Background: Undernutrition disorder is a prevalent comorbidity (up to 25%) in type 2 diabetes (T2D) patients which significantly compromises their health. We aimed to assess the association between single nucleotide polymorphysms (SNPs) adiponectin (ADIPOQ) +276 (G/T) and resistin (RETN) −420 (C/G) with the risk of developing T2D and undernutrition in patients with T2D. Methods: The research was conducted as prospective case-control study among 106 patients with T2D and 106 healthy control individuals in the territory of the Bosnia and Herzegovina from Sep 1st 2022 to May 1st 2023. For assessing the nutritional status, the mini nutritional assessment (MNA) was used. DNA analysis was carried out by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. The data were analyzed using chi-square test, t-test for independent samples and binary multivariate logistic regression. Results: The research included 212 subjects of which 124 (58.5%) were male. The mean age of the subjects was 68.48±4,67 yr. Almost 20% of subjects were undernourished, significantly more T2D patients when compared to controls (33% vs. 6.6%; P<0.001). ADIPOQ +276 GT genotype was identified as significant predictor of T2D (OR: 3.454; 95% CI: 1.400–8.521; P=0.007) and undernutrition disorder (OR: 3.453; 95% CI: 1.331–8.961; P=0.011) in T2D population, while the presence of RETN −420 CG genotype had protective effect against occurrence of T2D (OR: 0.353; 95% CI: 0.144–0.867; P=0.023). However, RETN genotypes were not associated with undernutrition disorder. Conclusion: ADIPOQ +276 gene polymorphism represent a significant predictor for development of T2D and undernutrition disorder in T2D population, while RETN −420 gene polymorphism was identified as a significant factor associated with a reduced risk for T2D, but was not associated with undernutrition.

<p><strong>Introduction. </strong>The aim of this article was to present a case of a foreign body in the external auditory canal described as a pseudotumor of the middle ear, as well as to point out diagnostic and therapeutic aspects of this problem.</p> <p><strong>Case report. </strong>An 8-year-old girl was hospitalized several times in our department due to the surgery of left-sided chronic otitis media. Mastoidectomy and posterior atticotomy were performed during initial hospitalization. Six months later, she was admitted for the second act of the left-sided tympanoplasty. However, two months prior hospitalization, symptoms regarding the right ear appeared: sense of fullness, gradual hearing loss and occasional pain. An otoscopic finding on the right indicated the presence of &ldquo;tumefaction&rdquo; in the external auditory canal with a surface that was markedly hyperemic. This pseudotumor was finally interpreted as the foreign body in the external auditory canal.</p> <p><strong>Conclusion. </strong>Foreign bodies in the external auditory canal (EAC) are relatively common in pediatric population. The medical history sometimes is not reliable, and the clinical and radiological interpretation of pseudotumor in the external auditory canal or middle ear must include this possibility in the differential diagnosis as well. Surgical exploration and pathohistological diagnosis are necessary to make a definitive diagnosis and to avoid potential complications.</p>

<p>The participation of deaf and hard of hearing people in sports activities contributes to the improvement of the quality of life in all its domains, and compared to people with some other types of disabilities, deaf and hard of hearing people achieve higher scores in sports activities. Practicing sports activities improves physical health, mental state, degree of independence and social relationships. Sports activities have a positive effect on building and strengthening the self-esteem of individuals. Subjective experience and individual perception have a great influence on the quality of an individual&rsquo;s life, therefore, self-esteem is a very important factor that contributes to this. The aim of this paper is to review the literature from the period 2000&ndash;2021 on the impact of sports activities on the psychophysical health of deaf and hard of hearing people. The subject of interest was: to determine the role of sports activities in the quality of life of deaf and hard of hearing people, as well as how they affect their level of self-esteem. The following search engines were used for the literature search: Ebscohost, ScienceDirect, Wiley Inter Science and SpringerLink, KoBSON, Google Scholar. The results of the literature review showed that sports activities contributed to the preservation and development of the overall psychophysical health of deaf and hard of hearing people. Participation in sports activities, whether recreational or professional in nature, has proven to be a significant factor in raising the level of self-esteem, alleviating symptoms of anxiety and stress. Participation in sports activities leads to better social functioning among peers and building an inclusive society.</p>

Introduction. Tinnitus is a perception of a sound in the ears in the absence of acoustic stimulation whose pathophysiological mechanisms have not been evaluated yet. Approximately, 1-2% of people report distress which can negatively affect their daily performance. Our study aimed to assess the incidence of anxiety in patients with tinnitus. Methods. The study was designed as a cross-sectional study. The participants were divided into two groups: a group of 73 patients with tinnitus (with two subgroups in relation to the duration of tinnitus-less than one year and more than one year) and a control group of 43 patients without tinnitus. We examined the presence of anxiety in all patients using the Burns Anxiety Inventory (BAI). The quality of life of all patients was estimated by Tinnitus Handicap Inventory (THI). Results. In the group of patients with tinnitus, 56.2% of them had mild and 24.7% moderate hearing loss, while 27.7% of respondents from control group had mild and 8.5% moderate levels of hearing impairment. THI results showed that patients with tinnitus less than 1 year had a significantly (p= 0.002) higher level of disorders in daily life, compared with the group who had tinnitus for more than 1 year. The 30.8% of respondents had minimal anxiety, 26.7% borderline anxiety, 17.5% mild anxiety, the same percentage of respondents moderate, 5% severe, while 2.5% had extreme anxiety based on BAI. Conclusion. Anxiety can be considered as potentially significant modulators of changes in brain structures observed in people with tinnitus.

Introduction. Chronic rhinosinusitis with sinonasal polyposis is a chronic inflammatory process of the mucous membranes of the nasal and paranasal sinuses, clinically manifested by the appearance of polyps in the nasal cavity. The presence of polyps in the nose and sinuses is the cause of the characteristic symptoms that affect the quality of life of the patient. The study investigates the correlation between endoscopic, microbiological and radiological findings and symptom severity in patients with chronic rhinosinusitis and sinonasal polyposis. Methods. The research included 45 patients with chronic rhinosinusitis and sinonasal polyps, for whom surgery treatment was indicated after the failure of conservative therapy, and 25 healthy subjects. Intensity of symptoms in subjects was assessed by A Visual Analogue Scale. The bacteriological examination of secretion of the medial nasal corridor was carried out. Clinical and radiological assessment of the severity of the condition was done by the endoscopy and computerized tomography score (CT score). Results. A statistically significant difference was found in symptom severity between the experimental and control groups. There was a statistically significant correlation between endoscopy score and the symptom severity (r = 0.315; p = 0.035), CT-score (r = 0.720; p < 0.001) and the presence of asthma (r = 0.335; p = 0.025). Furthermore, there was a statistically significant correlation between CT score and the presence of asthma (r = 0.419; p =0.004). By binary logistic regression, a statistically significant correlation between the endoscopy score and symptom severity (OR = 1.513; p = 0.044) was found. Conclusion. In comparison with the objective clinical parameters, the severity of symptoms in patients with sinonasal polyposis is in a statistically significant correlation with the endoscopy score.

Introduction. Chronic rhinosinusitis with sinonasal polyposis is a chronic inflammatory process of the mucous membranes of the nasal and paranasal sinuses, clinically manifested by the appearance of polyps in the nasal cavity. The presence of polyps in the nose and sinuses is the cause of the characteristic symptoms that affect the quality of life of the patient. The study investigates the correlation between endoscopic, microbiological and radiological findings and symptom severity in patients with chronic rhinosinusitis and sinonasal polyposis. Methods. The research included 45 patients with chronic rhinosinusitis and sinonasal polyps, for whom surgery treatment was indicated after the failure of conservative therapy, and 25 healthy subjects. Intensity of symptoms in subjects was assessed by A Visual Analogue Scale. The bacteriological examination of secretion of the medial nasal corridor was carried out. Clinical and radiological assessment of the severity of the condition was done by the endoscopy and computerized tomography score (CT score). Results. A statistically significant difference was found in symptom severity between the experimental and control groups. There was a statistically significant correlation between endoscopy score and the symptom severity (r = 0.315; p = 0.035), CT-score (r = 0.720; p < 0.001) and the presence of asthma (r = 0.335; p = 0.025). Furthermore, there was a statistically significant correlation between CT score and the presence of asthma (r = 0.419; p =0.004). By binary logistic regression, a statistically significant correlation between the endoscopy score and symptom severity (OR = 1.513; p = 0.044) was found. Conclusion. In comparison with the objective clinical parameters, the severity of symptoms in patients with sinonasal polyposis is in a statistically significant correlation with the endoscopy score.

Introduction. Acute rhinosinusitis (ARS) encompasses a heterogeneous group of inflammatory disorders affecting nasal mucosa and paranasal sinuses. Rhinosinusitis is the most common condition in the United States. It is estimated that over 30 million people annually visit the doctor due to this condition, while every sixth adult suffers from ARS. Among all ARS complications, over 91% are orbital complications (OC) with an average prevalence of 6% and a higher incidence in children compared to adults. Case report. Twelve-year-old boy, accompanied by his mother, was urgently referred to the Department of Otorhinolaryngology at the University Hospital in Foca due to a sudden red and painful left periorbital edema, pain in the left eye and a fever reaching 38.5ºC. After laboratory and CT scan diagnostics, an ophthalmologic examination and inpatient clinical findings after 36 hours of parenteral triple antibiotic therapy, the patient was referred to a tertiary-type institution for further treatment. The same procedure was performed conservatively during the hospitalization within 6 days. Conclusion. The initial treatment of orbital complications in children is conservative. Treatment should be started empirically, using triple antibiotic therapy. The choice of antibiotics and treatment protocols among pediatric population have not been agreed yet. If 36-48 hours after the beginning of the conservative treatment, there is lack of the clinical response, surgical treatment is absolutely indicated, regardless of the stage of orbital complication.

Introduction. Matrix metalloproteinase-9 (MMP-9) plays one of the key roles in the migration of inflammatory cells and the destructive behavior of acquired middle ear cholesteatoma. The aim of the study was to determine the expression levels of MMP-9 in chronic otitis media, with and without acquired cholesteatoma, as well as to determine the correlation between them and the pathomorphological changes in the tympanic membrane (TM). Methods. Immunohistochemical study included 178 patients of both sexes, aged 5-75 years, who underwent microsurgical treatment of chronic otitis media (COM) at the Ear, Nose and Throat Department of the University Clinical Center of the Republic of Srpska in Banja Luka from 2015 to 2018. Patients were divided into two groups on the basis of the presence or absence of acquired cholesteatoma: 97 (CCOM) and 81 (COMWC). The samples of the perimatrix of acquired cholesteatoma (n=97) and inflamed middle ear mucosa (n=81) were taken intraoperatively. The presence of retraction and certain types and subtypes of TM perforations were examined by intraoperative exploration. MMP-9 expression levels were determined by immunohistochemical analysis. Results. In the presence of cholesteatoma and highly positive expression of MMP-9, the marginal type of TM perforation was more likely to occur (p<0.01) while in negative expression of MMP-9 in the COMWC group, the central type was more likely to occur (p<0.01). There was a higher probability of the presence of attic subtype of TM perforation in patients with cholesteatoma and moderate positive expression of MMP-9 (p<0.01). There was not a statistically significant contribution of any of the factors in the prediction of the influence on the occurrence of TM retraction. Conclusion. The presence of acquired middle ear cholesteatoma and highly positive expression of MMP-9 are statistically significant predictors of the presence of marginal type and attic subtype of TM perforation. Expression levels of MMP-9 may have potential clinical significance in the development of irreversible pathomorphological changes on TM in middle ear cholesteatoma.