The aim of the research was to examine the prevalence of unpleasant emotional states among students. An online survey was conducted in the month of April, 2023, and the participants were students of public universities in Bosnia and Herzegovina (N=170). Among the measuring instruments used was the DASS-21questionnaire (The Depression, Anxiety and Stress Scale-21, Lovibond and Lovibond 1995) and a sociodemographic questionnaire, constructed for the purposes of this research. It is expected that students will experience unpleasant emotional states such as anxiety, depression and stress, and that there will be certain differences in the manifestation of symptoms with regard to gender and age. The obtained findings showed that 34.3% of the subjects are in the category of moderate, severe and extremely severe depressive symptoms, then 49,9% of the subjects feel moderate, severe or extremly severe anxiety, while 38.2% of the subjects show moderate, severe and extremly severe symptoms of stress. As for gender and age differences, the results show that female students are more susceptible to the prevalence of unpleasant emotional states, while the hypotesis related to age differences was not confirmed. Namely, the findings indicate that there are no age differences in the manifestation of unpleasant emotional states. Considering the obtained findings, we believe that it is necessary to raise awareness about the significant growing problems of mental health among students and to highlight the need for preventive and intervention programs at universities.

Introduction: Breast cancer (BC) is a malignant disease that predominantly affects women, with known genetic components such as mutations in tumor suppressor genes BRCA1 and BRCA2. Other risk factors include unhealthy lifestyles, lack of physical activity, and consumption of alcohol and cigarettes. Aging also plays a role in BC development, with hormonal influences such as estrogen and progesterone promoting cancer growth. Material and Methods: Research was conducted using data collection tools for risk factors and tumor markers from primary healthcare unit records. The sample comprised 200 women, divided into two groups based on BC diagnosis, with complete medical documentation. Male BC cases were excluded. Results: Statistical significance was found between genetic components, family history, aging, obesity, alcohol and cigarette consumption, longer hormone exposure, and female BC development using the Chi-Square test, confirmed by Fisher's Exact test. Tumor markers CA 15-3, CEA, CA 19-9, and CA 125 were useful for BC screening and metastasis detection, as determined by the One Sample T-test. In Sarajevo Canton, invasive ductal BC was the most common type among women, while lobular carcinoma in situ was the least common. Conclusion: Correlations between risk factors, including aging, unhealthy lifestyles, and hormone exposure, and increased BC risk were confirmed. Tumor markers CA 15-3, CEA, CA 19-9, and CA 125 were effective in diagnosis, screening, and metastasis detection in females, with sensitivity for regression detection at 81.8% and specificity at 100%.

The concept of usufruct as an independent right, ius in re aliena, was not questioned in Justinian’s sources, while on the other hand, its systematisation, development, and legal nature in analyses of classical law were the subject of serious debates among Romance experts, mainly in Italian Romance studies from the beginning of the 20th century. Some experts in Romance studies understood usufruct as pars dominii, i.e. part of the property right that the owner retains for himself, thereby denying him the position of a special right. Such a concept originates from the glossator and post-glossator schools and, the paper analyses strong reflections of their teaching on contemporary legal doctrine. The paper deals with the concept and definition of usufruct and conducts analysis into the legal sources and reasons that led to differences in the understanding of the legal nature of the institute in the Roman legal tradition.

Skin sensitization is a crucial endpoint in the safety assessment of chemicals, with the Direct Peptide Reactivity Assay (DPRA) emerging as a valuable in chemico method for evaluating a substance's sensitization potential. This review delves into the principles, applicability, and limitations of the DPRA within the context of the Adverse Outcome Pathway (AOP) framework for skin sensitization. We examine the DPRA'srole in addressing the molecular initiating event of skin sensitization, its integration into Integrated Approaches to Testing and Assessment (IATA), and its performance in predicting sensitizers. The review also highlights the challenges in testing certain categories of chemicals and the importance of considering the DPRA's results alongside other complementary methods. By providing a comprehensive overview of the DPRA, this review aims to inform researchers, regulators, and clinicians about its utility and limitations in the context of skin sensitization testing.

Consumption of fish has increased in last 50 years. Fish as a food is changing red meat because it has unsaturated fat and it is the best source of omega 3 fatty acids. Beside it is full of minerals, vitamins and it has high biological value of proteins.The content of heavy metals in the muscle tissue of fish is directly related to the pollution of the water they come from The analysis of the content of heavy metals was done by the Institute of Public Health of the Federation of Bosnia and Herzegovina.The content of lead (Pb) in the tested samples of fresh fish ranged from 0.0015 to 0.0381 mg/kg. The measured content of cadmium (Cd) in the examined samples was in the range of 3.3*10-5 to 0.0053 mg/kg. The content of arsenic (As) in the tested samples ranged from 0.0085 to 1.1668 mg/kg. The mercury (Hg) content in the tested samples of fresh fish ranged from 0.0033 to 0.0991 mg/kg, which is within the allowed values prescribed by the Rulebook. It has been statistically proven that there is a significant difference in the measured values of lead, arsenic and cadmium in the samples of sea and freshwater fish. Aim of this work was to establish do the samples of fresh fish contain concentration of heavy metals more than concentrations prescribed in Rule book about allowed amounts of certain contaminants in food. Thereby ten samples of fresh fish were tested, five samples of marine fish and five samples of freshwater fish. Results showed that all samples of fish satisfy allowed concentration of heavy metals according to the Rule book.

We use the Kolmogorov-Arnold-Moser (KAM) theory to investigate the stability of solutions of a system of difference equations, a certain class of a generalized May's host-parasitoid model. We show the existence of the extinction, interior, and boundary equilibrium points and examine their stability. When the rate of increase of hosts is less than one, the zero equilibrium is globally asymptotically stable, which means that both populations are extinct. We thoroughly describe the dynamics of 1:1 non-isolated resonance fixed points and have used the KAM theory to determine the stability of interior equilibrium point. Also, we have conducted several numerical simulations to support our findings by using the software package Mathematica.

The process of deep sheet metal drawing is accepted in all industrial branches. This process is, therefore, very important to maintain a certain level of quality. For this reason, measurements and tests must be carried out to determine how much sheet metal deformation occurred after the deep drawing process. For this purpose, an experiment of deep drawing of sheet metal was carried out using the example of kitchen utensils. In addition, the Taguchi method was used in this experiment to test the quality of the obtained kitchenware. In the experiment, three factors were taken with three alternatives that affect the deep drawing of sheet metal, and 27 experiments were used for the Taguchi method. The results of this experiment showed that the best results were achieved by the smallest drawing depth of 65 mm and the worst results were obtained by the drawing thickness of 70 mm. Regarding the thickness of the material, the best results were achieved by the material of 21 mm, and the material of 15 mm achieved the worst results. In addition, an analysis of variance was carried out, which determined the relationship between force and deformation of the material.

Background: Thyroid dysfunction includes hyper- and hypofunction of the thyroid gland (hyperthyroidism and hypothyroidism). The spectrum encompasses both subclinical and clinical disease presentation. The etiology is vast and varied, as are the risk factors and simptoms. Objective: The main aim of the research is to indicate the leading symptom for initial thyroid hormone status evaluation, as well as to identify the distribution of positive and negative test results, and specific disorders according to sex and age groups. Methods: The research is designed as a retrospective, clinical, descriptive study. There were 500 participants included, 355 female and 145 male. Patients were referred to the Department of endocrinology by their primary care physicians. The data was collected through patient documentation. Results: The study included 500 participants, 71% of diagnostic requests made were for women. 80% of subjects had normal thyroid hormone status, p<0.001. Most requests were made for the 41-60 age group, p<0.001. Women had similar number of positive and negative test outcomes, as well as men. When it comes to the age groups, outcomes were similar in all of them, 15-23% positive and 77-85% negative. There were significant differences in the type of symptom expressed in both men and women, as well as all the age groups. Men reported high blood pressure as the most common symptom (30.3%), while women reported weight gain (22.3%). In the 18-25 and 26-40 age groups most common symptom belongs to the category of other. Age group of 41-60 reported weight gain as the most common symptom, while in participants older than 60, high blood pressure is proven to be the most common. Hypothyroidism is the most common disorder in both men and women, as well as in all age groups. Conclusion: It is statistically proven that there were more requests made for women, and older age groups. Leading symptom for initial thyroid hormone status evaluation is high blood pressure. There is no statistically significant difference in distribution of thyroid disorders according to sex or age groups.