRSs for ADHD were associated with less optimal senses. PRSs for ASD and those for ADHD both were associated with autistic traits. The single nucleotide polymorphism-based heritability of overall motor development was 20% (SE = .21) and of autistic traits was 68% (SE = .26). The genetic correlation between overall motor development and autistic traits was .35 (SE = .21, p < .001). CONCLUSIONS We found that genetic liabilities for ASD and ADHD covary with neuromotor development during infancy. Shared genetic liability might partly explain the association between nonoptimal neuromotor development during infancy and autistic traits in childhood.

Aside from vast deployment cost reduction, Industrial Wireless Sensor and Actuator Networks (IWSAN) introduce a new level of industrial connectivity. Wireless connection of sensors and actuators in industrial environments not only enables wireless monitoring and actuation, it also enables coordination of production stages, connecting mobile robots and autonomous transport vehicles, as well as localization and tracking of assets. All these opportunities already inspired the development of many wireless technologies in an effort to fully enable Industry 4.0. However, different technologies significantly differ in performance and capabilities, none being capable of supporting all industrial use cases. When designing a network solution, one must be aware of the capabilities and the trade-offs that prospective technologies have. This paper evaluates the technologies potentially suitable for IWSAN solutions covering an entire industrial site with limited infrastructure cost and discusses their trade-offs in an effort to provide information for choosing the most suitable technology for the use case of interest. The comparative discussion presented in this paper aims to enable engineers to choose the most suitable wireless technology for their specific IWSAN deployment.

Atopic dermatitis (AD) is a heterogeneous disease with various biological origins and clinical appearances. It is likely that different therapies or treatment intensities are not equally effective for all AD endotypes. The strongest genetic risk factor for AD is a null muta‐ tion in the filaggrin gene (FLG).1 Patients with eczema who carry a FLG null mutation are also prone to more persistent, severe eczema, and earlier onset of AD compared to patients without a FLG null mutation. Stratification of patients based on the FLG null endotype could enable more targeted treatment. Methods to determine FLG null mutations based on genotyping are time consuming and require specialized laboratory infrastructure, further complicated by the existence of over 50 different polymorphisms with widely varying prevalences between ethnic groups.2 In the stratum corneum (SC) filaggrin is enzymatically degraded into its constituting amino acids and their derivatives, together with specific salts and sugars collec‐ tively named natural moisturizing factor (NMF). Decreased NMF provides an accurate surrogate marker for the presence of FLG null polymorphisms.3 This can be measured rapidly and noninvasively by Raman spectroscopy in a clinically compatible test. We have assessed the potential of NMF as a novel clinical marker in AD by examining the association of clinically measured NMF val‐ ues with severity of AD, early onset of AD, and the co‐morbidities of AD: allergic sensitization, food allergy, bronchial hyperreactivity (BHR), asthma, and allergic rhinitis. Of 207 children with AD (0‐18 years of age), NMF values had been measured routinely during a visit to the pediatric atopy cen‐ ter KinderHaven‐Sophia Children's Hospital‐Erasmus MC University Medical Center Rotterdam in The Netherlands. The retrospective study protocol was approved by the medical ethics committee of Erasmus MC (MEC‐2016‐244). AD was diagnosed by a dermatologist according to the UK Working Party's Diagnostic Criteria for Atopic Dermatitis.4 NMF had been measured noninvasively on the palm of the hand by Raman spectroscopy using an in vivo Raman skin ana‐ lyzer (gen2‐SCA, RiverD International BV, Rotterdam). NMF values were classified as normal NMF (>1.14 arbitrary units) or decreased NMF (<0.995 arbitrary units), using a 0.07 confidence interval around the threshold of 1.07 as established by O’Regan et al.3 Patients with a NMF value between 0.995‐1.14 were excluded. The interval was the estimated 95% confidence interval, calculated as the standard error (SE) of the NMF value, averaged over the entire cohort, and multiplied by 1.96. Disease characteristics and comorbidity status were retrieved from the electronic medical patient files by two in‐ dependent researchers (see Appendix S1). Severity (mild to moderate or severe) of AD was measured by proxy of therapy based on the cri‐ teria as described by Wollenberg et al5 (Appendix S1). Associations between NMF status and the clinical parameters were tested by uni‐ variate and multivariate logistic regression models with adjustment for age and gender. Sixty‐seven out of 207 (32.4%) patients had decreased NMF. Figure 1 shows the distribution of disease severity in relation to the groups normal NMF and decreased NMF. Patients with decreased NMF had increased risk of severe AD, OR 2.12 (95% CI 1.02‐4.43), sensitization for food allergens, OR 2.27 (95%CI 1.21‐4.23), sensiti‐ zation for inhalation allergens, OR 2.22 (95%CI 1.13‐4.34), and food allergies, OR 2.79 (95% CI 1.33‐5.86; Table 1 and Table S1). Having decreased NMF did not show an association with early‐onset AD, allergic rhinitis, BHR, asthma and combined asthma, and/or BHR. In this retrospective study, we examined the associations between NMF values and the clinical parameters of the atopic syndrome. NMF

Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.

Abstract This paper explores the impact of education-job mismatch on the net income of workers in the context of Bosnia-Herzegovina. We used an OLS linear regression method on data from the Measure BiH Youth Survey. A log-transformation of the dependent variable created the left-side semilog functional form, which is typically used in models of the earnings of individuals. Our findings strongly support the statement that education-job mismatch has a significant effect on net income. Workers can expect net income differences between 13% and 15% if their level of education does not match that required for their job. However, our results show that the impact of education-job mismatch depends on the level of schooling and age of respondents. Results regarding education-job mismatch vary across studies, but our study is the first to examine the effect of education-job mismatch on net income in the context of Bosnia-Herzegovina. Second, the effect of education-job mismatch might depend on the choice of estimation method for incidences of overeducation and undereducation. Third, we emphasise the importance of understanding interactions, and fourth, we introduce new variables to understand how they influence earnings. These include religiousness, and the importance of belonging to a family, or a particular city.

Abstract This article uses data from the National Survey of Citizens’ Perceptions in Bosnia-Herzegovina to investigate the determinants of offering a bribe in the form of money, gifts or services to medical personnel, professors, judicial personnel, police officers and public servants. We presented evidence about the spread of corruption in these five sectors of the economy in Bosnia-Herzegovina, and analysed the effects of determinants at the individual level on the likelihood of engaging in bribery. Our results confirmed that specific personal characteristics predicted corrupt behaviour, but results varied across sectors. Logistic regression was used to generate models from which predictions could be made about the likelihood of an individual engaging in corrupt behaviour. Our research shows that corruption is a widespread phenomenon in Bosnia-Herzegovina, and more educated people, people living in urban areas, and individuals with higher incomes are more likely to engage in bribery in several sectors. Measures and policies aimed at reducing corrupt behaviour should be designed in a way that considers the specific characteristics of these individuals.