Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency associated with prematurity. Timely diagnosis and adequate treatment are crucial to reduce the morbidity and mortality of the affected infants. The aim of this study was to evaluate the diagnostic yield of bowel dilatation on plane abdominal radiography (AR) in the early diagnosis and NEC severity in preterm infants. Methods: We retrospectively reviewed initial ARs of 50 preterm infants with NEC ≥ stage II admitted to the neonatal intensive care unit (NICU) in a tertiary-care hospital. The largest bowel loops diameters (AD), the latero-lateral diameters of the peduncle of the first lumbar vertebra (L1), and the distance of the upper edge of the first lumbar vertebra and the lower edge of the second one, including the disc space (L1–L2), were measured. All anteroposterior ARs were done in a supine projection on the day of onset of the initial symptoms of NEC. Results: Preterm infants with surgical NEC showed a statistically significant increase in the AD/L1 ratio (p < 0.001) and AD/L1-L2 ratio (p < 0.001) compared with preterm infants with medical NEC. We found no significant association between the site of the most distended bowel loop and the severity of NEC (p > 0.05). Conclusion: Bowel loop distension on initial AR may serve as an additional diagnostic tool in the early diagnosis and severity of stages II/III NEC. Further prospective clinical studies should validate the results from this study.

Nonorthogonal multiple access (NOMA) significantly improves the connectivity opportunities and enhances the spectrum efficiency (SE) in the fifth generation and beyond (B5G) wireless communications. Meanwhile, emerging B5G services demand for higher SE in the NOMA-based wireless communications. However, traditional ground-to-ground (G2G) communications are hard to satisfy these demands, especially for the cellular uplinks. To solve these challenges, this article proposes a multiple unmanned-aerial-vehicles (UAVs)-aided uplink NOMA method. In detail, multiple hovering UAVs relay data for a half of ground users (GUs) and share the spectrums with the other GUs that communicate with the base station (BS) directly. Furthermore, this article proposes a K-means clustering-based UAV deployment scheme and location-based user pairing (UP) scheme to optimize the transceiver association for the multiple UAVs-aided NOMA uplinks. Finally, a sum power minimization-based resource allocation problem is formulated with the lowest Quality-of-Service (QoS) constraints. We solve it with the message-passing algorithm and evaluate the superior performances of the proposed scheduling and paring schemes on SE and energy efficiency (EE). Extensive simulations are conducted to compare the performances of the proposed schemes with those of the single UAV-aided NOMA uplinks, G2G-based NOMA uplinks, and the proposed multiple UAVs-aided uplinks with a facility location framework-based UAV deployment. Simulation results demonstrate that the proposed multiple UAVs deployment and UP-based NOMA scheme significantly improves the EE and the SE of the cellular uplinks at the cost of only a little relaying power consumption of UAVs.

This paper integrates a different perspective into the diaspora literature, by placing it within the frame of digital diasporas and war time engagement in actions and initiatives traditionally considered as diplomatic. We reconstruct how digital diaspora diplomacy developed during a time when the Internet was relatively new and diplomatic tools were limited due to an ongoing conflict in Bosnia and Herzegovina. We examine BOSNET, an online epistemic community of Bosnian diaspora IT pioneers, with a shared set of normative and principled set of beliefs about the independence of their homeland, and collected, shared and spread information about what was going on in their country. We label their work as ‘policy innovation’ engagement and performativity as 'informal' behaviour, as it was unscripted, uncoded and unregulated by any written conventions or state strategies.

The paper proposes a problem-solving approach in the area of underground mining, related to the evaluation and selection of the optimal mining method, employing fuzzy multiple-criteria optimization. The application of fuzzy logic to decision-making in multiple-criteria optimization is particularly useful in cases where not enough information is available about a given system, and where expert knowledge and experience are an important aspect. With a straightforward objective, multiple-criteria decision-making is used to rank various mining methods relative to a set of criteria and to select the optimal solution. The considered mining methods represent possible alternatives. In addition, various criteria and subcriteria that influence the selection of the best available solution are defined and analyzed. The final decision concerning the selection of the optimal mining method is made based on mathematical optimization calculations. The paper demonstrates the proposed approach as applied in a case study.

We show that scattering from the boundary of static, higher-order topological insulators (HOTIs) can be used to simulate the behavior of (time-periodic) Floquet topological insulators. We consider D-dimensional HOTIs with gapless corner states which are weakly probed by external waves in a scattering setup. We find that the unitary reflection matrix describing back-scattering from the boundary of the HOTI is topologically equivalent to a (D-1)-dimensional nontrivial Floquet operator. To characterize the topology of the reflection matrix, we introduce the concept of `nested' scattering matrices. Our results provide a route to engineer topological Floquet systems in the lab without the need for external driving. As benefit, the topological system does not to suffer from decoherence and heating.

Abstract The goal of this study was to determine the content of 12 metals in 23 samples of teeth from two cities in Bosnia and Herzegovina (B&H): Sarajevo, a capital city with heavy traffic, industrial facilities, and long periods of smog during winter and Bihac, a picturesque small city, with no industrialization, settled among vivid national park and rivers. The teeth were separated into enamel and dentin. Dissolution of samples was performed in concentrated HNO3 with the addition of H2O2 followed by flame atomic absorption spectroscopy (FAAS) analysis. The results showed expected high contents of Ca, Na, Mg, and K, while elevated contents of Cu, Fe, and Zn were present in some samples. K and Na showed uniform distributions throughout enamel and dentin. Alkaline and earth-alkaline metals showed significant positive correlations. Zinc and manganese exhibited differences in the dentin content based on the place of residence. Zinc also displayed statistically significant differences between smokers’ and nonsmokers’ dentin samples. The differences were more pronounced between intra groups (within one sample) than for inter groups (within different groups, such as location, gender, and smoking).

Background: The Emergency Severity Index (ESI) is a widely used tool to triage patients in Emergency Departments. The ESI tool is employed to assess all complaints and has significant limitation for accurately triaging patients with suspected acute coronary syndrome (ACS). Objective: We evaluated the accuracy of ESI in predicting serious outcomes in suspected ACS, and to assess the incremental re-classification performance if ESI is supplemented with a clinically validated tool used to risk stratify suspected ACS. Methods: We used existing-data from an observational cohort study of chest pain patients. We extracted ESI scores documented by triage nurses during routine medical care. Two independent reviewers adjudicated the primary outcome, incidence of 30-day major adverse cardiac events (MACE). We compared ESI to the well-established modified HEAR/T (patient History, Electrocardiogram, Age, Risk factors, but without Troponin) score. Results: Our sample included 750 patients (age 59 ± 17 years, 43% female, 40% black). A total of 145 patients (19%) experienced MACE. The area under the receiver operating characteristic curve for ESI score for predicting MACE was 0.656, compared to 0.796 for the modified HEAR/T score. Using the modified HEAR/T score, 181 out of the 391 (46%) false positives and 16 out of the 19 (84%) false negatives assigned by ESI could be reclassified correctly. Conclusion: The ESI score is poorly associated with serious outcomes in patients with suspected ACS. Supplementing the ESI tool with input from other validated clinical tools can greatly improve the accuracy of triage in patients with suspected ACS.

Abstract Wine fermentation is a complex process driven by yeasts, which influence the key properties of wine quality: aroma, flavour and colour. We investigated 95 different Saccharomyces and non-Saccharomyces strains for their impact on wine colour through the synthesis of the stable pigments, pyranoanthocyanins. All strains were screened for their hydroxycinnamate decarboxylase (HCDC) activity that varied from 0.0% to 91.1%. Eight strains that showed more than 40% HCDC activity were further studied for vinylphenolic pyranoanthocyanin formation. Fermentations were carried out in deep well microtiter plates using synthetic grape must containing Pinot Noir skin extract supplemented with p-coumaric acid. Two strains Pichia guilliermondii ZIM624 and Wickerhamomyces anomalus S138 synthesized vinylphenolic pyranoanthocyanins in the highest concentration in single culture fermentations, 40.2 and 38.5 mg L−1, respectively. The highest produced concentration of vinylphenolic pyranoanthocyanins in co-inoculation experiments was 16.4 mg L−1 compared to 29.8 mg L−1 in sequential fermentations. For the first time, S. paradoxus strains were assessed for pyranoanthocyanin formation. Selected strains were also tested as mono-cultures for adsorption of anthocyanins on yeast cell walls and all strains showed anthocyanin and pyranoanthocyanin adsorption to their cell wall with Metschnikowia reukafii ZIM2019 showing the highest adsorbing capability (9.1%).

BACKGROUND Vaccination coverage in Bosnia and Herzegovina has been declining over recent years. A World Health Organization Tailoring Immunization Programmes (TIP) project is underway to gain insights into the underlying reasons for this, to develop tailored interventions. As part of TIP, this study aimed to investigate the views of health workers on their barriers and drivers to positive childhood vaccination practices. METHODS Face-to-face qualitative interviews explored 38 health workers' views on vaccination coverage, their vaccination attitudes, and system, programme and institutional influences on their vaccination practices. The data were analysed using content analysis and organised by the COM (Capability, Opportunity and Motivation) factors. FINDINGS Very few differences in barriers and drivers were evident between high and low coverage primary care centres or across different professional roles. Capability: Drivers included awareness of the risks of low vaccination coverage, regular use of the Rulebook and Order, knowledge of how to advise parents on mild side effects and recognition of the importance of good communication with parents. Key barriers were the use of false contraindications to postpone vacination and poor skills in tailoring communication with parents. Opportunity: Drivers were sufficient time for adminstering vaccination and good availability of vaccines. Several barriers were evident: lack of implementation of mandatory vaccination, no uniform recall and reminder system or system for detecting under-vaccinated children, staff shortages and lack of time to discuss vaccination with parents. MOTIVATION Drivers were a belief in the value, safety and effectiveness of vaccination and seeing that they have an important role to play. Barriers were a tendency to blame external factors e.g. anti-vax movement and a fear of being blamed for adverse events. CONCLUSIONS The study identified complex and inter-related barriers and drivers to health worker positive vaccination practices. These insights will now inform a process to identify and prioritize interventions.

Background White spot lesions (WSLs) are a common complication after orthodontic treatment. The aim of this study was to characterize and compare the antimicrobial properties of selenium-containing vs. fluoride-containing orthodontic materials. Material/Methods Antibacterial efficacy of orthodontic materials (SeLECT Defense bonding agent, Adhesive agent, Band Cement, Transbond Plus SEP bonding agent, Transbond Plus Adhesive agent, Fuji I Band cement, Fuji Ortho LC Adhesive agent, Ortho Solo Bonding agent, Transbond XT bonding agent, and Transbond XT primer) was tested with the inhibition of 2 bacterial strains: S. mutans (ATCC 10449) and L. acidophilus (ATCC 4356). The antimicrobial efficacy of the materials was measured by agar diffusion test. The diameters of inhibition zones around each disk were measured in millimeters (mm). Results Materials containing selenium and fluoride showed significant differences from the negative control (both p<0.001). Orthodontic materials containing fluoride as a potential antimicrobial agent showed larger zones of inhibition in total (9.1±2.6 mm), the selenium group was the second-most effective (4.7±4.9 mm), and the group without any potential antimicrobial agent showed the least antimicrobial effect (0.9±1.0 mm). Materials from the group with no antibacterial agent were not significantly different from the negative control group (p>0.05). Conclusions Materials containing selenium carried the most significance when comparing microorganisms with the agent, since they were the only ones showing difference between the 2 microorganisms. They showed statistically significant difference in efficacy against S. mutans, and poor antimicrobial effect against L. acidophilus. These data suggest that orthodontic materials containing selenium might have the potential to prevent WSLs due to their antimicrobial properties.