Through the use of hydrogen bond driven solid-state synthesis, mononuclear complexes are transformed into crystalline materials.
Abstract This observational clinical study was composed of two substudies: a non-comparative one (n = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (n = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chemotherapy. The density of ulcerations has decreased significantly after the treatment with lysozyme in both substudies. The density of ulcerations in the radiotherapy group was lower in patients treated with LBCs compared to patients treated with BBCs (p < 0.001). In the chemotherapy group, reduction of ulceration density was similar with both LBCs and BBCs. The LBCs reduced pain intensity during the intake of solid food and speech more than BBCs in both patient cohorts (p < 0.05). In the radiotherapy cohort, pain intensity when consuming liquid foods was reduced more with LBCs than with BBCs (p < 0.05). No adverse events were recorded. This study demonstrates the advantages of treating oral mucositis during radiotherapy or chemo-therapy with LBCs.
This paper investigates the specific models and patterns of production, dissemination and dynamics of news in the Bosnia and Herzegovina online sphere, as well as the mechanisms which prolong or reduce news cycles. The research assumption is that the news network is created and maintained under the influence of the specifics of journalism, as well as based on the interest of the audience for a particular topic and under the influence of the mainstream influencers who, within the context of political influence, the dominant ideologies and participatory cultures determine the news cycles and create the prevailing discourse. This research was carried out based on the media coverage of the topics related to the recent war history (revision of the verdict by the Hague Tribunal on Bosnia and Herzegovina's lawsuit against Serbia), and on the topics related to the future of Bosnia and Herzegovina (coordination mechanism in the process of Euro-Atlantic integration), all in order to prove that the topics related to the past have an extended lifecycle and a stronger impact on the audience.
Abstract Twelve previously synthesized, biologically active 2,6,7-trihydroxyxanthen-3-one derivatives were evaluated in vitro for antiproliferative activity. Compounds were screened against HeLa, SW620, HepG2 and A549 tumor cell lines. Compound with the trifluormethyl group on C-4’ position of the phenyl ring showed the best inhibitory activity towards HeLa and A549 tumor cells with IC50 of 0.7 and 4.1 µmol L−1, resp. Compound with chlorine and fluorine substituents on aryl ring showed the best antiproliferative activity against SW620 with IC50 of 4.1 µmol L–1 and against HepG2 tumor cell line with IC50 of 4.2 µmol L–1. Analyses of cytotoxic and genotoxic potential of the trifluormethyl derivative were performed with cytokinesis-block micronucleus cytome assay in human lymphocyte culture and revealed no genotoxic and cytotoxic effects. The most potent compounds were subjected to molecular docking simulations in order to analyse bindings to molecular targets and, at the same time, further support the results of experimental cytotoxic tests. Docking studies showed sites of importance in forming hydrogen bonds of the most potent compounds with targets of interest.
analysis of visual records of protests in both countries, which consist of pictures taken by media reporters and activists as well as the author and his associate, provides evidence for this argument. Chapters 5, 6 and 7 discuss the possibilities for Ukraine’s development in the aftermath of military aggression by Russia, which is still ongoing in the eastern provinces. Underlining fragmented support for tougher sanctions within the European countries in response to Russia’s annexation of Crimea and its involvement in the Donbas conflict, Oleinik argues that Europe’s dependence on Russian energy might play a key role in this outcome. In a way, Europe’s inability to form a united response against Russia proves his point that the Ukrainian people might need to rely on their own social, cultural and economic resources in building the country. Along this line, Oleinik surveys how Ukrainians view a number of concepts that he suggests correspond with different perceptions of power—such as human rights and honour—and assesses whether Ukrainian people might be able to overcome authoritarian culture while rebuilding the country. Yet, partly because Ukrainian territories have historically been under Russian rule—imperial and then Soviet—for such a long time, Ukrainians’ perceptions of these concepts are very close to the Russian way of thinking. For example, Oleinik’s findings indicate that in both countries power is closely associated with violence. While Ukrainians made efforts to resist this notion of power during the 2013–2014 mass protests, according to Oleinik, continued active efforts by forces other than established elites will still be required if Ukraine is to depart from the Russian path. Chapters 8 and 9 focus on internal solutions to the economic difficulties that Ukraine is currently facing. For a start, Oleinik argues, simply turning from Russia to the West for inspiration for economic policies to best serve national interests is not the answer. Instead, Ukrainian economists should try to start a national debate and focus on how to build the domestic market. Next, Oleinik suggests that Ukraine could strengthen its economy by pursuing temporary protectionist policies to allow national businesses to develop, while securing free access by national producers to the Western markets. His study of the timber industry is a case in point. Chapter 10 evaluates the potential of volunteer movement that emerged in 2013–2014 to take the lead in the process of nation-state building. As Oleinik remarks, over recent years, volunteer initiatives have earned the trust of the Ukrainian people (p. 365), while the ruling elite failed to make any significant changes. His analysis of survey data reveals a significant level of support among Ukrainian volunteers for a democratic independent Ukraine (pp. 393–95). Given all this, Oleinik argues that ‘the volunteer movement may well become a base for consolidation of the traditionally divided country’ (p. 406). Even though volunteer initiatives still need foreign assistance in building a nation-state, Oleinik concludes that the West should leave geopolitical considerations aside in lending a hand to Ukraine. Overall, this book presents a descriptive study of the current state of Ukraine, with a thorough analysis of a large amount of qualitative and quantitative data.
We propose a simple $SU(5)$ model that connects the neutrino mass generation mechanism to the observed disparity between the masses of charged leptons and down-type quarks. The model is built out of $5$-, $10$-, $15$-, $24$-, and $35$-dimensional representations of $SU(5)$ and comprises two (three) $3 \times 3$ ($3 \times 1$) Yukawa coupling matrices to accommodate all experimentally measured fermion masses and mixing parameters. The gauge coupling unification considerations, coupled with phenomenological constraints inferred from experiments that probe neutrino masses and mixing parameters and/or look for proton decay, fix all relevant mass scales of the model. The proposed scenario places several multiplets at the scales potentially accessible at the LHC and future colliders and correlates this feature with the gauge boson mediated proton decay signatures. It also predicts that one neutrino is massless.
At university, you are continually engaged with other people’s ideas: You read them in texts, hear them in lectures and seminars, discuss them in class, and incorporate them into your own writing. Not least, you build on other people’s ideas in developing your own ideas. As a consequence, it is very important that you give credit where it is due. If you do not do that, you plagiarize. Plagiarism is using others’ ideas and words without clearly acknowledging these sources.
Rapid population growth and urbanisation has entailed a strong motivation to develop more sustainable construction solutions in line with the 7th basic requirement for construction works sustainable use of natural resources. One of the strategies is to use materials available in abundant quantities as partial replacement for cement, or to create alternative binders for concrete. The aim of the paper is to provide an overview of the current state of the art in the field of alternative binders for concrete, and to point to the opportunities and challenges for their more systematic application in engineering practice. The state of the art review is connected to scientific projects currently undertaken at the Department of Materials, Faculty of Civil Engineering University of Zagreb, Croatia.
Feohromocitom je neuroendokrini tumor, čija je glavna karakteristika sekrecijakateholamina sa posljedičnom hipertenzijom. Vrlo je rijedak u pedijatrijskoj populaciji,uobičajeno se javlja u bolesnika srednje životne dobi. Klinička slika podrazumijevaparoksizmalne napade glavobolje, bljedila, palpitacije i znojenja. Cilj rada je prikazslučaja feohromocitoma kod desetogodišnjeg dječaka, kao rijetkog tumora u pedijatrijskojpopulaciji.
In this paper, the room temperature mechanical properties, as well as the microstructure of HK 30 Nb steel, were tested in the initial as-cast and solution annealed condition. Results show that tensile properties after the solution annealing have a slightly lower value than as-cast samples. Microstructural analysis of samples after solution annealing showed dissolution of primary carbides present in the initial as-cast condition. The morphology and composition of carbides were changed during a solution annealing. Analysis of microstructure was done by optical microscopy (OM) and scanning electron microscope (SEM), whereas hardness and tensile tests were performed for characterization of mechanical properties.
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