The sequential extraction procedure was applied for partitioning of metals in river sediments collected along the course of the river Tisa (Serbia). Eight elements (Sb, Sn, As, Cd, Cu, Hg, Pb and Zn) from twenty-one sampling site were analyzed using the modified BCR sequential extraction procedure in combination with ICP-OES. The results of sequential extraction, statistical analyses and calculation of EF and lithogenic and anthro?pogenic ratio of metals are similar. In the river Tisa sediments Sn, Cd, Hg, Pb and Zn are of anthropogenic origin, while As, Cu and Sb are of lithogenic and anthropogenic origin. The sediments from the river Tisa show high risk for Cd, medium risk for Hg and Zn, low risk for Sn, As, Cu and Pb, whereas Sb does not show the risk for the aquatic environment.

Cytochrome P450 3A4 is the most significant enzyme in metabolism of medications. Flavonoids are common secondary plant metabolites found in fruits and vegetables. Some flavonoids can interact with other drugs by inhibiting cytochrome P450 enzymes. Thus, the objective of this study was to determine inhibition kinetics of cytochrome P450 3A4 by flavonoids: acacetin, apigenin, chrysin and pinocembrin. For this purpose, testosterone was used as marker substrate, and generation of the 6β-hydroxy metabolite was monitored by high performance liquid chromatography coupled with diode array detector. IC50 values, inhibition constants, and rates of inhibition were determined. IC50 values ranged between 0.6 and 11.4 μM. The strongest inhibitor was chrysin (IC50 0.6 μM, inhibition constant 0.6 μM, inhibition rate constant 0.065 min–1, inhibition efficacy 0.108 min–1 μM–1). Compared to other flavonoids analyzed, chrysin’s inhibitory effect can be attributed to the hydrophobic nonsubstituted B ring, as well as rigidity of the structure. When foods rich in chrysin are consumed, e.g. honey and propolis, chrysin can cause food-drug interactions. Further in vitro studies are needed to determine the reactive intermediate responsible for inactivation of cytochrome P450 3A4 enzyme, as well as in vivo studies to determine possible clinical significance of this inhibition.

Rad se bavi počecima znanstvenog promišljanja hrvatske književnosti u Bosni i Hercegovini te predstavlja biografska i biobibliografska istraživanja sedmorice autora, počevši od Filipa Lastrića u 18. do Tugomira Alaupovića u prvoj polovici 20. stoljeća. Promatramo kako su ovi autori razumijevali književnost i njezinu povijesnu dimenziju, osobito kako su pristupili osnovnim problemima povijesti književnosti kao što su definiranje korpusa, izbor pisaca, periodizacija, književnopovijesna interpretacija i vrednovanje te koja su rješenja ponudili. Analizira se i postupno napuštanje okvira biobibliografije te primjena složenijih književnopovijesnih pristupa.

Teaching sustainability and resilience on the level of both materials and structure is today's imperative for a more environmentally friendly tomorrow, but also for the enrichment of human life and preservation of historical structures. Re-examining sustainability in its reverence for pre-existing structures, conceiving projects by first taking inventory of what already exists, has become the starting point of defining research cases for students in the past few years at the Džemal Bijedić University of Mostar's Civil Engineering Faculty. The paper presents the approach developed and work done in the past several years, mainly within two subjects at the Civil Engineering Faculty. The developed methodological approach was based on the combination of the knowledge creation and case-based learning method. Case studies are always based on heritage buildings. The aim of the approach is to teach how to find an opportunity of doing more with existing structures, and argues their future use and possibilities for improvement, upgrade and re-use. Demolishment is a decision of easiness and has a major impact on the history and identity of the city and its community. Therefore, it is our task to search for various conservation approaches in order to preserve the city's layers and provide progress.

In the article we determine the suitability of the phytocenose as a basic unit for determining soil susceptibility to mechanized logging. A total of 90 measurements of skid trail profiles were taken on a 13.9 km long sample transect. The forest infrastructure studied was categorized into primary and secondary skid trails, trails intended for CTL harvesting and undocumented trails. The following indicators were determined on the profiles: tyre track depth, trail width, trail slope, amount of rock present, presence of roots and road category. The deepest ruts were found in Blechno-Fagetum (6.9 cm), followed by Galio rotundifolii-Abietetum (6.4 cm) and Hacquetio-Fagetum (5.6 cm), while the shallowest ruts were found in Omphalodo-Fagetum (5.3 cm). The deepest ruts were found on primary skid trails (7.0 cm), followed by secondary skid trails (5.8 cm), while the shallowest ruts were found on skid trails used by CTL technology and on undocumented trails (1.9 cm). No significant difference in track depth was found between the four individual phytosociological units, but more extensive research should be conducted in the future.

The influence of German language onto Croatian language has been going on for centuries. It was most intensive during the 19th century. Therefore we can find German loanwords all over Croatia. The focus of the research is put onto the presence of German loanwords in the carnival newspapers of Sinj in the time span from 1929 till 2015. The German loanword is presented in context in a corpus, contrastively analysed on the semantic level in the process of secondary adaptation, ie. the extention of meaning in a number and in a field.