A candidate identification questionnaire (CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a prospective, open-label, multicenter international study in patients with postmenopausal osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate for at least 3 months. Patients completed a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM) at baseline for 6 months. Scores were converted to composite satisfaction scores (CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in the treatment phase and comprised the intent-to-treat (ITT) population, and 630 completed the study. In the ITT population, 68.1% patients answered “yes” to one or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of life and overall satisfaction domains (p scores for the side effects domains were significant (p preferred the once-monthly dosing schedule and 563 patients (90.7%) found it more convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%), and upper abdominal pain (0.9%). Patients are likely to prefer treatment with monthly ibandronate to a weekly or monthly bisphosphonate irrespective of their stated preference before switching treatment.

We present a new approach to quantifying pole parameters of single-channel processes based on a Laurent expansion of partial-wave T-matrices in the vicinity of the real axis. Instead of using the conventional power-series description of the non-singular part of the Laurent expansion, we represent this part by a convergent series of Pietarinen functions. As the analytic structure of the non-singular part is usually very well known (physical cuts with branch points at inelastic thresholds, and unphysical cuts in the negative energy plane), we find that one Pietarinen series per cut represents the analytic structure fairly reliably. The number of terms in each Pietarinen series is determined by the quality of the fit. The method is tested in two ways: on a toy model constructed from two known poles, various background terms, and two physical cuts, and on several ∞

The division of responsibilities in complex states is a difficult issue. Of how these divisions depend on the organization of state administration at all levels of government. As Bosnia and Herzegovina is a complex state and thus its administration is very complex and diversified. Hence, Bosnia and Herzegovina has a large number of government agencies and organizations at all levels of government. Between these agencies and organizations, there is a relationship of cooperation and relations of mutual rights and obligations. Therefore, there is no hierarchical relationship except in the civil administration of the Republic of Srpska. The paper analyzes the status of state administration at all levels of government with regard to key administrative institutions.

Introduction: Psoriasis is a chronic inflammatory skin disease that affects about 2% of general population. Clinically, disease can present with cutaneous and nails lesions. Nail abnormalities can be seen in up to two-thirds of patients with psoriasis and both fingernails and toenails may be affected. Objective: The objectives of our study were to evaluate the frequency and clinical presentations of nail abnormalities in patients with psoriasis. Also, we aimed to find correlation between nail changes and some clinical parameters. Methods: One hundred and ten patients with psoriasis were included in this study. A detailed history and examination was recorded for all study subjects, including the age and gender of the patients, type of psoriasis, duration, and extent of disease. Finger and toe nails were clinically examined and nail changes were noted. In the case of clinically suspected of fungal infection, further mycological investigations were performed. Results: Nail abnormalities were present in 67 patients (60.9%) with psoriasis. Nail pitting was the most common lesion observed on fingernails, followed by discoloration of nail plate. Subungual hyperkeratosis of nail plates were significantly more frequent on the toenails. Positive mycological culture was in 14 (20.8%) psoriatic patients with nail involvement. Also, positive correlation between nail abnormalities and duration of psoriasis was found. Conclusions: Nail involvement is common in patients with psoriasis and accompanies skin lesions on the body surface. Pitting and subungual hyperkeratosis are the most frequent nail abnormality in psoriatic patients.

In this paper, we analyze the impact of nonlinear high-power amplifier (HPA) on the performance of cooperative network based on orthogonal frequency division multiplexing combined with time-division multiplexing (OFDM/TDM) using minimum mean-square-error frequency-domain combining (MMSE-FDC) in a frequency-selective fading channel. We design a novel MMSE-FDC weights while taking into account the nonlinearity of HPA at source and relay. Closed-form symbol error rate and outage probability expressions are derived while approximating the residual inter-slot interference after the MMSE-FDC as a random Gaussian variable. We discuss and address the nonlinear OFDM/TDM system design issues in cooperative network using the obtained simulation and theoretical results. We show that the OFDM/TDM with MMSE-FDC can be used to reduce the impact of nonlinear HPA on overall performance of cooperative network in comparison to OFDM while providing the target quality-of-service for reduced required signal-to-noise ratio. This is because OFDM/TDM with MMSE-FDC achieves frequency diversity in addition to cooperative diversity, while reduced peak-to-average power ratio makes it more robust on nonlinear degradation due to HPA saturation in comparison to conventional OFDM.