The COVID-19 pandemic led to an increase in healthcare waste (HCW). HCW management treatment needs to be re-taken into focus to deal with this challenge. In practice, there are several treatments of HCW with their advantages and disadvantages. This study is conducted to select the appropriate treatment for HCW in the Brčko District of Bosnia and Herzegovina. Six HCW management treatments are analyzed and observed through twelve criteria. Ten-level linguistic values were used to bring this evaluation closer to human thinking. A fuzzy rough approach is used to solve the problem of inaccuracy in determining these values. The OPA method from the Bonferroni operator is used to determine the weights of the criteria. The results of the application of this method showed that the criterion Environmental Impact ( 𝐶 4 ) received the highest weight, while the criterion Automation Level ( 𝐶 8 ) received the lowest value. The ranking of HCW management treatments was performed using MARCOS methods based on the Aczel–Alsina function. The results of this analysis showed that the best-ranked HCW management treatment is microwave (A6) while landfill treatment (A5) is ranked worst. This study has provided a new approach based on fuzzy rough numbers where the Bonferroni function is used to determine the lower and upper limits, while the application of the Aczel–Alsina function reduced the influence of decision-makers on the final decision because this function stabilizes the decision-making process.

The stainless steel cannula inserting method was used to observe effects of alpha-adrenoceptor agonists, 5-HT and KCl before and after cold storage (3-5 days, at 4 degrees C) in skeletal muscle branches of the simian deep femoral artery. Epinephrine (EPI), norepinephrine (NE), phenylephrine (PE), methoxamine (MT) and 5-hydroxytryptamine (5-HT) induced marked monophasic vasoconstrictions in a dose-dependent manner. 5-HT induced a greater vasoconstriction in larger diameter vessels (old animals) than that in smaller ones (young animals), suggesting age-related responses. A selective alpha 2-stimulant, clonidine (CLO) or xylazine (XYL), produced only a slight vasoconstriction. Tyramine (TYR) also produced only a slight vasoconstrictor response. The order of potencies for inducing vasoconstrictions was EPI greater than or equal to 5-HT greater than or equal to NE greater than MT = PE much greater than KCl greater than CLO = XYL = TYR. The vasoconstrictor responses to all used adrenergic agonists and 5-HT were not significantly influenced by the prolonged cold storage. However, KCI-induced constrictions were significantly suppressed by the cold storage. These results suggest that the postjunctional alpha-adrenoceptor in simian skeletal muscle arteries is mainly of the alpha 1-type. Since cold storage caused a significant suppression of the KCl-induced response but not those of adrenoceptor agonists and 5-HT, it was considered that the mechanism of calcium entry to the vascular smooth muscle of skeletal muscle arteries might be significantly damaged by the cold storage.