Este artigo tem como proposta relacionar o papel da farmácia hospitalar diante de um cenário de pandemia, como a do novo coronavírus, e ressaltar a importância de um plano de contingência para o enfrentamento do impacto causado por esta pandemia em um hospital. A partir de uma revisão teórica, onde buscou-se trabalhos científicos e literaturas sobre o tema, em plataformas de pesquisa Scielo e Google Acadêmico, foi possível selecionar e analisar planos de contingência da farmácia hospitalar propostos em âmbito nacional e internacional, assim como artigos, livros, dados estatísticos, declarações, manuais, normas técnicas, dentre outros materias, que permeiam essa temática, correlacionando-os com as atribuições de um serviço de farmácia em unidades de saúde. Os resultados da revisão bibliográfica corroboram para as evidências da necessidade de se elaborar um plano de contingência específico para este cenário. Com isso concluiu-se que compete ao farmacêutico entender do processo assistencial e de gestão para se implementar e executar um plano de contingência na farmácia hospitalar específico para a pandemia por COVID-19. De forma a combater o vírus SARS-CoV-2 e mitigar seu impacto no âmbito hospitalar e na sociedade como um todo, garantindo a qualidade e a segurança dos pacientes e colaboradores.

Objective: Sentinel lymph node harvesting is an essential step in the surgical treatment of a growing number of malignancies. Various techniques are available to facilitate this purpose. The present study reports a new laparoscopic technique for lymph node harvesting using magnetic nanoparticles containing a superparamagnetic iron-oxide core and dextran coating. This study assesses the clinical relevance of the prototype and provides input for further technological development on the way to clinical implementation. Methods: A laparoscopic differential magnetometer prototype was built, utilizing a nonlinear detection principle (differential magnetometry) for magnetic identification of lymph nodes. The iron content sensitivity, depth & spatial sensitivity, and angular sensitivity were analyzed to investigate clinical options. Results: The minimum detectable amount of iron was 9.8 μg at a distance of 1 mm. The detection depth was 5, 8, and 10 mm for samples containing 126, 252, and 504 μg iron, respectively. The maximum lateral detection distance was 5, 7, and 8 mm for samples containing 126, 252, and 504 μg iron, respectively. A sample containing 504 μg iron was detectable at all angulations assessed (0°, 30°, 60° and 90°). Conclusion: The laparoscopic differential magnetometer demonstrates promising results for further investigation and development towards laparoscopic lymph node harvesting using magnetic nanoparticles. Significance: The laparoscopic differential magnetometer facilitates a novel method for sentinel lymph node harvesting, which helps to determine prognosis and treatment of cancer patients.

The increase of global fish consumption brings with it the problem of fish mislabeling, which leads to economic losses for consumers or may even result in consumers’ health risk. Thus, continuous development of methods used in identification of exact fish species is essential. There are numerous modern identification methods, which use DNA or specific fish proteins as biomarkers, but they all come with various benefits and drawbacks. Protein-based methods include electrophoretic methods, ELISA, HPLC and MALDI-ToF Mass Spectrometry, while the methods that use DNA as a biomarker include PCR-RFLP, SSCP, qPCR, RAPD, FINS, DNA microarray, DNA barcoding, pyrosequencing and metabarcoding. There is a continuous development of new or improved methods. Most of the methods display a much better performance when analyzing raw or lightly processed fish, such as chilled or frozen, while heat treatment often leads to changes in the biomarker molecules, making the species identification difficult. The ideal method does not yet exist, but methods such as DNA barcoding, MALDI-ToF Mass Spectrometry and metabarcoding are the ones that show most potential.