Introduction/Objective. The purpose of this study was to assess the effectiveness of different approaches in the treatment of metastatic melanoma in daily clinical practice in a situation with limited and late availability of new drugs in a resource-limited country and to compare these parameters with those reported in clinical studies and from other real-world data. Methods. Main methods included assessment of overall survival (OS) and progression-free survival (PFS). Patients were included in the study if they were treated with first or second-line systemic therapy for radiologically/pathologically confirmed metastatic melanoma. Patients were divided into four groups based on the type of therapy they received: chemotherapy (dacarbazin), BRAF inhibitor (vemurafenib), BRAF/MEK inhibitors (vemurafenib/cobimetinib and trametinib/dabrafenib) and anti PD-1 therapy with pembrolizumab. Results. Regardless of the line of therapy, the calculated median OS in chemotherapy and vemurafenib group was nine months. The median OS in the BRAF/MEK inhibitor group was 14 months and 15 months in the pembrolizumab group. Median PFS in the chemotherapy group was four months, seven months for vemurafenib, in the BRAF/MEK inhibitor group nine months and in the pembrolizumab group six months. There was a statistically significant difference in survival between first and second-line therapy in the pembrolizumab group. Conclusion. Our results showed lower median OS and PFS in comparison to reported data from clinical trials. Compared to other real-world data from countries with similar problems related to the late reimbursement of new drugs, our research has shown similar results.

Celiac disease is defined as an autoimmune disorder that is the result of a reaction of adaptive immune response of sensitive individuals, to gluten-containing cereals. The aim of this study was to assess the nutritional habits of patients with the diagnosis and people without the diagnosis, to evaluate the importance of adhering to a strict gluten-free diet, recognizing properly declared gluten-free products and to assess the quality of life of people diagnosed with celiac disease. Anthropometric and dietary tests were conducted through a survey by a total of 96 people, 56 respondents were diagnosed with celiac disease, while the remaining 40 respondents were undiagnosed, and of whom 32 were on a gluten-free diet. The majority of respondents (58.92%) have an adequate level of nutrition; however, 30.37% of respondents are overweight, including the degree of obesity in four cases. The most consumed cereals are rice, corn and white ready-made gluten-free flour mixtures, while the respondents consume the least pseudo-cereals, whole grains and micro-cereals. Within the survey CD-QOL (Celiac Disease Quality of Life) we assessed the quality of life, general the attitude of patients according to the given claims related to celiac disease. The obtained results led us to the conclusion that the dietary habits of celiac patients are somewhat worse than those of the undiagnosed group, although these are very small differences. It has been found that there is some confusion among people diagnosed regarding properly declared and certified gluten-free products, while most respondents believe that a strict gluten-free diet is the only effective treatment for the disease.

Introduction. A newly discovered SARS-CoV-2 virus that causes an infectious disease called Coronavirus Disease 2019 (COVID-19) has spread around the world. Objectives. The study aims to explore the impact of the COVID-19 pandemic on speech-language pathologists (SLPs) clinical service delivery. Accordingly, this study aims to determine which modifications were used in the provision of speech-language pathology (SLP) services and which procedures were used by SLPs in their clinical practice in Bosnia and Herzegovina (B&H) during the third pandemic wave. The second aim of the study was to analyze how many SLPs from B&H used telepractice and what are the barriers to performing this type of work. Methods. The study included 107 SLPs, who voluntarily joined the survey, after sending the questionnaire directly to the e-mail or placing the questionnaire in online SLPs groups. The survey comprised questions to assess participants' demographics, personal protective equipment, procedures, provision of telepractice, and barriers and limitations to telepractice implementation. Results. Results showed that 93.4% of SLPs reported they use measures to prevent and control the COVID-19 pandemic. Only 28% of SLPs used telepractice in their work, which is a very low rate. The majority of SLPs (59.2%) reported that they did not receive the appropriate education about using telepractice. Conclusion. The COVID-19 pandemic led to a change in service delivery by SLPs requiring them to modify their work or to provide services through telepractice.

The subject of our research is the evolution of the principle of immediacy in general criminal proceedings in Serbian law, with the aim of observing the basic tendencies in that development. In this article, the results of the first part of the research were published, in which the analysis and comparison of the principle of immediacy in our first two procedural codes was carried out: The Code of Criminal Procedure of the Kingdom of Serbia from 1865 and The Code of Criminal Procedure of the Kingdom of Yugoslavia from 1929. Both codes generally respected the structural, personal and temporal segments of the principle of immediacy, allowing for a number of exceptions from it. These exceptions were much more radical in the reactionary Code of Criminal Procedure from 1865, of a moderately inquisitorial type. Not only is the principle of immediacy not implemented in it with all its consequences, but it is also made illusory. The adoption of the principle of positive legal evaluation of evidence and the dominance of the inquisitorial principle contributed to that. The main trial was only a facade, behind which there was a significant possibility of penetration of investigative materials, regardless of whether it came from judicial or police authorities. In contrast, the Criminal Procedure Code of 1929 was based on procedural principles, such as accusatory, immediacy, publicity, orality, adversary, material truth and free evaluation of the criminal proceedings. The principle of immediacy was consistently implemented, with some reasonable and mostly acceptable exceptions in the structural and personal party segment. In some cases, the judgment could be based on investigative materials, but they were always CORT records. That code consistently adhered to rhe rule that no one could be tried and convicted in absentia. Its provisions aimed at preserving the continuity of the main trial are to be commended.

Purpose – The pandemic caused by the COVID-19 virus left a significant negative mark on the world economy, and tourism industry. It has also significantly affected the perception and behavior of tourists when it comes to the safety of a tourist destination. To continue to record a positive recovery trend, destinations must undertake scientific and professional research, and based on the results consider and develop new development strategies for the development of tourism in the post-pandemic period. The perception of risk in tourists is changing, which ultimately has an impact on their future behavior when choosing a holiday destination. Opatija Riviera is a destination with a rich and long tourist tradition, which until before the pandemic was perceived as safe, as evidenced by the continuous growth of tourist turnover. The purpose of this paper is to emphasize the importance of monitoring whether and to what extent tourists perceive Opatija Riviera as a safe tourist destination and based on the findings to offer developmental guidelines for the post-pandemic period. Methodology – Data collection was conducted during June and July 2022, using an online survey questionnaire. 152 respondents agreed to participate in research. The basic measurement instrument was based on the Tourists’ Perceived Safety at Destinations (TPSD) scale developed by Xie et al. (2020b), i.e. initial items (25) proposed by these authors. To extract the dimensions of perceived tourist safety, the authors primarily used exploratory factor analysis. Findings – by using the exploratory factor analysis the following factors were identified: perception of safety of human elements (PSH), safety of facilities and equipment (PSFE), safety of natural environments (PSNE), perceived safety of social environments (PSSE) and safety of management elements (PSM). The results for PSH, PSFE, PSNE and PSSE have proven to be satisfactory in terms of how tourists perceive them as safe and reliable, which is not the case with the PSM. The f indings for PSM indicate the need for additional investments aimed towards improvement of protection of tourist´s safety (safety of the construction, safety of information and visibility of warning sign about security in Opatija Riviera). Originality of the research – this research contributes to the theory by presenting relevant literature content in safety perception in tourism. The empirical contribution derives from the fact that no similar research was conducted on Opatija Riviera until now. Its findings set the basis for future empirical research that will be conducted in the post-COVID period in Opatija Riviera, based on which it will be possible to plan further developmental activities aimed towards improving tourist´s safety during their stay.

We examined dermatoglyphics of children in three Albanian and one Roma population sample (collected from 641 individuals from the Albanian populations and 226 individuals from the Roma population of both sexes). We compared Albanian and Roma populations based on four finger (whorl, radial and ulnar loop, and arch) and thirteen palmar traits (pattern frequencies in the Thenar/I interdigital area, II, III, and IV interdigital area, Hypothenar and axial »t« triradius position). The differences between the populations were more evident for palmar traits. In our study the Albanian and the Roma populations showed the best separation when finger and palmar traits are separately analyzed. As expected, the Albanian and the Roma populations separated in statistical analyses of most traits; the main reason for this is the different origins of two ethnic groups. The observed difference also indicates a low level of admixture between the Albanians and the Roma despite them living beside one another for several centuries.