Adresa za dopisivanje Dr. Samir Prohic Stomatoloski fakultet Sveucilista u Sarajevu Bolnicka 4a, 1000 Sarajevo sprohic@gmail.com Sažetak Koristiti se tvarima koje sprjecavaju resorpciju korijena bila bi alternativa slucajevima neuspjesnih replantacija zuba. Svrha: Željelo se ispitati otopinu alendronata (ALNa) kao intrakanalnog terapijskog sredstva za kasno reimplantirane zube. Materijali i postupci: Upotrijebljeni su zreli korjenovi mandibularnih premolara cetiriju pasa. Bili su endodontski tretirani, zatim ekstrahirani i suseni 45 minuta. Nakon toga su podijeljeni u dvije skupine: u prvoj skupini intrakanalno su ispirani otopinom 1mMola ALN-a te topikalnom aplikacijom ALN-a 1mMola; u drugoj skupini ucinjena je topikalna aplikacija ALN-a 1mMola. Zubi su replantirani u njihove odgovarajuce alveole. Životinje su žrtvovane cetiri mjeseca nakon reimplantacije te su uzorci procesirani za morfometrijsku i mikroskopsku analizu. Preostala korijenska masa mjerena je kako bi se dobio opseg gubitka strukture korjenova. Rezultati: Statisticka analiza bila je obavljena multiplim usporednim testom Scheffe F i pokazala je znatnu razliku između tretiranih skupina (p<0,005). Zakljucak: Rezultati upucuju na to da alendronati mogu smanjiti resorpciju korijena ako se primjenjuju u obliku intrakanalne i topikalne otopine i to mnogo uspjesnije nego kada se rabe samo kao topikalna otopina. Kljucne rijeci zub, replantacija; zub, korijen; zub, avulzija; alendronat Stomatoloski fakultet Sveucilista u Sarajevu, Bosna i Hercegovina School of Dental Medicine University of Sarajevo, Bosnia and Herzegovina

The aim of the study was to compare quantitative dermatoglyphic traits of two ethnic groups with different origin and customs, living on the same territory. The dermatoglyphic prints were collected from 800 inhabitants of the Dukagjin valley in southwest Kosovo, of Albanian (400) and Turkish (400) ethnic origin. The quantitative analysis comprised the number of ridges and triradii on the fingers, and the number of ridges in the interdigital areas on the palm (a-b, b-c, and c-d) as well as the size of the atd angle. The statistical analysis showed significant differences between the Albanian and the Turkish males for two fingers and pattern intensity index left, and on palms for a-b rc and c-d rc on both hands and b-c re on the left hand, and between females for six fingers and almost all palmar traits. Significant inter-population variations were observed for most palmar areas in both sexes but more pronouncedly in females. The differences found between the examined population groups show that admixture between Albanian and Turkish population in Kosovo has been small, and the Turks have retained their ethnic identity for several centuries.

Quality of life in patients with cervical cancer FIGO IIb stage after concomitant chemoradiotherapy Background. The literature reports are unclear regarding the quality of life in patients after the concomitant chemoradiotherapy. Our aim was to define and compare the quality of life of patients with cervical cancer FIGO IIb stage before and after the concomitant chemoradiotherapy. Methods. Nineteen patients were irradiated to 45 Gy in 25 fractions over 5 weeks to the pelvis and additional 20-24 Gy in 4-6 fractions were given by intracavitary high dosage rate (HDR) brachytherapy. Patients received 40 mg/m2 of cisplatin once a week, starting from the first day of the intracavitary brachytherapy treatment, which is a total of 4-6 cycles of cisplatin. Patients were surveyed with two questionnaires for the assessment of the quality of life. They were developed by the European Organisation for Research and Treatment of Cancer (EORTC): one was cancer specific (EORTC QLQ-C30) and one was site specific (EORTC QLQ-Cx24). Patients answered the questions for the period immediately before diagnosed cervical cancer (thus being a control group) and for the period starting 12 months after the completion of the concomitant chemoradiotherapy (thus being an experimental group). Results. A statistically significant difference between the median scores of these two groups has been found in the quality of life, role function, emotional function, social function, pain, fatigue and vaginal problems. Conclusions. The quality of life of patients with cervical cancer FIGO IIb stage was better after concomitant chemoradiotherapy than before it.

BackgroundSaturated brines are extreme environments of low diversity. Salinibacter ruber is the only bacterium that inhabits this environment in significant numbers. In order to establish the extent of genetic diversity in natural populations of this microbe, the genomic sequence of reference strain DSM 13855 was compared to metagenomic fragments recovered from climax saltern crystallizers and obtained with 454 sequencing technology. This kind of analysis reveals the presence of metagenomic islands, i.e. highly variable regions among the different lineages in the population.ResultsThree regions of the sequenced isolate were scarcely represented in the metagenome thus appearing to vary among co-occurring S. ruber cells. These metagenomic islands showed evidence of extensive genomic corruption with atypically low GC content, low coding density, high numbers of pseudogenes and short hypothetical proteins. A detailed analysis of island gene content showed that the genes in metagenomic island 1 code for cell surface polysaccharides. The strain-specific genes of metagenomic island 2 were found to be involved in biosynthesis of cell wall polysaccharide components. Finally, metagenomic island 3 was rich in DNA related enzymes.ConclusionThe genomic organisation of S. ruber variable genomic regions showed a number of convergences with genomic islands of marine microbes studied, being largely involved in variable cell surface traits. This variation at the level of cell envelopes in an environment devoid of grazing pressure probably reflects a global strategy of bacteria to escape phage predation.