This systematic review considers the most recent attitudes and news regarding the influence of the stroma on tumor initiation and progression. It is now widely accepted that tumor stroma plays an active role in carcinogenesis. Many different signaling molecules, ligands and signaling pathways recently have been discovered. This review considers the complexity of interactions between malignant cells and its stroma (cross-talk). The recent advances and better understanding of the tumor-stroma interactions will have important impact on the new and combined therapeutic approaches and modalities.

Cilj ovog rada bio je utvrditi metabolicki status visokomlijecnih krava u prvih 120 dana laktacije na tri obiteljske farme razlicite s obzirom na pasminsku strukturu, nacin ishrane i držanje životinja. Istraživanjem je bilo obuhvaceno ukupno 65 krava (farma A, n=30, Holstein-Frisien pasmina-HF, slobodni nacin držanja ; farma B, n=16, simentalska pasmina, vezani nacin držanja ; farma C, n=19, HF pasmina, vezani nacin držanja), starosti između tri i sedam godina. Uzorci krvi i mlijeka za analizu uzeti su od svake krave u prvih 30 dana laktacije, između 30. i 60. dana, 60. i 90. dana i 90. i 120. dana laktacije. U prvih 30 dana laktacije utvrđena je znacajno niža (p<0, 05) koncentracija glukoze i albumina, manja aktivnost ALT i veca aktivnost AST u odnosu na ostala promatrana razdoblja. Koncentracija BHMK i uree u krvi i mlijeku nije se znacajno mijenjala tijekom razdoblja rane laktacije, dok je na njihovu koncentraciju kao i na koncentraciju UP u krvi znacajan utjecaj imala farma. Najniža proizvodnja mlijeka kao i znacajno niža koncentracija UP, uree i BHMK u krvi te uree i BHMK u mlijeku utvrđena je na farmi B u odnosu na ostale dvije farme (P<0, 05).

AIM To assess the psychological health of war-traumatized children in different foster settings and compare them with children living with one or both parents, 7 years after the 1992-1995 war in Bosnia and Herzegovina. METHOD The study was carried out in Tuzla, Bosnia and Herzegovina, in March 2002. We assessed 186 (93 girls and 93 boys) elementary school children aged 12.7-/+1.8 years for war trauma, presence of posttraumatic stress disorder (PTSD), and depression. There were 38 (14 girls) children from the government orphanage, 48 (24 girls) children from the non-governmental organization (NGO) SOS Children's Village, 50 (24 girls) children who lost a parent in the war but lived with the surviving parent, and 50 (31 girls) children who lived with both parents. For data collection, we used Children's Posttraumatic Stress Reaction Index and Children's Depression Inventory. Basic sociodemographic data were also collected. RESULTS Of 186 children, 90 (48.4%) had been forced into refuge because of the war. Loss of a family member was most frequent among children in the SOS Children's Village, who also experienced the highest number of other types of trauma. PTSD was present in 51.6% of 186 children, with the highest prevalence among children in the SOS Children's Village (39/48). PTSD prevalence was higher among children who lost a parent but lived with the surviving parent (29/50) then among children in the orphanage (15/38) or children living with both parents (13/50) (chi(2)(3)=33.075, P<0.001). Depression was present in 42 of 186 (22.6%) children, but with no statistical difference among the groups (chi(2)(3)=6.337, P=0.096). The prevalence of PTSD and depression was similar in boys and girls. Loss of a parent was associated with higher frequency of PTSD and depression. The loss of both parents was associated with high prevalence of PTSD, but not depression. Prevalence of PTSD was positively correlated with the prevalence of depression (Spearman's rho=0.188; P=0.01). CONCLUSIONS All children experienced war trauma and many had psychological consequences. The highest prevalence of PTSD, often comorbid with depression, was found among children who lost one or both parents. The children with the lowest rate of psychological disturbances were those living with both parents.

Speaking about transition in agriculture, we think on agriculture in transition countries, that is Central and Eastern European Countries. Such development is observed from the perspective of the European Union, discussing about possibilities as well as restrictions brought with accession of the CEECs to the Union, but also from the CEECs point of view. In this analysis we examine some consequences of changes in agricultural policy in the case of Bosnia and Herzegovina. The general conception should help in recognizing strategical guidelines for local development of agriculture and rural areas within the current and coming frame of Bosnia and Herzegovina. By the process of adjusting the agricultural sector, but also the agricultural policy, it should be improved competitiveness of domestic agriculture. That is why in this paper we use the cost-benefi t analysis in estimation the consequences of changes in subsidies and custom rates in specifi c case of construction new plantations and production of apples, that is in evaluation advantages and limitations of agriculture. The results of the analysis provide more objective illustration of domestic agricultural sector in internatioal environment.

A general approach for calculating spectral and optical properties of pigment-protein complexes of known atomic structure is presented. The method, that combines molecular dynamics simulations, quantum chemistry calculations, and statistical mechanical modeling, is demonstrated by calculating the absorption and circular dichroism spectra of the B800-B850 bacteriochlorophylls of the LH2 antenna complex from Rs. molischianum at room temperature. The calculated spectra are found to be in good agreement with the available experimental results. The calculations reveal that the broadening of the B800 band is mainly caused by the interactions with the polar protein environment, while the broadening of the B850 band is due to the excitonic interactions. Since it contains no fitting parameters, in principle, the proposed method can be used to predict optical spectra of arbitrary pigment-protein complexes of known structure.

The ovarian hormone privation causes functional and hormonal disorders, as sexual dysfunction, loss of libido, increase of osteoporosis risk and heart disease, lioprotein levels change and ponderal gain. Osteoporosis is a systemic skeletal disease characterized by an disorder between resorption and bone formation with a consequent increase in bone fragility. The objective of the present investigation was to describe the experimental ovariectomy (OVT) effects on the bone metabolism and on the ponderal gain of the adults wistar rats. Adult rats were under the OVT procedure or sham operated. After 30 days, blood was collectded for the quantitative serum estrogen and after 60 days the animals were sacrified for the serum and bone analysis. The dietary consumption and the weight increase were evaluated twice and once a week respectively. The OVT rats had statistically higher averages (p > 0,05) for the dietary consumption, weight gain and alkaline phosphatase activity in the serum and lower (p < 0,05) for the serum estrogen concentration, calcium content, radiodensity and bone proportional limit comparing to the sham-operated rats. Besides the quantitative analysis, the OVT rats had femurs with theirs surface containing deep resorption gaps, confirming that the ovariectomy rats are a great osteoporosis study model on post menopause women.