The paper presents the determination of the maximum load of load-bearing structures with terrain contact according to EN 1997-1 (Geotechnical design) and EN 1998-5 (Foundations, supporting structures and geotechnical issues). Processed is a concrete example of SPP Crna rijeka which will be based in rock material, and which does not require “additional“ interventions for the stability of structures (water intake with sedimentation tank and engine room).

In the context of dental age assessment, two significant factors can be studied; tooth mineralisation and tooth emergence. Little is known about the role of a second molar eruption in forensic age estimation. This paper aims to contribute to forensic age estimation using an age threshold of 14 years, studying the eruption stages of permanent mandibular premolars and second molars. Totally 640 orthopantomograms (OPGs) of south Indian children, aged between 10 and 18 years, were evaluated using Olze et al. staging of tooth eruption stages (A-D). Spearman's rho correlation showed a strong, positive, and statistically significant correlation between the chronological age and the eruption stages of both sexes' teeth. Accuracy, sensitivity, specificity, likelihood ratios, and post-test probability values were calculated for all tested teeth. The best performance to discriminate individuals above or below 14 years showed stage D in second molars. The sensitivity varied between 89% and 94% and specificity between 75% and 84%, respectively. Receiver operating characteristic curve analysis revealed high diagnostic performance for stage D, with area under the ROC curve (AUC) values of 84% and 85% for tooth 37 and 85% and 83% for tooth 47 in males and females, respectively. In conclusion, it is possible to predict age over 14 years in south Indian children using tooth emergence stages from OPGs with a relatively high interobserver agreement and good diagnostic accuracy. However, there are some limitations and, therefore, must be used in conjunction with other methods.

The paper shows the calculation of the system by second order theory on elastic supports. At the calculate it adopted a linear relationship of stress-displacement soil. The method of calculating the beams based on rigid and deformed supports was presented by introducing geometric nonlinearity into the calculate. Expressions were performed for the rigidity of the supports in the vertical direction and on the rotation of the foundation, due to the elastic deformation of the soil. Numerical examples show the application of the procedure described. Through diagrams and charts of static and deformation, a comparison of calculate results was made.

Abstract Accurate state-estimation is a vital prerequisite for fast feedback control methods such as Nonlinear Model Predictive Control (NMPC). For efficient process control, it is of great importance that the estimation process is carried out as fast as possible to provide the feedback mechanism with fresh information and enable fast reactions in case of any disturbances. We discuss how Multi-Level Iterations (MLI), known from NMPC, can be applied to the Moving Horizon Estimation (MHE) method for estimating the states and parameters of a system described by a Differential Algebraic Equation model. A challenging field of application for the proposed MLI-MHE method are electric microgrids. These push current control approaches to their limits due to the rising penetration of volatile renewable energy sources and the fast electrical system dynamics. We investigate the closed-loop control performance of the proposed MLI-MHE algorithm in combination with an NMPC controller for a realistic sized microgrid as a numerical example.

Abstract This article discusses how to use optimization-based methods to efficiently operate microgrids with a large share of renewables. We discuss how to apply a frequency-based method to tune the droop parameters in order to stabilize the grid and improve oscillation damping after disturbances. Moreover, we propose a centralized real-time feasible nonlinear model predictive control (NMPC) scheme to achieve efficient frequency and voltage control while considering economic dispatch results. Centralized NMPC for secondary control is a computationaly challenging task. We demonstrate how to reduce the computational burden using the Advanced Step Real-Time Iteration with nonuniform discretization grids. This reduces the computational burden up to 60 % compared to a standard uniform approach, while having only a minor performance loss. All methods are validated on the example of a 9-bus microgrid, which is modeled with a complex differential algebraic equation.

The coordinate ring of the Grassmannian variety of $k$-dimensional subspaces in $\mathbb{C}^n$ has a cluster algebra structure with Plucker relations giving rise to exchange relations. In this paper, we study indecomposable modules of the corresponding Grassmannian cluster categories ${\rm CM}(B_{k,n})$.\ Jensen, King, and Su have associated a Kac-Moody root system $J_{k,n}$ to ${\rm CM}(B_{k,n})$ and shown that in the finite types, rigid indecomposable modules correspond to roots. In general, the link between the category ${\rm CM}(B_{k,n})$ and the root system $J_{k,n}$ remains mysterious and it is an open question whether indecomposables always give roots. In this paper, we provide evidence for this association in the infinite types: we show that every indecomposable rank 2 module corresponds to a root of the associated root system. We also show that indecomposable rank 3 modules in ${\rm CM}(B_{3,n})$ all give rise to roots of $J_{3,n}$. For the rank 3 modules in ${\rm CM}(B_{3,n})$ corresponding to real roots, we show that their underlying profiles are cyclic permutations of a certain canonical one. We also characterize the rank 3 modules in ${\rm CM}(B_{3,n})$ corresponding to imaginary roots. By proving that there are exactly 225 profiles of rigid indecomposable rank 3 modules in ${\rm CM}(B_{3,9})$ we confirm the link between the Grassmannian cluster category and the associated root system in this case. We conjecture that the profile of any rigid indecomposable module in ${\rm CM}(B_{k,n})$ corresponding to a real root is a cyclic permutation of a canonical profile.

Quantum algorithms can be expressed as quantum circuits when the circuit model of computation is adopted. Such a circuit description is usually hardware-agnostic, that is, it does not consider the limitations that the quantum hardware might have. In order to make quantum algorithms executable on quantum devices they need to comply to their constraints, which mainly affect the parallelism of quantum operations and the possible interactions between the qubits. The process of adapting a quantum circuit to meet the quantum chip restrictions is known as mapping. The resulting circuit usually has a higher number of gates and depth, decreasing the algorithm's reliability. Different mapping solutions have been already proposed. Most of them are meant for a specific quantum processor and differ in methodology, approach and features. In addition, they are usually only compared in terms of added gates, circuit depth and compilation time. No thorough comparative analysis of the different mapping solutions performance and features has been performed so far.In this paper, we propose to apply structured design space exploration (DSE) methodologies to the mapping procedures. This will allow not only to have a more in depth and structured analysis of their performance but also to identify what features are key and worth to implement. By using DSE we will be able to: i) determine in what regimes some mapping solutions outperform others; ii) derive optimal mapping strategies for specific quantum algorithms and quantum processors; and iii) perform an scalability analysis. In addition, DSE techniques cannot only be applied to the mapping layer that is key for bridging quantum applications to quantum devices, but also to the full-stack quantum computing system allowing for its crosslayer co-design.

Introduction: Overcrowded emergency departments (ED) and undifferentiated patients make the provision of care and resources challenging. We examined whether machine learning algorithms could identi...

BACKGROUND Isolated iliac artery aneurysms are rare and occur predominantly in men at an older age. Such aneurysms can rupture into an adjacent organ (such as the bowel, bladder or ureter) or into the adjacent common iliac vein, resulting in an arteriovenous fistula. INTRODUCTION Formation of an internal iliac arteriovenous fistula caused by spontaneous rupture of an atherosclerotic iliac artery aneurysm wall is an exceedingly rare yet serious complication. Methods / Results: This article presents a case of an internal iliac arteriovenous fistula caused by rupture of an atherosclerotic giant iliac artery aneurysm. CONCLUSION Rapid diagnosis and meticulous surgical technique improve outcomes in patients with this rare vascular complication.

Software development requires understanding of users, user needs, user tasks and context in which they are operating. These skills are familiar to entrepreneurs, product managers, and marketing experts. However, our teaching experience suggests that students generally find these topics less attractive as they perceive them to be far too theoretical and thus, not as useful. During the years of teaching the Human Computer Interaction course we have noticed students' preferences for learning technology oriented methods, or what we refer to topics belonging to solution domain. The changes in the modernized HCI course introduced Product Market Fit canvas in order to bridge the gap between 'theoretical' and 'practical' part of the course.

Neuroendocrine carcinoma of the cervix (NEC) is a rare and highly aggressive cervical malignancy. Given that no targeted therapy has been approved specifically to NEC, we investigated the presence of novel, potentially targetable biomarkers in a large cohort of NEC. Sixty-two NEC were molecularly profiled for biomarkers of targeted therapies including antibody-drug conjugates [delta-like canonical notch ligand 3 (DLL3), a trophoblast cell surface antigen 2 (TROP-2), and folate receptor 1 (FOLR1)], NTRK1-3 gene fusions, and immune checkpoint inhibitors [programmed death-ligand 1 (PD-L1), tumor mutational burden, and microsatellite instability] using immunohistochemistry and DNA/RNA next-generation sequencing assays. A cohort of squamous cell carcinomas of the cervix (n=599) was used for comparison for immune-oncology biomarkers. DLL3 expression was observed in 81% of the cases. DLL3 expression was inversely correlated with commonly observed pathogenic mutations in PIK3CA (17%) (P=0.018) and PTEN (10%) (P=0.006). Other more frequently seen pathogenic mutations (TP53 17%, KRAS 11%, and CTNNB1 5%) were not associated with DLL3 expression. TROP-2 expression was detected in only 1 case and no case expressed FOLR1. Although NTRK protein expression was observed in 21% of the cases, none of these had an NTRK gene fusion. PD-L1 expression (10%) and high tumor mutational burden (3%) were significantly less frequent in NEC compared with the squamous cell carcinoma cohort (79% and 11%, respectively). None of the NEC exhibited high microsatellite instability status. Despite frequent DLL3 expression in NEC, a potential therapeutic benefit of DLL3-targeted drugs remains uncertain given the recent failure of the Rova-T therapeutic trial in small cell lung carcinomas. Small cohorts of NEC enriched in PIK3CA/PTEN/AKT and programmed cell death protein 1/PD-L1 alterations indicate therapeutic roles for their respective inhibitors.

Abstract The formation of the freshwater lakes and travertine limestone was caused by the tectonic depression, which occurred in the Dinarides during the Miocene. This stone has been exploited and used since far back on the territory of Bosnia and Herzegovina as a building stone and for different architectural purposes. Most of the investigations were concentrated on the “tenelija” stone due to its massive use and construction of the famous Stari Most (Old Bridge) in Mostar. Not much investigation was devoted to “miljevina” (mudstone) which belongs to the same petrographic type. This is a soft carbonate rock that is highly porous, has small density, relatively low strengths, poor wear resistance, and low resistance to frost. In this paper, the influence of layers (planes of anisotropy - foliation) of the mudstone was investigated. Within an experimental campaign, numerous sets of tests were performed on different samples. Tests include uniaxial compressive strength (UCS) on cube and cylinder specimens, flexural strength under concentrated load and constant moment, tensile strength based on Brazilian tests, determination of Young’s modulus, modulus of deformations, and Poisson ratio. Prediction of UCS and Young’s modulus, as elastic mechanical characteristics, represent the main goal in engineering projects. Additionally, the influence of sample conditions and planes of anisotropy was investigated. Results have been compared and correlations are established. As a result, a new relation between uniaxial compressive strength obtained on cube and cylinder samples for a stone of low compressive strength is proposed.

Fluid-Structure Interaction (FSI) simulations have applications to a wide range of engineering areas. One popular technique to solve FSI problems is the Arbitrary Lagrangian-Eulerian (ALE) method. Both academic and industry communities developed codes to implement the ALE method. One of them is Alya, a Finite Element Method (FEM) based code developed in Barcelona Supercomputing Center (BSC). By analyzing the application on a simplified artery case and compared to another commercial code, which is Finite Volume Method (FVM) based, this paper discusses the mathematical background of the solver for domains, and carries out verification work on Alya’s FSI capability. The results show that while both codes provide comparable FSI results, Alya has exhibited better robustness due to its Subgrid Scale (SGS) technique for stabilization of convective term and the subsequent numerical treatments. Thus this code opens the door for more extensive use of higher fidelity finite element based FSI methods in future.